An interventional study of Structured Aerobic exercise in Depressive Disorder, sponsored by Manahil Gill. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-09-17.
Sponsored by Manahil Gill · Not applicable, Interventional, and Treatment
The goal of this study is to compare the reduction in the severity of depression after a duration of 06 weeks between patients receiving conventional therapy (antidepressant; Sertraline) only and those receiving both conventional therapy and a structured aerobic exercise (cycling, brisk walking).
This study will compare two groups A and B for 06 weeks to study the reduction in severity of depression.
855 studies on the registry are indexed under Depressive Disorder; 159 are open to participants now.
This study's planned enrollment of 66 is below the median of 88 across 689 interventional studies indexed under Depressive Disorder.
Browse Depressive Disorder studies →This is the only study on the registry with Manahil Gill as lead sponsor.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
i. All new patients diagnosed with moderate and severe depression using BDI scale according to ICD-11 criteria between the ages of 18-55 years.
ii. Both genders will be included.
Exclusion Criteria:
i. Patients with severe physical disabilities such as Spinal cord injuries, severe osteoporosis or medical conditions that prevent exercise such as ischemic changes in pre-exercise.
ii. Pregnant females. iii. Individuals already engaging in physical activities like athletes.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive conventional treatment only for 06 weeks
Participants will receive structured aerobic exercise cycling or brisk walking in addition to conventional treatment for 06 weeks
Behavioral: Structured Aerobic exercise
Participants will receive structured, supervised aerobic exercise ( cycling, brisk walking), in addition to conventional treatment consisting of 03 sessions per week, 35 minutes each for 06 weeks.
Change in Beck Depression Inventory (BDI) score
The primary outcome will be the mean change in Beck Depression Inventory (BDI) score from baseline to the end of 06 weeks intervention period. It is a 21- item self-report scale with total scores ranging from 0 to 63. Lower scores indicate fewer depressive symptoms and therefore a better outcome. The mean change in BDI score will be compared between the aerobic exercise (plus conventional treatment ) group and the non exercise group. (conventional treatment only).
Time frame: Baseline to 06 weeks
Plan to share: No
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