An interventional study of rTMS and methylphenidate in Alzheimer Disease, Apathy in Dementia and Dementia, sponsored by Sunnybrook Health Sciences Centre. Recruiting at 1 site in Canada. Per ClinicalTrials.gov, last updated 2026-04-13.
Sponsored by Sunnybrook Health Sciences Centre · Not applicable, Interventional, and Treatment
Among 16 studies in Alzheimer Disease by Sunnybrook Health Sciences Centre — 8 open to participants now, 8 under way, 1 of them phase 3. Alzheimer Disease · Sunnybrook Health Sciences Centre.
Among the 16 studies in Alzheimer Disease by Sunnybrook Health Sciences Centre, this one is the 12th largest by planned enrollment of the 13 interventional ones that give a count, is one of 2 that started in 2023, is one of 3 with no phase, and was the 11th registered.
3,965 studies on the registry are indexed under Alzheimer Disease; 926 are open to participants now.
This study's planned enrollment of 10 is below the median of 70 across 3,019 interventional studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →8 of the 16 studies in Alzheimer Disease by Sunnybrook Health Sciences Centre are open now, in 1 country. Each count lists the studies.
Of the 641 Alzheimer Disease studies recruiting now, 283 (44%) set no upper age limit and 54 (8%) stop at 75 or younger; 34 take children under 18; 283 take healthy volunteers.
This study: all sexes · no healthy volunteers.
The full table on the hub →16 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 2 6 · Phase 3 3 · Phase 4 2
First in 2003; this study’s year is marked. 2 started in 2023.
Median enrollment 40 across the 13 interventional studies, 345 across the 3 observational. Of the 7 that completed or were terminated, 0 (0%) have results posted.
Sunnybrook Health Sciences Centre is the lead sponsor of 584 studies on the registry; 135 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
4 of the studies in Alzheimer Disease by Sunnybrook Health Sciences Centre that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04335994Sunnybrook Health Sciences CentreENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing | 2026-12 |
| NCT05561205Sunnybrook Health Sciences CentrerTMS for Apathy Clinical Trial | 2026-12-01 |
| NCT06014424Sunnybrook Health Sciences CentreCannabidiol Medication Intervention Trial | 2026-12-29 |
| NCT07279740Sunnybrook Health Sciences CentreCombined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia | 2027-10-01 |
Among the 16 studies in Alzheimer Disease by Sunnybrook Health Sciences Centre, from their registry updates:
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiving methylphenidate and individuals not receiving medication for apathy.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
repetitive transcranial magnetic stimulation (rTMS) and methylphenidate
Device: rTMS · Drug: methylphenidate
repetitive transcranial magnetic stimulation (rTMS) only
Device: rTMS
repetitive transcranial magnetic stimulation
methylphenidate
Neuropsychiatric Inventory-apathy
Measure of apathy on a scale from 0 to 12 with a higher score indicating greater apathy
Time frame: 2 weeks
Started Feb 2023 (actual). Primary completion is estimated for Dec 2026, 45 months after the start.
Of 882 non-industry interventional studies with no phase under Alzheimer Disease, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 51. This study's planned 45 months is above that.
Counting every sponsor, half of 959 studies reached it within 29 months; a quarter within 15 and three quarters within 51.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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Studies of the drug tested here: Methylphenidate
Sunnybrook Health Sciences Centre →