An observational study in Capillary Refill Time and Peripheral Tissue Perfusion, sponsored by Assistance Publique - Hôpitaux de Paris. Not yet recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-16.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
This prospective, monocenter observational study aims to validate a smartphone application (CRTApp) that automatically measures capillary refill time (CRT) from a short video of a standardized finger compression. Sixty adult intensive care unit (ICU) patients will undergo a CRT measurement recorded with a professional Android smartphone. Clinical CRT will be determined from the video by three blinded observers (reference = median of the three measurements). The application will analyze the same video locally to provide an automated CRT measurement. Agreement between automated and clinical reference CRT will be assessed, and predefined subgroup analyses will explore performance across skin tone, ambient lighting, smartphone characteristics, and severity of peripheral hypoperfusion.
Capillary refill time (CRT) is a bedside indicator of peripheral perfusion, but visual assessment is prone to inter-observer variability. In this study, CRT is measured using a standardized method (10-second finger compression with a glass slide). A video of the fingertip is captured without audio; framing is strictly limited to the fingers. Files are pseudonymized at acquisition. Videos are transferred via USB to an AP-HP workstation and stored on an AP-HP server; no cloud or messaging is used, and videos are deleted from the smartphone after import. Automated CRT is computed locally from the video by CRTApp without network transmission and without retaining the video. Statistical analyses will include intraclass correlation coefficient and Bland-Altman analysis for agreement. Secondary analyses will evaluate agreement stratified by skin tone (Monk scale / ITA), ambient lighting (lux), smartphone characteristics, and severity of peripheral hypoperfusion.
487 studies on the registry are indexed under Shock; 107 are open to participants now.
This study's planned enrollment of 60 is below the median of 100 across 247 observational studies indexed under Shock.
Browse Shock studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,592 studies on the registry; 1,033 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults (≥18 years) admitted to the medical intensive care unit at Hôpital de Bicêtre (AP-HP) for whom a standardized capillary refill time measurement can be performed.
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Exclusion Criteria:
Agreement Between Automated and Clinical Capillary Refill Time Measurement
Agreement between capillary refill time measured by the smartphone application and the clinical reference measurement performed by expert clinicians using the standardized method (10-second glass slide compression). Agreement is assessed using the intraclass correlation coefficient between the automated measurement and the median of three blinded observers.
Time frame: At inclusion (single assessment)
Inter-Observer Variability of Clinical Capillary Refill Time Measurement
At inclusion (single assessment)
Time frame: Inter-observer variability of clinically measured capillary refill time assessed by three independent observers, expressed as the coefficient of variation.
Agreement Stratified by Skin Tone
Intraclass correlation coefficient between automated and clinical capillary refill time measurements stratified according to skin tone using the Monk Skin Tone Scale.
Time frame: At inclusion (single assessment)
Agreement Stratified by Ambient Lighting Conditions
At inclusion (single assessment)
Time frame: Intraclass correlation coefficient between automated and clinical capillary refill time measurements stratified according to ambient light intensity measured in lux.
Agreement Stratified by Smartphone Model Characteristics
At inclusion (single assessment)
Time frame: Intraclass correlation coefficient between automated and clinical capillary refill time measurements stratified by smartphone type (iOS or Android) and camera resolution.
Agreement Stratified by Severity of Peripheral Hypoperfusion
At inclusion (single assessment)
Time frame: Intraclass correlation coefficient between automated and clinical capillary refill time measurements stratified by clinical capillary refill time (< 3 seconds versus ≥ 3 seconds).
Start is estimated for Jun 2026; primary completion for Jun 2026, 0 months later.
Of 120 non-industry observational studies under Shock, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 52. This study's planned 0 months is below that.
Counting every sponsor, half of 127 studies reached it within 26 months; a quarter within 12 and three quarters within 52.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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