An interventional study of Nitroglycerin (NTG) and Dexmedetomidine in Hemodynamics and Arterial Pressure, sponsored by Mayo Hospital Lahore. Completed at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by Mayo Hospital Lahore · Not applicable, Interventional, and Supportive care
Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →
This randomized controlled study compared nitroglycerine and dexmedetomidine for controlling blood pressure after insertion of a breathing tube in adults undergoing spine surgery under general anesthesia. The study hypothesis was that average blood pressure, measured as mean arterial pressure, differed between patients who received the two medicines.
The study included 80 patients aged 18-60 years at the Department of Anesthesia, King Edward Medical University and its affiliated hospital in Lahore, Pakistan. Patients were randomly assigned by a lottery method to two groups of 40. One group received nitroglycerine through an intravenous infusion, while the other received dexmedetomidine. Both groups received the same general anesthesia protocol. Blood pressure was recorded before anesthesia and five minutes after insertion of the breathing tube. The main outcome was mean arterial pressure at five minutes after tube insertion, which was compared between the two groups.
Mayo Hospital Lahore is the lead sponsor of 16 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Forty participants received intravenous nitroglycerin during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg.
Drug: Nitroglycerin (NTG)
Forty participants received intravenous dexmedetomidine during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg.
Drug: Dexmedetomidine
Nitroglycerin was administered by intravenous infusion at 120 micrograms/kg/hour and titrated to the target mean arterial pressure.
Dexmedetomidine was administered intravenously, followed by a continuous infusion at 1.0 microgram/kg/hour, titrated to the target mean arterial pressure.
Mean Arterial Pressure
Mean arterial pressure was assessed using noninvasive blood pressure measurements and expressed in millimeters of mercury. It was calculated as \[systolic blood pressure + (2 × diastolic blood pressure)\] ÷ 3. Mean arterial pressure measured five minutes after endotracheal intubation was compared between the nitroglycerin and dexmedetomidine groups.
Time frame: Five minutes after endotracheal intubation.
Ran from Jan 2026 to primary completion in Jun 2026, 5 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drug tested here: Dexmedetomidine
Mayo Hospital Lahore