Drug
Psilocybin clinical trials
Also written PEX010, COMP360 and Indocybin.
Includes 1 study of Psilocybin trihydrate.
- studies test it
- 235
- open now
- 116
- in phase 3
- 11
- first study started
- 2004
Keep track of what changes. Save the Psilocybin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
229 studies that test it; most in 2026 (52); 6 more planned to start later
| Year | Studies |
|---|---|
| 2004 | 1 |
| 2007 | 1 |
| 2009 | 2 |
| 2012 | 2 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 3 |
| 2017 | 3 |
| 2018 | 4 |
| 2019 | 6 |
| 2020 | 5 |
| 2021 | 18 |
| 2022 | 20 |
| 2023 | 31 |
| 2024 | 39 |
| 2025 | 38 |
| 2026 | 52 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 19
- Phase 1
- 84
- Phase 2
- 124
- Phase 3
- 11
- No phase
- 11
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 20 · Other 215
Johns Hopkins University (24) · Yale University (13) · COMPASS Pathways (8) · NYU Langone Health (8) · Centre for Addiction and Mental Health (7) · University of Washington (5) · University of Wisconsin, Madison (5) · University Health Network, Toronto (4)
Often tested with
Tested in the same studies.
N-Methyl-3,4-methylenedioxyamphetamine (4) · Lysergic Acid Diethylamide (3) · Risperidone (2) · Psilocin (1) · Methylphenidate (1) · Midazolam (1) · Trazodone (1) · Dextromethorphan (1)
Studies
Open first, then newest update. How each study uses Psilocybin is read from its arms, and is right about nine times in ten.
Testing it · 235
- Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use DisorderNot yet recruitingPhase 1/2Indiana UniversityNCT07499583Written as Psilocybin
- Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderRecruitingPhase 2/3COMPASS PathwaysNCT07570654Written as COMP360 psilocybin
- Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingPhase 3VA Office of Research and DevelopmentNCT07226232Written as Psilocybin
- Neuroplasticity Enhancement From Cognitive Training Reinforced by PsilocybinRecruitingPhase 2National Institute on Aging (NIA)NCT07721467Written as Psilocybin
- Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)RecruitingPhase 2Centre for Addiction and Mental HealthNCT06518720Written as Psilocybin 25 mg
- Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled TrialNot yet recruitingPhase 2University Health Network, TorontoNCT07820033Written as Psilocybin (high dose)
- Psilocybin Effects on Healthy Aging Biomarkers and Purpose in LifeNot yet recruitingPhase 1Charles RaisonNCT07719088Written as Psilocybin (Usona Institute)
- Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use DisorderNot yet recruitingPhase 2Brigham and Women's HospitalNCT07296094Written as Psilocybin
- Pilot Study on the Effects of Psilocybin on Belief Updating and Insight FormationRecruitingPhase 1Brown UniversityNCT07818564Written as Psilocybin (Usona Institute)
- NeuroGuard: Psilocybin Trial for Preventing Chemo-induced NeuropathyNot yet recruitingPhase 2M.D. Anderson Cancer CenterNCT07227909Written as Psilocybin (drug)
- Effects of Psilocybin on Craving in Nicotine DependenceNot yet recruitingPhase 2University of British ColumbiaNCT07852832Written as Psilocybin (drug)
- Consciousness and Psilocybin Effects on Well-Being: The CoPEWell StudyNot yet recruitingPhase 1University of Wisconsin, MadisonNCT07360301Written as Psilocybin
- The Efficacy of Psilocybin Therapy for Depression in Parkinson's DiseaseRecruitingPhase 2Yale UniversityNCT07610369Written as Psilocybin (drug)
- Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility StudyRecruitingPhase 1Oregon Health and Science UniversityNCT06988319Written as Psilocybin (Usona Institute)
- ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality DisorderNot yet recruitingPhase 1University of MinnesotaNCT07833761Written as Psilocybin
- Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)RecruitingPhase 2Centre Hospitalier St AnneNCT07210112Written as Psilocybin 25 mg per os
- Safety and Tolerability Trial of Psilocybin in Healthy Older AdultsRecruitingPhase 1University of Colorado, DenverNCT07516405Written as Psilocybin (Usona Institute)
- Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II DisorderRecruitingPhase 2Lakshmi N YathamNCT06943573Written as psilocybin (25 mg)
- PRoMiSS: Psilocybin and the Role of Music in Set and SettingRecruitingPhase 1Johns Hopkins UniversityNCT07180108Written as Psilocybin (high dose)
- Psilocybin as a Novel Therapy for Residual AnhedoniaRecruitingPhase 1NYU Langone HealthNCT07607938Written as Psilocybin
See all 235 studies that test Psilocybin →
Given in every arm · 17 — Psilocybin is usual care beside what is tested
- The ENHANCE Study: taVNS and PsilocybinRecruitingPhase 1University of Wisconsin, MadisonNCT05866471Written as Psilocybin
- Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)RecruitingPhase 2Centre for Addiction and Mental HealthNCT06512220Written as Psilocybin 25 mg
- Psilocybin-Assisted TherapyRecruitingPhase 2Emory UniversityNCT07332143Written as psilocybin
- Psilocybin Efficacy With or Without Pimavanserin PretreatmentRecruitingPhase 1/2Johns Hopkins UniversityNCT07610135Written as Psilocybin
- Psilocybin Administration With 5-HT1a BlockadeRecruitingEarly Phase 1Johns Hopkins UniversityNCT07565493Written as Psilocybin
- Psilocybin-Assisted Therapy for Physician Well-Being and BurnoutRecruitingPhase 1/2University of California, San DiegoNCT06814522Written as Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
- The RECAP2 Study: Midazolam and PsilocybinRecruitingPhase 1University of Wisconsin, MadisonNCT06692192Written as Psilocybin
- Investigation to Understand and Optimize PsilocybinRecruitingPhase 2Charles RaisonNCT06512194Written as Psilocybin
- A Randomized Neuroimaging Trial of Psilocybin in DepressionRecruitingPhase 2Sunnybrook Health Sciences CentreNCT06072898Written as Psilocybin
- Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory DepressionRecruitingPhase 1/2Federal University of Latin American IntegrationNCT06898606Written as Psilocybin and Psilocyn
- RCT of Psilocybin-assisted CBT for DepressionRecruitingPhase 1/2University of California, Los AngelesNCT07281352Written as Psilocybin (drug)
- Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive DisorderRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT06592833Written as Psilocybin
- The Neurobiological Effect of 5-HT2AR ModulationRecruitingPhase 1Gitte Moos KnudsenNCT03289949Written as Psilocybine
- A Study of Psilocybin for PTSDActive, not recruitingPhase 1Johns Hopkins UniversityNCT06407635Written as Psilocybin
- Optimizing Microdosing and MeditationWithdrawnNot applicableNational University of Natural MedicineNCT06560658Written as Psilocybin
- Consciousness, Psilocybin, and Well-BeingCompletedPhase 1University of Wisconsin, MadisonNCT05592379Written as Psilocybin
- Efficacy and Safety of Psilocybin in Treatment-Resistant Major DepressionCompletedPhase 2Central Institute of Mental Health, MannheimNCT04670081Written as Psilocybin
As the comparator · 6 — what is tested is compared with Psilocybin
- Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNot yet recruitingPhase 2University of CalgaryNCT06885996Written as Psilocybin
- Mindfulness-Assisted Psychedelic TherapyRecruitingPhase 2University of Southern CaliforniaNCT06233344Written as Psilocybin
- Investigation of Psychedelic Effects in Psychoactive SubstancesRecruitingPhase 1Johns Hopkins UniversityNCT06772753Written as Psilocybin
- Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy SubjectsCompletedPhase 1University Hospital, Basel, SwitzerlandNCT05523401Written as Psilocybin
- Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative MechanismsCompletedPhase 2Imperial College LondonNCT03429075Written as Psilocybin + Escitalopram
- Comparative Acute Effects of LSD, Psilocybin and MescalineCompletedPhase 1University Hospital, Basel, SwitzerlandNCT04227756Written as Psilocybin
Codes
What other systems call Psilocybin · ClinicalTrials.gg INT008125
- MeSH (NLM) D011562PsilocybinConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 2RV7212BP0PSILOCYBINConfirmed FDA, NLM, Wikidata
- Wikidata Q208118psilocybinConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62529PsilocybineOne source FDA
- DrugBank DB11664One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011562 | Psilocybin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 2RV7212BP0 | PSILOCYBIN | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q208118 | psilocybin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62529 | Psilocybine | One source FDA |
| DrugBank | DB11664 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.