An interventional study of Graded Motor Imagery + Therapeutic exercises and Sham-GMI (non-motor mental imagery) + Therapeutic exercises in Complex Regional Pain Syndromes, sponsored by Nantes University Hospital. Not yet recruiting at 20 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-14.
Sponsored by Nantes University Hospital · Not applicable, Interventional, and Treatment
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Among 17 studies in Complex Regional Pain Syndromes with a site in France — 6 open to participants now, 6 under way, none of them phase 3. Complex Regional Pain Syndromes · France.
Among the 17 studies in Complex Regional Pain Syndromes with a site in France, this one is the 5th largest by planned enrollment of the 13 interventional ones that give a count, is one of 2 that started in 2026, is one of 10 with no phase, and was the 17th registered.
206 studies on the registry are indexed under Complex Regional Pain Syndromes; 55 are open to participants now.
Browse Complex Regional Pain Syndromes studies →6 of the 17 studies in Complex Regional Pain Syndromes with a site in France are open now. Recruiting first, the newest first:
Polyclinique de l'Europe · Sites in France
Ages 18+
Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est · Sites in France
Ages 18+ · Healthy volunteers
Hospices Civils de Lyon · Sites in France
Ages 12–20
Elsan · Sites in France
Ages 18–75
Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape · Sites in France
Ages 18+
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 39 Complex Regional Pain Syndromes studies recruiting now, 17 (44%) set no upper age limit and 16 (41%) stop at 75 or younger; 3 take children under 18; 5 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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17 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 2 1 · Phase 3 3
First in 2012; this study’s year is marked. 2 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 80 is above the median of 40 across 152 interventional studies indexed under Complex Regional Pain Syndromes.
Median enrollment 60 across the 13 interventional studies, 33 across the 4 observational. Of the 11 that completed or were terminated, 1 (9%) have results posted.
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1 of 17 have an industry lead sponsor. The 10 most frequent:
Nantes University Hospital is the lead sponsor of 839 studies on the registry; 195 are open to participants now.
Nantes University Hospital has 1 study filed under Complex Regional Pain Syndromes — fewer than ten, so there is no comparison to draw.
2 of the studies in Complex Regional Pain Syndromes with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07361692Polyclinique de l'EuropeEffectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome | 2027-06-01 |
| NCT07349173Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord EstPeripersonal Space Representation in Upper Limb Segmental Exclusion | 2027-07 |
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Among the 17 studies in Complex Regional Pain Syndromes with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Complex Regional Pain Syndrome (CRPS) is a debilitating pain condition that usually develops following trauma. Patients with CRPS experience intense, continuing, disproportionate pain and multiple symptoms such as changes or asymmetry in colour, temperature or oedema, as well as stiffness, tremors or dystonia and body perception disturbances. Body perception disturbances are now recognised as part of the typical presentation of CRPS and have been shown to correlate, in particular, with pain intensity.
Managing CRPS is challenging and treatment options are limited. Among these, treatments aimed at cortical reorganisation, such as Graded Motor Imagery (GMI), have shown evidence of efficacy in terms of pain and function. However, with regard to body perception disorders, the evidence is limited and emerging.
Our aim is to evaluate the effects of Graded Motor Imagery on body perception disorders in patients with upper limb CRPS. Method: a randomised controlled trial comparing an intervention group - therapeutic exercises plus GMI for 6 weeks (implicit motor imagery, explicit motor imagery followed by mirror therapy) - with a control group - therapeutic exercises plus sham-GMI (non-motor mental imagery) for 6 weeks.
Outcome measures: body perception disorders (Bath Scale), pain intensity (Numerical Rating Scale), quality of life (PROMIS 29), catastrophising (PCS), fear of pain, CRPS Severity Score, patient-reported global impression of change, medication use and self-efficacy. Interventions are carried out in private practice by independent physiotherapists. Assessors are blinded for the primary outcome. A qualitative component will explore the experiences and perceptions of patients and therapists regarding body perception disturbances, GMI and participation in a research project.
This study aims are to improve treatment options for the management of SDRC and to improve the recognition and treatment of body perception disorders in SDRC.
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Exclusion Criteria:
Graded Motor Imagery (left/right discrimination, explicit motor imagery, mirror therapy) and exercises (15 minutes, 3 times per day, 6 weeks)
Other: Graded Motor Imagery + Therapeutic exercises
Sham-GMI (non-motor mental imagery) + Therapeutic exercises
Other: Sham-GMI (non-motor mental imagery) + Therapeutic exercises
Functional, mobility, strengthening, and mobilization exercises, both passive and active. The exercises are designed to improve mobility and function in the affected limb. In addition to this standard treatment, the intervention group will receive care using Gradual Motor Imagery. The protocol lasts 6 weeks (3 sessions of 15 minutes per day), divided into 3 phases: implicit motor imagery, explicit motor imagery followed by mirror therapy
Functional, mobility, strengthening, and mobilization exercises, both passive and active. The exercises are designed to improve mobility and function in the affected limb. In addition to this standard treatment, the control group will receive a non-motor mental imagery intervention (visual imagery or sham-GMI), designed not to stimulate the sensorimotor areas of the brain while resembling IMG (3 sessions of 15 minutes per day for 6 weeks).
Body perception disorders (Bath Scale)
Assessment of body perception disturbances; 7 items
Time frame: End of intervention (Week 6)
Body perception disorders (Bath Scale)
Assessment of body perception disturbances; 7 items
Time frame: 3 months after intervention (M3)
Mean pain intensity (Numeric rating scale)
Mean pain during the last week, mean pain during the last week during movement, mean pain during the last week at rest
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
QuickDash
Self-reported assessment of upper limb function :
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
PROMIS 29
Self-reported assessment of quality of life (7 domains, 29 items)
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Pain Catastrophizing Scale (PCS)
Self-reported assessment of pain catastrophizing
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Tampa Scale of Kinesiophobia (short form)
Self-reported assessment of fear of movement (6 items)
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Pain Self Efficacy Questionnaire (PSEQ)
Self-reported assessment of confidence in performing activities despite ongoing pain
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Patient Global Impression of Change (PGIC)
Self-administered questions asking respondents to rate how their condition has changed since the intervention
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Medication Quantification Scale (MQS)
MQS quantifies pain medication use and provides a score.
Time frame: End of intervention (Week 6), 3 months after intervention (M3)
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for May 2028, 19 months later.
Of 64 non-industry interventional studies with no phase under Complex Regional Pain Syndromes, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 60. This study's planned 19 months is below that.
Counting every sponsor, half of 65 studies reached it within 24 months; a quarter within 14 and three quarters within 60.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Complex Regional Pain Syndromes →