An interventional study of Dexamethasone and Dexmedetomidine in Postoperative Pain, sponsored by Recep Karakaşoğlu. Not yet recruiting. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-04-13.
Sponsored by Recep Karakaşoğlu · Not applicable, Interventional, and Supportive care
This study aims to evaluate whether adding intravenous dexamethasone to standard intravenous dexmedetomidine improves pain control after shoulder arthroscopy performed under a superior trunk block. Shoulder arthroscopy is a common surgical procedure that can cause moderate to severe postoperative pain.
In this study, adult patients undergoing elective arthroscopic shoulder surgery will receive a nerve block called a superior trunk block to control pain during and after surgery. All participants will also receive intravenous dexmedetomidine, a medication commonly used to enhance analgesia.
Participants will be randomly assigned to one of two groups. One group will receive intravenous dexamethasone, while the other group will receive a placebo (saline solution). Neither the patients nor the healthcare providers nor the outcome assessors will know which treatment each participant receives.
The main goal of the study is to determine how long it takes before patients require their first additional pain medication after surgery. Secondary outcomes include pain scores, total pain medication use, duration of nerve block, rebound pain, side effects, and patient satisfaction.
The findings of this study may help improve postoperative pain management strategies for patients undergoing shoulder arthroscopy.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,137 are open to participants now.
This study's planned enrollment of 70 is close to the median of 75 across 4,341 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →This is the only study on the registry with Recep Karakaşoğlu as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Dexamethasone · Drug: Dexmedetomidine
Drug: Dexmedetomidine · Drug: Sodium Chloride 0.9%
Dexamethasone will be administered intravenously at a dose of 0.15 mg/kg before surgery.
Dexmedetomidine will be administered intravenously at a dose of 0,5 mcg/kg as a 30-minute infusion.
Normal saline (0.9% sodium chloride) will be administered intravenously as a placebo in a volume matched to the dexamethasone dose.
Time to first rescue analgesic request
Time from completion of the superior trunk block to the first administration of rescue analgesia, defined as analgesic requirement for Numeric Rating Scale (NRS) \>3 or upon patient request.
Time frame: From completion of superior trunk block to first rescue analgesic request, up to 72 hours postoperatively
Rebound pain incidence
Incidence of rebound pain, defined as severe pain with an NRS score of 7 or higher after block resolution.
Time frame: Through 72 hours postoperatively
No study locations are listed for this record.
Plan to share: No
This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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