Shock, Septic clinical trials
The registry lists 1,078 studies for Shock, Septic across more than 10 countries. 232 are recruiting or about to start. 926 of them are mainly about Shock, Septic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
ClinicalTrials.gov finds 1,191 studies for Shock, Septic. How that becomes 1,077 here
This page counts the studies the registry files under Shock, Septic, and those it files under no condition that list Shock, Septicthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,191Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −9List Shock, Septic as a condition, but the registry did not file them under itMost often written as “Severe Sepsis Without Septic Shock” (3), “Severe Sepsis With Septic Shock” (2), and “Septic Shock Hyperdynamic” (2). The registry filed them under other conditions only, most often Sepsis (6) and Hemostatic Disorders (1).
- −105Match it another way90 name it in the title, 3 in a keyword, and 12 by a synonym or other text the search reads.
- 1,077The count on this page14 of them list Shock, Septic in their own words; the registry filed them under no condition.
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Who runs them
Assistance Publique - Hôpitaux de Paris (30) · Cairo University (17) · Southeast University, China (16) · Assiut University (16) · Hospices Civils de Lyon (14) · Mahidol University (14) · Centre Hospitalier Universitaire, Amiens (11) · University Hospital, Strasbourg, France (11)
What is being tested here
Drugs under test in Shock, Septic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Norepinephrine | 4 | 8 | 17 |
| Angiotensin II | 4 | 1 | 12 |
| Dexmedetomidine | 4 | 4 | 11 |
| Hydrocortisone | 3 | 8 | 20 |
| Arginine Vasopressin | 3 | 3 | 11 |
| Fludrocortisone | 3 | 4 | 7 |
| Epinephrine | 3 | 1 | 5 |
| Shen-Fu | 3 | 1 | 4 |
| Ascorbic Acid | 2 | 7 | 23 |
| Methylene Blue | 2 | 7 | 11 |
Drug classes tested here Beta blockers 4 open · Statins 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Early Methylene Blue in the Microhemodynamics of Septic Patients · Phase 3 · Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
- Dec 2026A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections · Phase 3 · Angela HUTTNER
- Dec 2026Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · Odense University Hospital
- Jun 2027Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility · Phase 3 · Centre Hospitalier Universitaire, Amiens
- Jun 2027Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Aug 2027Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis · Phase 3 · Hospital do Coracao
- Nov 2026Early Optimization of Ceftazidime Regimen in Critical Care · Centre Hospitalier Universitaire de Saint Etienne
- Nov 2026Doppler Echocardiography Versus Clinical Targets Guided Therapy on the Outcome of Postpartum Septic Shock. · Assiut University
- Nov 2026Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients · Ain Shams University
- Nov 2026ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock · Rennes University Hospital
Who these studies take
Of the 136 Shock, Septic studies recruiting now, 102 (75%) set no upper age limit and 19 (14%) stop at 75 or younger. 12 (9%) take children under 18. 2 (1%) are for women only and 1 (1%) for men only; 13 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 9 (7%) | 9 (7%) |
| 18 | 125 (92%) | 123 (90%) |
| 30 | 127 (93%) | 125 (92%) |
| 40 | 127 (93%) | 125 (92%) |
| 50 | 126 (93%) | 126 (93%) |
| 65 | 123 (90%) | 123 (90%) |
| 75 | 118 (87%) | 118 (87%) |
| 85 | 111 (82%) | 110 (81%) |
Across all 1,078 studies, recruiting or not: 11% stop at 75 or younger and 8% at 65; 9% take children; <1% are for women only and <1% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Shock, Septic studies take
Of 46 phase 3 interventional studies under Shock, Septic, half reached primary completion within 42 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 29 mo15–42 · 41 studies | — | 29 mo15–42 · 36 studies |
| Phase 2/3 | 24 mo12–40 · 13 studies | — | — |
| Phase 3 | 42 mo16–59 · 46 studies | — | 42 mo16–59 · 45 studies |
| Phase 4 | 24 mo16–38 · 40 studies | — | 24 mo16–38 · 39 studies |
| Interventional, no phase | 25 mo12–42 · 172 studies | — | 25 mo12–41 · 164 studies |
| Observational | 25 mo12–47 · 202 studies | — | 25 mo13–47 · 189 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting3
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyOct 28, 2026NCT07896018
- Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.Oct 27, 2026NCT07628023
- Systematic Adjunction of Vasopressine in Septic ShockOct 26, 2026NCT07052084
Newly registered9
- AI-ECHO Hemodynamic Phenotyping in Septic ShockNov 9, 2026NCT07924501
- Thymosin Alpha 1 and IgM Levels in SepsisNov 6, 2026NCT07922954
- PF-Organized Corticosteroid-Associated Heterogeneity in SepsisNov 3, 2026NCT07913464
- Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in SepsisOct 30, 2026NCT07906561
- A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic ResponseOct 27, 2026NCT07898462
Show 4 moreShow fewer
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyOct 26, 2026NCT07896018
- Neutrophil Activation and NETosis in SepsisOct 22, 2026NCT07888036
- Internal Jugular Vein and Inferior Vena Cava Collapsibility Indices as a Guidance of Fluid Responsiveness in Septic Shock Cancer PatientsOct 16, 2026NCT07879287
- Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic ShockOct 13, 2026NCT07871305
Studies
Recruiting first, then most recently updated. Showing 50 of 1,078. Browse all 1,078 → or search them.
- Restricted or Liberal Fluid for Haemodynamic Resuscitation in SepsisNot yet recruitingNCT05453565
- AI-ECHO Hemodynamic Phenotyping in Septic ShockNot yet recruitingNCT079245011 country
- Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled TrialNot yet recruitingNCT07184866Not applicable
- ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their CaregiversNot yet recruitingNCT07778004Not applicable1 country
- Serum GDF-15 and LGALS3BP as Prognostic Biomarkers in SepsisNot yet recruitingNCT07906561
- A Trial of Adjunctive Fludrocortisone (50mcg, 100mcg or Placebo) in Critically Ill Patients With Septic Shock Receiving Hydrocortisone, Evaluating Survival and Functional Recovery and the Influence of Transcriptomic ResponseRecruitingNCT07898462Phase 31 country
- Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational StudyRecruitingNCT078960181 country
- Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic ShockRecruitingNCT07179276Not applicable1 country
- Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.RecruitingNCT076280231 country
- Systematic Adjunction of Vasopressine in Septic ShockRecruitingNCT07052084Phase 31 country
- Neutrophil Activation and NETosis in SepsisNot yet recruitingNCT07888036
- Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic ShockRecruitingNCT06481410Not applicable1 country
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Personalized Fluid Resuscitation in the Emergency Department: A Pilot TrialRecruitingNCT07779720Not applicable1 country
- Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic ShockNot yet recruitingNCT07871305
- Immune Dysregulation During Sepsis: A Natural History CohortNot yet recruitingNCT077357411 country
- Remote Ischemic Postconditioning in Septic ShockNot yet recruitingNCT07273942Not applicable1 country
- Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood SamplesNot yet recruitingNCT065310313 countries
- HOPE-Sepsis: Hemoadsorption Therapy for SepsisNot yet recruitingNCT07865585Not applicable1 country
- Sepsis ICU Gut Microbiome AnalysisNot yet recruitingNCT078648181 country
- Plasma Exchange in Children With Severe Sepsis and Septic ShockRecruitingNCT07706413Not applicable1 country
- Non-invasive Hemodynamic Optimization of Sepsis in Internal Medicine: a Randomized Study Comparing Therapy Guided by Non-invasive Hemodynamic Indices Versus Standard of Care.RecruitingNCT07863323Not applicable1 country
- Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock PatientsRecruitingNCT06140147Not applicable3 countries
- Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock PatientsRecruitingNCT07716956Not applicable1 country
- Dynamic SvO2 in Predicting Fluid Responsiveness in Septic ShockRecruitingNCT075162361 country
- Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.RecruitingNCT059287671 country
- Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort StudyNot yet recruitingNCT07667153
- Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic ShockNot yet recruitingNCT06746753Phase 41 country
- Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill PatientsNot yet recruitingNCT07184593
- Prognostic Power of the VEXUS Score in Septic Shock: Effectiveness in Mortality PredictionRecruitingNCT071247411 country
- PRIME Sepsis Trial: Early Sepsis Detection in the Emergency Department Using Presepsin and Immature GranulocytesNot yet recruitingNCT078224121 country
- Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic ShockRecruitingNCT04494074Not applicable1 country
- Early Optimization of Ceftazidime Regimen in Critical CareNot yet recruitingNCT07085624Not applicable1 country
- Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.RecruitingNCT065392341 country
- Dynamic POCUS of Diaphragm Function to Predict Respiratory Failure in Septic ShockNot yet recruitingNCT078202671 country
- Microbiology Operations & Time Optimization in SepsisNot yet recruitingNCT078170431 country
- Ionized Calcium as a Severity Marker in Septic Shock PatientsNot yet recruitingNCT07812051
- Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care UnitNot yet recruitingNCT07811180Not applicable1 country
- Early Endotoxin Burden Reduction With oXiris in Septic Shock Patients Requiring CRRTRecruitingNCT07807410Not applicable1 country
- Early Angiotensin II in the Emergency DepartmentRecruitingNCT06693726Phase 41 country
- This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume OverloadNot yet recruitingNCT07797751
- Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICUNot yet recruitingNCT07398703
- Early Versus Late Adjunctive Vasopressin in Septic ShockRecruitingNCT06709573Phase 41 country
- Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic CoagulopathyNot yet recruitingNCT07214103Phase 21 country
- Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory FailureRecruitingNCT06881927Phase 41 country
- Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic ShockRecruitingNCT077749621 country
- EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory PhenotypesNot yet recruitingNCT077604151 country
- Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical StudyRecruitingNCT042886351 country
- Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter StudyNot yet recruitingNCT07746050Not applicable1 country
- Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.Not yet recruitingNCT07733206Not applicable1 country