Depression, Postpartum clinical trials
The registry lists 569 studies for Depression, Postpartum across more than 10 countries. 134 are recruiting or about to start. 437 of them are mainly about Depression, Postpartum (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 656 studies for Depression, Postpartum. How that becomes 566 here
This page counts the studies the registry files under Depression, Postpartum, and those it files under no condition that list Depression, Postpartumthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 656Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −2List Depression, Postpartum as a condition, but the registry did not file them under itMost often written as “Maternal Post-partum Depression” (1) and “Sleep Quality, Depression, Postnatal Care, Single-Blind Method, Fatigue, Social Support” (1). The registry filed them under other conditions only, most often Hypertension, Pregnancy-Induced (1) and Premature Birth (1).
- −88Match it another way25 name it in the title, 5 in a keyword, and 58 by a synonym or other text the search reads.
- 566The count on this page4 of them list Depression, Postpartum in their own words; the registry filed them under no condition.
Get an email when these change. Save the Depression, Postpartum studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
McMaster University (16) · Northwestern University (11) · Women and Infants Hospital of Rhode Island (9) · University of North Carolina, Chapel Hill (7) · Supernus Pharmaceuticals, Inc. (7) · Peking University First Hospital (6) · Columbia University (6) · Istanbul University - Cerrahpasa (6)
What is being tested here
Drugs under test in Depression, Postpartum studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Brexanolone | 1 | 5 | 9 |
| Esketamine | 1 | 0 | 7 |
| Ketamine | 1 | 2 | 7 |
| Quetiapine | 1 | 0 | 4 |
| MI078 | 1 | 1 | 3 |
| Trazodone | 1 | 0 | 2 |
| Dexmedetomidine | 1 | 0 | 1 |
| HS-10353 | 1 | 0 | 1 |
| Vitamin D | 1 | 0 | 1 |
| Vitamin B 6 | 1 | 0 | 1 |
Drug classes tested here Antipsychotics 1 open · SSRIs 7
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women · Phase 3 · Cedars-Sinai Medical Center
- Aug 2027Brexanolone Lifting Outcomes Of Moms · Phase 3 · Lipocine Inc.
- Nov 2026The DC Mother-Infant Behavioral Wellness Program · Children's National Research Institute
- Nov 2026Clinical Validation of a Predictive Test for Postpartum Depression · University of Virginia
- Dec 2026MOther-Child Interaction Assessment TRAINING for Pediatricians · University Hospital, Lille
- Dec 2026Effect of Listening to Surah Al-Inshirah (The Opening-Up of the Heart) After Cesarean Birth on Postpartum Outcomes · Selcuk University
- Dec 2026HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis · Children's Hospital Medical Center, Cincinnati
- Dec 2026Implementation of a Clinical Decision Support Tool for Postpartum Depression · Weill Medical College of Cornell University
- Dec 2026The Effect of Lullaby During Bath Time on Mother-Infant Bonding, Postpartum Depression, and Parental Self-Efficacy in Infants · Istanbul University - Cerrahpasa
- Dec 2026Comparing Integrative Midwife-led vs. Fragmented Inpatient Postpartum Care: Impact on Satisfaction and Transition to Motherhood · Medical University of Vienna
Who these studies take
Of the 86 Depression, Postpartum studies recruiting now, 54 (63%) set no upper age limit and 29 (34%) stop at 75 or younger. 13 (15%) take children under 18. 74 (86%) are for women only and 1 (1%) for men only; 40 (47%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (5%) | 1 (1%) |
| 18 | 79 (92%) | 10 (12%) |
| 30 | 83 (97%) | 11 (13%) |
| 40 | 83 (97%) | 11 (13%) |
| 50 | 69 (80%) | 11 (13%) |
| 65 | 57 (66%) | 10 (12%) |
| 75 | 56 (65%) | 10 (12%) |
| 85 | 56 (65%) | 10 (12%) |
Across all 569 studies, recruiting or not: 49% stop at 75 or younger and 49% at 65; 19% take children; 85% are for women only and <1% for men only; 44% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Depression, Postpartum studies take
Of 14 phase 2 interventional studies under Depression, Postpartum, half reached primary completion within 17 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 17 mo10–30 · 14 studies | — | — |
| Interventional, no phase | 23 mo11–36 · 262 studies | — | 23 mo11–36 · 256 studies |
| Observational | 25 mo6–50 · 52 studies | — | 25 mo5–52 · 50 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Started recruiting3
- Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal DepressionNov 3, 2026NCT07774559
- The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.Oct 23, 2026NCT07787845
- Maternal Outcomes: Mood, Alcohol Use, and Depressive SymptomsOct 13, 2026NCT07485036
Results posted2
- A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic CareNov 4, 2026NCT04998721
- The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee WellbeingOct 14, 2026NCT06014892
Newly registered7
- Transcranial Magnetic Therapy (TMS) for Treatment of Perinatal DepressionNov 10, 2026NCT07928908
- Evaluation of the EPDS and PC-PTSD-5 Scales for Screening Postpartum Mental Health Disorders Among Migrant Women.Nov 10, 2026NCT07929272
- Smartphone-Assisted Single-Session Psychotherapy Intervention for Postpartum DepressionNov 9, 2026NCT07925762
- Restoring Emotional Needs With Exogenous Ketones for Women With Postpartum DepressionNov 5, 2026NCT07919392
- A Web-based Intervention Program for Postpartum DepressionOct 28, 2026NCT07902141
Show 2 moreShow fewer
- Methyl Donor-Rich Diet in the Postpartum PeriodOct 21, 2026NCT07887178
- Postpartum Care in the NICU Multi-SiteOct 14, 2026NCT07873190
Studies
Recruiting first, then most recently updated. Showing 50 of 569. Browse all 569 → or search them.
- Maternal Stress on Human Milk and Infant OutcomesRecruitingNCT04821544Not applicable1 country
- Evaluation of the EPDS and PC-PTSD-5 Scales for Screening Postpartum Mental Health Disorders Among Migrant Women.Not yet recruitingNCT07929272Not applicable2 countries
- Smartphone-Assisted Single-Session Psychotherapy Intervention for Postpartum DepressionRecruitingNCT07925762Not applicable1 country
- Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean DeliveryRecruitingNCT06767566Phase 11 country
- Restoring Emotional Needs With Exogenous Ketones for Women With Postpartum DepressionRecruitingNCT07919392Not applicable1 country
- Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal DepressionRecruitingNCT07774559Not applicable1 country
- A Web-based Intervention Program for Postpartum DepressionRecruitingNCT07902141Early Phase 11 country
- The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.RecruitingNCT07787845Not applicable1 country
- AI-Enabled Wearable Monitoring for Detection of Postpartum Depression and AnxietyNot yet recruitingNCT078660531 country
- Methyl Donor-Rich Diet in the Postpartum PeriodRecruitingNCT07887178Not applicable1 country
- Mother-infant Bonding in the Brain: a Mindfulness-based InterventionRecruitingNCT05830266Not applicable1 country
- Postpartum Care in the NICU Multi-SiteNot yet recruitingNCT07873190Not applicable1 country
- Maternal Outcomes: Mood, Alcohol Use, and Depressive SymptomsRecruitingNCT07485036Not applicable1 country
- Deconstructing Maternal Burdens: Doulas and the Community Unite for HealthRecruitingNCT07799805Not applicable1 country
- SAINT in Postpartum Depression (PPD)RecruitingNCT07210255Not applicable1 country
- Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum DepressionRecruitingNCT06833788Phase 41 country
- Accelerated TMS for Perinatal DepressionRecruitingNCT06968390Not applicable1 country
- Admission to Kangaroo Mother Care (KMC) Ward and Maternal Postpartum DepressionRecruitingNCT06545760Not applicable1 country
- LLM-Generated Medical Summaries During Hospitalization to Improve Patient Activation in High-Risk PregnanciesNot yet recruitingNCT07823517Not applicable1 country
- Brexanolone Lifting Outcomes Of MomsRecruitingNCT07822321Phase 31 country
- Narrative Nursing for Cesarean Mothers' Anxiety and Breastfeeding ConfidenceRecruitingNCT07272252Not applicable1 country
- Midwife-Led Digital Follow-Up After Cesarean SectionRecruitingNCT07523932Not applicable1 country
- A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting ZuranoloneRecruitingNCT073984691 country
- Effect of Peripartum 40 Hz Audiovisual Stimulation on Postpartum Depression in Women Undergoing Elective Cesarean Section: A Randomized Clinical TrialNot yet recruitingNCT07807462Not applicable1 country
- OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum DepressionRecruitingNCT06991166Not applicable1 country
- The Effects of a Caregiver-initiated Reading Intervention to Their Infant in the Neonatal Intensive Care UnitNot yet recruitingNCT07789145Not applicable
- Early Detection of Perinatal Depression With Wearable TechnologyNot yet recruitingNCT07784244Not applicable1 country
- Engage & Connect: A Psychotherapy for Postpartum DepressionRecruitingNCT05585164Not applicable1 country
- Informing Implementation of a Circadian-Focused Intervention for Postpartum DepressionRecruitingNCT07766161Not applicable1 country
- Understanding the Role of Doulas in Supporting People With PMADsRecruitingNCT05763537Not applicable1 country
- Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical TrialNot yet recruitingNCT07460063Not applicable
- Multimodal Biomarkers and Precision TMS for Postpartum DepressionNot yet recruitingNCT07757815Not applicable1 country
- Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime UkraineRecruitingNCT075519341 country
- RCT of At-Home tDCS for Depression in PregnancyRecruitingNCT05097586Not applicable1 country
- Feasibility and Acceptability of a Novel Digital Intervention For Perinatal Men Who Have Depression or AnxietyNot yet recruitingNCT07742566Not applicable1 country
- Parents and Babies PilotRecruitingNCT07607613Not applicable1 country
- POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual HealthNot yet recruitingNCT07747285Not applicable1 country
- Implementation of a Clinical Decision Support Tool for Postpartum DepressionRecruitingNCT06818734Not applicable1 country
- A Study of MI078 for Postpartum DepressionRecruitingNCT07721961Phase 31 country
- Feasibility and Acceptability of a Novel Digital Intervention to Prevent Paternal Postpartum DepressionRecruitingNCT07594743Not applicable1 country
- Vitamin B6 and Depression in Pregnant and Peri-partum WomenRecruitingNCT06445933Not applicable1 country
- Essential Coaching Postpartum: Evaluating a Parent-focused Postpartum Text Message Program in Nova ScotiaRecruitingNCT06996067Not applicable1 country
- Midwife-led Childbirth Review and Psychological Outcomes in New ParentsNot yet recruitingNCT07678801Not applicable1 country
- Whole-Body Hyperthermia for Mood and Anxiety DisordersNot yet recruitingNCT06144294Not applicable1 country
- Mental and Reproductive Health Integration and AccessNot yet recruitingNCT07659509Not applicable1 country
- NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)RecruitingNCT07214597Not applicable1 country
- Intranasal Esketamine-dexmedetomidine Combination and Postpartum DepressionNot yet recruitingNCT07639099Phase 41 country
- Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal DeliveryNot yet recruitingNCT075822891 country
- Accelerated iTBS for Post Partum DepressionRecruitingNCT03417960Not applicable1 country
- A Descriptive Study of the Correlation Between Postpartum Depression and Body Image Dissatisfaction, Self-objectification, and Social Media Appearance ComparisonNot yet recruitingNCT07603063