Drug
Metformin clinical trials
Also written Glucophage, Riomet, siofor 850 and BR3006C.
Includes 12 studies of Extended Release Metformin Hydrochloride.
- studies test it
- 1,377
- open now
- 169
- in phase 3
- 246
- first study started
- 1996
Keep track of what changes. Save the Metformin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
1,362 studies that test it; most in 2012 (84); 1 more planned to start later
| Year | Studies |
|---|---|
| 1996 | 2 |
| 1997 | 1 |
| 1999 | 1 |
| 2000 | 5 |
| 2001 | 11 |
| 2002 | 16 |
| 2003 | 28 |
| 2004 | 24 |
| 2005 | 31 |
| 2006 | 32 |
| 2007 | 24 |
| 2008 | 42 |
| 2009 | 42 |
| 2010 | 50 |
| 2011 | 69 |
| 2012 | 84 |
| 2013 | 80 |
| 2014 | 81 |
| 2015 | 72 |
| 2016 | 80 |
| 2017 | 60 |
| 2018 | 61 |
| 2019 | 72 |
| 2020 | 42 |
| 2021 | 49 |
| 2022 | 68 |
| 2023 | 58 |
| 2024 | 58 |
| 2025 | 69 |
| 2026 | 50 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 44
- Phase 1
- 338
- Phase 2
- 362
- Phase 3
- 246
- Phase 4
- 289
- No phase
- 181
What it is tested for
Each study’s main condition, where its own words name it.
- Obesity
- 19
Who runs them
Industry 382 · Other 995
Boehringer Ingelheim (41) · AstraZeneca (29) · Novo Nordisk A/S (21) · Merck Sharp & Dohme LLC (18) · Janssen Research & Development, LLC (16) · Takeda (16) · Sanofi (16) · GlaxoSmithKline (14)
Often tested with
Tested in the same studies.
Sitagliptin (49) · Pioglitazone (41) · Empagliflozin (40) · Dapagliflozin (35) · Rosuvastatin (30) · Linagliptin (29) · Digoxin (26) · Glimepiride (23)
Studies
Open first, then newest update. How each study uses Metformin is read from its arms, and is right about nine times in ten.
Testing it · 1,377
- Canagliflozin Plus Progestin for Atypical Endometrial Hyperplasia and Early-Stage Endometrial CancerNot yet recruitingPhase 2Wang YingmeiNCT07890064Written as Metformin
- Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the BodyRecruitingPhase 1BayerNCT07753252Written as Metformin
- Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid CancerRecruitingPhase 3Medical University of BialystokNCT05468554Written as metformin
- Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) EpendymomaRecruitingPhase 2University of California, San FranciscoNCT07226453Written as Metformin
- Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing ChemotherapyRecruitingPhase 3City of Hope Medical CenterNCT06763328Written as Extended Release Metformin Hydrochloride
- Metformin IN Asthma for Overweight and Obese Individuals (MINA)RecruitingPhase 2Johns Hopkins UniversityNCT06273072Written as Metformin hydrochloride extended-release tablets
- Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Study- Formative Aim 3RecruitingNot applicableWashington University School of MedicineNCT07589387Written as Metformin
- Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOSRecruitingNot applicableDicle UniversityNCT07770711Written as Metformin
- A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy AdultsNot yet recruitingPhase 1InventisBio Co., LtdNCT07875842Written as Metformin
- A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation TherapyRecruitingPhase 1University of ArkansasNCT06044025Written as Metformin
- Preventing Injured Knees From osteoArthritis: Severity OutcomesRecruitingPhase 2Brigham and Women's HospitalNCT06096259Written as Metformin
- Osteogenic Potential of Topical Metformin Gel on Cystic Jaw DefectsNot yet recruitingNot applicableFayoum UniversityNCT07867236Written as For the Experimental Arm: 1% Metformin Gel
- DDI Study of ECC0509 With Metformin, Midazolam, and CaffeineNot yet recruitingPhase 1EccogeneNCT07873229Written as Metformin
- A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast CancerRecruitingPhase 1/2Hoffmann-La RocheNCT03424005Written as Metformin
- DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational DiabetesRecruitingPhase 4Ohio State UniversityNCT06445946Written as Metformin
- Metformin in Safety and Efficacy in Gouty PatientsRecruitingPhase 2Mostafa BahaaNCT06924658Written as Metformin
- PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm PreeclampsiaRecruitingPhase 3Lina BergmanNCT06033131Written as Metformin ER
- Cardioprotective Effect of Empagliflozin in Breast Cancer PatientsNot yet recruitingPhase 3Tanta UniversityNCT07815808Written as Metformin
- Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain TumourRecruitingPhase 3Donald MabbottNCT05230758Written as Metformin hydrochloride (HCl) 500mg tablet
- Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)RecruitingNot applicableThe University of Texas Health Science Center at San AntonioNCT02969798Written as Metformin
See all 1,377 studies that test Metformin →
Given in every arm · 321 — Metformin is usual care beside what is tested
- Efficacy and Safety of Hebenrun in Patients With Type 2 DiabetesNot yet recruitingNot applicableJiangxi University of Traditional Chinese MedicineNCT07768280Written as Metformin
- TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin TherapyNot yet recruitingPhase 2Myopharm LimitedNCT07139405Written as Metformin XR
- First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid TumorsRecruitingPhase 1/2Eli Lilly and CompanyNCT05768139Written as Metformin
- Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol in Non-Diabetic PCOS PatientsRecruitingPhase 3Beni-Suef UniversityNCT07630779Written as Metfomin
- Effects of Cofrogliptin on Beta-Cell Function in LADA PatientsNot yet recruitingNot applicableSecond Xiangya Hospital of Central South UniversityNCT07460336Written as Metformin
- Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary SyndromeRecruitingPhase 2Al-Mustansiriyah UniversityNCT07182526Written as MetFORMIN 500 Mg Oral Tablet
- A Phase IV Clinical Trial to Compare the Efficacy and Safety of Metformin+Sodium-Glucose Cotransporter 2 Inhibitor(SGLT2-i)+Thiazolidinedione (TZD) in Patients With Type 2 DiabetesRecruitingPhase 4Boryung Pharmaceutical Co., LtdNCT06972732Written as Metformin
- Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and MetforminRecruitingPhase 3CelltrionNCT07093476Written as Metformin
- Enhancing the Efficacy and Tolerability of Metformin by add-on Polyherbal Formulation: a Gut Microbiome StudyEnrolling by invitationNot applicablePauls Stradins Clinical University HospitalNCT06846138Written as Metformin (Standard Treatment for Type 2 Diabetes)
- Effects of GLP-1RAs on Reproductive Outcomes in PCOS and ObesityNot yet recruitingNot applicablePeking University Third HospitalNCT06775093Written as Metformin
- Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DMNot yet recruitingPhase 4Xiqiao ZhouNCT06762223Written as Metformin 1700 mg daily
- Study of Time-restricted Eating (TRE) to Clinical Pregnancy Rate in PCOS Women With Glucose Metabolism Disorder Via IVF/ICSIEnrolling by invitationNot applicableRenJi HospitalNCT06666933Written as Metformin
- Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 DiabetesNot yet recruitingPhase 3Chengdu Brilliant Pharmaceutical Co., Ltd.NCT06339086Written as Metformin
- Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary SyndromeNot yet recruitingPhase 4Ping Li,MDNCT06256289Written as Metformin Hydrochloride
- Effect of Laser Puncture Versus Ultraviolet Radiation on Women With Polycystic Ovarian SyndromeRecruitingNot applicableCairo UniversityNCT05986838Written as Metformin
- To Compare the Safety and Efficacy of Dapagliflozin Plus Metformin Versus Sitagliptin Plus Metformin for Treatment of Diabetes in Patients With Compensated and Stable Decompensated CirrhosisNot yet recruitingNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT06147518Written as Metformin
- Efficacy of Empagliflozin and Pioglitazone in Diabetic Patients With NAFLDNot yet recruitingPhase 4Jinnah Postgraduate Medical CentreNCT05942963Written as Metformin
- The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome PatientsCompletedPhase 3Cairo UniversityNCT06836128Written as Metfomin
- Efficacy of Metformin With and Without Probiotics in Women With PCOSCompletedNot applicableDhivyaprasath PalaniappanNCT07874646Written as Metformin
- ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy AgingCompletedPhase 2Sheba Medical CenterNCT07871799Written as Metformin
Showing 20 of 321.
As the comparator · 156 — what is tested is compared with Metformin
- Comparison of Metformin Versus Glyburide for Blood Sugar Control in Women With Gestational DiabetesRecruitingPhase 4Nishtar Medical UniversityNCT07802561Written as Metformin
- An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer's DiseaseRecruitingPhase 3University College, LondonNCT07724132Written as Metformin 1000 mg Oral Tablet
- Focusing on the Menopausal Transition to Improve Mid-Life Women's HealthRecruitingPhase 2/3University of Colorado, DenverNCT06975111Written as Metformin
- Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOSNot yet recruitingNot applicablePeking University Third HospitalNCT07687667Written as Metformin
- Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A Pragmatic Pilot Randomized Controlled TrialNot yet recruitingPhase 4Sultan Qaboos UniversityNCT07342764Written as Metformin
- Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative StudyNot yet recruitingPhase 1Fatima TariqNCT07459595Written as Metformin
- Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin MonotherapyNot yet recruitingPhase 4Mansoura UniversityNCT07436182Written as Metformin 1000 mg Oral Tablet
- Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to MetforminRecruitingNot applicableMst.Sumyara KhatunNCT07307677Written as Metformin 500mg
- Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With ObesityRecruitingNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT07293325Written as Metformin
- Efficacy and Safety of Madalena Association in the Treatment of Type II Diabetes MellitusRecruitingPhase 3EMSNCT04670666Written as METFORMIN
- Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetesRecruitingPhase 4National Institute of Cardiology, Warsaw, PolandNCT07254572Written as Metformin
- Metformin Hydrochloride Sustained-release Tablets (Ⅲ) in Patients With Type 2 Diabetes Mellitus Complicated With Coronary Heart DiseaseRecruitingPhase 4China National Center for Cardiovascular DiseasesNCT06932874Written as Glucophage (Metformin Hydrochloride Tablets)
- Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 DiabetesNot yet recruitingNot applicableS.LAB (SOLOWAYS)NCT06911983Written as Metformin
- The EMPA-FIT StudyRecruitingPhase 4Seoul National University Bundang HospitalNCT06846411Written as Metformin
- SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 DiabetesRecruitingPhase 3The George InstituteNCT05345327Written as Metformin
- The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced DiabetesRecruitingNot applicableImperial College LondonNCT06318442Written as Metformin Oral Tablet
- Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshNot yet recruitingPhase 4Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic DisordersNCT06449235Written as Metformin
- Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET)RecruitingPhase 3Karolinska InstitutetNCT05182970Written as Metformin
- Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary SyndromeRecruitingPhase 4Peking University First HospitalNCT05702905Written as Metformin Hydrochloride 500 MG
- The Effect of Short-term Insulin Intensive Therapy Based on the Application of Insulin Pump and Real-time Dynamic Glucose Monitoring Technology on Reversing the Newly Diagnosed Type 2 DiabetesRecruitingPhase 4Sun Yat-sen UniversityNCT06127433Written as Metformin
Showing 20 of 156.
Codes
What other systems call Metformin · ClinicalTrials.gg INT007796
- MeSH (NLM) D008687MetforminConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 9100L32L2NMETFORMINConfirmed FDA, NLM, Wikidata
- RxNorm 6809Confirmed FDA, Wikidata
- Wikidata Q19484metforminConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61612MetforminOne source FDA
- DrugBank DB00331One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008687 | Metformin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 9100L32L2N | METFORMIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6809 | — | Confirmed FDA, Wikidata |
| Wikidata | Q19484 | metformin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61612 | Metformin | One source FDA |
| DrugBank | DB00331 | — | One source Wikidata |
Also registered as metformin hydrochloride (UNII 786Z46389E · RxNorm 235743).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.