DrugBiological
Botulinum toxin type A clinical trials
Also written Botox, OnabotulinumtoxinA, Xeomin and NT 201.
Includes 1 study of daxibotulinumtoxinA-lanm.
- studies test it
- 754
- open now
- 87
- in phase 3
- 229
- first study started
- 1997
Keep track of what changes. Save the botulinum toxin type A studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Other names
Studies by the year they started
749 studies that test it; most in 2012 (45); 3 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 2 |
| 1999 | 1 |
| 2000 | 1 |
| 2002 | 5 |
| 2003 | 16 |
| 2004 | 11 |
| 2005 | 25 |
| 2006 | 21 |
| 2007 | 30 |
| 2008 | 15 |
| 2009 | 32 |
| 2010 | 25 |
| 2011 | 44 |
| 2012 | 45 |
| 2013 | 38 |
| 2014 | 44 |
| 2015 | 31 |
| 2016 | 42 |
| 2017 | 27 |
| 2018 | 40 |
| 2019 | 37 |
| 2020 | 23 |
| 2021 | 35 |
| 2022 | 31 |
| 2023 | 35 |
| 2024 | 36 |
| 2025 | 25 |
| 2026 | 32 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 22
- Phase 1
- 62
- Phase 2
- 231
- Phase 3
- 229
- Phase 4
- 157
- No phase
- 107
What it is tested for
Each study’s main condition, where its own words name it.
- Dystonia
- 24
Who runs them
Industry 273 · Other 481
Allergan (72) · Ipsen (45) · Merz Pharmaceuticals GmbH (23) · Medy-Tox (23) · AbbVie (22) · Revance Therapeutics, Inc. (20) · Cairo University (11) · Galderma R&D (10)
Often tested with
Tested in the same studies.
Saline Solution (3) · abobotulinumtoxinA (3) · Lidocaine (3) · Onabotulinum toxin A (2) · Prabotulinumtoxin A (2) · Baclofen (2) · rimabotulinumtoxinB (2) · Hyaluronic Acid (2)
Studies
Open first, then newest update. How each study uses botulinum toxin type A is read from its arms, and is right about nine times in ten.
Testing it · 754
- Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Essential TremorRecruitingPhase 2AbbVieNCT07673107Written as AGN-151607-DP
- Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle SyndromeNot yet recruitingPhase 2Centre Hospitalier Universitaire de NīmesNCT07624045Written as Botulinum Toxin - A injections
- Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic NeuropathyNot yet recruitingPhase 2Assiut UniversityNCT07882238Written as Botulinum Toxin Type A
- Cleft Lip Scarring After BotoxRecruitingPhase 2Children's National Research InstituteNCT07880860Written as Botulinum Toxin Type A (BOTOX) Injection
- Botulinum Toxin Type A Versus Triamcinolone for Facial MyalgiaNot yet recruitingPhase 4Riyadh Elm UniversityNCT07867379Written as Botulinum Toxin A (Botox )
- Study to Assess Participant Satisfaction After Jawline and Neck TreatmentRecruitingPhase 4AbbVieNCT07794891Written as OnabotulinumtoxinA
- Efficacy of Botulinum Toxin A Versus Nanofat in the Treatment of Androgenetic Alopecia: A Comparative Clinical TrialNot yet recruitingPhase 2/3Sherief Ayman Hussein ShaamashNCT07863856Written as Botulinum Toxin Type A
- Botulinum Toxin-A for Bruxism Using Digital Occlusal AnalysisNot yet recruitingEarly Phase 1Bilecik Seyh Edebali UniversitesiNCT07640035Written as Botulinum Toxin-A injection
- DaxibotulinumtoxinA for BlepharospasmRecruitingPhase 2University of PennsylvaniaNCT07489430Written as Botulinum Neurotoxin Type A
- Clinical Evaluation of Botulinum Toxin a in the Management of Temporomandibular Myofascial PainRecruitingPhase 2Riphah International UniversityNCT07847541Written as Botulinum Toxin Type A (BoNT-A)
- Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic MigraineNot yet recruitingPhase 4Assiut UniversityNCT07837570Written as OnabotulinumtoxinA
- Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic MigraineNot yet recruitingPhase 4Assiut UniversityNCT07780136Written as OnabotulinumtoxinA
- Botulinum Toxin Blockade of Neuronal Signals to Immune Cells as a Novel Treatment for Hidradenitis SuppurativaNot yet recruitingPhase 2University of Massachusetts, WorcesterNCT07756346Written as Botulinum Toxin A (Allergan, Inc, Irvine CA)
- Early BOTOX After Spinal Cord InjuryEnrolling by invitationEarly Phase 1University of WashingtonNCT06793683Written as Bladder chemodenervation (Botox)
- A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar LinesRecruitingPhase 1AbbVieNCT07756580Written as BOTOX
- Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate CancerNot yet recruitingPhase 1/2The Methodist Hospital Research InstituteNCT07796490Written as OnabotulinumtoxinA (BOTOX®)
- Botulinum Toxin Type A for Wound Healing After Laparoscopic ColectomyRecruitingNot applicablePham Ngoc Thach University of MedicineNCT07795463Written as Botulinum toxin type A (Botox®, Allergan)
- Impact of Dysport on PMFF Donor ScarNot yet recruitingPhase 4Vanderbilt University Medical CenterNCT07720726Written as Abobotulinumtoxin-A
- Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia RepairRecruitingPhase 2AbbVieNCT07226791Written as AGN-151607-DP
- Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar RhytidesRecruitingPhase 4Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT06448676Written as Botulinum toxin type A
See all 754 studies that test botulinum toxin type A →
Given in every arm · 39 — botulinum toxin type A is usual care beside what is tested
- Efficacy of Intracavernosal Xeomin With Tadalafil for Mild-Moderate Erectile DysfunctionNot yet recruitingPhase 2Northwestern UniversityNCT07537855Written as IncobotulinumtoxinA (100 Units)
- Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral PalsyNot yet recruitingPhase 3Kocaeli UniversityNCT06128616Written as Botulinum Toxin Type A
- Botox or Botox With Esophageal Dilation in Patients With AchalasiaCompletedPhase 4Vanderbilt University Medical CenterNCT03654066Written as Botulinum toxin type A
- Efficacy of Focused Shock Wave Therapy Before and After Botulinum Toxin Injection in Patients With Post-Stroke Spastic Equinus/Equinovarus Foot: A Randomized Clinical TrialActive, not recruitingNot applicableMaría Belén Martínez LunaNCT07758322Written as Botulinum toxin type A
- Zinc Supplementation Prior to Botox Injections for Spasmodic DysphoniaCompletedPhase 1/2University of FloridaNCT05892770Written as Botulinum toxin type A
- A Study to Evaluate Sequential Administration of AGN-151586 and OnabotulinumtoxinA (BOTOX) Injections in Adult Participants for Treatment of Glabellar LinesCompletedPhase 1AbbVieNCT05496335Written as BOTOX
- A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica ProductsCompletedPhase 4AbbVieNCT06783621Written as OnabotulinumtoxinA
- BTX-A and Mirror Therapy for Chronic Stroke SpasticityCompletedNot applicableFatih Sultan Mehmet Training and Research HospitalNCT07331844Written as Botulinum toxin type A (Botox®, Allergan)
- A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)CompletedPhase 1AbbVieNCT06834789Written as OnabotulinumtoxinA
- Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox InjectionsCompletedPhase 2Cheng-Hsin General HospitalNCT04502264Written as Botulinum toxin type A injection
- A Study to Evaluate Participant Satisfaction With Facial Appearance Overall and the Aesthetic and Psychosocial Impact of Combined Facial TreatmentCompletedPhase 4AllerganNCT03712449Written as BOTOX Cosmetic®
- Botulinum Toxin A & Weekly Serial Casting in ABI Inpatients With Lower Extremity SpasticityWithdrawnPhase 2Hamilton Health Sciences CorporationNCT03903653Written as Botulinum toxin type A
- Neurotoxin and Physical TherapyCompletedPhase 4University of FloridaNCT02177617Written as Botox injection
- Intragastric Injections of Botox for the Treatment of ObesityStatus unknownPhase 2Norwegian University of Science and TechnologyNCT02035397Written as Botulinum Toxin Type A
- Split-face Study: Cosmetic Botulinum Toxin Type A Injection Under Electromyography-guidance Versus Conventional Palpation TechniqueCompletedNot applicableMohamed Hayder Oleish SalihNCT05517538Written as Botulinum toxin type A
- The Effect of Botulinum Toxin A In Patients With Excessive Gingival Display With And Without Zinc SupplementationCompletedPhase 3Cairo UniversityNCT03717987Written as Botulinum toxin type A
- A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive EfficiencyCompletedPhase 4Cady, Roger, M.D.NCT01700387Written as onabotulinumtoxinA
- Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum OintmentCompletedPhase 4The University of Texas Health Science Center, HoustonNCT03799484Written as Botulinum toxin type A
- Integrated Management Enhances Functional Gains in Children With Cerebral Palsy Treated by BoNT-ACompletedPhase 3Kocaeli UniversityNCT03302871Written as Botulinum toxin type A
- Integrated Management of Pronation Deformity in Cerebral PalsyCompletedPhase 3Kocaeli UniversityNCT03472261Written as Botulinum toxin type A
Showing 20 of 39.
As the comparator · 43 — what is tested is compared with botulinum toxin type A
- A Study to Assess the Safety and Efficacy of Co-Reconstituted TrenibotulinumtoxinE and OnabotulinumtoxinA in Adult Participants With Moderate to Severe Upper Facial LinesRecruitingPhase 2AbbVieNCT07871513Written as OnabotulinumtoxinA
- To Evaluate HU-045 With Moderate to Severe Glabellar LinesRecruitingPhase 3Huons BiopharmaNCT07870694Written as Xeomin®
- Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection to Treat Moderate to Severe Glabellar LinesRecruitingPhase 3JHM BioPharma (Tonghua) Co. , Ltd.NCT06937944Written as OnabotulinumtoxinA (Botox)
- Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled TrialNot yet recruitingNot applicableMudher MB AlsunbuliNCT07736521Written as Botulinum Toxin-A
- A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in AdultsRecruitingPhase 2/3Chongqing Claruvis Pharmaceutical Co., Ltd.NCT06783114Written as BOTOX®
- Evaluate the Efficacy and Safety of DWP712 With Moderate to Severe Glabellar LinesNot yet recruitingPhase 3Daewoong Pharmaceutical Co. LTD.NCT07013279Written as Botox® 100 Units
- Efficacy of Nerve Block Versus Botox in Chronic Migraine ManagementRecruitingNot applicableZagazig UniversityNCT06684249Written as Botulinum Toxin A
- To Evaluate HU-045 in the Treatment of Glabellar Lines(Phase III)RecruitingPhase 3Huons BiopharmaNCT06205797Written as Xeomin®
- SURGERY VS BOTULINUM TOXIN ON QUALITY OF LIFE IN STROKE PATIENTS: RANDOMIZED TRIALRecruitingNot applicableFundación Pública Andaluza para la Investigación Biomédica Andalucía OrientalNCT06392633Written as Botulinum Toxin A
- A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial LinesActive, not recruitingPhase 1/2IpsenNCT04821089Written as Dysport
- A Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A for Injection (CU-20101)CompletedPhase 3Cutia Therapeutics（Wuxi）Co.,LtdNCT06585696Written as BOTOX®
- Evaluation of Three Types of Injection for the Treatment of Lateral EpicondylalgiaTerminatedNot applicableCentre Hospitalier Universitaire de NīmesNCT02325063Written as Botox injection
- A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar LinesCompletedPhase 1/2JHM BioPharma (Tonghua) Co. , Ltd.NCT06199336Written as BOTOX®
- Double-blind Comparative Randomized MulticenterCompletedPhase 3Innopharm LLCNCT06840158Written as BOTOX®
- Study to Demonstrate Safety and Duration of Effect of 40 Units of PrabotulinumtoxinA-xvfs to Treat Glabellar LinesCompletedPhase 2Evolus, Inc.NCT05320393Written as OnabotulinumtoxinA
- A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar LinesCompletedPhase 3Chongqing Claruvis Pharmaceutical Co., Ltd.NCT06499688Written as OnabotulinumtoxinA
- DWP450 for Treating Moderate to Severe Glabellar LinesCompletedPhase 3Daewoong Pharmaceutical Co. LTD.NCT06354127Written as Botox®
- Evaluate the Safety and Explore the Efficacy of DWP712 With Moderate to Severe Glabellar LinesCompletedPhase 1Daewoong Pharmaceutical Co. LTD.NCT06212960Written as BOTOX®
- Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead RhytidesCompletedEarly Phase 1Lupo Center for Aesthetic and General DermatologyNCT05807412Written as OnabotulinumtoxinA
- Efficacy and Safety of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines in Phase 3 TrialCompletedPhase 3CKD Bio CorporationNCT05804656Written as Botox®
Showing 20 of 43.
Codes
What other systems call botulinum toxin type A · ClinicalTrials.gg INT008669
- MeSH (NLM) D019274Botulinum Toxins, Type AConfirmed ClinicalTrials.gov, Wikidata
- UNII (FDA) E211KPY694BOTULINUM TOXIN TYPE AConfirmed FDA, Wikidata
- RxNorm 1712Confirmed FDA, Wikidata
- Wikidata Q4095199botulinum toxin type AConfirmed FDA, Wikidata
- NCI Thesaurus C82623Botulinum Toxin Type AOne source FDA
- DrugBank DB00083One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D019274 | Botulinum Toxins, Type A | Confirmed ClinicalTrials.gov, Wikidata |
| UNII (FDA) | E211KPY694 | BOTULINUM TOXIN TYPE A | Confirmed FDA, Wikidata |
| RxNorm | 1712 | — | Confirmed FDA, Wikidata |
| Wikidata | Q4095199 | botulinum toxin type A | Confirmed FDA, Wikidata |
| NCI Thesaurus | C82623 | Botulinum Toxin Type A | One source FDA |
| DrugBank | DB00083 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.