Postoperative Nausea and Vomiting clinical trials
The registry lists 638 studies for Postoperative Nausea and Vomiting across more than 10 countries. 110 are recruiting or about to start. 446 of them are mainly about Postoperative Nausea and Vomiting (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 764 studies for Postoperative Nausea and Vomiting. How that becomes 637 here
This page counts the studies the registry files under Postoperative Nausea and Vomiting, and those it files under no condition that list Postoperative Nausea and Vomitingthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 764Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −8List Postoperative Nausea and Vomiting as a condition, but the registry did not file them under itMost often written as “Post-Operative Nausea and Vomiting (PONV)” (3), “Post Operative Nausea and Vomiting (PONV)” (2), and “Incidence of Postoperative Nausea and Vomiting” (1). The registry filed them under other conditions only, most often Vomiting (8) and Tonsillitis (1).
- −120Match it another way57 name it in the title, 2 in a keyword, and 61 by a synonym or other text the search reads.
- 636Counted here and found by its search2 of them list Postoperative Nausea and Vomiting in their own words; the registry filed them under no condition.
- +1
Counted here, but its search does not find them
- 637The count on this page
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Who runs them
Assiut University (14) · Yonsei University (11) · Acacia Pharma Ltd (10) · Tanta University (7) · Cairo University (7) · Bezmialem Vakif University (6) · Insel Gruppe AG, University Hospital Bern (6) · Instituto do Cancer do Estado de São Paulo (6)
What is being tested here
Drugs under test in Postoperative Nausea and Vomiting studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 10 | 12 | 82 |
| Propofol | 4 | 0 | 9 |
| Dexmedetomidine | 3 | 2 | 17 |
| Ondansetron | 2 | 4 | 41 |
| Aprepitant | 2 | 4 | 27 |
| Amisulpride | 2 | 7 | 11 |
| Dexamethasone palmitate | 2 | 0 | 3 |
| Granisetron | 1 | 3 | 12 |
| Ketamine | 1 | 0 | 8 |
| Methylprednisolone | 1 | 0 | 5 |
Drug classes tested here Corticosteroids 11 open · Antiemetics 7 open · 5-HT3 antagonists 3 open · NK1 receptor antagonists 3 open · Local anesthetics 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children · Phase 3 · Arash Afshari
- Nov 2026Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer Surgery · Shanghai Chest Hospital
- Nov 2026Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain · Federal University of Bahia
- Nov 2026Dexamethasone Palmitate for PONV After Open Surgery · Beijing Tiantan Hospital
- Dec 2026Advancing Strategies to Optimize the PerIopeRativE Management of PostOperative Nausea and Vomiting (ASPIRE-PONV) Trial · Vanderbilt University Medical Center
- Dec 2026Aromatherapy in Reducing PONV for Total Joint Replacement Patients · Hong Kong Buddhist Hospital
- Dec 2026Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery · United States Naval Medical Center, Portsmouth
- Dec 2026Effects of taVNS Combined With Dexmedetomidine on POVN · Affiliated Hospital of Nantong University
- Dec 2026Post-operative Emesis and Pain Outcomes After Cesarean Delivery · KK Women's and Children's Hospital
- Dec 2026ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery · University of California, Davis
Who these studies take
Of the 65 Postoperative Nausea and Vomiting studies recruiting now, 22 (34%) set no upper age limit and 37 (57%) stop at 75 or younger. 14 (22%) take children under 18. 14 (22%) are for women only and 0 (0%) for men only; 11 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (8%) | 5 (8%) |
| 18 | 58 (89%) | 45 (69%) |
| 30 | 59 (91%) | 45 (69%) |
| 40 | 59 (91%) | 45 (69%) |
| 50 | 57 (88%) | 45 (69%) |
| 65 | 51 (78%) | 40 (62%) |
| 75 | 31 (48%) | 27 (42%) |
| 85 | 25 (38%) | 23 (35%) |
Across all 638 studies, recruiting or not: 56% stop at 75 or younger and 46% at 65; 16% take children; 27% are for women only and <1% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Postoperative Nausea and Vomiting studies take
Of 67 phase 4 interventional studies under Postoperative Nausea and Vomiting, half reached primary completion within 11 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 22 mo13–29 · 17 studies | — | — |
| Phase 3 | 12 mo6–27 · 22 studies | — | — |
| Phase 4 | 11 mo5–23 · 67 studies | — | 11 mo5–23 · 67 studies |
| Interventional, no phase | 13 mo5–26 · 181 studies | — | 13 mo5–26 · 181 studies |
| Observational | 11 mo4–37 · 52 studies | — | 11 mo4–37 · 52 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered5
- Comparison of Postoperative Pain, Nausea, and Vomiting Between Veress Needle and Direct Trocar Entry in Laparoscopic CholecystectomyNov 9, 2026NCT07924254
- Trigonelline Plus Sufentanil for Postoperative Analgesia After Laparoscopic Hysterectomy: A Randomized Controlled Clinical TrialNov 4, 2026NCT07914946
- Preoperative Gastric Volume and PONV in Pediatric Appendectomy CasesNov 4, 2026NCT07916077
- Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic SurgeryOct 23, 2026NCT07891312
- Binaural Beats and Postoperative Nausea and Vomiting in Laparoscopic CholecystectomyOct 16, 2026NCT07879274
Studies
Recruiting first, then most recently updated. Showing 50 of 638. Browse all 638 → or search them.
- Preoperative Gastric Volume and PONV in Pediatric Appendectomy CasesNot yet recruitingNCT079160771 country
- Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic SurgeryNot yet recruitingNCT07891312Not applicable
- Binaural Beats and Postoperative Nausea and Vomiting in Laparoscopic CholecystectomyNot yet recruitingNCT07879274Not applicable1 country
- Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus SurgeryNot yet recruitingNCT07871292Phase 4
- The Use of a Comfort Tote to Improve Recovery in Pediatric and Adolescent Patients After SurgeryRecruitingNCT07632833Not applicable1 country
- A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy AdultsRecruitingNCT07868861Phase 11 country
- The Effect of White and Pink Noise in Patients Undergoing Total Hip and Knee ArthroplastyNot yet recruitingNCT07858058Not applicable1 country
- Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic CholecystectomyRecruitingNCT07553143Not applicable1 country
- Effects of taVNS Combined With Dexmedetomidine on POVNRecruitingNCT07271147Not applicable1 country
- Opioid-Free Anesthesia in FESS: A Prospective ERAS StudyRecruitingNCT078123891 country
- Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.Not yet recruitingNCT07806162Not applicable
- Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic CholecystectomyRecruitingNCT07638527Phase 41 country
- Postoperative Nausea, Vomiting and Pain After Bariatric Surgery - a National Registry StudyRecruitingNCT077973741 country
- Remote Assessment of Pain and Recovery Quality After Surgery Using a Digital Form: A Pilot StudyNot yet recruitingNCT077942671 country
- Effect of a Multimodal Antiemetic Protocol on Postoperative Nausea and Vomiting in Patients Undergoing Flap Surgery for Head and Neck CancerNot yet recruitingNCT07786155Not applicable
- Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)Not yet recruitingNCT07777276Phase 42 countries
- Early PONV - a Registry Based Study in Sweden.RecruitingNCT044336761 country
- MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in ChildrenRecruitingNCT05541276Phase 31 country
- Recovery Trajectories After Propofol-Based Intravenous Anesthesia in Toddlers and Older ChildrenNot yet recruitingNCT07766629
- The PREVENT AGITATION Trial II - Children ≤1 YearRecruitingNCT05091242Phase 2/32 countries
- Risk Factors for Postoperative Nausea and Vomiting After Nasal Surgery Under General AnesthesiaNot yet recruitingNCT07749079
- Autonomic Neural Blockade in Bariatric SurgeryRecruitingNCT07104825Not applicable1 country
- Association Between Pain Catastrophizing and PONV in Laparoscopic Cholecystectomy PatientsRecruitingNCT077122111 country
- Effect of TEAS on PONV After Spinal SurgeryRecruitingNCT03187535Not applicable1 country
- Menstrual Status, Anesthetic Consumption, and PONVRecruitingNCT074562021 country
- Efficacy and Safety Between Tegileridine and Sufentanil in Laparoscopic Surgery Patients at High Risk of Postoperative Nausea and VomitingNot yet recruitingNCT07691086
- Recovery With Virtual Reality for Stress and PainNot yet recruitingNCT07679022Not applicable
- Catheter Redosing of Autonomic Neural Blockade After Sleeve GastrectomyNot yet recruitingNCT07655908Not applicable
- Effect of Lidocaine Through Gastric Tube on PONVRecruitingNCT07643298Not applicable1 country
- Use of Transcutaneous Electrical Nerve Stimulation Device, Reletex Reliefband, With Current ERAS (Enhanced Recovery After Surgery) Protocol to Further Decrease Postoperative Nausea and Vomiting in the Bariatric Surgical Patient Within the First 24 Hours Postoperatively.RecruitingNCT07063979Not applicable1 country
- Aprepitant to Improve Same Day Discharge for TKANot yet recruitingNCT07639723Phase 41 country
- Transauricular Vagus Nerve Stimulation Frequencies for Postoperative PainRecruitingNCT07633444Not applicable1 country
- Application of Multimodal Intervention in the Prevention of Postoperative Nausea and Vomiting After Gynecological Laparoscopic SurgeryNot yet recruitingNCT07631910Not applicable1 country
- Dexamethasone to Prevent Side Effects of Spinal Anesthesia in Cesarean DeliveryEnrolling by invitationNCT07615595Phase 41 country
- Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle SurgeryRecruitingNCT07479446Not applicable1 country
- Amisulpride for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic SurgeryNot yet recruitingNCT07554040
- Ginger to Prevent Nausea and Vomiting After Laparoscopic CholecystectomyRecruitingNCT07190495Phase 41 country
- Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis SurgeryRecruitingNCT06357234Phase 21 country
- Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic SurgeryRecruitingNCT075398311 country
- The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric PatientsRecruitingNCT07534956Not applicable1 country
- Dexmedetomidine for Improving Emergence Quality in Thyroid SurgeryRecruitingNCT07462195Phase 41 country
- Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer SurgeryRecruitingNCT07515027Not applicable1 country
- The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative OutcomesRecruitingNCT070229511 country
- Effectiveness of Unilateral Transversus Abdominis Plane (TAP) Block vs Bilateral TAP Block in Patients Undergoing Laparoscopic Cholecystectomy.Enrolling by invitationNCT07513012Not applicable1 country
- Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective ProceduresRecruitingNCT074884681 country
- TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk PatientsRecruitingNCT07480785Not applicable1 country
- Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative RecoveryNot yet recruitingNCT07469332Not applicable1 country
- Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean SectionRecruitingNCT07440667Not applicable1 country
- Intraoperative Pyloric Balloon Dilatation to Reduce Delayed Gastric Emptying After PPPDNot yet recruitingNCT07451392Not applicable
- Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General AnesthesiaRecruitingNCT072445751 country