Neurocognitive Disorders clinical trials
The registry lists 274 studies for Neurocognitive Disorders across more than 10 countries. 90 are recruiting or about to start. 87 of them are mainly about Neurocognitive Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 27 narrower conditions too, such as Alzheimer Disease: 11,450 studies, 2,893 open.
Get an email when these change. Save the Neurocognitive Disorders studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
Centre Hospitalier Universitaire de Nice (6) · Rsocialform - Geriatria, Lda (6) · Hospices Civils de Lyon (6) · Eli Lilly and Company (4) · Universitätsklinikum Hamburg-Eppendorf (4) · University of Michigan (4) · UMC Utrecht (4) · University of Pennsylvania (4)
What is being tested here
Drugs under test in Neurocognitive Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| ML-007C | 2 | 0 | 2 |
| Nitrous Oxide | 1 | 0 | 3 |
| Dexmedetomidine | 1 | 0 | 3 |
| Donanemab | 1 | 1 | 2 |
| Methylphenidate | 1 | 1 | 2 |
| Sevoflurane | 1 | 0 | 2 |
| Propofol | 1 | 0 | 2 |
| Cerebrolysin | 1 | 0 | 1 |
| Creatine monohydrate | 1 | 0 | 1 |
| Creatine | 1 | 0 | 1 |
Drug classes tested here Inhaled anesthetics 2 open · Stimulants 1 open · Cholinesterase inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders · KompanionCare SAS
- Dec 2026tFUS for Memory in mNCD and Healthy Adults · Medical University of South Carolina
- Dec 2026rTMS for Apathy Clinical Trial · Sunnybrook Health Sciences Centre
- Dec 2026Personalized Interventions Via Health Portraits in Mild Behavioral Impairment · Fujian Provincial Hospital
- Dec 2026Validation of the Modified Cognitive Assessment Scale (MoCA Blind) for the Diagnosis of Postoperative Neurocognitive Disorders in Patients With Corneal Pathology in Russia. · The S.N. Fyodorov Eye Microsurgery State Institution
- Dec 2026Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling · Nanjing First Hospital, Nanjing Medical University
- Jan 2027Impact of Preoperative Mild Cognitive Impairment on Postoperative Delirium in Patients Undergoing Cardiac Surgery · Chinese Academy of Medical Sciences, Fuwai Hospital
- Jan 2027Deep rTMS for Mild Neurocognitive Disorder in Older Adults · St. Joseph's Healthcare Hamilton
- Jan 2027Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia · Advanced Technology & Communications
- Jan 2027The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial Surgery · Xijing Hospital
Who these studies take
Of the 59 Neurocognitive Disorders studies recruiting now, 36 (61%) set no upper age limit and 2 (3%) stop at 75 or younger. 4 (7%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 17 (29%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (7%) | 4 (7%) |
| 18 | 19 (32%) | 19 (32%) |
| 30 | 21 (36%) | 21 (36%) |
| 40 | 22 (37%) | 22 (37%) |
| 50 | 28 (47%) | 28 (47%) |
| 65 | 52 (88%) | 52 (88%) |
| 75 | 58 (98%) | 58 (98%) |
| 85 | 54 (92%) | 54 (92%) |
Across all 274 studies, recruiting or not: 13% stop at 75 or younger and 9% at 65; 8% take children; 1% are for women only and 2% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Neurocognitive Disorders studies take
Of 17 phase 2 interventional studies under Neurocognitive Disorders, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 24 mo12–30 · 17 studies | — | — |
| Interventional, no phase | 32 mo17–46 · 82 studies | — | 32 mo17–46 · 79 studies |
| Observational | 44 mo20–78 · 53 studies | — | 44 mo20–78 · 52 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 274. Browse all 274 → or search them.
- Prediction and Prevention of Postoperative Mortality and MorbidityNot yet recruitingNCT06042413Not applicable1 country
- Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older PatientsNot yet recruitingNCT07914803Phase 41 country
- A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)RecruitingNCT07589595Phase 24 countries
- A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's DiseaseRecruitingNCT06297590Phase 13 countries
- Creatine and Perioperative Brain HealthNot yet recruitingNCT07310043Not applicable
- Preventing Loss of Independence Through Exercise in Community Living CentersEnrolling by invitationNCT06972004Not applicable1 country
- Impact of Preoperative Mild Cognitive Impairment on Postoperative Delirium in Patients Undergoing Cardiac SurgeryNot yet recruitingNCT078786761 country
- Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After SurgeryNot yet recruitingNCT07576517Phase 41 country
- A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease PsychosisRecruitingNCT06887192Phase 215 countries
- Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSSRecruitingNCT06143488Not applicable1 country
- Modulating Neurocognitive Processes of Learning to Trust and Distrust in AgingRecruitingNCT05457725Not applicable1 country
- Validation of the Modified Cognitive Assessment Scale (MoCA Blind) for the Diagnosis of Postoperative Neurocognitive Disorders in Patients With Corneal Pathology in Russia.Not yet recruitingNCT07423416
- Adaptation of the Mini-Mental State Examination (MMSE) for the Reunion Island PopulationNot yet recruitingNCT07251647Not applicable1 country
- Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized EldersRecruitingNCT05929703Not applicable1 country
- Post-operative Cognitive Decline After Ambulatory Cataract Surgery in the Elderly PopulationNot yet recruitingNCT077141741 country
- An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease PsychosisEnrolling by invitationNCT07459660Phase 23 countries
- Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation ConditionsRecruitingNCT071144581 country
- Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family CaregiversRecruitingNCT077217011 country
- Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease - EUNot yet recruitingNCT07708675Not applicable
- The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial SurgeryNot yet recruitingNCT07665099Not applicable1 country
- Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid SurgeryRecruitingNCT07200180Phase 31 country
- Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-Not yet recruitingNCT06382389Phase 2
- Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic UncouplingNot yet recruitingNCT07652008
- Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive AphasiaRecruitingNCT05741853Not applicable2 countries
- Assessment of Motor Reserve in the Preclinical Stages of DementiaRecruitingNCT076340551 country
- Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)Not yet recruitingNCT07626567
- SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot StudyNot yet recruitingNCT07468305Not applicable1 country
- Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive DisordersRecruitingNCT072050031 country
- Brain Stimulation and Cognitive Training for MCIRecruitingNCT07526740Not applicable1 country
- Effects of Remimazolam on Neurocognitive Function in Patients Undergoing Cardiovascular SurgeryNot yet recruitingNCT075980191 country
- Integration of Neurocognitive Biomarkers Into a Neuro-Oncology ClinicRecruitingNCT055046811 country
- ACT for Individuals With MNCD and Their Care PartnersRecruitingNCT07239609Phase 11 country
- Creation of an Ecological Tool Assessing Episodic Memory in GeriatricsRecruitingNCT05668598Not applicable1 country
- Validation Study of the ExéSem Battery Designed to Differentiate the Contribution of Executive Functions in Semantic DisordersNot yet recruitingNCT075730461 country
- Cognitive Disorders and Brain PulseRecruitingNCT051291501 country
- Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's DementiaRecruitingNCT06088121Not applicable1 country
- rTMS for Apathy Clinical TrialRecruitingNCT05561205Not applicable1 country
- CONCEPTT Kids International Neurodevelopmental Outcomes Among Offspring of Women With Type 1 DiabetesRecruitingNCT057545673 countries
- Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA)RecruitingNCT059438341 country
- Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive DisordersRecruitingNCT072370091 country
- The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)RecruitingNCT074180081 country
- "Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort"Not yet recruitingNCT074129771 country
- Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive ImpairmentRecruitingNCT07334392Not applicable1 country
- Description of Neurocognitive and Psychiatric Disorders Associated With Targeted Therapies Used in the Treatment of Lung Cancers With ALK/ROS1 Fusion and Their Impact on Patients' Quality of Life: Construction of an Experimental Patient-researcher Collaborative Care and Research PathwayRecruitingNCT067819051 country
- Efficacy and Safety of Oral Midazolam Used for the Delivery of Care in Elderly Patient With Neurocognitive Disorders and Refusing Care.RecruitingNCT06638710Phase 21 country
- Nutrition-based Interventions to Prevent Cognitive DeclineRecruitingNCT06853405Not applicable1 country
- Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery PatientsRecruitingNCT04289142Phase 41 country
- Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative DiseasesRecruitingNCT072351111 country
- tFUS for Memory in mNCD and Healthy AdultsEnrolling by invitationNCT06718140Phase 11 country
- Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular SurgeryRecruitingNCT07048002Not applicable1 country