Acute Kidney Injury clinical trials
The registry lists 1,691 studies for Acute Kidney Injury across more than 10 countries. 393 are recruiting or about to start. 1,247 of them are mainly about Acute Kidney Injury (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
ClinicalTrials.gov finds 1,909 studies for Acute Kidney Injury. How that becomes 1,690 here
This page counts the studies the registry files under Acute Kidney Injury, and those it files under no condition that list Acute Kidney Injurythemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,909Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −17List Acute Kidney Injury as a condition, but the registry did not file them under itMost often written as “Contrast-induced Acute Kidney Injury” (5), “Postoperative Acute Kidney Injury” (4), and “Acute Kidney Injury Due to Sepsis” (2). The registry filed them under other conditions only, most often Coronary Artery Disease (2) and ST Elevation Myocardial Infarction (2).
- −205Match it another way161 name it in the title, 11 in a keyword, and 33 by a synonym or other text the search reads.
- 1,687Counted here and found by its search66 of them list Acute Kidney Injury in their own words; the registry filed them under no condition.
- +3
Counted here, but its search does not find them
- 1,690The count on this page
Get an email when these change. Save the Acute Kidney Injury studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Assiut University (39) · Yonsei University (21) · Assistance Publique - Hôpitaux de Paris (21) · Seoul National University Hospital (18) · Hospices Civils de Lyon (17) · Children's Hospital Medical Center, Cincinnati (15) · Ain Shams University (14) · Peking University First Hospital (14)
What is being tested here
Drugs under test in Acute Kidney Injury studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dapagliflozin | 4 | 3 | 8 |
| Amino Acids | 4 | 1 | 5 |
| Sodium Bicarbonate | 3 | 3 | 17 |
| Norepinephrine | 3 | 0 | 6 |
| Dexmedetomidine | 2 | 3 | 11 |
| Angiotensin II | 2 | 3 | 9 |
| Aminophylline | 2 | 3 | 6 |
| Pantoprazole | 2 | 1 | 4 |
| Nafamostat | 2 | 0 | 4 |
| Arginine Vasopressin | 2 | 0 | 3 |
Drug classes tested here SGLT2 inhibitors 4 open · Phosphodiesterase inhibitors 2 open · Beta-lactamase inhibitors 2 open · Diuretics 1 open · Statins 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF) · Phase 3 · Ebima Clifford Okundaye
- Jan 2027Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT · Phase 3 · Vantive Health LLC
- Jan 2027Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II · Phase 3 · Universität Münster
- Feb 2027Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial · Phase 3 · Hamilton Health Sciences Corporation
- Apr 2027N-Acetylcysteine Roles in Preserving Renal Function Measured by Urinary KIM-1 (Kidney Injury Molecule-1) and Serum Creatinine on Cancer Patients With Cisplatin Based Chemotherapy: A Randomized Placebo-Controlled Trial · Phase 3 · Fakultas Kedokteran Universitas Indonesia
- Jun 2027Melatonin for Prevention of Kidney Injury · Phase 3 · Rutgers, The State University of New Jersey
- Nov 2026Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy · Nazmy Edward Seif
- Nov 2026Amino Acids for Cardiac Surgery Associated AKI · Stanford University
- Nov 2026Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Nov 2026SIRAKI 02 Posthoc Analysis. · Hospital Universitari de Bellvitge
Who these studies take
Of the 230 Acute Kidney Injury studies recruiting now, 162 (70%) set no upper age limit and 35 (15%) stop at 75 or younger. 22 (10%) take children under 18. 2 (1%) are for women only and 1 (<1%) for men only; 25 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 18 (8%) | 18 (8%) |
| 18 | 208 (90%) | 207 (90%) |
| 30 | 211 (92%) | 210 (91%) |
| 40 | 211 (92%) | 210 (91%) |
| 50 | 214 (93%) | 213 (93%) |
| 65 | 214 (93%) | 213 (93%) |
| 75 | 203 (88%) | 202 (88%) |
| 85 | 182 (79%) | 182 (79%) |
Across all 1,691 studies, recruiting or not: 14% stop at 75 or younger and 10% at 65; 14% take children; 1% are for women only and 1% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Acute Kidney Injury studies take
Of 57 phase 2 interventional studies under Acute Kidney Injury, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 29 mo16–42 · 57 studies | — | 30 mo13–42 · 39 studies |
| Phase 3 | 33 mo14–63 · 35 studies | — | — |
| Phase 4 | 30 mo14–57 · 46 studies | — | 28 mo14–57 · 45 studies |
| Interventional, no phase | 26 mo12–44 · 267 studies | — | 27 mo12–44 · 249 studies |
| Observational | 24 mo12–42 · 365 studies | — | 24 mo12–43 · 350 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting4
- Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-CNov 13, 2026NCT07818265
- Acute Kidney Injury and Ultra-endurance RunningNov 5, 2026NCT07519408
- Clinical Decision Support for SGLT2i After AKI in Type 2 DiabetesNov 4, 2026NCT07868666
- COordiNated CommuNication, Education, and Care Transitions After Acute Kidney Injury (CONNECT-AKI)Oct 20, 2026NCT07626268
Results posted1
- Multi-hospital Electronic Decision Support for Drug-associated Acute Kidney InjuryNov 10, 2026NCT06264752
Newly registered11
- Acute Kidney Injury and Intermittent Dialysis DoseNov 9, 2026NCT07924137
- Diastolic Shock Index for Predicting Hemodynamic Instability During Continuous Renal Replacement TherapyNov 5, 2026NCT07918742
- Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney InjuryNov 4, 2026NCT07915713
- Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac SurgeryOct 30, 2026NCT07907887
- Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKIOct 29, 2026NCT07903519
Show 6 moreShow fewer
- Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal SurgeryOct 23, 2026NCT07891026
- Preventing Kidney Injury Using Carbon Dioxide as Contrast Medium in Patients With Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) Having Arterial InterventionOct 23, 2026NCT07891988
- Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial FluidOct 23, 2026NCT07893223
- Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve SurgeryOct 22, 2026NCT07888634
- Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver TransplantationOct 21, 2026NCT07885657
- Amino Acid Therapy Evaluating the Incidence of New-Onset AKIOct 19, 2026NCT07880951
Studies
Recruiting first, then most recently updated. Showing 50 of 1,691. Browse all 1,691 → or search them.
- Prevention of Nephrotoxin-Induced Acute Kidney Injury Using CilastatinRecruitingNCT06886464Phase 21 country
- Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-CRecruitingNCT078182651 country
- Renal Oxygenation-Guided AKI Reduction TrialNot yet recruitingNCT07816640Not applicable1 country
- UPTAKE - Virtual Care: Virtual Home Hospital With Remote Monitoring to Reduce Acute Care HospitalizationRecruitingNCT06537453Not applicable1 country
- Acute Kidney Injury and Intermittent Dialysis DoseNot yet recruitingNCT07924137
- Improving Preterm Kidney Outcomes With CaffeineRecruitingNCT07262060Phase 21 country
- Acute Kidney Injury and Ultra-endurance RunningRecruitingNCT07519408Not applicable1 country
- Early Biomarker Kidney Injury Assessment After Acumen Directed Fluid Management in Cardiac SurgeryNot yet recruitingNCT06109714Not applicable
- Diastolic Shock Index for Predicting Hemodynamic Instability During Continuous Renal Replacement TherapyNot yet recruitingNCT079187421 country
- PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatinRecruitingNCT067142141 country
- Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney InjuryNot yet recruitingNCT07915713Not applicable1 country
- Clinical Decision Support for SGLT2i After AKI in Type 2 DiabetesRecruitingNCT07868666Not applicable1 country
- Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal FailureRecruitingNCT05817539Not applicable1 country
- Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney InjuryRecruitingNCT07016074Phase 21 country
- Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney InjuryNot yet recruitingNCT07217808Not applicable1 country
- Effect of a Furosemide Stress Test-Guided Strategy on Liberation From Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney InjuryRecruitingNCT06229990Phase 41 country
- ProNephro NGAL Test for Early Detection of Acute Kidney Injury in Adult ICU Patients (ALPACA)Enrolling by invitationNCT077519131 country
- Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKINot yet recruitingNCT079035191 country
- Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal SurgeryRecruitingNCT06753409Not applicable1 country
- Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic ShockNot yet recruitingNCT07481097Not applicable1 country
- Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0Enrolling by invitationNCT0682311533 countries
- LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)RecruitingNCT06446739Not applicable3 countries
- A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung MachineRecruitingNCT06772025Not applicable2 countries
- Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal SurgeryNot yet recruitingNCT078910261 country
- Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial FluidNot yet recruitingNCT078932231 country
- NIRS Monitoring in the NICU and AKIRecruitingNCT07222722Not applicable1 country
- Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve SurgeryRecruitingNCT07888634Not applicable1 country
- Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney InjuryRecruitingNCT05758077Not applicable1 country
- Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver TransplantationNot yet recruitingNCT07885657Not applicable1 country
- Amino Acid Therapy Evaluating the Incidence of New-Onset AKINot yet recruitingNCT07880951Phase 2
- Structured Hemodynamic Assessment to Guide Care After Cardiac SurgeryNot yet recruitingNCT07792707Not applicable1 country
- COordiNated CommuNication, Education, and Care Transitions After Acute Kidney Injury (CONNECT-AKI)RecruitingNCT07626268Not applicable1 country
- Perioperative Ursodeoxycholic Acid for Renal Protection in Adults Undergoing Partial Nephrectomy for Renal TumorsRecruitingNCT07672860Phase 21 country
- The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)RecruitingNCT07556107Phase 41 country
- Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control.Enrolling by invitationNCT07873372Not applicable1 country
- Immune Evaluation for Postoperative Sepsis-AKIEnrolling by invitationNCT078115441 country
- Infliximab for Immune Checkpoint Inhibitor Associated AKIRecruitingNCT07683975Phase 41 country
- Automated System for Monitoring Urine Output in Intensive Care PatientsNot yet recruitingNCT052320451 country
- Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive CrisisRecruitingNCT06699849Phase 23 countries
- Renal Angina Index for Predicting Acute Kidney Injury in Adult ICU PatientsNot yet recruitingNCT078635051 country
- Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement TherapyRecruitingNCT07596043Not applicable1 country
- Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.RecruitingNCT05147831Not applicable1 country
- Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRTRecruitingNCT05399537Phase 31 country
- Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement TherapyRecruitingNCT07346118Not applicable1 country
- Safety and Efficacy of Ultrasound-Guided Percutaneous Nephrostomy in Oncology PatientsNot yet recruitingNCT07855666Not applicable
- Uric Acid to Albumin Ratio for Predicting Contrast Associated Acute Kidney Injury After Cardiac and Non Cardiac ProceduresNot yet recruitingNCT07855653
- Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill PatientsNot yet recruitingNCT07853911
- Hamburg Acute Kidney Injury Study (HAKIS)RecruitingNCT073386691 country
- High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)Not yet recruitingNCT078504921 country
- An Observational Study of Percutaneous Glomerular Filtration Rate (TGFR) in the Early Warning of Contrast-induced Acute Kidney Injury During the Peri-examination Period of Emergency Enhanced CTNot yet recruitingNCT078509471 country