Complex Regional Pain Syndromes clinical trials

The registry lists 206 studies for Complex Regional Pain Syndromes across more than 10 countries. 55 are recruiting or about to start. 125 of them are mainly about Complex Regional Pain Syndromes (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Reflex Sympathetic Dystrophy too: 226 studies, 57 open.

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Status

Completed: 101
Recruiting: 39
Terminated: 19
Status unknown: 16
Not yet recruiting: 11
Withdrawn: 9

Phase

Phase 3: 22
Phase 2: 18
Phase 4: 8
Early Phase 1: 3
Phase 1: 3

Where

United States: 88
France: 17
Canada: 17
Turkey: 14
United Kingdom: 8
Korea, Republic of: 7

Who runs them

Stanford University (10) · Hospital for Special Surgery, New York (6) · Seoul National University (5) · Amgen (4) · The Cleveland Clinic (4) · Children's Hospital Medical Center, Cincinnati (3) · Ambros Therapeutics, Inc. (3) · McMaster University (3)

What is being tested here

Drugs under test in Complex Regional Pain Syndromes studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Neridronic acid	2	5	5
Ketamine	2	0	5
Naltrexone	2	0	2
Botulinum toxin type A	1	0	2
Medication	1	0	1
Prednisone	1	0	1
BRC-002	1	0	1
Lidocaine	0	1	5
HZT-501	0	3	3
Ascorbic Acid	0	1	2

Drug classes tested here Local anesthetics 7 · Opioids 4

Coming up

2phase 3 studies under way

16studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Dec 2026CSS-SR Validation Study · Hospital for Special Surgery, New York
Dec 2026Transcranial Magnetic Stimulation for Chronic Neuropathic Pain · University of California, San Francisco
Dec 2026Observational Study of Ketamine Infusions for the Treatment of Chronic Pain · Theresa Lii
Feb 2027Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients · Hospital for Special Surgery, New York
Feb 2027Transcutaneous Auricular Vagus Nerve Stimulation Added to Rehabilitation for Complex Regional Pain Syndrome Type I · Liv Hospital Vadistanbul
Mar 2027Neuro-modulation of Central Pain Pathways in Non Inflammatory Musculoskeletal Pain Syndrome · Istituto Giannina Gaslini
Apr 2027CRPS-Hand: Contrast + Compression vs Whirlpool · Ankara Etlik City Hospital
May 2027Prednisone for CRPS in Distal Radius Fracture · University of British Columbia
Jun 2027Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome · Polyclinique de l'Europe
Jun 2027ESWT for CRPS-I After Distal Radius Fracture · Dilek ün oguzhanasilturk

Who these studies take

Of the 39 Complex Regional Pain Syndromes studies recruiting now, 17 (44%) set no upper age limit and 16 (41%) stop at 75 or younger. 3 (8%) take children under 18. 1 (3%) are for women only and 0 (0%) for men only; 5 (13%) take healthy volunteers.

Recruiting studies that take each age, of 39
Age	Women	Men
10	2 (5%)	2 (5%)
18	31 (79%)	30 (77%)
30	36 (92%)	35 (90%)
40	36 (92%)	35 (90%)
50	35 (90%)	34 (87%)
65	34 (87%)	34 (87%)
75	27 (69%)	27 (69%)
85	19 (49%)	19 (49%)

Across all 206 studies, recruiting or not: 29% stop at 75 or younger and 16% at 65; 12% take children; 2% are for women only and 0% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Complex Regional Pain Syndromes studies take

Of 65 interventional studies with no phase under Complex Regional Pain Syndromes, half reached primary completion within 24 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	24 mo14–60 · 65 studies	—	24 mo14–60 · 64 studies
Observational	68 mo13–147 · 18 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 206. Browse all 206 → or search them.