Peripheral Nervous System Diseases clinical trials
The registry lists 476 studies for Peripheral Nervous System Diseases across more than 10 countries. 103 are recruiting or about to start. 177 of them are mainly about Peripheral Nervous System Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05. Counting its 40 narrower conditions too, such as Diabetic Foot: 5,937 studies, 1,435 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
NeurogesX (11) · Mayo Clinic (7) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Assiut University (6) · Washington University School of Medicine (6) · National Taiwan University Hospital (6) · M.D. Anderson Cancer Center (5) · National Institute of Neurological Disorders and Stroke (NINDS) (5)
What is being tested here
Drugs under test in Peripheral Nervous System Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Adezunap | 4 | 4 | 4 |
| Pregabalin | 2 | 5 | 7 |
| Duloxetine | 1 | 3 | 6 |
| Acetylcysteine | 1 | 0 | 3 |
| Immunoglobulin G | 1 | 1 | 3 |
| Venlafaxine | 1 | 0 | 2 |
| Mecobalamin | 1 | 1 | 2 |
| Immunoglobulins, Intravenous | 1 | 0 | 2 |
| Vitamin D | 1 | 0 | 2 |
| Amantadine | 1 | 0 | 1 |
Drug classes tested here SNRIs 2 open · Local anesthetics 7 · Opioids 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Apr 2027Neuroprotection of Memantine and Rosuvastatin · Phase 3 · Tanta University
- Jun 2027Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia · Phase 3 · Brainfarma Industria Química e Farmacêutica S/A
- Jul 2027A Phase 3 Study of NTLA-2001 in ATTRv-PN · Phase 3 · Intellia Therapeutics
- Nov 2026Exploring the Effects of Hand and Foot Exercise Intervention in Older Adults With Gynecological Cancer Receiving Chemotherapy Improvement of Peripheral Neuropathy and Quality of Life · Taipei Veterans General Hospital, Taiwan
- Dec 2026Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain · Dogwood Therapeutics Inc.
- Dec 2026Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends · Axogen Corporation
- Dec 2026This Study Aims to Investigate the Efficacy of Photobiomodulation in the Treatment of Anti-MAG-induced Peripheral Neuropathy (LASER-MAG) · Centre Hospitalier de Cornouaille
- Dec 2026Peripheral Neuropathy in Patients Receiving Enfortumab Vedotin and Pembrolizumab as First Line Treatment for Metastatic or Locally Advanced Urothelial Carcinoma · Comprehensive Cancer Center Munich (CCCM)
- Dec 2026The Role of TRP Channels in CIPN · Universitaire Ziekenhuizen KU Leuven
- Dec 2026Comparison of the Efficacy of Cryotherapy Combined With Compression in Preventing Neuropathy · Centre Antoine Lacassagne
Who these studies take
Of the 65 Peripheral Nervous System Diseases studies recruiting now, 44 (68%) set no upper age limit and 10 (15%) stop at 75 or younger. 8 (12%) take children under 18. 2 (3%) are for women only and 0 (0%) for men only; 10 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (9%) | 6 (9%) |
| 18 | 59 (91%) | 57 (88%) |
| 30 | 60 (92%) | 58 (89%) |
| 40 | 61 (94%) | 59 (91%) |
| 50 | 62 (95%) | 60 (92%) |
| 65 | 62 (95%) | 60 (92%) |
| 75 | 60 (92%) | 58 (89%) |
| 85 | 50 (77%) | 48 (74%) |
Across all 476 studies, recruiting or not: 25% stop at 75 or younger and 11% at 65; 10% take children; 9% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Peripheral Nervous System Diseases studies take
Of 20 phase 2 interventional studies under Peripheral Nervous System Diseases, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 26 mo13–49 · 20 studies | — | — |
| Interventional, no phase | 25 mo12–43 · 132 studies | — | 25 mo12–43 · 122 studies |
| Observational | 43 mo16–93 · 38 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Comparison of Wrist Splint Positions in Carpal Tunnel SyndromeNov 4, 2026NCT07458152
Stopped1
Newly registered2
- Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer PatientsOct 22, 2026NCT07889115
- Peripheral Neuropathy in Patients Receiving Enfortumab Vedotin and Pembrolizumab as Perioperative Systemic Therapy for Urothelial CarcinomaOct 13, 2026NCT07870577
Studies
Recruiting first, then most recently updated. Showing 50 of 476. Browse all 476 → or search them.
- Comparison of Wrist Splint Positions in Carpal Tunnel SyndromeRecruitingNCT07458152Not applicable1 country
- Study of Inherited Neurological DisordersRecruitingNCT000045682 countries
- Acupuncture and Exercise for EV-Pembro-Induced Peripheral NeuropathyRecruitingNCT07548476Not applicable1 country
- Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer PatientsNot yet recruitingNCT07889115Phase 2
- Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal CuffRecruitingNCT06127264Not applicable1 country
- The Effects of AFO Heel Height and Stiffness on GaitRecruitingNCT04800484Not applicable1 country
- Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal NeuralgiaRecruitingNCT05152368Phase 12 countries
- PT-112 in Subjects With Thymoma and Thymic CarcinomaRecruitingNCT05104736Phase 21 country
- Alternate Day Fasting After Surgery for Patients Undergoing ChemotherapyRecruitingNCT05990426Not applicable1 country
- Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial CancerRecruitingNCT07484022Phase 11 country
- Peripheral Neuropathy in Patients Receiving Enfortumab Vedotin and Pembrolizumab as Perioperative Systemic Therapy for Urothelial CarcinomaRecruitingNCT078705771 country
- Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord InjuryRecruitingNCT06330181Not applicable1 country
- Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance ProblemsRecruitingNCT06959277Not applicable1 country
- Activity Reduction vs Advice for Plantar Hotspots in DiabetesNot yet recruitingNCT07840300Not applicable1 country
- A Mixed-Methods Exploratory Pilot Study of the Investigational MYNERVA Leia Sensory Prosthesis in U.S. Adults With Peripheral NeuropathyNot yet recruitingNCT07840157Not applicable1 country
- Natural History Study for Charcot Marie Tooth DiseaseRecruitingNCT059023511 country
- Investigational Use of Neuromuscular UltrasoundRecruitingNCT052379731 country
- SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.RecruitingNCT06614322Phase 21 country
- Study Evaluating the Predictive Value of the Terminal Latency Index (TLI) for Treatment Response in Patients With Anti-MAG NeuropathyNot yet recruitingNCT077941371 country
- Desloratadine to Prevent Taxane-induced Peripheral Neuropathy in Patients With Breast CancerRecruitingNCT07109817Phase 21 country
- Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic PainRecruitingNCT076390601 country
- Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic NeuralgiaRecruitingNCT07712913Phase 31 country
- Randomized, Sham-Controlled Investigation of the Leia Sensory Prosthesis in Individuals With Peripheral NeuropathyRecruitingNCT07236515Not applicable1 country
- WIREDUP: Wearable Insoles for Recurrent Diabetic Ulcer PreventionRecruitingNCT05950659Not applicable1 country
- Randomized Clinical Investigation of Photobiomodulation (PBM) for the Management of Early Peripheral Neuropathy Related to Medical Oncologic TherapyNot yet recruitingNCT07681921Not applicable1 country
- Self-applied taVNS for CIPNRecruitingNCT07596030Not applicable1 country
- Wearable Sensory Prosthesis to Improve Coordination, Walking, and Physical ActivityRecruitingNCT07554443Not applicable1 country
- Sacituzumab Tirumotecan vs MMAE-ADCs in Advanced Urothelial Carcinoma (FUSCC-SPARE-UC-01)Not yet recruitingNCT07662863Phase 21 country
- Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Early-stage CancerNot yet recruitingNCT07663396Not applicable1 country
- This Study Aims to Investigate the Efficacy of Photobiomodulation in the Treatment of Anti-MAG-induced Peripheral Neuropathy (LASER-MAG)Enrolling by invitationNCT076616671 country
- Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel SyndromeNot yet recruitingNCT07654621Not applicable1 country
- Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer SurvivorsRecruitingNCT05582551Not applicable1 country
- Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Advanced CancerNot yet recruitingNCT07644533Not applicable1 country
- Assessment of Peripheral Neuropathy in Ankylosing SpondylitisNot yet recruitingNCT076419201 country
- Study of Peripheral Neuropathy in Patients With Advanced Urothelial Cancer Treated With Enfortumab Vedotin and Pembrolizumab With Supportive Neuridase (ENDEAVOR)Not yet recruitingNCT07629700Not applicable
- Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)RecruitingNCT07481149Phase 31 country
- Balance Rehabilitation With Modified Visual Input in Patients With NeuropathyRecruitingNCT03881930Not applicable1 country
- Physical Activity Level at Home in CMT1A Patients: Wearable Sensor AssessmentNot yet recruitingNCT075917791 country
- Prevention of Oxaliplatin-induced Nerve Damage in the Body's ExtremitiesRecruitingNCT05404230Not applicable1 country
- Efficacy of Extracorporeal Shockwave Therapy on Plantar Fasciitis in Patients With Peripheral NeuropathyNot yet recruitingNCT07587255Phase 2
- Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis TreatmentRecruitingNCT07477119Phase 41 country
- Effect of Hands and Feet Exercises on Taxane Based Chemotherapy Induced Peripheral Neuropathy in Patients With Solid TumorsNot yet recruitingNCT07321236Not applicable
- The Role of TRP Channels in CIPNRecruitingNCT04415892Not applicable1 country
- The Treatment of Painful Diabetic Neuropathy With DietRecruitingNCT07509671Not applicable1 country
- Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral NeuropathyRecruitingNCT07423390Phase 31 country
- Nerve Excitability in Cisplatin-Induced Peripheral NeuropathyRecruitingNCT07095998Not applicable1 country
- Cryocompression for CIPNRecruitingNCT07064798Not applicable1 country
- Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot StudyRecruitingNCT07501663Not applicable1 country
- Neuroprotection of Memantine and RosuvastatinNot yet recruitingNCT07504198Phase 2/31 country
- The Effect of Oral DLBS1033 in Patients With Diabetic PolyneuropathyNot yet recruitingNCT07475065Phase 2/31 country