A Phase 4 interventional study of Dexmedetomidine and saline in Gonarthrosis, sponsored by Diskapi Yildirim Beyazit Education and Research Hospital. Completed. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Diskapi Yildirim Beyazit Education and Research Hospital · Phase 4, Interventional, and Treatment
The effect of deksmedetomidine infusion on ischemia-reperfusion injury related to tourniquet application during total knee replacement will be evaluated by malondialdehyde and total antioksidant status.
Spinal anestesia will be performed to patients undergoing total knee replacement . A continuos infusion (0.1 micg/kg/min for 10 minutes followed by 0.2-0.7 micg/kg/hr) of deksmedetomidine will be used until the end of the surgery in the Deksmedetomidine group, an equivalent volume of salin will be delivered to the saline group. The venous blood sample will be obtained before spinal anestesia, and 1 minute before tourniquet inflation and 15 minutes after tourniquet deflation to determine malondialdehyde and total anti-oksidant status.
3,391 studies on the registry are indexed under Osteoarthritis, Knee; 628 are open to participants now.
This study's enrollment of 60 is below the median of 69 across 2,808 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Diskapi Yildirim Beyazit Education and Research Hospital is the lead sponsor of 70 studies on the registry; 12 are open to participants now.
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ASA1-3 patients
Exclusion Criteria:
ASA 4-5 patients, antioksidant drug use, contrandication for spinal anesthesia
0.1 mcg/kg/min 10 minutes dexmedetomidine infusion followed by 0.2-0.7 mcg/kg/hour dexmedetomidine infusion
Drug: Dexmedetomidine
0.1 mcg/kg/min 10 minutes saline infusion followed by 0.2-0.7 mcg/kg/hour saline infusion
Drug: saline
0.1 mcg/kg/min 10 minutes dexmedetomidine infusion followed by 0.2-0.7 mcg/kg/hour dexmedetomidine infusion
Also known as: precedex
0.1 mcg/kg/min 10 minutes saline infusion followed by 0.2-0.7 mcg/kg/hour saline infusion
blood malondialdehide levels
5 minutes before commencing spinal aneashesia
Time frame: 5 minutes before commencing spinal aneashesia
blood malondialdehide levels
1 minute before turniquet deflation
Time frame: 1 minute before turniquet deflation
blood malondialdehide levels
15 minutes after turniquet deflation
Time frame: 15 minutes after turniquet deflation
blood total antioksidant status
5 minutes before commencing spinal aneashesia
Time frame: 5 minutes before commencing spinal aneashesia
blood total antioksidant status
1 minute before turniquet deflation
Time frame: 1 minute before turniquet deflation
blood total antioksidant status
15 minutes after turniquet deflation
Time frame: 15 minutes after turniquet deflation
No study locations are listed for this record.
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Dexmedetomidine
Diskapi Yildirim Beyazit Education and Research Hospital