An observational study in Neurocognitive Disorders, sponsored by University Hospital, Tours. Recruiting at 1 site in France. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by University Hospital, Tours · Observational
Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.
Patients will be included at the time of the day hospital assessment. All patients received in the day hospital of the MRRC of Tours will be offered the TPI examination. The patients included will be followed up for a period of 5 years and the TPI examination will be repeated according to the same modalities, as part of their follow-up at the MRRC and/or in the context of a new day hospital if necessary.
246 studies on the registry are indexed under Neurocognitive Disorders; 88 are open to participants now.
This study's planned enrollment of 300 is above the median of 165 across 93 observational studies indexed under Neurocognitive Disorders.
Browse Neurocognitive Disorders studies →University Hospital, Tours is the lead sponsor of 304 studies on the registry; 78 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions
Exclusion Criteria:
Assessment of cognitive disorders with an ultrasound examination performed in routine care during a day hospital.
Other: Ultrasound examination
Ultrasound examination with Tissue Pulsatility Imaging (TPI) TPI is a relatively simple, rapid and non-invasive ultrasound examination which consists of applying a standard ultrasound probe to the acoustic window of the temporal bone to first measure the velocity of the middle cerebral artery in Doppler mode and secondly the cerebral pulsatility (CP) of a region of approximately 10cm2 centred on the middle cerebral artery in B-Echo mode. After collecting the information, the TPI examination will be performed by MRRC staff specially trained in TPI by engineers. The duration of the examination is between 20 and 30 minutes, including hardware installation. Four 30-second PC acquisitions will be collected per examination, with the patient lying supine on the bed in the day hospital room, then one measurement every minute for 3 minutes after standing.
maximum amplitude of brain movements
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
Time frame: one a year from inclusion visit to 5 years
mean of brain movements
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
Time frame: one a year from inclusion visit to 5 years
standard deviation of brain movements
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
Time frame: one a year from inclusion visit to 5 years
powers in frequency analysis
Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
Time frame: one a year from inclusion visit to 5 years
Brain pulse
Longitudinal comparison between converter patients (patients with mNCD progressing to MNCD) and non-converters patients
Time frame: one a year from inclusion visit to 5 years
Brain pulse
Cross-sectional and longitudinal analysis between the different types of pathologies underlying NCD (Alzheimer's disease, Vascular NCD, Frontotemporal Lobar Degeneration, Lewy body disease, etc.) according to the Diagnostic and Statistical Manual of mental disorders criteria for these pathologies
Time frame: one a year from inclusion visit to 5 years
Hippocampal volume
Measured in MRI. Comparison with brain pulse according to Schelten classification
Time frame: one a year from inclusion visit to 5 years
leucoaraiosis load
Measured in MRI. Comparison with brain pulse according to Fazekas classification
Time frame: one a year from inclusion visit to 5 years
Carbohydrate metabolism
Measured with PET-FDG in regions of interest involved in neurodegenerative diseases. Comparison with brain pulse
Time frame: one a year from inclusion visit to 5 years
Spinal fluid biomarkers
Determination of amyloid and tau proteins in spinal fluid. Comparison with brain pulse
Time frame: one a year from inclusion visit to 5 years
cohort study on brain pulsatility with neuropsychological measures
Comparison between brain pulsatility parameters and standard neuropsychological test scores used for cognitive assessment of patients with NCD. neuropsychological test scores are optional at each visit
Time frame: one a year from inclusion visit to 5 years
Plan to share: Undecided
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University Hospital, Tours