Multiple Organ Failure clinical trials
The registry lists 193 studies for Multiple Organ Failure across more than 10 countries. 47 are recruiting or about to start. 58 of them are mainly about Multiple Organ Failure (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
University of Ulm (4) · Hospices Civils de Lyon (3) · University of Leicester (3) · University of Rostock (3) · Massachusetts General Hospital (3) · Nationwide Children's Hospital (3) · Chang Gung Memorial Hospital (3) · University of Pecs (2)
What is being tested here
Drugs under test in Multiple Organ Failure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study · Ozkul Yilmaz Colak
- Dec 2026Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis · The University of Texas Health Science Center, Houston
- Dec 2026Safety, Tolerability and Performance of the NucleoCapture Extracorporeal Therapeutic Apheresis Device in the Reduction of Circulating cfDNA/NETs in Subjects With Pancreatitis · Liverpool University Hospitals NHS Foundation Trust
- Dec 2026Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators · Second Affiliated Hospital of Wenzhou Medical University
- Dec 2026The Impact and Effect of Traditional Chinese Medicine Treatment on Organ Failure in Critically Ill Patients · China Medical University Hospital
- Dec 2026Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study · Seoul National University Bundang Hospital
- Jan 2027Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection · Shanghai Zhongshan Hospital
- Mar 2027OXiris for Abdominal SEptic Shock (OASES Study) · RenJi Hospital
- Apr 2027Metabolic and Functional Study of γδ T Cells in Critically Ill Patients · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- May 2027ICU Background Early Awareness for Critical deterioratiON · ETH Zurich
Who these studies take
Of the 28 Multiple Organ Failure studies recruiting now, 16 (57%) set no upper age limit and 3 (11%) stop at 75 or younger. 3 (11%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (11%) | 3 (11%) |
| 18 | 24 (86%) | 24 (86%) |
| 30 | 27 (96%) | 27 (96%) |
| 40 | 27 (96%) | 27 (96%) |
| 50 | 27 (96%) | 27 (96%) |
| 65 | 26 (93%) | 26 (93%) |
| 75 | 26 (93%) | 26 (93%) |
| 85 | 21 (75%) | 21 (75%) |
Across all 193 studies, recruiting or not: 17% stop at 75 or younger and 12% at 65; 17% take children; 0% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Multiple Organ Failure studies take
Of 44 observational studies under Multiple Organ Failure, half reached primary completion within 32 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 24 mo12–54 · 28 studies | — | — |
| Observational | 32 mo16–69 · 44 studies | — | 32 mo16–69 · 44 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting1
- Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic DissectionNov 10, 2026NCT07156656
Newly registered1
- Prehospital mSOFA-Kit Decision Support for the Detection of Multiple Organ FailureNov 10, 2026NCT07928674
Studies
Recruiting first, then most recently updated. Showing 50 of 193. Browse all 193 → or search them.
- Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic DissectionRecruitingNCT07156656Phase 41 country
- Prehospital mSOFA-Kit Decision Support for the Detection of Multiple Organ FailureNot yet recruitingNCT07928674Not applicable1 country
- Metabolic and Functional Study of γδ T Cells in Critically Ill PatientsRecruitingNCT076808161 country
- pSOFA Score in Predicting Mortality in Pediatric Intensive CareNot yet recruitingNCT07858487
- Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill PatientsNot yet recruitingNCT07853911
- FOUR-Based Modification of ICU Severity ScoresNot yet recruitingNCT078327731 country
- Efferon LPS Hemoadsorption in Cardiac Surgery PatientsRecruitingNCT07532174Not applicable1 country
- AI-Based Precision Transfusion Prediction Model in Critically Ill PatientsNot yet recruitingNCT07762131
- Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical StudyRecruitingNCT042886351 country
- Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety EvaluationNot yet recruitingNCT07661303Not applicable1 country
- ICU Background Early Awareness for Critical deterioratiONRecruitingNCT071194111 country
- Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS StudyNot yet recruitingNCT075862541 country
- Heterogeneity of Critical Illness: a Cohort StudyRecruitingNCT045025111 country
- Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort StudyRecruitingNCT075398831 country
- Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODSRecruitingNCT05267821Phase 2/31 country
- Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1Not yet recruitingNCT072497621 country
- TDAP in Burn Patients (Group 2)Not yet recruitingNCT072236841 country
- Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving MediatorsNot yet recruitingNCT07353970
- Extracorporeal Blood Purification Using Oxiris for Septic Shock (EXPLORE Study)Not yet recruitingNCT07334327Not applicable
- Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized TrialNot yet recruitingNCT07293078Phase 1/21 country
- Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat StrokeNot yet recruitingNCT051553581 country
- Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic ShockEnrolling by invitationNCT068081001 country
- Impact of Fourier Transform Infrared Spectroscopy (FTIRS) in ICUsRecruitingNCT05872152Not applicable1 country
- Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)RecruitingNCT03547232Phase 41 country
- Alveolar Dead Space as Predictor of Organ Failure in Severe SepsisNot yet recruitingNCT013157821 country
- Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.RecruitingNCT05044403Not applicable1 country
- High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically IllRecruitingNCT058831371 country
- Safety, Tolerability and Performance of the NucleoCapture Extracorporeal Therapeutic Apheresis Device in the Reduction of Circulating cfDNA/NETs in Subjects With PancreatitisNot yet recruitingNCT06566638Not applicable1 country
- Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic ShockRecruitingNCT05726825Not applicable3 countries
- Electronic Archive of Internal Medicine for the Treatment of Severe Organ Failure and Liver Transplantation-MITIGORecruitingNCT067815021 country
- Quantitative Ultrasound Assessment of Abdominal Cavity SpaceNot yet recruitingNCT066347321 country
- Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 PneumoniaRecruitingNCT051816961 country
- Safety and Efficacy of Fecal Microbiota TransplantationRecruitingNCT04014413Not applicable1 country
- OXiris for Abdominal SEptic Shock (OASES Study)Not yet recruitingNCT06504316Not applicable1 country
- Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe TraumaRecruitingNCT061675121 country
- Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial SepsisRecruitingNCT064919661 country
- The Impact and Effect of Traditional Chinese Medicine Treatment on Organ Failure in Critically Ill PatientsRecruitingNCT06452966Not applicable1 country
- Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill PatientsRecruitingNCT06265259Phase 41 country
- Burden, Mortality and Supply Costs in Intensive Care Unit PatientsRecruitingNCT040944281 country
- Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver DysfunctionRecruitingNCT06129617Not applicable1 country
- The PRE-OP ENERGY TrialRecruitingNCT04015973Not applicable1 country
- Severe Sepsis/Septic Shock on Admission to the General Surgical ICURecruitingNCT013636351 country
- Acute Cardiac Dysfunction in Critical IllnesRecruitingNCT058605041 country
- Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and MortalityRecruitingNCT05895240Phase 41 country
- European Registry for Hemadsorption in Sepsis With the Seraph FilterRecruitingNCT056080961 country
- Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic InflammationRecruitingNCT05182723Not applicable1 country
- Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic DissectionNot yet recruitingNCT04356300Not applicable
- Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care UnitCompletedNCT06330610Not applicable1 country
- Remimazolam Versus Propofol for Procedural Sedation in Gastrointestinal Endoscopy: A Single-Centre Prospective Observational Comparative Study in a High-Risk PopulationCompletedNCT073621731 country
- Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ FailureActive, not recruitingNCT05710315Not applicable1 country