Consciousness Disorders clinical trials
The registry lists 290 studies for Consciousness Disorders across more than 10 countries. 109 are recruiting or about to start. 172 of them are mainly about Consciousness Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 6 narrower conditions too, such as Syncope: 799 studies, 206 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
University of Liege (17) · First Affiliated Hospital of Zhejiang University (17) · Hangzhou Normal University (13) · Massachusetts General Hospital (10) · Xijing Hospital (8) · Beijing Tiantan Hospital (7) · University of California, Los Angeles (7) · Assistance Publique - Hôpitaux de Paris (6)
What is being tested here
Drugs under test in Consciousness Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amantadine | 1 | 1 | 4 |
| Esketamine | 1 | 0 | 2 |
| Ketamine | 1 | 1 | 2 |
| Dexmedetomidine | 1 | 0 | 2 |
| Apomorphine | 1 | 1 | 2 |
| Melatonin | 1 | 0 | 2 |
| Psilocybin | 1 | 0 | 1 |
| Prucalopride | 1 | 0 | 1 |
| Cerebrolysin | 1 | 0 | 1 |
| Citalopram | 0 | 0 | 2 |
Drug classes tested here Serotonin receptor agonists 2 open · SSRIs 3 · SNRIs 3 · Antipsychotics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Apomorphine in Severe Brain-injured Patients · Phase 3 · University of Liege
- Nov 2026The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression · The First Hospital of Jilin University
- Dec 2026fNIRS for Disorders of Consciousness · University of California, Los Angeles
- Dec 2026REcovery From DEXmedetomidine-induced Unconsciousness · Massachusetts General Hospital
- Dec 2026Micro-movements in Patients With Prolonged Disorders of Consciousness · First Affiliated Hospital of Zhejiang University
- Dec 2026Micro-expressions in Patients With Prolonged Disorders of Consciousness · First Affiliated Hospital of Zhejiang University
- Dec 2026InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI · University of Washington
- Dec 2026A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity · Ancestral Supplements, LLC
- Dec 2026Evaluation of the MuSICCA for Measuring Awareness · The Children's Trust, United Kingdom
- Dec 2026Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment · The Third People's Hospital of Huizhou
Who these studies take
Of the 73 Consciousness Disorders studies recruiting now, 29 (40%) set no upper age limit and 25 (34%) stop at 75 or younger. 11 (15%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 14 (19%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 6 (8%) | 6 (8%) |
| 18 | 69 (95%) | 69 (95%) |
| 30 | 68 (93%) | 68 (93%) |
| 40 | 68 (93%) | 68 (93%) |
| 50 | 68 (93%) | 68 (93%) |
| 65 | 66 (90%) | 66 (90%) |
| 75 | 52 (71%) | 52 (71%) |
| 85 | 36 (49%) | 36 (49%) |
Across all 290 studies, recruiting or not: 38% stop at 75 or younger and 26% at 65; 21% take children; <1% are for women only and 1% for men only; 24% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Consciousness Disorders studies take
Of 94 interventional studies with no phase under Consciousness Disorders, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 19 mo8–52 · 94 studies | — | 20 mo9–52 · 89 studies |
| Observational | 40 mo22–95 · 58 studies | — | 41 mo24–95 · 56 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low MoodNov 9, 2026NCT07848477
- Sleep to Predict Recovery In Unconscious Patients With Acute Brain InjuryNov 2, 2026NCT07794605
Newly registered6
- Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICUNov 4, 2026NCT07917728
- Heat and Mental Health - PART 2Oct 29, 2026NCT07903896
- REM Sleep Disruption and Its Potential Uses in Depression ManagementOct 23, 2026NCT07891806
- A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental ClarityOct 23, 2026NCT07892911
- Two Sessions of Coach-Delivered Core Transformation for Distress and Well-BeingOct 16, 2026NCT07879196
Show 1 moreShow fewer
- Temporal Interference Stimulation for Disorders of ConsciousnessOct 14, 2026NCT07874178
Studies
Recruiting first, then most recently updated. Showing 50 of 290. Browse all 290 → or search them.
- Music Intervention and Transcranial Electrical Stimulation for Neurological DiseasesRecruitingNCT05706831Not applicable1 country
- PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low MoodRecruitingNCT07848477Not applicable1 country
- Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICURecruitingNCT079177285 countries
- Sleep to Predict Recovery In Unconscious Patients With Acute Brain InjuryRecruitingNCT077946051 country
- Heat and Mental Health - PART 2RecruitingNCT07903896Not applicable1 country
- A Speaking-Valve-Based Decannulation Protoco for Patients With a Prolonged Disorders of ConsciousnessEnrolling by invitationNCT071836701 country
- Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of ConsciousnessNot yet recruitingNCT07274683Not applicable1 country
- The Electroencephalographic Mechanisms of Anesthesia and Human ConsciousnessRecruitingNCT07145697Phase 41 country
- Two Sessions of Coach-Delivered Core Transformation for Distress and Well-BeingNot yet recruitingNCT07879196Not applicable1 country
- Temporal Interference Stimulation for Disorders of ConsciousnessNot yet recruitingNCT07874178Not applicable
- An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental TraumaNot yet recruitingNCT07863817Not applicable1 country
- Investigating Near-Threshold Perception During Ultrasonic Deep Brain StimulationNot yet recruitingNCT07840521Not applicable1 country
- AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of ConsciousnessNot yet recruitingNCT07855848Not applicable1 country
- Prognostic Factors to Regain ConsciousnessRecruitingNCT044456491 country
- Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC)Not yet recruitingNCT077095591 country
- Behavioral Activation for Treatment of Depression in Autistic Adolescents With Below Average IntelligenceRecruitingNCT07812870Not applicable1 country
- Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled TrialRecruitingNCT06469983Not applicable1 country
- Impact of Lifestyle on Health Maintenance: A Randomized Controlled TrialNot yet recruitingNCT07314957Not applicable1 country
- Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College StudentsNot yet recruitingNCT07677930Not applicable
- Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal AssessmentNot yet recruitingNCT07551076Not applicable
- Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)RecruitingNCT07209657Not applicable1 country
- Transcutaneous Auricular Vagus Nerve Stimulation for Recovery of Consciousness After Surgery for Spontaneous Intracerebral HemorrhageRecruitingNCT07761507Not applicable1 country
- Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of ConsciousnessRecruitingNCT07535593Phase 2/31 country
- Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)Not yet recruitingNCT077368201 country
- Prognostication of Recovery in Early Disorders of Consciousness StudyEnrolling by invitationNCT07074678Not applicable1 country
- Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in AdolescentsNot yet recruitingNCT07717112Not applicable1 country
- Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)Not yet recruitingNCT077111191 country
- Spontaneous Eye Blinking in Disorders of ConsciousnessRecruitingNCT063230314 countries
- China Research for Severe Spontaneous Intracerebral Hemorrhage(CRISIH)RecruitingNCT059753981 country
- Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of ConsciousnessRecruitingNCT07694258Not applicable1 country
- Supplementing Inpatient Behavioral Activation Group PsychotherapyEnrolling by invitationNCT07611916Not applicable1 country
- Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac ArrestRecruitingNCT06617377Not applicable1 country
- REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT StudyRecruitingNCT07228286Early Phase 11 country
- Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of ConsciousnessRecruitingNCT06930716Not applicable1 country
- Promoting Recovery After Brain Injury Using Focused UltrasoundRecruitingNCT07277309Not applicable1 country
- fNIRS for Disorders of ConsciousnessRecruitingNCT074853611 country
- mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of ConsciousnessEnrolling by invitationNCT06426602Not applicable1 country
- Recovery Trajectory for Coma and Disorders of ConsciousnessRecruitingNCT076140741 country
- Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined ApproachesRecruitingNCT073855081 country
- Speaking Valve Trial vs. Capping Trial for Tracheostomy Decannulation in Prolonged Disorders of ConsciousnessEnrolling by invitationNCT07173634Not applicable1 country
- Ultrasound Stimulation for Patients in a Disorder of ConsciousnessRecruitingNCT06939348Not applicable1 country
- Efficacy and Safety of Cerebrolysin on Prolonged Disorders of ConsciousnessRecruitingNCT04427241Phase 41 country
- SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain InjuryRecruitingNCT07560631Not applicable1 country
- Prognostication of Recovery in Early Disorders of Consciousness StudyNot yet recruitingNCT04692922
- Effectiveness of tTIs for Improving Consciousness in Patients With DoCRecruitingNCT07539740Not applicable1 country
- ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1RecruitingNCT075280141 country
- Investigation of Mnesic Capacities in Patients With a Disorder of ConsciousnessRecruitingNCT06959212Not applicable1 country
- Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Patients With Disorders of ConsciousnessRecruitingNCT07284732Not applicable1 country
- Assessment of Consciousness With CRS-R and SECONDsRecruitingNCT074560201 country
- Auditory Processing in DOC PatientsNot yet recruitingNCT074556821 country