An observational study in Wrist Fracture and Complex Regional Pain Syndrome, sponsored by Cambridge University Hospitals NHS Foundation Trust. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-20.
Sponsored by Cambridge University Hospitals NHS Foundation Trust · Observational
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Among 10 studies in Wrist Fractures with a site in United Kingdom — 1 open to participants now, 2 under way, none of them phase 3. Wrist Fractures · United Kingdom.
Among the 10 studies in Wrist Fractures with a site in United Kingdom, this one is the only one that started in 2026, is one of 5 observational ones, and was the 9th registered.
330 studies on the registry are indexed under Wrist Fractures; 72 are open to participants now.
Browse Wrist Fractures studies →1 of the 10 studies in Wrist Fractures with a site in United Kingdom is open now.
A study can be open while its sites in United Kingdom have not opened yet or have stopped. Only those recruiting at a site in United Kingdom →
Of the 43 Wrist Fractures studies recruiting now, 20 (47%) set no upper age limit and 15 (35%) stop at 75 or younger; 7 take children under 18; 6 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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10 studies; the count open now beside each. This study's row is marked.
First in 2001; this study’s year is marked. 1 started in 2026.
This study's planned enrollment of 200 is above the median of 100 across 53 observational studies indexed under Wrist Fractures.
Median enrollment 86 across the 5 interventional studies, 111 across the 5 observational. Of the 7 that completed or were terminated, 1 (14%) have results posted.
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2 of 10 have an industry lead sponsor. The 10 most frequent:
Cambridge University Hospitals NHS Foundation Trust is the lead sponsor of 171 studies on the registry; 38 are open to participants now.
Cambridge University Hospitals NHS Foundation Trust has 1 study filed under Wrist Fractures — fewer than ten, so there is no comparison to draw.
1 of the studies in Wrist Fractures with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04113044AO Innovation Translation CenterGo Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® | 2026-12-31 |
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Among the 10 studies in Wrist Fractures with a site in United Kingdom, from their registry updates:
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What is the problem? A wrist fracture is a common injury, affecting about 100,000 people in the UK each year. While most people recover well, a significant minority, between 10% and 20%, develop persistent pain and disability that lasts long after the bone has healed. In some cases this leads to a severe chronic pain condition called Complex Regional Pain Syndrome (CRPS). Currently we cannot easily predict who will recover and who may not, making it challenging to provide early targeted support.
What are we trying to find out? We want to see if we can identify "signs" in the body, such as genetic markers, chemical messengers in the blood, and heart rate rhythms, that predict a person's recovery. We are also investigating the brain's "internal map" of the body. After an injury, this map can sometimes become "blurred" or less precise, which we believe is linked to ongoing pain. Our goal is to use this information to help in identify patients at high risk of chronic pain so they could receive better treatment in the future.
What will happen in the study? We are inviting 250 participants: 200 people with a recent wrist fracture and 50 people who already live with long-term CRPS to act as a comparison group.
All participants will first take part in a baseline assessment. This involves completing questionnaires (including a 0-10 pain rating scale), providing a blood sample, and taking part in simple bedside tests. These tests will also measure your internal body map by checking how accurately you can identify finger touches with your eyes closed and how you compare the size or weight of your limbs.
Based on the results of these objective tests, we will invite some participants with recent wrist fractures to take part in specific sub-studies:
Who are we? Our research team includes experts in genetics, brain imaging, pain, and modern digital technologies who have experience in delivering clinical trials.
How will we tell people what we found out?
We are committed to sharing what we learn with the people who make our research possible. We will therefore inform participants and public. Once the study is complete, we will:
Study Design Prospective cohort Study Participants (1) Patients aged 18 years and older, with an acute fracture of the distal radius within the past 6 weeks, willing and competent to complete the informed consent process. Patients with multiple trauma; have had an open fracture; have a unilateral sensory deficit; significant neurological disease or patients who would be unable to follow trial procedures will be excluded.
(2) Participants with Chronic Complex Regional Pain Syndrome (CRPS), willing and competent to complete the informed consent process.
Planned Size of Sample Total of 250 participants
Key research questions
Domain level objectives Objectives Outcome measures Time point(s) of evaluation
2a) To identify predictive neural signatures in hypothesis-driven regions of interest (e.g. insula, parietal cingulate and ventral premotor cortices) Functional MRI Functional connectivity measures and Brain activation patters measured as Blood-Oxygen-Level-Dependent (BOLD) fMRI performed at month 0 and 6 n. 24 DRF
2:1 ratio between disturbed and normal body representation (16 BRD Vs 6 non-BRD
2b) To quantify the impact of BRD on pain severity, perception and quality of life in participants following a distal radius fracture Patient reported outcome measures (PROMS)
Patient reported outcome measures (PROMS)
Patients with a single wrist fracture Patients with chronic CRPS
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Distal radius fracture (DRF) within past 6 weeks 18 and older Willing and competent to complete the process
Exclusion Criteria:
Inability to understand the process (Language, competence) Multiple trauma Significant neurological disease (multiple sclerosis, previous traumatic brain injury, previous stroke or cerebral haemorrhage and substantial tremor - including Parkinson's, significant resting tremor, or other aetiology) Amputation or medical confirmation of unilateral sensory deficit
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Blood sample for genetic analysis and other blood biomarkers
For functional MRI scanning in participants with and without body scheme disruption
Blood sample for genetic analysis and other blood biomarkers
For functional MRI scanning in participants with CRPS
Rare SNPs in genetic analysis
A whole blood sample will be collected from each participant at baseline. DNA will be analysis to identify the presence or absence of pre-specified candidate Single Nucleotide Polymorphisms (SNP) alleles, previously associated with chronic CRPS, via Polymerase Chain Reaction (PCR). Participants will then be categorised as variant positive or negative.
Time frame: 5 years
Functional MRI biomarkers
Structural and functional MRI scans will be performed at month 0 and 6 using 3T MRI facilities at the Wolfson Brain Imaging Centre in Cambridge. This will involve a 1-hour scanning time, including stuctural (T1-weighted and Diffusion Tensor Imaging (DTI)) and functional (task-based and resting-state BOLD) fMRI.
Time frame: 5 years
Plan to share: Undecided — Data may not be in an appropriate format to be shared
Started Aug 2026 (actual). Primary completion is estimated for Aug 2031, 60 months after the start.
Of 20 observational studies under Wrist Fractures, half reached primary completion within 32 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 63. This study's planned 60 months is above that.
How these figures are worked out, and which studies are left out of them.
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Cambridge University Hospitals NHS Foundation Trust →