ClinicalTrials.gg
Sign In

Depressive Disorder clinical trials

The registry lists 855 studies for Depressive Disorder across more than 10 countries. 159 are recruiting or about to start. 363 of them are mainly about Depressive Disorder (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 6 narrower conditions too, such as Major Depressive Disorder: 1,955 studies, 445 open.

ClinicalTrials.gov finds 12,977 studies for Depressive Disorder. How that becomes 855 here

This page counts the studies the registry files under Depressive Disorder, and those it files under no condition that list Depressive Disorderthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 12,977Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −1,096Filed under a narrower condition, counted on its own pageDepression, Postpartum 552 · Depressive Disorder, Treatment-Resistant 406 · Dysthymic Disorder 63 · Premenstrual Dysphoric Disorder 41 · Seasonal Affective Disorder 30
  3. −2,452List Depressive Disorder as a condition, but the registry did not file them under itMost often written as “Major Depressive Disorder” (1,538), “Depressive Disorder, Major” (286), and “Major Depressive Disorder (MDD)” (186). The registry filed 90 of them under no condition at all, and the others under other conditions only, most often Depressive Disorder, Major (2,119) and Depression (780).
  4. −8,574Match it another way226 name it in the title, 100 in a keyword, and 8,248 by a synonym or other text the search reads.
  5. 855The count on this page

Get an email when these change. Save the Depressive Disorder studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

Watch these studies
See an example email

Example · made-up studies

Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

One email a week for all your saved searches. Stop any time.

Status

Completed
520
Recruiting
115
Status unknown
81
Terminated
45
Not yet recruiting
33
Active, not recruiting
25

Phase

Phase 2
108
Phase 3
78
Phase 1
67
Phase 4
64
Early Phase 1
7

Where

United States
318
Germany
77
France
57
China
54
Canada
49
United Kingdom
42

Who runs them

GlaxoSmithKline (39) · National Institute of Mental Health (NIMH) (26) · VA Office of Research and Development (14) · Stanford University (13) · Sanofi (13) · New York State Psychiatric Institute (11) · Ludwig-Maximilians - University of Munich (11) · University of Oxford (10)

What is being tested here

Drugs under test in Depressive Disorder studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Fluoxetine228
Psilocybin205
Brenipatide222
Ketamine1426
Vortioxetine1710
Sertraline108
Citalopram117
Estradiol102
Metformin102
Bifidobacterium spp.101

Drug classes tested here SSRIs 3 open · Serotonin receptor agonists 2 open · Psychedelics 2 open · Antipsychotics 1 open · Estrogens 1 open

Coming up

6phase 3 studies under way
50studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 115 Depressive Disorder studies recruiting now, 43 (37%) set no upper age limit and 66 (57%) stop at 75 or younger. 24 (21%) take children under 18. 7 (6%) are for women only and 0 (0%) for men only; 25 (22%) take healthy volunteers.

Recruiting studies that take each age, of 115
AgeWomenMen
107 (6%)7 (6%)
1895 (83%)90 (78%)
3091 (79%)86 (75%)
4089 (77%)84 (73%)
5087 (76%)83 (72%)
6582 (71%)79 (69%)
7555 (48%)54 (47%)
8547 (41%)46 (40%)

Across all 855 studies, recruiting or not: 60% stop at 75 or younger and 49% at 65; 18% take children; 5% are for women only and 2% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Depressive Disorder studies take

Of 43 phase 2 interventional studies under Depressive Disorder, half reached primary completion within 30 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 15 mo1–12 · 39 studies3 mo1–6 · 28 studies—
Phase 230 mo17–39 · 43 studies——
Interventional, no phase29 mo15–46 · 274 studies—29 mo15–46 · 260 studies
Observational38 mo21–104 · 57 studies—39 mo19–104 · 54 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Stopped1

Newly registered3

Studies

Recruiting first, then most recently updated. Showing 50 of 855. Browse all 855 → or search them.