An interventional study of usual treatment with compression garments (CERECARE) and usual treatment without compression garments (CERECARE) in Complex Regional Pain Syndromes, sponsored by Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-10-06.
Sponsored by Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape · Not applicable, Interventional, and Treatment
The aim is to study another alternative for the treatment of pain in people with CRPS. Indeed, the TRAB / Medullary occupational therapy department of the CMRRF in Kerpape used compression garments to reduce edema when it was present.In the case of CRPS of the upper limbs, gloves or compression sleeves are used to decrease the edema which is sometimes associated, although they are not supported for this indication. In this context, our clinical experience leads us to believe that there would also be some efficacy in neuropathic pain, this improvement being regularly described by patients.This study is expected to show a notable reduction in neuropathic pain thanks to the wearing of a compression garment.
205 studies on the registry are indexed under Complex Regional Pain Syndromes; 55 are open to participants now.
This study's planned enrollment of 60 is above the median of 40 across 152 interventional studies indexed under Complex Regional Pain Syndromes.
Browse Complex Regional Pain Syndromes studies →Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape is the lead sponsor of 10 studies on the registry; 6 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Patients with CRPS of the upper limb with neuropathic pain
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Childbearing potential
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Usual care in day hospitals, i.e. 3 occupational therapy sessions / week for 3 months, with the usual protocol of desensitization by Aquaroll (hydro-massage ball device) and by Vibralgic (device generating electronic transcutaneous vibrations) + wearing a compression garment for 3 months.
Device: usual treatment with compression garments (CERECARE)
Usual care in day hospitals, i.e. 3 occupational therapy sessions / week for 3 months, with the usual protocol of desensitization by Aquaroll (hydro-massage ball device) and by Vibralgic (device generating electronic transcutaneous vibrations).
Other: usual treatment without compression garments (CERECARE)
For 3 months, the pain will be assessed every week, tolerance and compliance with compression garments will also be monitored. Participants will be reviewed specifically at a follow-up consultation for the 6-month and 1-year study. Various assessments will be carried out during these visits : assessment of pain, range of motion, muscle strength, sensitivity test, assessment of anxiety, depression and even quality of life.
For 3 months, the pain will be assessed every week, tolerance and compliance with compression garments will also be monitored. Participants will be reviewed specifically at a follow-up consultation for the 6-month and 1-year study. Various assessments will be carried out during these visits : assessment of pain, range of motion, muscle strength, sensitivity test, assessment of anxiety, depression and even quality of life.
The evolution of pain through Visual Analog Scale (VAS), measured every week for 3 months in the last 24 hours and in the last 7 days
The VAS is a self-rated scale. It comes in the form of a 10 cm plastic ruler graduated in mm. On the face presented to the patient is a cursor which he moves along a straight line, one end of which corresponds to "No pain" and the other to "Maximum pain imaginable". The patient should, along this line, position the cursor where the pain is best located. On the other side, there are millimeter graduations seen only by the caregiver. The position of the cursor mobilized by the patient makes it possible to read the intensity of the pain, which is measured in mm.
Time frame: up to 3 months
Visual Analog Scale (VAS)
The VAS is a self-rated scale. It comes in the form of a 10 cm plastic ruler graduated in mm. On the face presented to the patient is a cursor which he moves along a straight line, one end of which corresponds to "No pain" and the other to "Maximum pain imaginable". The patient should, along this line, position the cursor where the pain is best located. On the other side, there are millimeter graduations seen only by the caregiver. The position of the cursor mobilized by the patient makes it possible to read the intensity of the pain, which is measured in mm.
Time frame: At 6 months
Visual Analog Scale (VAS)
The VAS is a self-rated scale. It comes in the form of a 10 cm plastic ruler graduated in mm. On the face presented to the patient is a cursor which he moves along a straight line, one end of which corresponds to "No pain" and the other to "Maximum pain imaginable". The patient should, along this line, position the cursor where the pain is best located. On the other side, there are millimeter graduations seen only by the caregiver. The position of the cursor mobilized by the patient makes it possible to read the intensity of the pain, which is measured in mm.
Time frame: At 1 year
Neuropathic Pain Symptom Inventory (NPSI)
It's a tool developed and validated in French, composed of 12 items. It provides an overall score and 5 sub-scores
Time frame: Day 0
Neuropathic Pain Symptom Inventory (NPSI)
It's a tool developed and validated in French, composed of 12 items. It provides an overall score and 5 sub-scores
Time frame: At 1,5 months
Neuropathic Pain Symptom Inventory (NPSI)
It's a tool developed and validated in French, composed of 12 items. It provides an overall score and 5 sub-scores
Time frame: At 3 months
Neuropathic Pain Symptom Inventory (NPSI)
It's a tool developed and validated in French, composed of 12 items. It provides an overall score and 5 sub-scores
Time frame: At 6 months
Neuropathic Pain Symptom Inventory (NPSI)
It's a tool developed and validated in French, composed of 12 items. It provides an overall score and 5 sub-scores
Time frame: At 1 year
Modification of analgesic drug treatment
The increase or decrease in doses between each visit will be collected by the doctor. He can rely on the booklet filled out by the patient.
Time frame: Day 0
Modification of analgesic drug treatment
The increase or decrease in doses between each visit will be collected by the doctor. He can rely on the booklet filled out by the patient.
Time frame: At 1,5 months
Modification of analgesic drug treatment
The increase or decrease in doses between each visit will be collected by the doctor. He can rely on the booklet filled out by the patient.
Time frame: At 3 months
Modification of analgesic drug treatment
The increase or decrease in doses between each visit will be collected by the doctor. He can rely on the booklet filled out by the patient.
Time frame: At 6 months
Modification of analgesic drug treatment
The increase or decrease in doses between each visit will be collected by the doctor. He can rely on the booklet filled out by the patient.
Time frame: At 1 year
Measurement of range of motion
The range of motion is measured exploratory at different levels, for both sides: * Wrist range of motion, measured using posture foam and goniometer. This measures the amplitude in flexion, extension, radial tilt, ulnar tilt, and pronation and supination, both passively and actively. * Pulp-palm and pulp palmar fold distances of the fingers, measured using wedges of different lengths. One measurement is made per finger * Kapandji score, which is a score out of 10 based on achievable opposition for the thumb. 0 being the lowest score and 10 a normal score.
Time frame: Day 0
Measurement of range of motion
The range of motion is measured exploratory at different levels, for both sides: * Wrist range of motion, measured using posture foam and goniometer. This measures the amplitude in flexion, extension, radial tilt, ulnar tilt, and pronation and supination, both passively and actively. * Pulp-palm and pulp palmar fold distances of the fingers, measured using wedges of different lengths. One measurement is made per finger * Kapandji score, which is a score out of 10 based on achievable opposition for the thumb. 0 being the lowest score and 10 a normal score.
Time frame: At 1,5 months
Measurement of range of motion
The range of motion is measured exploratory at different levels, for both sides: * Wrist range of motion, measured using posture foam and goniometer. This measures the amplitude in flexion, extension, radial tilt, ulnar tilt, and pronation and supination, both passively and actively. * Pulp-palm and pulp palmar fold distances of the fingers, measured using wedges of different lengths. One measurement is made per finger * Kapandji score, which is a score out of 10 based on achievable opposition for the thumb. 0 being the lowest score and 10 a normal score.
Time frame: At 3 months
Measurement of range of motion
The range of motion is measured exploratory at different levels, for both sides: * Wrist range of motion, measured using posture foam and goniometer. This measures the amplitude in flexion, extension, radial tilt, ulnar tilt, and pronation and supination, both passively and actively. * Pulp-palm and pulp palmar fold distances of the fingers, measured using wedges of different lengths. One measurement is made per finger * Kapandji score, which is a score out of 10 based on achievable opposition for the thumb. 0 being the lowest score and 10 a normal score.
Time frame: At 6 months
Measurement of range of motion
The range of motion is measured exploratory at different levels, for both sides: * Wrist range of motion, measured using posture foam and goniometer. This measures the amplitude in flexion, extension, radial tilt, ulnar tilt, and pronation and supination, both passively and actively. * Pulp-palm and pulp palmar fold distances of the fingers, measured using wedges of different lengths. One measurement is made per finger * Kapandji score, which is a score out of 10 based on achievable opposition for the thumb. 0 being the lowest score and 10 a normal score.
Time frame: At 1 year
Measurement of muscle strength in both hands
* the JAMAR® hydraulic hand dynamometer: measurement of the gripping force in kilograms * the PINCH® hydraulic pinch gauge: measures the pinch force in kilograms
Time frame: Day 0
Measurement of muscle strength in both hands
* the JAMAR® hydraulic hand dynamometer: measurement of the gripping force in kilograms * the PINCH® hydraulic pinch gauge: measures the pinch force in kilograms
Time frame: At 1,5 months
Measurement of muscle strength in both hands
* the JAMAR® hydraulic hand dynamometer: measurement of the gripping force in kilograms * the PINCH® hydraulic pinch gauge: measures the pinch force in kilograms
Time frame: At 3 months
Measurement of muscle strength in both hands
* the JAMAR® hydraulic hand dynamometer: measurement of the gripping force in kilograms * the PINCH® hydraulic pinch gauge: measures the pinch force in kilograms
Time frame: At 6 months
Measurement of muscle strength in both hands
* the JAMAR® hydraulic hand dynamometer: measurement of the gripping force in kilograms * the PINCH® hydraulic pinch gauge: measures the pinch force in kilograms
Time frame: At 1 year
Measurement of hand circumference
The circumference of the hand is measured in different places. A total of 15 measurements are taken. Both hands are measured. The analysis will be based on the difference of the sum of the 15 measures for each of the hands.
Time frame: Day 0
Measurement of hand circumference
The circumference of the hand is measured in different places. A total of 15 measurements are taken. Both hands are measured. The analysis will be based on the difference of the sum of the 15 measures for each of the hands.
Time frame: At 1,5 months
Measurement of hand circumference
The circumference of the hand is measured in different places. A total of 15 measurements are taken. Both hands are measured. The analysis will be based on the difference of the sum of the 15 measures for each of the hands.
Time frame: At 3 months
Measurement of hand circumference
The circumference of the hand is measured in different places. A total of 15 measurements are taken. Both hands are measured. The analysis will be based on the difference of the sum of the 15 measures for each of the hands.
Time frame: At 6 months
Measurement of hand circumference
The circumference of the hand is measured in different places. A total of 15 measurements are taken. Both hands are measured. The analysis will be based on the difference of the sum of the 15 measures for each of the hands.
Time frame: At 1 year
Saint-Antoine Pain Questionnaire (QDSA)
Illustrating the different components of pain, the QDSA (French version of the Mac Gill Pain Questionnary-MPQ) essentially allows a qualitative assessment of chronic pain, in particular neuropathic pain. It is a questionnaire of 58 qualifying words divided into subclasses: sensory pain on the one hand, affective and emotional pain on the other. The patient is asked to select the adjectives corresponding to his pain and then to note them from 0 (absent) to 4 (very strong). This self-assessment scale makes it possible in clinical practice to specify the involvement of the sensory and the emotional in pain intensity.
Time frame: Day 0
Saint-Antoine Pain Questionnaire (QDSA)
Illustrating the different components of pain, the QDSA (French version of the Mac Gill Pain Questionnary-MPQ) essentially allows a qualitative assessment of chronic pain, in particular neuropathic pain. It is a questionnaire of 58 qualifying words divided into subclasses: sensory pain on the one hand, affective and emotional pain on the other. The patient is asked to select the adjectives corresponding to his pain and then to note them from 0 (absent) to 4 (very strong). This self-assessment scale makes it possible in clinical practice to specify the involvement of the sensory and the emotional in pain intensity.
Time frame: At 1,5 months
Saint-Antoine Pain Questionnaire (QDSA)
Illustrating the different components of pain, the QDSA (French version of the Mac Gill Pain Questionnary-MPQ) essentially allows a qualitative assessment of chronic pain, in particular neuropathic pain. It is a questionnaire of 58 qualifying words divided into subclasses: sensory pain on the one hand, affective and emotional pain on the other. The patient is asked to select the adjectives corresponding to his pain and then to note them from 0 (absent) to 4 (very strong). This self-assessment scale makes it possible in clinical practice to specify the involvement of the sensory and the emotional in pain intensity.
Time frame: At 3 months
Saint-Antoine Pain Questionnaire (QDSA)
Illustrating the different components of pain, the QDSA (French version of the Mac Gill Pain Questionnary-MPQ) essentially allows a qualitative assessment of chronic pain, in particular neuropathic pain. It is a questionnaire of 58 qualifying words divided into subclasses: sensory pain on the one hand, affective and emotional pain on the other. The patient is asked to select the adjectives corresponding to his pain and then to note them from 0 (absent) to 4 (very strong). This self-assessment scale makes it possible in clinical practice to specify the involvement of the sensory and the emotional in pain intensity.
Time frame: At 6 months
Saint-Antoine Pain Questionnaire (QDSA)
Illustrating the different components of pain, the QDSA (French version of the Mac Gill Pain Questionnary-MPQ) essentially allows a qualitative assessment of chronic pain, in particular neuropathic pain. It is a questionnaire of 58 qualifying words divided into subclasses: sensory pain on the one hand, affective and emotional pain on the other. The patient is asked to select the adjectives corresponding to his pain and then to note them from 0 (absent) to 4 (very strong). This self-assessment scale makes it possible in clinical practice to specify the involvement of the sensory and the emotional in pain intensity.
Time frame: At 1 year
Cartographic assessment of pain
The cartographic assessment of pain is carried out following the QDSA. Using schematic representations of the hand (dorsal face and palmar face for each hand), the patient locates and describes his pain.
Time frame: Day 0
Cartographic assessment of pain
The cartographic assessment of pain is carried out following the QDSA. Using schematic representations of the hand (dorsal face and palmar face for each hand), the patient locates and describes his pain.
Time frame: At 1,5 months
Cartographic assessment of pain
The cartographic assessment of pain is carried out following the QDSA. Using schematic representations of the hand (dorsal face and palmar face for each hand), the patient locates and describes his pain.
Time frame: At 3 months
Cartographic assessment of pain
The cartographic assessment of pain is carried out following the QDSA. Using schematic representations of the hand (dorsal face and palmar face for each hand), the patient locates and describes his pain.
Time frame: At 6 months
Cartographic assessment of pain
The cartographic assessment of pain is carried out following the QDSA. Using schematic representations of the hand (dorsal face and palmar face for each hand), the patient locates and describes his pain.
Time frame: At 1 year
Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire
This is a subjective self-assessment questionnaire of the overall functional capacity of the two upper limbs, composed of 30 items, rated from 1 to 5 depending on the difficulty of the task described, leading to a score out of 100.
Time frame: Day 0
Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire
This is a subjective self-assessment questionnaire of the overall functional capacity of the two upper limbs, composed of 30 items, rated from 1 to 5 depending on the difficulty of the task described, leading to a score out of 100.
Time frame: At 1,5 months
Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire
This is a subjective self-assessment questionnaire of the overall functional capacity of the two upper limbs, composed of 30 items, rated from 1 to 5 depending on the difficulty of the task described, leading to a score out of 100.
Time frame: At 3 months
Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire
This is a subjective self-assessment questionnaire of the overall functional capacity of the two upper limbs, composed of 30 items, rated from 1 to 5 depending on the difficulty of the task described, leading to a score out of 100.
Time frame: At 6 months
Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire
This is a subjective self-assessment questionnaire of the overall functional capacity of the two upper limbs, composed of 30 items, rated from 1 to 5 depending on the difficulty of the task described, leading to a score out of 100.
Time frame: At 1 year
Hospital Anxiety and Depression (HAD) Scale
It comprises 14 items, allowing the obtaining of 2 scores out of 21 points, corresponding to the dimensions of anxiety and depression
Time frame: Day 0
Hospital Anxiety and Depression (HAD) Scale
It comprises 14 items, allowing the obtaining of 2 scores out of 21 points, corresponding to the dimensions of anxiety and depression
Time frame: At 1,5 months
Hospital Anxiety and Depression (HAD) Scale
It comprises 14 items, allowing the obtaining of 2 scores out of 21 points, corresponding to the dimensions of anxiety and depression
Time frame: At 3 months
Hospital Anxiety and Depression (HAD) Scale
It comprises 14 items, allowing the obtaining of 2 scores out of 21 points, corresponding to the dimensions of anxiety and depression
Time frame: At 6 months
Hospital Anxiety and Depression (HAD) Scale
It comprises 14 items, allowing the obtaining of 2 scores out of 21 points, corresponding to the dimensions of anxiety and depression
Time frame: At 1 year
The Short Form (36) Health Survey
This is a standardized test for measuring the quality of life. It includes 36 items divided into 8 dimensions (physical functioning, role limitations related to physical health, physical pain, general health, vitality \[energy / fatigue\], functioning or social well-being, role limitations related to mental health, Mental Health).
Time frame: Day 0
The Short Form (36) Health Survey
This is a standardized test for measuring the quality of life. It includes 36 items divided into 8 dimensions (physical functioning, role limitations related to physical health, physical pain, general health, vitality \[energy / fatigue\], functioning or social well-being, role limitations related to mental health, Mental Health).
Time frame: At 1,5 months
The Short Form (36) Health Survey
This is a standardized test for measuring the quality of life. It includes 36 items divided into 8 dimensions (physical functioning, role limitations related to physical health, physical pain, general health, vitality \[energy / fatigue\], functioning or social well-being, role limitations related to mental health, Mental Health).
Time frame: At 3 months
The Short Form (36) Health Survey
This is a standardized test for measuring the quality of life. It includes 36 items divided into 8 dimensions (physical functioning, role limitations related to physical health, physical pain, general health, vitality \[energy / fatigue\], functioning or social well-being, role limitations related to mental health, Mental Health).
Time frame: At 6 months
The Short Form (36) Health Survey
This is a standardized test for measuring the quality of life. It includes 36 items divided into 8 dimensions (physical functioning, role limitations related to physical health, physical pain, general health, vitality \[energy / fatigue\], functioning or social well-being, role limitations related to mental health, Mental Health).
Time frame: At 1 year
Observance of wearing the compression garment
Compliance with the wearing of the compression garment will be measured by the average number of hours of wearing the garment per day, which will be evaluated on the patient's statements in the experimental arm during the visits.
Time frame: Every week for 3 months
Tolerance of wearing the compression garment
The tolerance of wearing the compression garment will be assessed by recording the presence of irritation or surface skin lesion, compression felt as being too unpleasant or even unbearable by the patient in the experimental arm and leading to stopping wearing.
Time frame: Every week for 3 months
Plan to share: No
No publications or documents are linked to this record.
Started Oct 2021 (actual). Primary completion is estimated for May 2026, 55 months after the start.
Of 64 non-industry interventional studies with no phase under Complex Regional Pain Syndromes, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 60. This study's planned 55 months is above that.
Counting every sponsor, half of 65 studies reached it within 24 months; a quarter within 14 and three quarters within 60.
How these figures are worked out, and which studies are left out of them.
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