Drug
Methylphenidate clinical trials
Also written Ritalin, Concerta, OROS MPH and PRC-063.
- studies test it
- 321
- open now
- 35
- in phase 3
- 75
- first study started
- 1997
Keep track of what changes. Save the Methylphenidate studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
- MPH
- 17
Other names
Studies by the year they started
317 studies that test it; most in 2014 (26)
| Year | Studies |
|---|---|
| 1997 | 2 |
| 1998 | 4 |
| 1999 | 4 |
| 2000 | 2 |
| 2001 | 6 |
| 2002 | 8 |
| 2003 | 11 |
| 2004 | 13 |
| 2005 | 12 |
| 2006 | 19 |
| 2007 | 21 |
| 2008 | 16 |
| 2009 | 11 |
| 2010 | 17 |
| 2011 | 9 |
| 2012 | 14 |
| 2013 | 18 |
| 2014 | 26 |
| 2015 | 10 |
| 2016 | 12 |
| 2017 | 7 |
| 2018 | 13 |
| 2019 | 11 |
| 2020 | 6 |
| 2021 | 6 |
| 2022 | 7 |
| 2023 | 11 |
| 2024 | 9 |
| 2025 | 4 |
| 2026 | 8 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 11
- Phase 1
- 34
- Phase 2
- 56
- Phase 3
- 75
- Phase 4
- 113
- No phase
- 49
What it is tested for
Each study’s main condition, where its own words name it.
- Fatigue
- 10
Who runs them
Industry 56 · Other 265
Massachusetts General Hospital (16) · M.D. Anderson Cancer Center (10) · Rhodes Pharmaceuticals, L.P. (9) · Noven Therapeutics (8) · Shalvata Mental Health Center (7) · Icahn School of Medicine at Mount Sinai (6) · Children's Hospital Medical Center, Cincinnati (6) · New York State Psychiatric Institute (6)
Often tested with
Tested in the same studies.
Atomoxetine (11) · Modafinil (10) · N-Methyl-3,4-methylenedioxyamphetamine (4) · Reboxetine (4) · Guanfacine (4) · Lisdexamfetamine (4) · Caffeine (4) · Carbidopa, levodopa drug combination (3)
Studies
Open first, then newest update. How each study uses Methylphenidate is read from its arms, and is right about nine times in ten.
Testing it · 321
- Oxygen Toxicity: Mechanisms in HumansRecruitingNot applicableDuke UniversityNCT05761756Written as Methylphenidate
- Evaluation of Foquest in Adults 65 Years and Older With ADHDRecruitingPhase 4Dar Clinical Research Inc.NCT07710014Written as Methylphenidate hydrochloride extended-release capsules
- Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use DisorderNot yet recruitingPhase 4Massachusetts General HospitalNCT07838311Written as Delayed-release, extended-release methylphenidate
- Biomarker Validation in Motor System Physiology in Attention Deficit Hyperactivity DisorderRecruitingPhase 4Donald Gilbert, MD, MS, FAAN, FAAPNCT04421248Written as Methylphenidate
- Benefits of ADHD Treatment in Detained PeopleRecruitingPhase 3Stéphanie BaggioNCT05842330Written as Concerta
- Treating Young Children With Attention Deficit Hyperactivity DisorderRecruitingPhase 4Children's Hospital Medical Center, CincinnatiNCT07300956Written as Methylphenidate (MPH)
- Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell DiseaseRecruitingPhase 1St. Jude Children's Research HospitalNCT07226219Written as Extended-Release Methylphenidate
- Methylphenidate for the Treatment of PTSD With Associated Neurocognitive ComplaintsRecruitingPhase 4VA Office of Research and DevelopmentNCT05776056Written as Methylphenidate
- The Efficacy of a Pharmacological Treatment (Reboxetine Plus Ritalin) Versus Dog-Assisted Therapy in PTSDRecruitingPhase 2University of HaifaNCT07771530Written as methylphenidate (Ritalin®)
- Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and Emotional Dysregulation in Adults With PTSDRecruitingPhase 2University of HaifaNCT05133804Written as Methylphenidate
- Methylphenidate in KBG Syndrome: N-of-1 SeriesRecruitingPhase 4Radboud University Medical CenterNCT06465641Written as Methylphenidate Hydrochloride
- Medication Treatment of ADHD in Pediatric EpilepsyRecruitingPhase 4Hugo W. Moser Research Institute at Kennedy Krieger, Inc.NCT07594652Written as methylphenidate hydrochloride (Jornay PM)
- A Multimodal Imaging Study of Dopamine in Early PsychosisNot yet recruitingPhase 1New York State Psychiatric InstituteNCT06977308Written as Methylphenidate (MPH)
- Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related FatigueRecruitingPhase 3Odense University HospitalNCT06905587Written as Methylphenidate (MPH)
- EEG Biomarkers for ADHD Stimulant TreatmentNot yet recruitingPhase 4Boston Children's HospitalNCT07650643Written as methylphenidate HCl
- The Role of Brain Dopamine in Chronic PainRecruitingPhase 2University of RochesterNCT05285683Written as Methylphenidate
- An Open-Label Treatment With Randomization Observation, Investigator-Initiated Study, on the Duration and Efficacy of Jornay PM (Methylphenidate Hydrochloride Extended-Release Capsules) on Adult ADHD Symptoms and Executive Function and Emotional Regulation Throughout the Day Into Early EveningRecruitingPhase 4NYU Langone HealthNCT06577779Written as Methylphenidate Hydrochloride Extended Release Capsule
- Methylphenidate for the Treatment of Epilepsy-related Cognitive DeficitsRecruitingPhase 4VA Office of Research and DevelopmentNCT04419272Written as Methylphenidate
- rTMS for Apathy Clinical TrialRecruitingNot applicableSunnybrook Health Sciences CentreNCT05561205Written as methylphenidate
- The Psychiatric and Cognitive Phenotypes in Velocardiofacial SyndromeRecruitingPhase 4The Chaim Sheba Medical CenterNCT00768820Written as methylphenidate, fluoxetin, risperidone
See all 321 studies that test Methylphenidate →
Given in every arm · 16 — Methylphenidate is usual care beside what is tested
- A Trial to Assess How Centanafadine Interacts With Stimulants in the BodyCompletedPhase 1Otsuka Pharmaceutical Development & Commercialization, Inc.NCT07314333Written as Methylphenidate
- Precision Functional Brain Mapping in PsilocybinCompletedEarly Phase 1Washington University School of MedicineNCT04501653Written as Methylphenidate
- Impulsivity and Stimulant AdministrationCompletedPhase 1Yale UniversityNCT01978431Written as methylphenidate
- Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]CompletedPhase 1Craig RushNCT04178993Written as Methylphenidate
- Omega-3 Fatty Acid Supplementation to ADHD Pharmacotherapy in ADHD Adults With Deficient Emotional Self-Regulation TraitsCompletedPhase 2Massachusetts General HospitalNCT01399827Written as ADHD Medication
- Cognitive Behavioral Therapy for Adolescents With Attention-Deficit / Hyperactivity DisorderStatus unknownPhase 4McGill University Health Centre/Research Institute of the McGill University Health CentreNCT02566824Written as Methylphenidate or amphetamine product
- Methylphenidate-Duloxetine Combinations for Cocaine DependenceCompletedPhase 1University of KentuckyNCT02700711Written as Methylphenidate
- L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD AdultsCompletedPhase 2/3Massachusetts General HospitalNCT01853280Written as OROS-Methylphenidate
- EEG Studies of IV Methylphenidate-Induced Emergence From AnesthesiaWithdrawnPhase 1/2Massachusetts General HospitalNCT02429076Written as IV methylphenidate
- Treatment of Severe Childhood Aggression (The TOSCA Study)CompletedPhase 4Michael AmanNCT00796302Written as Methylphenidate HCl
- Psychopharmacology for Cocaine Dependence - BuspironeCompletedPhase 2The University of Texas Health Science Center, HoustonNCT01267292Written as Methylphenidate
- Prevention of Stimulant-Induced Euphoria With an Opioid Receptor AntagonistCompletedPhase 4Massachusetts General HospitalNCT01673594Written as SODAS MPH
- A Study of the Ability of Functional Magnetic Resonance Imaging (fMRI) to Detect and Characterize the Effects of Two Marketed Centrally Active Drugs, Placebo, and RO4917523 in Healthy VolunteersCompletedPhase 1Hoffmann-La RocheNCT01045083Written as methylphenidate
- A Study of Combination Therapy in Children With ADHDCompletedPhase 4Douglas SearsNCT01940978Written as Methylphenidate ER
- Memantine for Executive Dysfunction in Adults With ADHD: A Pilot StudyCompletedNot applicableMassachusetts General HospitalNCT01533493Written as OROS-Methylphenidate
- Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)Status unknownPhase 4Joseph BladerNCT00794625Written as Stimulant medication
As the comparator · 19 — what is tested is compared with Methylphenidate
- Orexin s Role in the Neurobiology of Substance Use DisorderRecruitingNot applicableNational Institute on Drug Abuse (NIDA)NCT05630781Written as Methylphenidate
- Psilocybin in Chronic Low Back Pain and DepressionRecruitingPhase 1Johns Hopkins UniversityNCT06355414Written as Methylphenidate
- Cognitive Remediation in ADHD Children : Comparison Between Three Therapeutic Strategies : Cognitive Remediation With a Virtual Classroom Software and Methylphenidate and Supportive PsychotherapyCompletedNot applicableUniversity Hospital, BordeauxNCT01821170Written as Methylphenidate
- Randomized, Double-blind Safety and Efficacy Study of Lisdexamfetamine Dimesylate (LDX) in Children and Adolescents Aged 6-17CompletedPhase 3ShireNCT00763971Written as Methylphenidate Hydrochloride
- Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity DisorderCompletedPhase 4ShireNCT01552902Written as Methylphenidate Hydrochloride
- Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity DisorderCompletedPhase 4ShireNCT01552915Written as Methylphenidate Hydrochloride
- Effect of Pycnogenol® on ADHDCompletedPhase 3Nina HermansNCT02700685Written as Methylphenidate
- Efficacy of Cognitive Behavioral Therapy in Treatment of Adults With Attention Deficit Hyperactivity DisorderStatus unknownNot applicableLily HechtmanNCT02210728Written as methylphenidate or amphetamine product
- The Effectiveness of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD)Status unknownNot applicableMcGill University Health Centre/Research Institute of the McGill University Health CentreNCT02788851Written as Methylphenidate compounds and /or Amphetamine compounds and/or Strattera or Guanfacine
- Effectiveness of a Personalized Neurofeedback Training Device (ADHD@Home) in Attention-Deficit/Hyperactivity DisorderStatus unknownPhase 1/2Mensia Technologies SANCT02778360Written as Methylphenidate MPH
- Train Your Brain and Exercise Your Heart? Advancing the Treatment for Attention Deficit Hyperactivity Disorder (ADHD)CompletedPhase 2/3R. van MourikNCT01363544Written as methylphenidate
- A Study to Test the Safety and Efficacy of MK0249 in Patients With ADHD (0249-018)(COMPLETED)CompletedPhase 2Merck Sharp & Dohme LLCNCT00475735Written as Concerta (methylphenidate)
- EAA/Therapy for Treating Children With ADHDStatus unknownNot applicableSamsung Medical CenterNCT02482649Written as Methylphenidate
- A Study of Pediatric Patients With Attention Deficit/Hyperactivity DisorderCompletedPhase 2/3Eli Lilly and CompanyNCT00922636Written as Methylphenidate
- Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult PatientsCompletedPhase 2Yaupon TherapeuticsNCT00664703Written as Methylphenidate HCl
- Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep DifficultiesStatus unknownPhase 4Assaf-Harofeh Medical CenterNCT01393574Written as Methylphenidate
- A Comparative Effectiveness Study Evaluating OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl), and Placebo for the Treatment of Attention Deficit Hyperactivity Disorder in ChildrenCompletedPhase 3Alza Corporation, DE, USANCT00269789Written as Ritalin
- A Multicenter Study Comparing the Efficacy and Safety of OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity DisorderCompletedPhase 3Alza Corporation, DE, USANCT00269802Written as Ritalin
- Amantadine Versus Ritalin in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD)Status unknownPhase 2Tehran University of Medical SciencesNCT01099059Written as ritalin
Codes
What other systems call Methylphenidate · ClinicalTrials.gg INT007821
- MeSH (NLM) D008774MethylphenidateConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 207ZZ9QZ49METHYLPHENIDATEConfirmed FDA, NLM, Wikidata
- RxNorm 6901Confirmed FDA, Wikidata
- Wikidata Q422112methylphenidateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62045MethylphenidateOne source FDA
- DrugBank DB00422One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008774 | Methylphenidate | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 207ZZ9QZ49 | METHYLPHENIDATE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6901 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422112 | methylphenidate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62045 | Methylphenidate | One source FDA |
| DrugBank | DB00422 | — | One source Wikidata |
Also registered as methylphenidate hydrochloride (UNII 4B3SC438HI).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.