Pulpitis clinical trials
The registry lists 316 studies for Pulpitis across more than 10 countries. 90 are recruiting or about to start. 280 of them are mainly about Pulpitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Pulpitis studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
Cairo University (59) · Postgraduate Institute of Dental Sciences Rohtak (25) · Ain Shams University (12) · Jamia Millia Islamia (10) · Suez Canal University (6) · Minia University (5) · Jordan University of Science and Technology (5) · Al-Azhar University (4)
What is being tested here
Drugs under test in Pulpitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 3 | 1 | 3 |
| Epinephrine | 1 | 0 | 3 |
| Diclofenac | 1 | 3 | 3 |
| Dexamethasone phosphate | 1 | 1 | 1 |
| Buffered Lidocaine | 1 | 0 | 1 |
| Prednisolone | 0 | 1 | 2 |
| Mineral trioxide aggregate | 0 | 0 | 2 |
| Carticaine | 0 | 0 | 2 |
| Lidocaine | 0 | 0 | 2 |
| Tricalcium silicate | 0 | 0 | 1 |
Drug classes tested here Corticosteroids 3 open · NSAIDs 1 open · Local anesthetics 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2027Submucosal Cryotherapy and Anti-inflammatory Drugs for Postoperative Pain Following Root Canal Treatment in Maxillary Molars · Phase 3 · Suez Canal University
- Nov 2026Effect of Intracanal Cryotherapy Versus Laser Application on Postoperative-pain and Bacterial Load Reduction in Single Visit Root Canal Treatment in Patients With Symptomatic Irreversible Pulpitis in Mandibular First Molar Teeth (Randomized Control Trial) · Future University in Egypt
- Nov 2026Clinical and Radiographic Evaluation of E-IodoCal in Primary Molar Pulpectomy · Tanta University
- Nov 2026Comparing Post Operative Pain With and Without Apical Patency Technique in Asymptomatic Irreversible Pulpitis Teeth · Bolan Medical Complex Hospital Quetta Pakistan
- Nov 2026This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. · Dow University of Health Sciences
- Nov 2026Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis · Dow University of Health Sciences
- Dec 2026Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment · Watim Medical & Dental College
- Dec 2026Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions · All India Institute of Medical Sciences
- Dec 2026R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis · University of Health Sciences Lahore
- Dec 2026Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment · Dow University of Health Sciences
Who these studies take
Of the 41 Pulpitis studies recruiting now, 9 (22%) set no upper age limit and 32 (78%) stop at 75 or younger. 19 (46%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 24 (59%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (10%) | 4 (10%) |
| 18 | 32 (78%) | 31 (76%) |
| 30 | 33 (80%) | 32 (78%) |
| 40 | 29 (71%) | 28 (68%) |
| 50 | 20 (49%) | 20 (49%) |
| 65 | 10 (24%) | 10 (24%) |
| 75 | 9 (22%) | 9 (22%) |
| 85 | 9 (22%) | 9 (22%) |
Across all 316 studies, recruiting or not: 81% stop at 75 or younger and 78% at 65; 36% take children; 1% are for women only and 1% for men only; 59% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pulpitis studies take
Of 15 phase 4 interventional studies under Pulpitis, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 8 mo5–13 · 15 studies | — | — |
| Interventional, no phase | 16 mo9–28 · 158 studies | — | 16 mo9–28 · 158 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 316. Browse all 316 → or search them.
- Submucosal Cryotherapy and Anti-inflammatory Drugs for Postoperative Pain Following Root Canal Treatment in Maxillary MolarsNot yet recruitingNCT07919938Phase 31 country
- Cost-Effectiveness of Upfront Supplemental Anaesthesia in Symptomatic Irreversible PulpitisNot yet recruitingNCT07907120Phase 41 country
- Effect of Menstrual Phase on the Anesthetic EfficacyRecruitingNCT07306533Not applicable1 country
- Effect of Ultrasonic and Diode Laser Activated Irrigation on Postoperative Pain Following Root Canal TreatmentRecruitingNCT07906808Not applicable1 country
- Clinical and Radiographic Evaluation of E-IodoCal in Primary Molar PulpectomyRecruitingNCT07883200Not applicable1 country
- Child's Behavior Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary MolarsRecruitingNCT07415694Not applicable1 country
- Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled TrialNot yet recruitingNCT07887087Not applicable
- Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical PeriodontitisNot yet recruitingNCT072890741 country
- Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible PulpitisRecruitingNCT07483788Not applicable1 country
- Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary TeethRecruitingNCT07386925Not applicable1 country
- "The Relationship Between Pulpal Inflammatory Marker Levels in Moderate and Severe Pulpitis and Outcome of Full Pulpotomy in Mandibular Molars With Extremely Deep Caries: A Prospective Cohort Study."RecruitingNCT07825415Not applicable1 country
- Outcome of Partial Pulpotomy in Permanent Mandibular Molars With Symptomatic Irreversible Pulpitis After Wound Lavage With Calcium Hypochlorite or Sodium HypochloriteRecruitingNCT07748676Not applicable1 country
- Comparing Post Operative Pain With and Without Apical Patency Technique in Asymptomatic Irreversible Pulpitis TeethNot yet recruitingNCT07648862Not applicable1 country
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis.Not yet recruitingNCT07264829Not applicable1 country
- Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic TreatmentNot yet recruitingNCT07699315Phase 4
- Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic RetreatmentRecruitingNCT07779148Not applicable1 country
- Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal TreatmentRecruitingNCT07759349Early Phase 11 country
- Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical PeriodontitisNot yet recruitingNCT07768852Not applicable
- Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Irreversible PulpitisRecruitingNCT06904781Not applicable2 countries
- Effect of Preoperative Diclofenac Potassium Dose on Endodontic PainNot yet recruitingNCT07743372Not applicable
- Comparative Evaluation of Direct Pulp Capping Between Deep and Extremely Deep Caries in Mature Permanent Mandibular Molars .RecruitingNCT07696702Not applicable1 country
- Hypertonic Saline as a Final Flush and Post-Operative Pain After Single Visit Root Canal Treatment in Mandibular Premolar.Not yet recruitingNCT07701551Phase 4
- Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With PulpitisRecruitingNCT07638254Not applicable1 country
- Influence of Proximal Caries on Outcome of Direct Pulp Capping in Permanent Mandibular Molars With Reversible PulpitisRecruitingNCT07578662Not applicable1 country
- Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in ChildrenRecruitingNCT07634900Not applicable1 country
- Salvadora Persica-Zinc Oxide Versus MTA as Pulpotomy Agents in Mature Permanent Molars With Irreversible PulpitisNot yet recruitingNCT07630181Not applicable1 country
- R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible PulpitisNot yet recruitingNCT07610057Not applicable1 country
- Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation ProtocolsNot yet recruitingNCT07546773Not applicable1 country
- The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious TissueRecruitingNCT058165251 country
- Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental CareNot yet recruitingNCT07533396
- Effects of Topical Anesthesia Approaches on Dental Pain During and After Restorative Management of Dental CariesNot yet recruitingNCT07379515Not applicable
- Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide AggregateNot yet recruitingNCT07522723Not applicable
- Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular IncisorsRecruitingNCT07517367Phase 41 country
- Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic BiomarkerRecruitingNCT07452614Not applicable1 country
- Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different ScaffoldsNot yet recruitingNCT07196683Not applicable1 country
- Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature Permanent TeethNot yet recruitingNCT07388862Early Phase 1
- Evaluation of Bacterial Reduction After Pulpectomy in Primary MolarsNot yet recruitingNCT07472751Not applicable1 country
- Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood.Not yet recruitingNCT07466095
- Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious LesionsNot yet recruitingNCT07302438Not applicable1 country
- Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy ControlsNot yet recruitingNCT074502351 country
- Postoperative Pain After Pulpectomy in Primary MolarsNot yet recruitingNCT07427420Not applicable1 country
- Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic RetreatmentsNot yet recruitingNCT07418840
- CGF Partial Pulpotomy Versus Endodontic TreatmentNot yet recruitingNCT07417098Not applicable1 country
- Postoperative Pain After Root Canal Obturation Using Bioceramic and Calcium Hydroxide SealersRecruitingNCT07410780Not applicable1 country
- Comparative Effectiveness in the Management of Irreversible PulpitisNot yet recruitingNCT04922229Not applicable1 country
- Comparative Evaluation of Indirect vs. Direct Pulp Capping in Deep Carious Mandibular MolarsRecruitingNCT06433297Not applicable1 country
- Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible PulpitisNot yet recruitingNCT07403578Not applicable
- Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible PulpitisNot yet recruitingNCT07300124Not applicable1 country
- Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of PremolarsNot yet recruitingNCT07281807Phase 4
- Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp SamplesNot yet recruitingNCT06938191