Drug
Lidocaine clinical trials
Also written Xylocaine, Lidoderm, ALGRX 3268 and Akten.
- studies test it
- 1,024
- open now
- 168
- in phase 3
- 149
- first study started
- 1997
Keep track of what changes. Save the Lidocaine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
1,019 studies that test it; most in 2024 (78); 2 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 1 |
| 2002 | 3 |
| 2003 | 4 |
| 2004 | 7 |
| 2005 | 14 |
| 2006 | 7 |
| 2007 | 21 |
| 2008 | 35 |
| 2009 | 22 |
| 2010 | 40 |
| 2011 | 45 |
| 2012 | 24 |
| 2013 | 37 |
| 2014 | 44 |
| 2015 | 46 |
| 2016 | 61 |
| 2017 | 46 |
| 2018 | 61 |
| 2019 | 65 |
| 2020 | 55 |
| 2021 | 57 |
| 2022 | 51 |
| 2023 | 70 |
| 2024 | 78 |
| 2025 | 69 |
| 2026 | 56 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 28
- Phase 1
- 56
- Phase 2
- 145
- Phase 3
- 149
- Phase 4
- 291
- No phase
- 412
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 42 · Other 982
Assiut University (31) · Cairo University (26) · Ain Shams University (21) · Mayo Clinic (10) · Copka Sonpashan (10) · Duke University (10) · Tanta University (9) · Northwestern University (8)
Often tested with
Tested in the same studies.
Dexmedetomidine (58) · Ketamine (43) · Bupivacaine (37) · Epinephrine (29) · Fentanyl (18) · Magnesium Sulfate (18) · Ropivacaine (17) · Propofol (16)
Studies
Open first, then newest update. How each study uses Lidocaine is read from its arms, and is right about nine times in ten.
Testing it · 1,024
- Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyRecruitingNot applicableCairo UniversityNCT07262242Written as Lidocaine (drug)
- This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.RecruitingPhase 4Northwell HealthNCT07889687Written as Lidocaine injection
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeRecruitingNot applicableCairo UniversityNCT07572994Written as Lidocaine 2 %
- Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck PainNot yet recruitingNot applicableMardin Artuklu UniversityNCT07876739Written as Lidocaine 1% Trigger Point Injection
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic SurgeryRecruitingPhase 3Centre Hospitalier Universitaire, AmiensNCT07414706Written as Lidocaine (intravenous infusion, perioperative)
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07877519Written as Lidocaine
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac SurgeryNot yet recruitingPhase 4Vanderbilt University Medical CenterNCT07224711Written as Lidocaine HCl 0.8% in D5W
- Pain Control During Hysterosalpingography: A Three-Arm Randomized TrialNot yet recruitingPhase 4Balikesir UniversityNCT07792668Written as Lidocaine %2 ampoule
- Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing TonsillectomyNot yet recruitingPhase 3Assiut UniversityNCT07871266Written as Lidocaine
- "Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study."Not yet recruitingPhase 3Nantes University HospitalNCT07869173Written as Lidocain
- Greater Occipital Nerve Block for Migraine With Medication Overuse HeadacheRecruitingNot applicableMahidol UniversityNCT07568496Written as Lidocaine 2% and Methylprednisolone 80 mg
- Opioid-Free Versus Opioid-Based Anesthesia in Thyroid SurgeryRecruitingNot applicableMalatya Egitim Ve Arastirma HastanesiNCT07864155Written as Dexmedetomidine and lidocaine
- Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache TreatmentRecruitingPhase 2Daniel A Tonetti, MDNCT07361549Written as Lidocaine (drug)
- Intravenous Lidocaine Infusion in Lumbar Fusion SurgeryRecruitingNot applicableAnkara City Hospital BilkentNCT07488832Written as Lidocaine
- Quality of Recovery After Primary Breast Cancer Surgery Comparing Thoracic Paravertebral Block and Intravenous Lidocaine Infusion.Not yet recruitingNot applicableMahidol UniversityNCT07823244Written as IV Lidocaine infusion
- MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAHNot yet recruitingPhase 2Rigshospitalet, DenmarkNCT07816159Written as Lidocaine hydrochloride
- Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell DiseaseRecruitingPhase 3Nantes University HospitalNCT07274254Written as Lidocain
- Intravenous Lidocaine for Postoperative Fatigue After Laparoscopic TAPP Inguinal Hernia RepairNot yet recruitingNot applicableHakan EmirkadıNCT07612839Written as Lidocaine
- ENDOTRACHEAL Tube LIDOCAINERecruitingEarly Phase 1Ohio State UniversityNCT07709390Written as 5% Lidocaine Ointment
- Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral NeuropathyNot yet recruitingPhase 4Wah Medical college , POF hospitalNCT07800468Written as Topical Lidocaine 2% Gel
See all 1,024 studies that test Lidocaine →
Given in every arm · 115 — Lidocaine is usual care beside what is tested
- Combined Ketorolac and Lidocaine Paracervical Block for Office HysteroscopyEnrolling by invitationPhase 1Icahn School of Medicine at Mount SinaiNCT06653400Written as Lidocaine
- Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After ThyroidectomyRecruitingPhase 4Pamukkale UniversityNCT07857356Written as Lidocaine %2 ampoule
- HPV Vaccine Reduced DoseRecruitingPhase 4Emory UniversityNCT06799494Written as Lidocaine injection
- Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the EyesNot yet recruitingPhase 3Prince of Wales Hospital, Shatin, Hong KongNCT07734740Written as Lignocaine 2% concentration solution
- Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture PatientsRecruitingNot applicableAin Shams UniversityNCT07687290Written as Xylocaine 2 %
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator PlacementRecruitingPhase 2Rush University Medical CenterNCT07487246Written as Lidocaine HCl 1%
- Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated CoagulationNot yet recruitingPhase 4NYU Langone HealthNCT07644923Written as Lidocaine
- A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox InjectionsNot yet recruitingPhase 4TriHealth Inc.NCT07387315Written as Standard Care for Bladder Botox Injection
- Particulate vs. Non-Particulate Steroid for Sacroiliac Joint InjectionRecruitingPhase 4University of New MexicoNCT06268704Written as 2% Lidocaine HCl Injection
- Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb SurgeryRecruitingPhase 4Fatima Memorial HospitalNCT07034300Written as Lidocaine (drug)
- The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic SurgeryNot yet recruitingPhase 1/2Ramathibodi HospitalNCT06983886Written as Lidocaine (drug)
- Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid SurgeryNot yet recruitingPhase 3Assiut UniversityNCT06789575Written as Lidocaine (drug)
- Is Combined Steroid and Sodium Hyaluronate Hydrodilatation More Effective Than Isolated Steroid Hydrodilatation in Treating Patients With Adhesive CapsulitisRecruitingNot applicableTaipei Veterans General Hospital, TaiwanNCT05861570Written as lidocaine hydrochloride
- Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional ProceduresCompletedNot applicableHarbin Medical UniversityNCT07035301Written as Lidocaine Intravenous Infusion
- Comparison of Ketorolac and Dexmedetomidine as An Adjunct to Lignocaine in Prevention of Tourniquet Induced Pain During Intravenous Regional AnesthesiaCompletedNot applicableMayo Hospital LahoreNCT07878962Written as Lidocaine
- Minimal Flow Anesthesia and Infection RiskCompletedNot applicableAnkara City Hospital BilkentNCT07092046Written as Lidocaine %2 ampoule
- Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal NeuralgiaCompletedPhase 4Nantes University HospitalNCT00851513Written as Lidocaine
- Comparison of the Effectiveness of Ultrasound-Guided Periradicular Injections in Patients With Lumbar Radicular PainActive, not recruitingNot applicableGaziler Physical Medicine and Rehabilitation Education and Research HospitalNCT07771374Written as Lidocaine Hydrochloride 2% Injection Solution
- Reducing Pain During Dental Nerve Block Injections in ChildrenCompletedNot applicableAl-Mustansiriyah UniversityNCT07667725Written as Lidocaine hydrochloride 2% with epinephrine 1:100 000
- Steroids in Occipital Nerve Block for Treatment of HeadacheCompletedPhase 4Mayo ClinicNCT05732532Written as Lidocaine
Showing 20 of 115.
As the comparator · 124 — what is tested is compared with Lidocaine
- Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic CholecystectomyNot yet recruitingPhase 4Assiut UniversityNCT07865455Written as Lidocaine
- Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural AnalgesiaRecruitingPhase 4Hadassah Medical OrganizationNCT06302257Written as Lidocaine
- Dexmedetomidine Versus Lidocaine for Optic Nerve Sheath Diameter During Craniotomy IntubationNot yet recruitingPhase 4Benha UniversityNCT07820540Written as Lidocaine
- Pain Control for Undergoing Costal Cartilage HarvestingRecruitingPhase 4Mayo ClinicNCT05285566Written as Xylocaine
- Needlefree Lidocaine Application for Vulvar BiopsiesNot yet recruitingNot applicableTufts Medical CenterNCT07793552Written as Lidocaine HCl 1%
- Cryotherapy vs Lidocaine Spray for Oral MucositisNot yet recruitingNot applicableHanady Jabbar MahmoodNCT07727031Written as Topical Lidocaine Spray
- Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKANot yet recruitingPhase 4Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)NCT07430085Written as Lidocaine (drug)
- Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.Not yet recruitingNot applicableMongi Slim HospitalNCT07632144Written as Lidocaine %2 ampoule
- Local Anesthetic Clinical TrialEnrolling by invitationPhase 4Baylor Research InstituteNCT07601750Written as Lidocaine
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal InjectionsEnrolling by invitationPhase 4Harrow IncNCT07456826Written as Lidocaine Hydrochloride Injection 2%
- Continous Infusion of Nefopam for Patients Undergoing PancreatoduodenectomyRecruitingPhase 4Iuliu Hatieganu University of Medicine and PharmacyNCT07423650Written as Lidocaine Infusion
- Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection PainNot yet recruitingNot applicableHayatabad Medical ComplexNCT07422558Written as Lidocaine
- Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic SurgeryRecruitingPhase 3Hans BahlmannNCT06349668Written as lidocaine infusion
- Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration RepairsRecruitingPhase 3Florida Atlantic UniversityNCT06910241Written as Lidocaine
- Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.RecruitingPhase 4Instituto Mexicano del Seguro SocialNCT07073846Written as Intravenous Lidocaine infusion + Standard Anesthesia
- Pain Control Alternatives in Pediatric Patients With Distal Radius FracturesRecruitingPhase 3State University of New York at BuffaloNCT07120763Written as Ketamine + Lidocaine
- Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic CholecystectomyRecruitingNot applicableDr. Waseem UllahNCT07192081Written as Lignocaine
- Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection PainNot yet recruitingPhase 4Baskent UniversityNCT07169227Written as Lidocaine %2 ampoule
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve GastrectomyNot yet recruitingNot applicableIVO JURISICNCT07084753Written as Lidocain
- Empathy Through Pain Control: Buffered Compared to Unbuffered 1% Lidocaine During IUD PlacementNot yet recruitingNot applicableUniversity of California, San DiegoNCT06974019Written as Lidocaine 1% Injectable Solution
Showing 20 of 124.
Codes
What other systems call Lidocaine · ClinicalTrials.gg INT007735
- MeSH (NLM) D008012LidocaineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 98PI200987LIDOCAINEConfirmed FDA, NLM, Wikidata
- RxNorm 6387Confirmed FDA, Wikidata
- Wikidata Q216935lidocaineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C614LidocaineOne source FDA
- DrugBank DB00281One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008012 | Lidocaine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 98PI200987 | LIDOCAINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6387 | — | Confirmed FDA, Wikidata |
| Wikidata | Q216935 | lidocaine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C614 | Lidocaine | One source FDA |
| DrugBank | DB00281 | — | One source Wikidata |
Also registered as lidocaine hydrochloride (UNII V13007Z41A · RxNorm 142440).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.