Drug

Dexmedetomidine clinical trials

Also written Precedex, Dexdor and BXCL501.

studies test it: 1,454
open now: 294
in phase 3: 230
first study started: 2003

How each study uses Dexmedetomidine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

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Approvals

The first approval found in each region, with its record

United States: 17 Dec 1999 · PRECEDEX · NDA 021038 (FDA, Drugs@FDA)
European Union: 15 Sept 2011 · Dexdor · EMEA/H/C/002268 (EMA)

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Dexmedetomidine: 1,024
Dexmedetomidine Hydrochloride: 61
Intranasal dexmedetomidine: 24
Dexmedetomidine infusion: 24
Dexmedetomidine injection: 23

Brand

Precedex: 304
Dexdor: 40
IGALMI: 2
Sileo: 1

Development codes

BXCL501: 9
DIN 02339366: 1

Other names

Dexdomitor: 1

In one entry with another drug

Given together, or one or the other

Dexmedetomidine & Bupivacaine.: 8
Dexmedetomidine-esketamine combination: 7
Ropivacaine + Dexmedetomidine: 5
Dexmedetomidine and propofol: 4
Esketamine combined with dexmedetomidine: 4
Dexamethasone and dexmedetomidine: 3
Propofol and dexmedetomidine: 3
Dexmedetomidine and Midazolam: 3

Studies by the year they started

1,451 studies that test it; most in 2024 (131); 2 more planned to start later

Studies that test Dexmedetomidine, by start year
Year	Studies
2003	1
2004	5
2005	8
2006	14
2007	13
2008	17
2009	27
2010	19
2011	34
2012	42
2013	37
2014	86
2015	63
2016	81
2017	94
2018	72
2019	87
2020	69
2021	99
2022	110
2023	109
2024	131
2025	118
2026	115

By phase

A phase 1/2 study counts in both.

Early Phase 1: 36
Phase 1: 84
Phase 2: 204
Phase 3: 230
Phase 4: 516
No phase: 490

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Pain, Postoperative: 94
Emergence Delirium: 67
Delirium: 55
Pain: 28
Breast Neoplasms: 11
Postoperative Nausea and Vomiting: 11
Shock, Septic: 11
Obesity: 10
Acute Kidney Injury: 9
Postoperative Complications: 9
Sleep Apnea, Obstructive: 9
Brain Injuries, Traumatic: 8

Who runs them

Industry 45 · Other 1,409

Assiut University (100) · Ain Shams University (58) · Tanta University (51) · Cairo University (35) · Peking University First Hospital (34) · Yonsei University (34) · Zagazig University (19) · Seoul National University Hospital (18)

Often tested with

Tested in the same studies.

Propofol (101) · Ketamine (85) · Midazolam (84) · Lidocaine (59) · Fentanyl (51) · Dexamethasone (49) · Remifentanil (45) · Bupivacaine (43)

Related medicines

As reviewed, each with the page that says it.

One of Hypnotics and Sedatives source

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Reaching primary completion within a year · 98, 14 in phase 3

Studies that test Dexmedetomidine, phase 3 first.

Nov 2026Comparative Dose-Response of Intrathecal Dexmedetomidine for Post-Spinal ShiveringPhase 3 · Al-Azhar University
Dec 2026A Study to Compare the Long-term Outcomes After Two Different AnaestheticsPhase 3 · Murdoch Childrens Research Institute
Dec 2026Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.Phase 3 · Children's Cancer Hospital Egypt 57357
Dec 2026MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)Phase 2/3 · Sixth Affiliated Hospital, Sun Yat-sen University
Jan 2027Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen SaturationPhase 3 · Tanta University
May 2027Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical StormPhase 3 · Ottawa Heart Institute Research Corporation
Jun 2027Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.Phase 3 · Institut Curie
Jul 2027Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in AdultsPhase 3 · Dr. Naveed Siddiqui
Jul 2027Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture RibsPhase 3 · Assiut University
Oct 2027Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain ManagementPhase 3 · Assiut University

Studies

Open first, then newest update. How each study uses Dexmedetomidine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 1,454

See all 1,454 studies that test Dexmedetomidine →

Given beside what is tested · 39 — Dexmedetomidine is usual care or a partner of the new treatment

Showing 20 of 39.

As the comparator · 37 — what is tested is compared with Dexmedetomidine

Showing 20 of 37.

What changed recently

From the registry's own updates since Oct 15, 2026.

Started recruiting7

ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee ArthroplastyNov 5, 2026NCT07677215
Intravenous Dexmedetomidine as a Perioperative Autonomic-Immune NeuromodulatorNov 5, 2026NCT07743853
Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean DeliveryOct 29, 2026NCT07567495
The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline AnesthesiaOct 28, 2026NCT07699523
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.Oct 28, 2026NCT07736352

Show 2 more

The Impact of a Dexmedetomidine Perfusion on Intraoperative Remifentanil ConsumptionOct 23, 2026NCT06684197
Perioperative Multimodal Analgesia for Supratentorial CraniotomyOct 15, 2026NCT07441421

Show 8 more

Comparison of Mean Arterial Pressure After Endotracheal Intubation in Patients Undergoing Spine Surgery With Pre-emptive Nitroglycerine Versus DexmedetomidineOct 28, 2026NCT07901023
Preoperative Nebulized Lignocaine Versus Nebulized Dexmedetomidine for Blunting the Pressor Response to Laryngoscopy and Intubation in Controlled Hypertensive PatientsOct 27, 2026NCT07897578
Effect of Low-Dose Esketamine Combined With Dexmedetomidine on the Incidence of Chronic Postsurgical Pain in Patients Undergoing Pancreatic SurgeryOct 22, 2026NCT07888413
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.Oct 16, 2026NCT07878156
Dexmedetomidine as an Adjuvant to Greater Auricular Nerve Block in Middle Ear SurgeriesOct 16, 2026NCT07878533
Comparison of Ketorolac and Dexmedetomidine as An Adjunct to Lignocaine in Prevention of Tourniquet Induced Pain During Intravenous Regional AnesthesiaOct 16, 2026NCT07878962
Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.Oct 15, 2026NCT07874919
Dexmedetomidine Infusion and Iscemia and Reperfusion InjuryOct 15, 2026NCT07875231

Codes

What other systems call Dexmedetomidine · ClinicalTrials.gg INT008783

MeSH (NLM) D020927DexmedetomidineConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) 67VB76HONODEXMEDETOMIDINEConfirmed FDA, NLM, Wikidata
RxNorm 48937Confirmed FDA, Wikidata
Wikidata Q412133dexmedetomidineConfirmed FDA, NLM, Wikidata
NCI Thesaurus C47479DexmedetomidineOne source FDA
DrugBank DB00633One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	D020927	Dexmedetomidine	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	67VB76HONO	DEXMEDETOMIDINE	Confirmed FDA, NLM, Wikidata
RxNorm	48937	—	Confirmed FDA, Wikidata
Wikidata	Q412133	dexmedetomidine	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C47479	Dexmedetomidine	One source FDA
DrugBank	DB00633	—	One source Wikidata

Also registered as dexmedetomidine hydrochloride (UNII 1018WH7F9I · RxNorm 228054).

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.