Pain, Procedural clinical trials
The registry lists 241 studies for Pain, Procedural across more than 10 countries. 64 are recruiting or about to start. 172 of them are mainly about Pain, Procedural (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
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Status
Who runs them
St. Justine's Hospital (9) · IRCCS Burlo Garofolo (7) · Istanbul Medeniyet University (5) · Nationwide Children's Hospital (4) · Akdeniz University (4) · Kaohsiung Medical University Chung-Ho Memorial Hospital (4) · Mersin University (4) · Marmara University (4)
What is being tested here
Drugs under test in Pain, Procedural studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fentanyl | 2 | 3 | 6 |
| Lidocaine | 1 | 6 | 11 |
| Ketamine | 1 | 2 | 4 |
| Dexmedetomidine | 1 | 1 | 3 |
| Remifentanil | 1 | 0 | 2 |
| Nitrous Oxide | 1 | 0 | 2 |
| Indomethacin | 1 | 0 | 1 |
| Nalbuphine | 1 | 0 | 1 |
| Ropivacaine | 1 | 0 | 1 |
| Magnesium Sulfate | 0 | 0 | 2 |
Drug classes tested here Opioids 4 open · Local anesthetics 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Distraction Cards Versus Emotion-Regulation Toy Squeezing During Intramuscular Vaccination in Preschool Children · Mersin University
- Nov 2026Impact of Virtual Reality in Hematology and Oncology During Invasive Procedures in Children, Adolescents and Young Adults, from 7 to Less Than 25 Years Old · Poitiers University Hospital
- Dec 2026A Study of the Impact of a Virtual Reality Medical Device (HypnoVR® Headset) on Anxiety and Pain in Interventional Radiology. · University Hospital, Clermont-Ferrand
- Dec 2026Oral Surgery Virtual Reality Glasses Study · Boston University
- Dec 2026The Effects of Endotracheal Suctioning on Pain and Serum Markers · Loma Linda University
- Dec 2026Cervical Preparation for Same-Day Dilation & Evacuation · Boston Medical Center
- Dec 2026RCT of Pain Perception With Fast and Slow Tenaculum Application · Women and Infants Hospital of Rhode Island
- Dec 2026Stress-Ball Distraction for Pain and Anxiety During Painful Procedures in Critically Ill Patients · Alexandria University
- Dec 2026Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural Analgesia · Ankara Etlik City Hospital
- Dec 2026Natural Sound Therapy on Procedural Pain and Anxiety During Negative Pressure Wound Therapy Dressing Changes · University of Basrah
Who these studies take
Of the 29 Pain, Procedural studies recruiting now, 13 (45%) set no upper age limit and 14 (48%) stop at 75 or younger. 14 (48%) take children under 18. 5 (17%) are for women only and 2 (7%) for men only; 5 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (17%) | 5 (17%) |
| 18 | 17 (59%) | 12 (41%) |
| 30 | 16 (55%) | 12 (41%) |
| 40 | 16 (55%) | 13 (45%) |
| 50 | 16 (55%) | 13 (45%) |
| 65 | 16 (55%) | 13 (45%) |
| 75 | 13 (45%) | 10 (34%) |
| 85 | 13 (45%) | 10 (34%) |
Across all 241 studies, recruiting or not: 70% stop at 75 or younger and 68% at 65; 64% take children; 8% are for women only and 2% for men only; 40% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pain, Procedural studies take
Of 141 interventional studies with no phase under Pain, Procedural, half reached primary completion within 7 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 7 mo3–15 · 141 studies | — | 7 mo3–15 · 141 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered9
- The Effect of 4-7-8 Breathing Exercises on Pain, Comfort, and Satisfaction During Intramuscular InjectionNov 10, 2026NCT07929883
- Effect of ShotBlocker and Warm Gel Pack on Heel Stick Pain in NewbornsNov 6, 2026NCT07921628
- Effects of Family-Proxy-Selected Natural Sound Therapy Versus Standardized Natural Sound and Noise Reduction on Procedural Pain During Endotracheal Suctioning in Non-Communicative Mechanically Ventilated Adults: A Four-Arm Randomized Controlled TrialNov 5, 2026NCT07920029
- Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural AnalgesiaNov 4, 2026NCT07916064
- Effect of Short-Video Distraction During Burn Dressing on Anxiety, Pain, and Fear in ChildrenOct 30, 2026NCT07906834
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- Virtual Reality for Pain and Anxiety During Surgical Uterine Evacuation After Early Pregnancy LossOct 30, 2026NCT07907679
- MOLI Technique and Virtual Reality Versus Conventional Venipuncture for Pain and Anxiety in ChildrenOct 16, 2026NCT07878117
- Effects of Binaural Beats on Pain and Anxiety During Flexible CystoscopyOct 16, 2026NCT07878182
- Comparison of Ketorolac and Dexmedetomidine as An Adjunct to Lignocaine in Prevention of Tourniquet Induced Pain During Intravenous Regional AnesthesiaOct 16, 2026NCT07878962
Studies
Recruiting first, then most recently updated. Showing 50 of 241. Browse all 241 → or search them.
- Effects of Family-Proxy-Selected Natural Sound Therapy Versus Standardized Natural Sound and Noise Reduction on Procedural Pain During Endotracheal Suctioning in Non-Communicative Mechanically Ventilated Adults: A Four-Arm Randomized Controlled TrialNot yet recruitingNCT07920029Not applicable1 country
- Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural AnalgesiaRecruitingNCT079160641 country
- Virtual Reality for Pain and Anxiety During Surgical Uterine Evacuation After Early Pregnancy LossNot yet recruitingNCT07907679Not applicable1 country
- Leg and Foot Massage for Pain in Newborns Receiving Heel StickNot yet recruitingNCT07893028Not applicable1 country
- Effect of Short-Video Distraction During Burn Dressing on Anxiety, Pain, and Fear in ChildrenNot yet recruitingNCT07906834Not applicable1 country
- Distraction Cards Versus Emotion-Regulation Toy Squeezing During Intramuscular Vaccination in Preschool ChildrenRecruitingNCT07669961Not applicable1 country
- Pain Control During Hysterosalpingography: A Three-Arm Randomized TrialNot yet recruitingNCT07792668Phase 4
- E-MOHS Trial of TENS and Vibration During Local AnesthesiaNot yet recruitingNCT07852455Not applicable1 country
- LI4 Acupuncture for Pain During Intrauterine Device InsertionNot yet recruitingNCT07854015Not applicable1 country
- Natural Sound Therapy on Procedural Pain and Anxiety During Negative Pressure Wound Therapy Dressing ChangesNot yet recruitingNCT07854717Not applicable1 country
- The Effect of Using a Stress Ball on Pain, Anxiety, and Vital Signs During Breast BiopsyRecruitingNCT07844395Not applicable1 country
- Stress-Ball Distraction for Pain and Anxiety During Painful Procedures in Critically Ill PatientsNot yet recruitingNCT07836842Not applicable
- Crochet Octopus in Reducing Procedural Pain During Heel Lance in Preterm NeonatesNot yet recruitingNCT07828795Not applicable
- Use of VR for Diagnostic HysteroscopyRecruitingNCT07173231Not applicable1 country
- Virtual Reality for Pain and Anxiety During HyFoSyNot yet recruitingNCT07816393Not applicable1 country
- VR-PAT and fNIRS to Identify CNS Biomarkers of PainNot yet recruitingNCT06303687Not applicable1 country
- Virtual Reality for Pain Control in US-Guided Obstetric Needle ProceduresRecruitingNCT07094451Not applicable1 country
- VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser ProceduresEnrolling by invitationNCT05645224Not applicable1 country
- Cold Spray and Helfer Skin Tap for Pain During Infant VaccinationNot yet recruitingNCT07779681Not applicable
- Virtual Reality (VR) Audiovisual Distraction to Reduce Pain and Anxiety for Prone Pain ProceduresNot yet recruitingNCT07779083Not applicable1 country
- THE EFFECT OF 'RHYTHMİC SKİN TAPPİNG' AND INTERNAL VİBRATİON APPLİED PROXİMAL TO THE PROCEDURE SİTE ON PAİN AND FEAR PERCEPTİON DURİNG PEDİATRİC PERİPHERAL VENİPUNCTURERecruitingNCT07650591Not applicable1 country
- TENS During Transperineal Prostate BiopsyRecruitingNCT07578324Not applicable1 country
- Comparison of Virtual Reality, EMLA Cream, and Standard Care for Pain During Blood Draws in ChildrenRecruitingNCT07763132Not applicable1 country
- The Effect of Kangaroo Care on Pain in Infants Receiving PhototherapyRecruitingNCT07761689Not applicable1 country
- Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the EDNot yet recruitingNCT07761637Not applicable1 country
- Effect of Multisensory Stimulation on Pain During Heel Lance in NewbornsRecruitingNCT07747649Not applicable1 country
- Virtual Reality for Pain and Fear in Children With BurnsNot yet recruitingNCT07740980Not applicable1 country
- VR-PAT During Home Burn Dressings - MultisiteEnrolling by invitationNCT05673551Not applicable1 country
- Offset Mechanisms in Evaluation of Lumbar Medial Branch BlocksRecruitingNCT05961800Not applicable1 country
- Oral Surgery Virtual Reality Glasses StudyRecruitingNCT06723158Not applicable1 country
- Pretibial TENS for Pain and Anxiety During Intravesical OnabotulinumtoxinA InjectionNot yet recruitingNCT07707791Not applicable
- Effect of 4-7-8 Breathing on AV Fistula Needle Pain in Dialysis PatientsNot yet recruitingNCT07700680Not applicable
- The Effects of Endotracheal Suctioning on Pain and Serum MarkersRecruitingNCT06692400Not applicable1 country
- Virtual Reality for Pain and Anxiety in Pediatric Dental TreatmentNot yet recruitingNCT07636330Not applicable1 country
- Cervical Preparation for Same-Day Dilation & EvacuationRecruitingNCT06799052Not applicable1 country
- Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm InfantsNot yet recruitingNCT07112430Phase 1/21 country
- A Study of the Impact of a Virtual Reality Medical Device (HypnoVR® Headset) on Anxiety and Pain in Interventional Radiology.Not yet recruitingNCT07668050Not applicable1 country
- TEAS for Sedation During ERCP: A Multicenter Trial With Mechanistic SubstudyNot yet recruitingNCT07440342Not applicable1 country
- Stress Ball and Empathic Verbal-Tactile Interventions for Reducing Anxiety and Pain in Mammography and Breast Ultrasonography: A Randomized TrialNot yet recruitingNCT07562828Not applicable
- Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in ChildrenNot yet recruitingNCT07548892Not applicable
- A Handheld Tool for Active Distraction of Children and Adolescents During Painful ProceduresRecruitingNCT06984939Not applicable1 country
- Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection PainNot yet recruitingNCT07422558Not applicable
- Palm Stimulator Use During Peripheral Venous CatheterizationNot yet recruitingNCT07387497Not applicable1 country
- Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of VasectomyRecruitingNCT05895383Phase 41 country
- The Effect of Two Different Interventions on Emotional State, Pain, and Fear During Respiratory Panel Removal in Children: A Randomized Controlled StudyEnrolling by invitationNCT07319806Not applicable1 country
- Procedural Sedation and Analgesia for Treatment of Adults With Fractures and Dislocations in the Emergency DepartmentRecruitingNCT073144501 country
- IM İnjection-PAIN-Cold Spray and Stress BallNot yet recruitingNCT07233694Not applicable1 country
- Ketamine as a Supplement to Local Anesthesia for Minor ProceduresRecruitingNCT06284473Phase 41 country
- Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm NeonatesRecruitingNCT07190625Early Phase 11 country
- Virtual Reality Adjunct for Procedural Pain and Anxiety Management in Burn Wound CareRecruitingNCT06913270Not applicable1 country