Drug
Phenylephrine clinical trials
Also written Neo-Synephrine and SCH 002063.
- studies test it
- 143
- open now
- 20
- in phase 3
- 21
- first study started
- 1996
Keep track of what changes. Save the Phenylephrine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Combined with it in one product
Studies by the year they started
143 studies that test it; most in 2012 (12)
| Year | Studies |
|---|---|
| 1996 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 3 |
| 2006 | 4 |
| 2007 | 4 |
| 2008 | 4 |
| 2009 | 5 |
| 2010 | 6 |
| 2011 | 6 |
| 2012 | 12 |
| 2013 | 3 |
| 2014 | 11 |
| 2015 | 7 |
| 2016 | 8 |
| 2017 | 9 |
| 2018 | 7 |
| 2019 | 11 |
| 2020 | 9 |
| 2021 | 5 |
| 2022 | 3 |
| 2023 | 8 |
| 2024 | 4 |
| 2025 | 6 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 5
- Phase 1
- 12
- Phase 2
- 18
- Phase 3
- 21
- Phase 4
- 46
- No phase
- 49
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 19 · Other 124
General Hospital of Ningxia Medical University (6) · Bayer (6) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (5) · Seoul National University Hospital (4) · University of California, San Francisco (3) · Cairo University (3) · Vanderbilt University Medical Center (3) · IWK Health Centre (3)
Often tested with
Tested in the same studies.
Norepinephrine (39) · Ephedrine (17) · Epinephrine (8) · Tropicamide (7) · Arginine Vasopressin (5) · Nitroprusside (4) · Cyclopentolate (4) · Omega-N-Methylarginine (3)
Studies
Open first, then newest update. How each study uses Phenylephrine is read from its arms, and is right about nine times in ten.
Testing it · 143
- ED50/ED90 of Phenylephrine Infusion for Preventing Spinal Anesthesia-Induced Hypotension: Supine vs Left-Tilt 15°Not yet recruitingPhase 4Peking University People's HospitalNCT07824713Written as Phenylephrine hydrochloride infusion
- Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal HypotensionRecruitingPhase 4Sohag UniversityNCT07662408Written as Phenylephrine
- The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac SurgeryRecruitingPhase 4University of California, San FranciscoNCT06802224Written as Phenylephrine
- Role of Sympathetic Overactivity and Angiotensin II in PTSD and CVRecruitingPhase 2Emory UniversityNCT02560805Written as Phenylephrine
- Phenylephrine Tumescence for Hemostasis in Surgery for Burn InjuryRecruitingPhase 1University of ManitobaNCT01731444Written as Phenylephrine
- Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-GrowthNot yet recruitingPhase 2/3Applied Biology, Inc.NCT06648850Written as Phenylephrine
- Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro StudyRecruitingNot applicableSamuel Lunenfeld Research Institute, Mount Sinai HospitalNCT06285396Written as Phenylephrine
- Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro StudyRecruitingNot applicableSamuel Lunenfeld Research Institute, Mount Sinai HospitalNCT04053478Written as Phenylephrine
- Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)RecruitingPhase 3Yonsei UniversityNCT06677970Written as BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Vasoactive Drugs in Intensive Care UnitRecruitingPhase 4University of ChicagoNCT02118467Written as Phenylephrine
- Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex DifferencesRecruitingPhase 4University of AlbertaNCT05997732Written as Phenylephrine Hydrochloride
- Autoimmune Basis for Postural Tachycardia SyndromeEnrolling by invitationNot applicableVanderbilt University Medical CenterNCT02725060Written as phenylephrine
- The GUARDIAN Trial - Vasopressor Sub-StudyEnrolling by invitationPhase 4The University of Texas Health Science Center, HoustonNCT04934748Written as Phenylephrine
- Use of Phenylephrine for Assessment of Mitral Regurgitation SeverityRecruitingPhase 1/2Montefiore Medical CenterNCT04500899Written as Mydfrin
- Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IVRecruitingPhase 4West-Ward PharmaceuticalNCT02323399Written as Phenylephrine
- Low Dose Vasopressin vs Phenylephrine in Cardiac SurgeryRecruitingPhase 4Thomas Jefferson UniversityNCT04602767Written as Phenylephrine
- ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment in Preeclamptic PatientsNot yet recruitingNot applicableGeneral Hospital of Ningxia Medical UniversityNCT06158035Written as Phenylephrine
- Cerebral Flow-metabolism Coupling During Adult SurgeryRecruitingPhase 4Jason ChuiNCT05941494Written as Phenylephrine
- Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)Not yet recruitingNot applicableBeijing Tiantan HospitalNCT05414877Written as Phenylephrine
- Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With PreeclampsiaNot yet recruitingNot applicableGeneral Hospital of Ningxia Medical UniversityNCT04576663Written as Phenylephrine
See all 143 studies that test Phenylephrine →
Given in every arm · 16 — Phenylephrine is usual care beside what is tested
- Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) SystemActive, not recruitingNot applicableKK Women's and Children's HospitalNCT03620942Written as Phenylephrine
- A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic StabilityCompletedPhase 2/3KK Women's and Children's HospitalNCT02277730Written as phenylephrine
- Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean SectionCompletedPhase 2/3KK Women's and Children's HospitalNCT04025918Written as Phenylephrine
- Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common ColdWithdrawnPhase 3SandozNCT05070650Written as Phenylephrine
- Cardiovascular Effects of Angiotensin (1-7) in Essential HypertensionTerminatedPhase 1Vanderbilt UniversityNCT02245230Written as Phenylephrine
- Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.CompletedNot applicableUniversity of AlbertaNCT05001048Written as Phenylephrine Hydrochloride
- The Impact of Carbon Monoxide and Altitude on Vascular FunctionCompletedNot applicableUniversity of AlbertaNCT04928183Written as Phenylephrine Hydrochloride
- Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise TrainingWithdrawnEarly Phase 1Colorado State UniversityNCT03972683Written as Phenylephrine
- Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under AnaesthesiaCompletedNot applicableAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)NCT03816072Written as Phenylephrine infusion
- Descemet Endothelial Thickness Comparison TrialStatus unknownPhase 4Oregon Health and Science UniversityNCT02373137Written as Phenylephrine
- Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV)CompletedPhase 4University Health Network, TorontoNCT02748265Written as Inhaled Epoprostenol and phenylephrine
- Decision Support for Intraoperative Low Blood PressureCompletedNot applicableVanderbilt University Medical CenterNCT02726620Written as Phenylephrine
- The Effect of Brimonidine on Intraocular Pressure When Dilating Routine PatientsCompletedPhase 1Wake Forest University Health SciencesNCT03139708Written as Phenylephrine
- Spinal Anesthesia Induced Hypotension During Cesarean SectionCompletedPhase 4Milton S. Hershey Medical CenterNCT00846651Written as phenylephrine infusion
- Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein CCompletedPhase 4Central Hospital, Nancy, FranceNCT02885168Written as Phenylephrine
- Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic SurgeryStatus unknownNot applicableHu AnminNCT02857153Written as Phenylephrine
As the comparator · 23 — what is tested is compared with Phenylephrine
- Superiority of Phenylephrine Versus Norepinephrine in Complex Spine Surgery (SPiNeS)Not yet recruitingPhase 4Mayo ClinicNCT07796282Written as Phenylephrine hydrochloride infusion
- Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During AnesthesiaRecruitingPhase 2/3University of AarhusNCT06083948Written as Phenylephrine
- CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioNNot yet recruitingPhase 3Yonsei UniversityNCT06770426Written as phenylephrine
- Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With PreeclampsiaRecruitingNot applicableGeneral Hospital of Ningxia Medical UniversityNCT05035498Written as Phenylephrine
- Comparing Between CO2 and Phenylephrine Treatment in Patients With Progressive Lacunar Infarction (CARBOGEN Study)TerminatedPhase 3Yonsei UniversityNCT04839224Written as phenylephrine
- Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe PreeclampsiaCompletedNot applicableGeneral Hospital of Ningxia Medical UniversityNCT05035485Written as Phenylephrine
- Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia HypotensionCompletedNot applicableGeneral Hospital of Ningxia Medical UniversityNCT05035888Written as Phenylephrine
- The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic PerformanceStatus unknownPhase 4Medical University of ViennaNCT05492968Written as Phenylephrine
- Study of the Safety, Efficacy and PK of EYN-1601 in Dilation of the PupilCompletedPhase 2Eyenovia Inc.NCT02946125Written as Phenylephrine 2.5% Eyedrop
- Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With PreeclampsiaCompletedNot applicableGeneral Hospital of Ningxia Medical UniversityNCT04556357Written as Phenylephrine
- Vasopressor Infusion in Cesarean DeliveryStatus unknownPhase 4Cairo UniversityNCT03248791Written as Phenylephrine
- The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia HypotensionStatus unknownNot applicableGeneral Hospital of Ningxia Medical UniversityNCT05035472Written as Phenylephrine
- A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens ReplacementCompletedPhase 3Omeros CorporationNCT02132312Written as Phenylephrine HCl
- Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal AnesthesiaCompletedPhase 4Centre Hospitalier Régional d'OrléansNCT03849508Written as Phenylephrine
- Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean DeliveryCompletedPhase 2Hospital dos Servidores do Estado do Rio de JaneiroNCT03702400Written as Phenylephrine 100 mcg
- Comparison of Phenylephrine and Norepinephrine for Spinal-induced HypotensionCompletedPhase 3Tribhuvan University Teaching Hospital, Institute Of Medicine.NCT04789005Written as Phenylephrine
- Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in PhacoemulsificationStatus unknownPhase 4Dar El Oyoun HospitalNCT03638726Written as Topical cyclopentolate and phenylephrine
- Role of Nitric Oxide in the Impact of Aging on Myocardial RemodelingCompletedNot applicableWashington University School of MedicineNCT00603720Written as Phenylephrine
- Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean DeliveryCompletedPhase 4Cairo UniversityNCT03328533Written as Phenylephrine
- Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean DeliveryStatus unknownPhase 4Jeju National University HospitalNCT02969239Written as Phenylephrine
Showing 20 of 23.
Codes
What other systems call Phenylephrine · ClinicalTrials.gg INT008001
- MeSH (NLM) D010656PhenylephrineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 1WS297W6MVPHENYLEPHRINEConfirmed FDA, NLM, Wikidata
- RxNorm 8163Confirmed FDA, Wikidata
- Wikidata Q421910phenylephrineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62067PhenylephrineOne source FDA
- DrugBank DB00388One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D010656 | Phenylephrine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 1WS297W6MV | PHENYLEPHRINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 8163 | — | Confirmed FDA, Wikidata |
| Wikidata | Q421910 | phenylephrine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62067 | Phenylephrine | One source FDA |
| DrugBank | DB00388 | — | One source Wikidata |
Also registered as phenylephrine hydrochloride (UNII 04JA59TNSJ · RxNorm 8164) and phenylephrine tannate (UNII DU5ATO7HYP · RxNorm 221139).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.