Autonomic Nervous System Diseases clinical trials
The registry lists 108 studies for Autonomic Nervous System Diseases across more than 10 countries. 29 are recruiting or about to start. 36 of them are mainly about Autonomic Nervous System Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 12 narrower conditions too, such as Multiple System Atrophy: 949 studies, 272 open.
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Who runs them
National Institute of Neurological Disorders and Stroke (NINDS) (10) · Vanderbilt University Medical Center (4) · Johns Hopkins University (3) · Centre Hospitalier Universitaire de Saint Etienne (3) · University of California, Los Angeles (2) · University of Calgary (2) · RWTH Aachen University (2) · Brigham and Women's Hospital (2)
What is being tested here
Drugs under test in Autonomic Nervous System Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Droxidopa | 1 | 1 | 4 |
| Guanfacine | 1 | 0 | 1 |
| Cromolyn | 1 | 0 | 1 |
| Beet juice | 1 | 0 | 1 |
| Albuterol | 1 | 0 | 1 |
| Ipratropium | 1 | 0 | 1 |
| Propranolol | 0 | 0 | 3 |
| Phenylephrine | 0 | 0 | 2 |
| Isoproterenol | 0 | 0 | 2 |
| Esmolol | 0 | 0 | 2 |
Drug classes tested here Bronchodilators 1 open · Beta blockers 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Modafinil and Cognitive Function in POTS · Vanderbilt University Medical Center
- Dec 2026Dysautonomia in Children With Type 1 Diabetes · Centre Hospitalier Universitaire de Saint Etienne
- Dec 2026Blood Pressure Effects on Cognition and Brain Blood Flow in PD · University of California, San Diego
- Feb 2027Autoimmune Basis for Postural Tachycardia Syndrome · Vanderbilt University Medical Center
- Sep 2027NightWare and Cardiovascular Health in Veterans With PTSD · VA Office of Research and Development
Who these studies take
Of the 21 Autonomic Nervous System Diseases studies recruiting now, 6 (29%) set no upper age limit and 12 (57%) stop at 75 or younger. 6 (29%) take children under 18. 3 (14%) are for women only and 0 (0%) for men only; 8 (38%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (24%) | 5 (24%) |
| 18 | 14 (67%) | 12 (57%) |
| 30 | 15 (71%) | 14 (67%) |
| 40 | 15 (71%) | 14 (67%) |
| 50 | 17 (81%) | 15 (71%) |
| 65 | 14 (67%) | 13 (62%) |
| 75 | 9 (43%) | 9 (43%) |
| 85 | 8 (38%) | 8 (38%) |
Across all 108 studies, recruiting or not: 50% stop at 75 or younger and 44% at 65; 25% take children; 6% are for women only and 2% for men only; 39% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Autonomic Nervous System Diseases studies take
Of 39 interventional studies with no phase under Autonomic Nervous System Diseases, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 17 mo5–49 · 39 studies | — | 17 mo5–49 · 39 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 108. Browse all 108 → or search them.
- Guanfacine and Cromolyn Sodium for POTS: The DBPOTS TrialNot yet recruitingNCT07757555Early Phase 11 country
- Effect of Ivabradine on Adolescent DysautonomiaNot yet recruitingNCT07881302Phase 21 country
- Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid HemorrhageNot yet recruitingNCT07577739Not applicable1 country
- NightWare and Cardiovascular Health in Veterans With PTSDRecruitingNCT06419959Not applicable1 country
- NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes DiseaseRecruitingNCT07398508Phase 1/21 country
- Data Collection of Standard Care of Patients in the EMG SectionRecruitingNCT050413871 country
- Hydroxyephedrine PET/CT in Sympathetic Nervous System DiseaseRecruitingNCT069519841 country
- Blood Pressure Effects on Cognition and Brain Blood Flow in PDRecruitingNCT05400174Not applicable1 country
- Non-Invasive Bioelectronic AnalyticsEnrolling by invitationNCT041004861 country
- Structured Combined Exercise Program in Postmenopausal Women: Effects on Heart Rate Variability and Menopausal SymptomsRecruitingNCT07615790Not applicable1 country
- Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal PainNot yet recruitingNCT07409363Not applicable1 country
- Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia SyndromeRecruitingNCT04271878Not applicable1 country
- Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 DiabetesNot yet recruitingNCT07560800Not applicable1 country
- Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant BradycardiaRecruitingNCT07468383Not applicable1 country
- Dysautonomia in Children With Type 1 DiabetesRecruitingNCT07455994Not applicable1 country
- Personalized Brain Stimulation to Treat Chronic Concussive SymptomsRecruitingNCT06073886Phase 21 country
- Autonomic Reactivity and Personalized NeurostimulationRecruitingNCT06863207Not applicable1 country
- Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary DiseaseRecruitingNCT048498061 country
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT048066201 country
- POLish Registry of CArdioneuroablation and CArdioneuromodulationRecruitingNCT071963971 country
- Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ)Not yet recruitingNCT06672861Not applicable1 country
- The Long COVID-19 Wearable Device StudyRecruitingNCT05741112Not applicable1 country
- Effects of Osteopathic Technique on Autonomic Nervous System ActivityRecruitingNCT06554834Not applicable1 country
- Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in ChildrenRecruitingNCT058075551 country
- Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus NervesNot yet recruitingNCT06271005Not applicable
- Role of Parasympathetic Activity in Mild to Severe Asthma With Fixed Airway Obstruction (PARASMA Study)RecruitingNCT05550402Not applicable1 country
- Essential Hypotension and Allostasis RegistryRecruitingNCT020184971 country
- Physiotherapy for Persistent Function by Superficial NeuromodulationRecruitingNCT05681455Not applicable1 country
- Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled TrialRecruitingNCT05855356Not applicable1 country
- Autoimmune Basis for Postural Tachycardia SyndromeActive, not recruitingNCT02725060Not applicable1 country
- Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex MechanismsCompletedNCT07536997Not applicable1 country
- Neuro-Emotional Release: Veins and Endocrine System (NERVE) Therapy for Children With DysautonomiaCompletedNCT074812921 country
- Prevalence of Chapman Reflex Points in Medical Students and Their Association With Visceral SymptomsCompletedNCT076911121 country
- The Effect of Reading Therapy on NewbornsActive, not recruitingNCT05004857Not applicable1 country
- NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn SyndromeCompletedNCT04977388Phase 1/21 country
- Programming Aquatic Therapy for POTSCompletedNCT07182578Not applicable1 country
- Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational StudyCompletedNCT04527198Not applicable1 country
- Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19Active, not recruitingNCT07405515Not applicable1 country
- Modafinil and Cognitive Function in POTSActive, not recruitingNCT01988883Early Phase 11 country
- Screening for Alterations in the Autonomic Nervous SystemCompletedNCT07029191Not applicable1 country
- Diagnostic Accuracy of The Water Immersion Wrinkle Test for Small Fiber NeuropathyCompletedNCT072555731 country
- Vagus Nerve Stimulation for Systemic Lupus ErythematousCompletedNCT05315739Not applicable1 country
- Biomarkers of Risk of Parkinson DiseaseCompletedNCT007758531 country
- Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Long COVIDCompletedNCT05638620Phase 11 country
- VNS for Long-COVID-19CompletedNCT05630040Not applicable1 country
- HUTT to Assess Cardiac Autonomic Nervous FunctionStatus unknownNCT062369451 country
- Randomised Clinical Trial to Determine the Effect of Vagus Nerve Neurodynamics on the Neurovegetative Nerve System in People With Chronic Stress.CompletedNCT06499662Not applicable1 country
- Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) DysautonomiaCompletedNCT05566379Not applicable1 country
- Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient OutcomesCompletedNCT06390748Phase 21 country
- Dysautonomia and Systemic Interactions in Traumatic Brain InjuryActive, not recruitingNCT055156401 country