Delirium clinical trials
The registry lists 933 studies for Delirium across more than 10 countries. 190 are recruiting or about to start. 628 of them are mainly about Delirium (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its narrower condition Emergence Delirium too: 1,579 studies, 425 open.
ClinicalTrials.gov finds 1,720 studies for Delirium. How that becomes 933 here
This page counts the studies the registry files under Delirium, and those it files under no condition that list Deliriumthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,720Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −643Filed under a narrower condition, counted on its own pageEmergence Delirium 636
- −55List Delirium as a condition, but the registry did not file them under itMost often written as “Delirium, Dementia, Amnestic, Cognitive Disorders” (10), “Delirium Confusional State” (10), and “Delirium in Old Age” (9). The registry filed them under other conditions only, most often Neurocognitive Disorders (12) and Confusion (10).
- −89Match it another way74 name it in the title, 13 in a keyword, and 2 by a synonym or other text the search reads.
- 933The count on this page52 of them list Delirium in their own words; the registry filed them under no condition.
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Who runs them
Charite University, Berlin, Germany (16) · Vanderbilt University Medical Center (15) · Assistance Publique - Hôpitaux de Paris (13) · Peking University First Hospital (11) · Vanderbilt University (11) · Johns Hopkins University (10) · Beth Israel Deaconess Medical Center (9) · University Health Network, Toronto (9)
What is being tested here
Drugs under test in Delirium studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexmedetomidine | 13 | 12 | 71 |
| Esketamine | 3 | 0 | 5 |
| Melatonin | 2 | 5 | 17 |
| Clonidine | 2 | 2 | 6 |
| Remimazolam | 2 | 0 | 2 |
| Lemborexant | 2 | 0 | 2 |
| Haloperidol | 1 | 8 | 20 |
| Midazolam | 1 | 2 | 10 |
| Ketamine | 1 | 3 | 8 |
| Ramelteon | 1 | 0 | 7 |
Drug classes tested here Inhaled anesthetics 2 open · Antipsychotics 1 open · Anxiolytics 1 open · Cholinesterase inhibitors 15 · Opioids 9
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Feb 2027Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy · Phase 3 · M.D. Anderson Cancer Center
- Apr 2027Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery · Phase 3 · Washington University School of Medicine
- Sep 2027The Danish Out-of-Hospital Cardiac Arrest Study · Phase 3 · Christian Hassager
- Oct 2027Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II) · Phase 3 · Massachusetts General Hospital
- Nov 2026Vasopressor SAT Study · University of Chicago
- Nov 2026The Effect of Eye Mask and Earplugs on Sleep Quality and Delirium in Coronary Artery Bypass Graft Patients: A Randomized Controlled Study · Necmettin Erbakan University
- Nov 2026Effects of Artificial Intelligence Nurse Orientation Program on Psychological Outcomes and Length of Hospital Stay in Intensive Care Unit · Koç University
- Nov 2026ABCDEF Bundle Compliance and ICU Outcomes in Latin America · Hospital H+ Queretaro
- Dec 2026Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery · University of British Columbia
- Dec 2026Pervasive Sensing and AI in Intelligent ICU · University of Florida
Who these studies take
Of the 127 Delirium studies recruiting now, 99 (78%) set no upper age limit and 8 (6%) stop at 75 or younger. 8 (6%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 15 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (6%) | 7 (6%) |
| 18 | 62 (49%) | 62 (49%) |
| 30 | 64 (50%) | 64 (50%) |
| 40 | 65 (51%) | 65 (51%) |
| 50 | 73 (57%) | 73 (57%) |
| 65 | 114 (90%) | 114 (90%) |
| 75 | 121 (95%) | 121 (95%) |
| 85 | 113 (89%) | 113 (89%) |
Across all 933 studies, recruiting or not: 9% stop at 75 or younger and 7% at 65; 8% take children; <1% are for women only and <1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Delirium studies take
Of 40 phase 4 interventional studies under Delirium, half reached primary completion within 44 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 28 mo23–46 · 19 studies | — | — |
| Phase 3 | 41 mo28–59 · 27 studies | — | — |
| Phase 4 | 44 mo25–65 · 40 studies | — | 44 mo25–65 · 40 studies |
| Interventional, no phase | 26 mo12–45 · 222 studies | — | 26 mo12–45 · 219 studies |
| Observational | 20 mo11–41 · 178 studies | — | 20 mo11–37 · 176 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted1
- TaVNS for DeliriumOct 30, 2026NCT07258082
Stopped1
- Electrophysiological Signatures of Cognitive Disorders Related to Intensive Care Unit (ICU) delirium_ BRAINSTORM-EEGTerminatedOct 29, 2026NCT06089538
Newly registered4
- Family-partnered Delirium Prevention, Detection, and Management in the ICUOct 27, 2026NCT07896356
- reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care UnitOct 21, 2026NCT07886567
- Effects of Music on Preoperative Anxiety and Emergence Delirium in ChildrenOct 16, 2026NCT07877428
- 40 Hz Gamma Auditory Stimulation for Delirium Prevention in Critically Ill ICU PatientsOct 15, 2026NCT07875374
Studies
Recruiting first, then most recently updated. Showing 50 of 933. Browse all 933 → or search them.
- DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)Not yet recruitingNCT07398066Not applicable
- Family-partnered Delirium Prevention, Detection, and Management in the ICUNot yet recruitingNCT07896356Not applicable1 country
- Behavioral Economic & Staffing Strategies in the ICURecruitingNCT06184945Not applicable1 country
- Prospective Observational Multimodal Neuromonitoring During High-Risk Adult SurgeryNot yet recruitingNCT075777261 country
- reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care UnitNot yet recruitingNCT07886567Early Phase 11 country
- 40 Hz Gamma Auditory Stimulation for Delirium Prevention in Critically Ill ICU PatientsNot yet recruitingNCT07875374Not applicable1 country
- Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion BundleNot yet recruitingNCT06824077Early Phase 1
- Lemborexant for Sleep and Delirium Prevention in Elderly ICU PatientsRecruitingNCT07407400Phase 41 country
- Mobilisation After Endovascular Stroke TreatmentRecruitingNCT078603332 countries
- Effects of PNB Timing on Postoperative Delirium for Hip FractureNot yet recruitingNCT078561081 country
- Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive CareNot yet recruitingNCT07542990Phase 31 country
- Neurosteer Bedside Monitoring SystemRecruitingNCT06718764Not applicable1 country
- Sleep Harmonization Via Bundled Team-Based Interventions in the ICUNot yet recruitingNCT07840560Not applicable2 countries
- Effects of Stellate Ganglion Block on Delirium and Circadian Rhythm in Geriatric Intensive Care PatientsRecruitingNCT07558642Not applicable1 country
- Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)RecruitingNCT06192615Phase 31 country
- CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELiriumRecruitingNCT07804498Phase 21 country
- Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized EldersRecruitingNCT05929703Not applicable1 country
- Virtual Reality-based Sensory Stimulation for Delirium Prevention in Intensive Care UnitsRecruitingNCT07806422Not applicable1 country
- A Study for Postoperative Delirium in Older Patients With Intracranial TumorsNot yet recruitingNCT077976601 country
- Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)RecruitingNCT043551951 country
- DElirium and LIGHT: Exploring Modifiable Risk Factors of Delirium - a Pilot StudyRecruitingNCT077914721 country
- Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older PatientsNot yet recruitingNCT07787832Not applicable
- Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart FailureNot yet recruitingNCT07781462Phase 41 country
- ABCDEF Bundle Compliance and ICU Outcomes in Latin AmericaNot yet recruitingNCT07783035
- ICU Delirium Playbook Training Study for ICU NursesRecruitingNCT07759310Not applicable1 country
- A Prospective Observational Study Using the FAM-CAMRecruitingNCT076946871 country
- Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter StudyNot yet recruitingNCT07746050Not applicable1 country
- Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation ConditionsRecruitingNCT071144581 country
- Cognitive Dysfunction and Delirium After TUR-M in Elderly PatientsRecruitingNCT077197121 country
- Ceribell Delirium Monitor Outcomes Pilot StudyRecruitingNCT07449416Not applicable1 country
- Predictors of Cognitive Decline and Delirium in Older Women With Ovarian CancerNot yet recruitingNCT07716800
- Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill PatientsNot yet recruitingNCT07710066
- Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major SurgeryRecruitingNCT077099751 country
- Pediatric DeliriumEnrolling by invitationNCT04669457Phase 41 country
- Volume Support/Assist Control Mode Ventilation and Diaphragmatic AtrophyRecruitingNCT03901924Not applicable1 country
- Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture SurgeryRecruitingNCT07202208Not applicable1 country
- Pervasive Sensing and AI in Intelligent ICURecruitingNCT051272651 country
- Inhaled Sedation in Critically Ill PatientsRecruitingNCT07000526Phase 41 country
- The Effect of Eye Mask and Earplugs on Sleep Quality and Delirium in Coronary Artery Bypass Graft Patients: A Randomized Controlled StudyNot yet recruitingNCT06752980Not applicable1 country
- Wheat Beer for Prevention of Delirium in Intensive Care PatientsRecruitingNCT04876742Not applicable1 country
- The Basel BOMP-AID Randomized TrialRecruitingNCT03438526Phase 41 country
- VR-Based Cognitive Stimulation Games for Delirium PreventionRecruitingNCT07641153Not applicable1 country
- Precision ICU Care: Evaluating an AI-Driven Nursing Decision Support System for Delirium PreventionNot yet recruitingNCT07631494Not applicable1 country
- Prevention of Delirium in ICU Using Multimodal InterventionsRecruitingNCT05950958Not applicable1 country
- Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and DepressionRecruitingNCT07610655Not applicable1 country
- How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP StudyRecruitingNCT06938789Not applicable1 country
- KetAmine and Recovery After Mechanical VentilAtion ( KARMA )Not yet recruitingNCT07590687Phase 31 country
- Pain After Cardiac Arrest and Resuscitation (PAINCARE)RecruitingNCT075647781 country
- Nocturnal Hypoxia in Geriatric Patients After Hip FractureRecruitingNCT04007432Not applicable1 country
- Computer-assisted Cognitive Stimulation Treatment for DeliriumRecruitingNCT07563244Not applicable1 country