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Depressive Disorder, Major clinical trials

The registry lists 3,046 studies for Depressive Disorder, Major across more than 10 countries. 592 are recruiting or about to start. 2,324 of them are mainly about Depressive Disorder, Major (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

ClinicalTrials.gov finds 3,664 studies for Depressive Disorder, Major. How that becomes 3,034 here

This page counts the studies the registry files under Depressive Disorder, Major, and those it files under no condition that list Depressive Disorder, Majorthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 3,664Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −154List Depressive Disorder, Major as a condition, but the registry did not file them under itMost often written as “Depression - Major Depressive Disorder” (127), “Major Depression Disorder” (5), and “Major Depressive Disorder With Psychotic Features” (4). The registry filed them under other conditions only, most often Depression (83) and Anxiety Disorders (52).
  3. −476Match it another way166 name it in the title, 7 in a keyword, and 303 by a synonym or other text the search reads.
  4. 3,034The count on this page63 of them list Depressive Disorder, Major in their own words; the registry filed them under no condition.

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Status

Completed
1,820
Recruiting
412
Status unknown
240
Terminated
194
Not yet recruiting
151
Withdrawn
97

Phase

Phase 2
520
Phase 3
442
Phase 4
341
Phase 1
216
Early Phase 1
28

Where

United States
1,499
Canada
312
China
206
Germany
164
France
126
United Kingdom
96

Who runs them

Massachusetts General Hospital (88) · National Institute of Mental Health (NIMH) (65) · Eli Lilly and Company (58) · New York State Psychiatric Institute (50) · Centre for Addiction and Mental Health (48) · Janssen Research & Development, LLC (39) · Shanghai Mental Health Center (39) · Stanford University (39)

What is being tested here

Drugs under test in Depressive Disorder, Major studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Ketamine211389
Psilocybin10430
Escitalopram62199
Sertraline5642
Esketamine5717
Osavampator556
Fluoxetine3629
Nitrous Oxide319
Pregnenolone308
Lumateperone377

Drug classes tested here SSRIs 15 open · Serotonin receptor agonists 14 open · Psychedelics 14 open · Antipsychotics 8 open · Inhaled anesthetics 3 open

Coming up

50phase 3 studies under way
220studies finish main data collection within a year16 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 412 Depressive Disorder, Major studies recruiting now, 93 (23%) set no upper age limit and 293 (71%) stop at 75 or younger. 55 (13%) take children under 18. 11 (3%) are for women only and 1 (<1%) for men only; 98 (24%) take healthy volunteers.

Recruiting studies that take each age, of 412
AgeWomenMen
1012 (3%)12 (3%)
18346 (84%)336 (82%)
30353 (86%)346 (84%)
40351 (85%)344 (83%)
50342 (83%)338 (82%)
65300 (73%)296 (72%)
75132 (32%)129 (31%)
85104 (25%)101 (25%)

Across all 3,046 studies, recruiting or not: 71% stop at 75 or younger and 57% at 65; 9% take children; 4% are for women only and 1% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Depressive Disorder, Major studies take

Of 195 phase 2 interventional studies under Depressive Disorder, Major, half reached primary completion within 22 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 116 mo5–45 · 88 studies5 mo1–12 · 40 studies43 mo16–… · 48 studies
Phase 1/236 mo18–75 · 31 studies——
Phase 222 mo14–37 · 195 studies17 mo11–23 · 96 studies35 mo23–57 · 99 studies
Phase 2/346 mo28–56 · 16 studies——
Phase 327 mo21–36 · 124 studies26 mo20–33 · 95 studies—
Phase 435 mo20–58 · 98 studies—44 mo25–60 · 79 studies
Interventional, no phase33 mo17–55 · 688 studies18 mo9–36 · 40 studies35 mo19–55 · 648 studies
Observational38 mo21–67 · 150 studies21 mo14–33 · 29 studies46 mo29–73 · 121 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting10

Show 5 more

Results posted3

Stopped5

Newly registered34

Show 29 more

Studies

Recruiting first, then most recently updated. Showing 50 of 3,046. Browse all 3,046 → or search them.