Drug
Naltrexone clinical trials
Also written Revia, Vivitrol and NB32.
- studies test it
- 267
- open now
- 21
- in phase 3
- 45
- first study started
- 1992
Keep track of what changes. Save the Naltrexone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
258 studies that test it; most in 2021 (19); 1 more planned to start later
| Year | Studies |
|---|---|
| 1992 | 1 |
| 1993 | 2 |
| 1995 | 2 |
| 1997 | 4 |
| 1998 | 5 |
| 1999 | 2 |
| 2000 | 6 |
| 2001 | 3 |
| 2002 | 2 |
| 2003 | 8 |
| 2004 | 3 |
| 2005 | 10 |
| 2006 | 16 |
| 2007 | 15 |
| 2008 | 15 |
| 2009 | 9 |
| 2010 | 8 |
| 2011 | 11 |
| 2012 | 13 |
| 2013 | 11 |
| 2014 | 9 |
| 2015 | 10 |
| 2016 | 15 |
| 2017 | 8 |
| 2018 | 8 |
| 2019 | 4 |
| 2020 | 11 |
| 2021 | 19 |
| 2022 | 6 |
| 2023 | 5 |
| 2024 | 4 |
| 2025 | 4 |
| 2026 | 9 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 8
- Phase 1
- 38
- Phase 2
- 113
- Phase 3
- 45
- Phase 4
- 64
- No phase
- 21
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 39 · Other 228
Yale University (20) · University of Pennsylvania (16) · Orexigen Therapeutics, Inc (13) · University of Minnesota (8) · New York State Psychiatric Institute (8) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (8) · University of California, Los Angeles (7) · Medical University of South Carolina (7)
Often tested with
Tested in the same studies.
Bupropion (16) · Buprenorphine (6) · Topiramate (5) · Metformin (4) · Ketamine (4) · Oxycodone (4) · Acetaminophen (3) · Varenicline (3)
Studies
Open first, then newest update. How each study uses Naltrexone is read from its arms, and is right about nine times in ten.
Testing it · 267
- Opioids and Social Support Enhanced Extinction EffectsEnrolling by invitationEarly Phase 1University of California, Los AngelesNCT04166071Written as Naltrexone
- Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use DisorderRecruitingPhase 4Milky KohnoNCT06426303Written as Naltrexone
- Combination Therapy for Alcohol Use DisorderNot yet recruitingPhase 2Johns Hopkins UniversityNCT07249554Written as Naltrexone (oral tablets)
- Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent PersonsNot yet recruitingPhase 2Go Medical Industries Pty LtdNCT05382091Written as naltrexone implant
- Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery PatientsNot yet recruitingPhase 1Medical University of South CarolinaNCT07224087Written as Naltrexone Hydrochloride
- Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)RecruitingPhase 2University of ArkansasNCT07224009Written as Naltrexone
- Predicting Response to Naltrexone With Eye Tracking in Gaming DisorderRecruitingPhase 2University of Sao PauloNCT04649892Written as Naltrexone
- Emergency Department-Initiated Medications for Alcohol Use DisorderRecruitingPhase 3Yale UniversityNCT05827159Written as Naltrexone Pill
- A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery PatientsNot yet recruitingPhase 1/2Medical University of South CarolinaNCT07398404Written as Naltrexone hydrochloride
- Naltrexone for Nonsuicidal Self-InjuryNot yet recruitingNot applicableSeoul National University HospitalNCT07641283Written as Naltrexone 50mg (Whanin Naltrexone Tab. 50mg)
- Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injuryNot yet recruitingPhase 2Seoul National University HospitalNCT06622239Written as Naltrexone
- Low-Dose Naltrexone for the Treatment of Painful Diabetic NeuropathyRecruitingPhase 2Dartmouth-Hitchcock Medical CenterNCT04678895Written as Naltrexone
- Individualized Pharmacological Approach to Obesity in Patients With Bipolar DisorderRecruitingPhase 4Mayo ClinicNCT07213466Written as naltrexone and bupropion (combination)
- Evaluate the Efficacy and Safety of Naltrexone Hydrochloride Implant in Patients With Alcohol Use DisorderNot yet recruitingPhase 3Shenzhen Sciencare Medical Industries Co., Ltd.NCT07433413Written as Naltrexone
- Naltrexone and Propranolol Combined With ImmunotherapyRecruitingPhase 1Sarah WeissNCT05968690Written as Naltrexone
- Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release TabletRecruitingPhase 4Laval UniversityNCT06620562Written as Naltrexone/Bupropion
- Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-CessationRecruitingPhase 2/3AgelessRxNCT07092618Written as Naltrexone
- Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.Not yet recruitingNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT06175507Written as Naltrexon
- Effectiveness of Low-dose Naltrexone in Patients With Different Types of VulvodyniaRecruitingPhase 2Medical University of LublinNCT05955313Written as Naltrexone Hydrochloride
- Exploring the PK of Different Doses of Naltrexone in Patients With AUDRecruitingPhase 1Shenzhen Sciencare Medical Industries Co., Ltd.NCT05919017Written as Naltrexone implant
See all 267 studies that test Naltrexone →
Given in every arm · 23 — Naltrexone is usual care beside what is tested
- Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)RecruitingPhase 2Stanford UniversityNCT05940324Written as Naltrexone Pill
- A Trial to Investigate the Effects of Cannabidiol Plus Naltrexone on Alcohol Craving in Patients With Alcohol DependenceRecruitingPhase 2Central Institute of Mental Health, MannheimNCT06845124Written as Naltrexone (drug)
- Lemborexant Augmentation of Naltrexone for Alcohol Craving and SleepCompletedPhase 3Baylor College of MedicineNCT05458609Written as Naltrexone
- Long-acting Naltrexone for Pre-release PrisonersCompletedPhase 3Friends Research Institute, Inc.NCT02867124Written as XR-NTX
- Study of PF614 Compared to OxyContin® in Healthy Volunteers (PF614-101)CompletedPhase 1Ensysce BiosciencesNCT02454712Written as Naltrexone Hydrochloride
- Pharmacokinetics of Oxycodone and PF614 Co-Administered with Nafamostat (PF614-MPAR-101)CompletedPhase 1Ensysce BiosciencesNCT05090280Written as Naltrexone Hydrochloride
- Evaluation of Oral PF614 Relative to OxyContin (PF614-102)CompletedPhase 1Ensysce BiosciencesNCT05043766Written as Naltrexone Hydrochloride
- Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use DisorderCompletedPhase 2/3Central Institute of Mental Health, MannheimNCT05093296Written as Naltrexone Pill
- Individualized Obesity PharmacotherapyCompletedPhase 3Mayo ClinicNCT03374956Written as Naltrexone/bupropion
- Glutamate and Opioid Mechanisms of Antidepressant Response to KetamineCompletedEarly Phase 1King's College LondonNCT04977674Written as Naltrexone
- Medication Maintenance Therapy in Community Pharmacy SettingsStatus unknownPhase 2/3LifespanNCT04139213Written as injectable naltrexone
- Improving Treatment Outcomes for Prescription Opioid DependenceCompletedPhase 2/3University of ArkansasNCT02543944Written as Naltrexone (oral)
- Buprenorphine as Adjunct to Outpatient Induction Onto VivitrolTerminatedPhase 2/3New York State Psychiatric InstituteNCT03113409Written as Naltrexone
- Study of a Novel Subcutaneous Depot Formulation of BuprenorphineCompletedPhase 1Indivior Inc.NCT03715634Written as Nalorex
- Memantine and Naltrexone Treatment for Opioid DependenceCompletedPhase 2New York State Psychiatric InstituteNCT00125515Written as Naltrexone
- Pharmacokinetic Evaluation of Intranasal, Intramuscular, and Oral Naltrexone in Healthy VolunteersCompletedPhase 1National Institute on Drug Abuse (NIDA)NCT02750748Written as Naltrexone
- Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy VolunteersCompletedPhase 1Pain TherapeuticsNCT02165930Written as Naltrexone
- Exploratory Bioavailability of Fentanyl Sublingual Spray Under Fasting ConditionsCompletedNot applicableINSYS Therapeutics IncNCT02138396Written as Naltrexone
- An Adherence Tool to Manage Narcotic -Addicted HIV PatientsCompletedNot applicableXhale AssuranceNCT02194764Written as Naltrexone and 2-butanol
- Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).CompletedPhase 1Incline Therapeutics, Inc.NCT01750060Written as Naltrexone
Showing 20 of 23.
As the comparator · 8 — what is tested is compared with Naltrexone
- Safety and PK Study of BICX104 With or Without Bupropion Compared to VivitrolRecruitingPhase 1BioCorRx Pharmaceuticals IncNCT07269873Written as Naltrexone (depot)
- Naltrexone for Prolonged Grief DisorderTerminatedPhase 4Texas Tech UniversityNCT06140420Written as Naltrexone Oral Product
- Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving JailActive, not recruitingPhase 2/3Friends Research Institute, Inc.NCT04408313Written as XR-NTX
- A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in AmericaCompletedPhase 4Novo Nordisk A/SNCT05579249Written as Naltrexone/Bupropion
- Pharmacokinetics of SP-104CompletedPhase 1Scilex Pharmaceuticals, Inc.NCT05002946Written as Naltrexone Hydrochloride 50Mg Oral Tablet
- Alcohol Disorder hOsPital Treatment TrialCompletedPhase 4Boston UniversityNCT02478489Written as Oral naltrexone (PO-NTX)
- ALK21-006: Long-Term Study of Medisorb® Naltrexone (VIVITROL®)CompletedPhase 3Alkermes, Inc.NCT01218997Written as Oral naltrexone 50 mg
- Effects of Omegas 3 and 6 on Alcohol DependenceCompletedPhase 3Federal University of São PauloNCT01211769Written as Naltrexone
Codes
What other systems call Naltrexone · ClinicalTrials.gg INT007867
- MeSH (NLM) D009271NaltrexoneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 5S6W795CQMNALTREXONEConfirmed FDA, NLM, Wikidata
- RxNorm 7243Confirmed FDA, Wikidata
- Wikidata Q409587naltrexoneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62055NaltrexoneOne source FDA
- DrugBank DB00704One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D009271 | Naltrexone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 5S6W795CQM | NALTREXONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7243 | — | Confirmed FDA, Wikidata |
| Wikidata | Q409587 | naltrexone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62055 | Naltrexone | One source FDA |
| DrugBank | DB00704 | — | One source Wikidata |
Also registered as naltrexone hydrochloride (UNII Z6375YW9SF · RxNorm 105069).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.