Shock clinical trials
The registry lists 487 studies for Shock across more than 10 countries. 107 are recruiting or about to start. 244 of them are mainly about Shock (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04. Counting its 15 narrower conditions too, such as Sepsis: 4,627 studies, 1,036 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Assistance Publique - Hôpitaux de Paris (14) · Assiut University (12) · Bicetre Hospital (8) · Hospices Civils de Lyon (8) · Southeast University, China (8) · Centre Hospitalier Universitaire de Nīmes (7) · Nantes University Hospital (7) · University Hospital, Bordeaux (6)
What is being tested here
Drugs under test in Shock studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Norepinephrine | 3 | 3 | 7 |
| Epinephrine | 3 | 1 | 4 |
| Centhaquine | 2 | 2 | 4 |
| Hydrocortisone | 1 | 4 | 7 |
| Arginine Vasopressin | 1 | 3 | 5 |
| Phenylephrine | 1 | 0 | 3 |
| Dobutamine | 1 | 1 | 3 |
| Midodrine | 1 | 0 | 2 |
| Angiotensin II | 1 | 0 | 2 |
| Remimazolam | 1 | 1 | 2 |
Drug classes tested here Bronchodilators 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · Odense University Hospital
- Jun 2027Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock · Phase 3 · Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Jun 2027REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults · Phase 3 · Yancheng First People's Hospital
- Nov 2026A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients · Pharmazz, Inc.
- Nov 2026Fecal Lactate and Resuscitation Outcomes in Critical Illness · Hospital H+ Queretaro
- Nov 2026Femoral Vein, Internal Jugular Vein and Inferior Vein Cava Collapsibility Indices in Polytrauma Patients by Sonographic Evaluation Before and After Resuscitation. · Assiut University
- Nov 2026IVC Ultrasound Versus Central Venous Pressure for Early Detection of Hypovolemia in Shock Patients · Assiut University
- Nov 2026Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis · German International University
- Dec 2026Evaluation of Plasma Renin Concentrations in Cardiac Surgery · Mayo Clinic
- Dec 2026CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock · Ottawa Heart Institute Research Corporation
Who these studies take
Of the 68 Shock studies recruiting now, 52 (76%) set no upper age limit and 11 (16%) stop at 75 or younger. 9 (13%) take children under 18. 1 (1%) are for women only and 0 (0%) for men only; 4 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (6%) | 4 (6%) |
| 18 | 57 (84%) | 57 (84%) |
| 30 | 59 (87%) | 58 (85%) |
| 40 | 61 (90%) | 60 (88%) |
| 50 | 59 (87%) | 58 (85%) |
| 65 | 58 (85%) | 58 (85%) |
| 75 | 58 (85%) | 58 (85%) |
| 85 | 55 (81%) | 55 (81%) |
Across all 487 studies, recruiting or not: 18% stop at 75 or younger and 16% at 65; 17% take children; 1% are for women only and 1% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Shock studies take
Of 127 observational studies under Shock, half reached primary completion within 26 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 25 mo8–43 · 70 studies | — | 22 mo8–38 · 67 studies |
| Observational | 26 mo12–52 · 127 studies | — | 26 mo12–52 · 120 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
- Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICUNov 4, 2026NCT07304648
Stopped1
- Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg PositioningWithdrawnNov 2, 2026NCT06418022
Studies
Recruiting first, then most recently updated. Showing 50 of 487. Browse all 487 → or search them.
- Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICURecruitingNCT073046481 country
- Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL)Not yet recruitingNCT078378431 country
- Individualised Blood Pressure Targets Versus Standard Care Among Critically Ill Patients With ShockRecruitingNCT05850962Not applicable1 country
- Synthetic Angiotensin II/Giapreza in Pediatric Patients With Refractory HypotensionEnrolling by invitationNCT07212686Phase 41 country
- French Observatory on the Management of Cardiogenic Shock 2Not yet recruitingNCT078687571 country
- Validation of the iCVS Model in Patients Admitted to the Intensive Care UnitNot yet recruitingNCT07256886
- Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement TherapyRecruitingNCT07346118Not applicable1 country
- Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICURecruitingNCT06581939Not applicable1 country
- A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative AgentNot yet recruitingNCT05251181Phase 3
- A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock PatientsRecruitingNCT05956418Phase 41 country
- The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective StudyRecruitingNCT064605192 countries
- Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.RecruitingNCT065392341 country
- Gastric Emptying and Enteral Nutrition Tolerance According to Vasopressor Dose in ICU PatientsRecruitingNCT078023791 country
- Peripheral pULSe Assessment and Arterial pRessure (PULSAR)RecruitingNCT076090951 country
- Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)RecruitingNCT07322133Phase 41 country
- Resuscitative TEE Collaborative RegistryRecruitingNCT049725261 country
- CRUISE System in FlightNot yet recruitingNCT07637240
- Evaluation of the Argos System to Estimate Cardiac OutputRecruitingNCT077242621 country
- Characterizing Perfusion and Congestion Responses to Fluid Loading in Critically Ill Septic PatientsNot yet recruitingNCT076850021 country
- Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With ShockNot yet recruitingNCT07670390
- Digital Out-of-hospital Management on Clinical Outcomes in Patients With Early Cardiogenic ShockRecruitingNCT07085221Not applicable1 country
- ICU Combined Assessment of Cardio-Respiratory ExerciseRecruitingNCT061939801 country
- ICU Background Early Awareness for Critical deterioratiONRecruitingNCT071194111 country
- Right Ventriculo-Arterial Coupling During Fluid Loading in ICU PatientsRecruitingNCT075376211 country
- Delphi Septic Shock: Sub-phenotypes Using Point-of-Care Ultrasound in Patients With Septic ShockEnrolling by invitationNCT076168171 country
- Effects of Extracorporeal Shockwave Therapy Versus Pulsed Electromagnetic Field Therapy in Females With Sexual Dysfunction.RecruitingNCT07584174Not applicable1 country
- SWedish Intensive Care BiobankNot yet recruitingNCT07582601
- Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter RatioRecruitingNCT075466561 country
- Hemodynamic and Respiratory Instability During Percutaneous Pulmonary ThrombectomyNot yet recruitingNCT075095411 country
- CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic ShockRecruitingNCT05267886Phase 42 countries
- Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: an Integrative Approach in the Immediate Postoperative PeriodNot yet recruitingNCT075470201 country
- A Proof-of-concept Study of Ultrasound Stimulation of the Neck to Enhance Anti-shock EfficacyNot yet recruitingNCT07467798Not applicable
- Efficacy of Early Argipressin in the Management of Intensive Care Patients With Norepinephrine-refractory Vasoplegic ShockRecruitingNCT07063680Phase 31 country
- Fluid-responsiveness Assessment Simplified by Electric Cardiometry in ChildrenRecruitingNCT075225801 country
- Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.RecruitingNCT07494643Not applicable1 country
- Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous PressureRecruitingNCT05655065Not applicable1 country
- Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee OsteoarthritisRecruitingNCT07468734Not applicable1 country
- Inova Cardiogenic Shock Registry (INOVA SHOCK)RecruitingNCT033787391 country
- Smartphone Application for Automated Measurement of Capillary Refill Time (CRT)Not yet recruitingNCT074738691 country
- Prehospital Analgesia INtervention Trial (PAIN)RecruitingNCT05437575Phase 31 country
- Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress SyndromeRecruitingNCT074508461 country
- Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and MortalityRecruitingNCT072736431 country
- Enteral Versus Parenteral Nutrition During Recovery After ShockNot yet recruitingNCT07411014Not applicable1 country
- Clinical Eficacy of Extracorporeal Shock Wave Therapy on Patellar TendinitisRecruitingNCT07401758Not applicable1 country
- Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume MeasurementNot yet recruitingNCT073859631 country
- Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Patients With ShockEnrolling by invitationNCT073737171 country
- Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient OutcomesEnrolling by invitationNCT05443321Not applicable1 country
- Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)RecruitingNCT05058612Phase 41 country
- Effectiveness of the MINUTES Bundle for Initial 30-Minute Management of Undifferentiated Circulatory Shock in the Emergency DepartmentNot yet recruitingNCT07209735Not applicable
- Vasoactive Drugs in Intensive Care UnitRecruitingNCT02118467Phase 41 country