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Not yet recruitingNCT07878676Updated Oct 16, 2026

Impact of Preoperative Mild Cognitive Impairment on Postoperative Delirium in Patients Undergoing Cardiac Surgery

An observational study in Neurocognitive Disorder and Cardiac Surgery, sponsored by Chinese Academy of Medical Sciences, Fuwai Hospital. Not yet recruiting at 1 site in China. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.

Sponsored by Chinese Academy of Medical Sciences, Fuwai Hospital · Observational

Updated Oct 16, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
261
Ages
60 Years and older
Sex
All
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Study summary

This study is intended to explore the impact of mild cognitive impairment on the incidence of delirium after cardiac surgery in older patients. The main question this study tries to answer is: Does preoperative mild cognitive impairment influence the incidence of postoperative delirium in cardiovascular surgery? Participants diagnosed with mild cognitive impairment who are supposed to perform cardiovascular surgery will answer questionnaires about cognitive function after surgery.

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Conditions studied

  • Neurocognitive Disorder
  • Cardiac Surgery
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In context

Neurocognitive Disorders

249 studies on the registry are indexed under Neurocognitive Disorders; 89 are open to participants now.

This study's planned enrollment of 261 is above the median of 165 across 95 observational studies indexed under Neurocognitive Disorders.

Browse Neurocognitive Disorders studies →

Lead sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital is the lead sponsor of 146 studies on the registry; 50 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Undergo elective cardiac surgery with cardiopulmonary bypass

Eligibility criteria

Inclusion Criteria: 1) Age≥60 years 2) Elective cardiac surgery with cardiopulmonary bypass 3) Written Informed consent provided -

Exclusion Criteria: 1) deep hypothermia and circulatory arrest; 2) unable to receive neurocognitive evaluation due to language, vision or hearing impairments 3) breastfeeding or pregnancy 4) terminal illness with a life expectancy of less than 3 months 5) mental or legal disability.

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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
261 participants (estimated)
Patient registry
No

Groups and cohorts

  • MCI

    participants who are diagnosed with MCI before surgery

  • non-MCI

    participants with normal cognitive function before surgery

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What researchers measure

Primary outcomes

  1. the 5-day incidence of postoperative delirium

    the incedence of delirium evaluated by CAM/CAM-ICU

    Time frame: within five days postoperatively

Secondary outcomes

  1. Time to extubation

    Time to extubation postoperatively

    Time frame: Perioperative

  2. Length of stay (LOS) in intensive care unit (ICU)

    Length of stay (LOS) in intensive care unit (ICU) postoperatively

    Time frame: Perioperative

  3. Length of stay (LOS) in hospital

    Length of stay (LOS) in hospital postoperatively

    Time frame: Perioperative

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Study locations

1 site
  • State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
    Beijing, 100037, China
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References and documents

Publications

  • Brown CH 4th, Probert J, Healy R, Parish M, Nomura Y, Yamaguchi A, Tian J, Zehr K, Mandal K, Kamath V, Neufeld KJ, Hogue CW. Cognitive Decline after Delirium in Patients Undergoing Cardiac Surgery. Anesthesiology. 2018 Sep;129(3):406-416. doi: 10.1097/ALN.0000000000002253. PubMed 29771710 ↗
  • Srivatsa S, Sujanthan S, Paleczny S, Ripsman DA, de Rivera SN, Dimagli A, Taghdiri F, Cheng PS, Lou W, Farkouh ME, Fremes SE, Gaudino MF, Rabin J, Razzouk L, Owen AM, Creber RM, Swartz RH. Cognitive Outcomes in Randomized Controlled Trials of Coronary Artery Bypass Graft Surgery From 2005 to 2025: A Systematic Review. J Am Heart Assoc. 2026 Jan 20;15(2):e041946. doi: 10.1161/JAHA.125.041946. Epub 2026 Jan 14. PubMed 41532517 ↗
  • Jongsiriyanyong S, Limpawattana P. Mild Cognitive Impairment in Clinical Practice: A Review Article. Am J Alzheimers Dis Other Demen. 2018 Dec;33(8):500-507. doi: 10.1177/1533317518791401. Epub 2018 Aug 1. PubMed 30068225 ↗
  • Hugo J, Ganguli M. Dementia and cognitive impairment: epidemiology, diagnosis, and treatment. Clin Geriatr Med. 2014 Aug;30(3):421-42. doi: 10.1016/j.cger.2014.04.001. Epub 2014 Jun 12. PubMed 25037289 ↗
  • Langa KM, Levine DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014 Dec 17;312(23):2551-61. doi: 10.1001/jama.2014.13806. PubMed 25514304 ↗

Individual participant data

Plan to share: No — Individual participant data (IPD) will not be shared in order to protect participant privacy and confidentiality.

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Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 16, 2026
Show all 1 update
  1. Oct 16, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07878676
Responsible party
SHI Jia (Vice Chair, Department of Anesthesiology, Chinese Academy of Medical Sciences, Fuwai Hospital) — Principal investigator
First posted
Oct 16, 2026
Start date
Oct 2026 (estimated)
Primary completion
Jan 2027 (estimated)
Completion
Jan 2027 (estimated)
Last update
Oct 16, 2026

Study contacts

Jia Shi, M.D.
Contact
shijia@fuwai.com
+86 10 88322467

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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