Drug class
Serotonin Receptor Agonists clinical trials
A class of medicines: the studies that test any of its 43 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the serotonin receptor agonists studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
- Eltoprazine
- 2
- Lisuride
- 2
- Bretisilocin
- 1
- Mescaline
- 1
- MK-212
- 1
- Piclozotan
- 1
- Ergotamine
- 1
- Gepirone
- 1
- Dexfenfluramine
- 1
And 3 more, each tested in fewer studies.
Studies by the year they started
757 studies that test it; most in 2026 (62); 7 more planned to start later
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1994 | 2 |
| 1995 | 7 |
| 1996 | 5 |
| 1997 | 2 |
| 1998 | 11 |
| 1999 | 3 |
| 2000 | 3 |
| 2001 | 3 |
| 2002 | 5 |
| 2003 | 10 |
| 2004 | 28 |
| 2005 | 15 |
| 2006 | 23 |
| 2007 | 29 |
| 2008 | 24 |
| 2009 | 26 |
| 2010 | 15 |
| 2011 | 15 |
| 2012 | 23 |
| 2013 | 29 |
| 2014 | 24 |
| 2015 | 31 |
| 2016 | 17 |
| 2017 | 32 |
| 2018 | 27 |
| 2019 | 29 |
| 2020 | 22 |
| 2021 | 40 |
| 2022 | 40 |
| 2023 | 45 |
| 2024 | 53 |
| 2025 | 56 |
| 2026 | 62 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 310 · Other 460
Johns Hopkins University (31) · Eli Lilly and Company (30) · Movetis (22) · University Hospital, Basel, Switzerland (21) · Novartis (20) · Eisai Inc. (17) · Yale University (13) · Organon and Co (12)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 770
- Psilocybin-Assisted Physical Therapy in Chronic Low Back PainNot yet recruitingPhase 2Yale UniversityNCT07306364Written as Psilocybin 10 mg
- Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderRecruitingPhase 2Centre for Addiction and Mental HealthNCT07405606Written as Psilocybin 25 mg
- Neuroplasticity Enhancement From Cognitive Training Reinforced by PsilocybinRecruitingPhase 2National Institute on Aging (NIA)NCT07721467Written as Psilocybin
- Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use DisorderNot yet recruitingPhase 1/2Indiana UniversityNCT07499583Written as Psilocybin
- Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderRecruitingPhase 2/3COMPASS PathwaysNCT07570654Written as COMP360 psilocybin
- Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingPhase 3VA Office of Research and DevelopmentNCT07226232Written as Psilocybin
- A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)RecruitingPhase 3Definium Therapeutics US, Inc.NCT07592689Written as DT120
- Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)RecruitingPhase 2Centre for Addiction and Mental HealthNCT06518720Written as Psilocybin 25 mg
- Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled TrialNot yet recruitingPhase 2University Health Network, TorontoNCT07820033Written as Psilocybin (high dose)
- A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)Enrolling by invitationPhase 3Longboard PharmaceuticalsNCT06908226Written as LP352
- Psilocybin Effects on Healthy Aging Biomarkers and Purpose in LifeNot yet recruitingPhase 1Charles RaisonNCT07719088Written as Psilocybin (Usona Institute)
- Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use DisorderNot yet recruitingPhase 2Brigham and Women's HospitalNCT07296094Written as Psilocybin
- Pilot Study on the Effects of Psilocybin on Belief Updating and Insight FormationRecruitingPhase 1Brown UniversityNCT07818564Written as Psilocybin (Usona Institute)
- LSD Treatment for Persons With Alcohol Use DisorderRecruitingPhase 2Felix MuellerNCT05474989Written as LSD
- PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low MoodNot yet recruitingNot applicableUniversity of OxfordNCT07848477Written as Prucalopride
- NeuroGuard: Psilocybin Trial for Preventing Chemo-induced NeuropathyNot yet recruitingPhase 2M.D. Anderson Cancer CenterNCT07227909Written as Psilocybin (drug)
- Effects of Psilocybin on Craving in Nicotine DependenceNot yet recruitingPhase 2University of British ColumbiaNCT07852832Written as Psilocybin (drug)
- Consciousness and Psilocybin Effects on Well-Being: The CoPEWell StudyNot yet recruitingPhase 1University of Wisconsin, MadisonNCT07360301Written as Psilocybin
- The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseRecruitingPhase 2Yale UniversityNCT07610369Written as Psilocybin (drug)
- A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine HeadacheRecruitingPhase 4Antonios LikourezosNCT06473597Written as Rizatriptan Benzoate
See all 770 studies that test one of the serotonin receptor agonists →