Drug
Sertraline clinical trials
Also written Zoloft and Lustral.
- studies test it
- 194
- open now
- 14
- in phase 3
- 37
- first study started
- 1992
Keep track of what changes. Save the Sertraline studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Combined with it in one product
Studies by the year they started
188 studies that test it; most in 2003 (14)
| Year | Studies |
|---|---|
| 1992 | 1 |
| 1995 | 1 |
| 1997 | 5 |
| 1998 | 1 |
| 1999 | 3 |
| 2000 | 4 |
| 2001 | 7 |
| 2002 | 13 |
| 2003 | 14 |
| 2004 | 13 |
| 2005 | 14 |
| 2006 | 9 |
| 2007 | 5 |
| 2008 | 8 |
| 2009 | 5 |
| 2010 | 9 |
| 2011 | 8 |
| 2012 | 5 |
| 2013 | 6 |
| 2014 | 9 |
| 2015 | 6 |
| 2016 | 10 |
| 2017 | 4 |
| 2018 | 2 |
| 2019 | 5 |
| 2020 | 1 |
| 2021 | 1 |
| 2022 | 4 |
| 2023 | 3 |
| 2024 | 4 |
| 2025 | 6 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 28
- Phase 2
- 42
- Phase 3
- 37
- Phase 4
- 68
- No phase
- 32
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 34 · Other 160
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (7) · Duke University (7) · New York State Psychiatric Institute (6) · Johns Hopkins University (5) · Vanderbilt University (5) · Yale University (4) · Otsuka Pharmaceutical Development & Commercialization, Inc. (3) · First Affiliated Hospital of Chongqing Medical University (3)
Often tested with
Tested in the same studies.
Venlafaxine (14) · Escitalopram (10) · Fluoxetine (7) · Citalopram (7) · Bupropion (6) · Aripiprazole (6) · Olanzapine (5) · Fluvoxamine (5)
Studies
Open first, then newest update. How each study uses Sertraline is read from its arms, and is right about nine times in ten.
Testing it · 194
- Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.RecruitingNot applicableHualien Tzu Chi General HospitalNCT06778824Written as Zoloft 50Mg Tablet
- Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental DisordersRecruitingPhase 2Holland Bloorview Kids Rehabilitation HospitalNCT06081348Written as Sertraline
- Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social AnxietyRecruitingNot applicableBoston University Charles River CampusNCT05683223Written as Sertraline
- Sertraline Combined With Multi-Strain Probiotics for Adolescent DepressionRecruitingPhase 2First Affiliated Hospital of Chongqing Medical UniversityNCT07645157Written as Sertraline
- Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric DisorderRecruitingPhase 4Johns Hopkins UniversityNCT06704594Written as sertraline 50 mg daily
- Establishing Multimodal Brain Biomarkers for Treatment Selection in DepressionRecruitingPhase 4University of Texas at AustinNCT05892744Written as Sertraline
- TDM-Guided Treatment With SSRIs in Hospitalized Adults and ChildrenRecruitingPhase 4Poznan University of Medical SciencesNCT07478796Written as Sertralin
- ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in DepressionRecruitingPhase 2Stanford UniversityNCT06408246Written as Sertraline
- Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)RecruitingPhase 1/2First Affiliated Hospital of Chongqing Medical UniversityNCT05814640Written as Sertraline
- Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureRecruitingPhase 3Dr. Inge WinterNCT05603104Written as Sertraline
- The Friendship Bench Plus TrialRecruitingNot applicableUniversity of BernNCT06384209Written as Sertraline Pill
- The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.RecruitingPhase 3Dr. Inge WinterNCT05973786Written as Sertraline
- Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)Not yet recruitingPhase 4Xinyu ZhouNCT07011693Written as Sertraline
- Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.RecruitingPhase 4University of CincinnatiNCT04221997Written as sertraline
- Treatment of Orthostatic IntoleranceActive, not recruitingPhase 1/2Satish R. RajNCT00262470Written as Sertraline
- Predicting SSRI Efficacy in Veterans With PTSDTerminatedPhase 4VA Office of Research and DevelopmentNCT04183205Written as sertraline
- Predictors of Cognitive Outcomes in Geriatric DepressionActive, not recruitingPhase 4David SteffensNCT05273996Written as Sertraline, bupropion, desvenlafaxine
- SMART Trial to Predict Anhedonia Response to Antidepressant TreatmentCompletedPhase 4Mclean HospitalNCT05537584Written as Sertraline
- Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)TerminatedNot applicableDuke UniversityNCT02813447Written as Sertraline
- Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSDCompletedPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT04124614Written as Sertraline
See all 194 studies that test Sertraline →
Given in every arm · 25 — Sertraline is usual care beside what is tested
- Allopurinol in DepressionRecruitingPhase 2/3Tanta UniversityNCT07574060Written as Sertraline 50 MG
- Dorsal Penile Nerve Cryoneurolysis for Lifelong PECompletedNot applicableBiruni UniversityNCT07879105Written as Sertraline (Oral Antidepressant)
- A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02493868Written as Sertraline (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02422186Written as Sertraline (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT03434041Written as Sertraline (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02417064Written as Sertraline (Oral Antidepressant)
- A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02497287Written as Sertraline (Oral Antidepressant)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedPhase 3Janssen Research & Development, LLCNCT02418585Written as Sertraline (Oral Antidepressant)
- A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant DepressionWithdrawnPhase 3Janssen-Cilag International NVNCT03852160Written as Sertraline
- A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive DisorderCompletedPhase 3BiogenNCT04476030Written as Sertraline
- Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With TinnitusStatus unknownPhase 2University of GuadalajaraNCT05646693Written as Sertraline
- The Therapeutic Effect of Transcranial Direct Current Stimulation on Depression in Parkinson's DiseaseTerminatedPhase 1/2National Cheng-Kung University HospitalNCT02917122Written as Sertraline
- A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent GlioblastomaCompletedPhase 1/2University of UlmNCT02770378Written as Sertraline
- Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety DisorderStatus unknownNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT04977544Written as Sertraline
- Symptomatic Therapy for Patients With Huntington's DiseaseStatus unknownPhase 1Second Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT04071639Written as Zoloft 50Mg Tablet
- Riluzole Augmentation Pilot in Depression (RAPID) TrialTerminatedPhase 2Brigham and Women's HospitalNCT01703039Written as Sertraline
- Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)CompletedPhase 3Otsuka Pharmaceutical Development & Commercialization, Inc.NCT01360866Written as Sertraline
- Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and OverweightCompletedPhase 4Washington University School of MedicineNCT00834652Written as Sertraline
- Effect of Lactobacillus Plantarum 299v Supplementation on Major Depression TreatmentCompletedPhase 2Medical University of BialystokNCT02469545Written as Sertraline
- Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled TrialCompletedPhase 4Research Foundation for Mental Hygiene, Inc.NCT01178671Written as Sertraline
Showing 20 of 25.
As the comparator · 20 — what is tested is compared with Sertraline
- NMDA Modulation in Major Depressive DisorderRecruitingPhase 2China Medical University HospitalNCT04637620Written as Sertraline
- Comparison of the Effectiveness Level of Virtual Reality Exposure Therapy With Sertraline Treatment in Social Anxiety DisorderRecruitingPhase 4Emine KanmazNCT07192367Written as Sertraline (Oral Antidepressant)
- The Research of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With DepressionNot yet recruitingPhase 3CSPC ZhongQi Pharmaceutical Technology Co., Ltd.NCT06827431Written as Sertraline
- Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth SyndromeRecruitingPhase 3Federico II UniversityNCT06025474Written as Sertraline 50 MG
- Specifying and Treating Anxiety in Autism ResearchCompletedPhase 2University of California, DavisNCT03279471Written as Sertraline
- A Non-randomized Controlled Trial Was Conducted to Observe the Improvement in the Level of HAMA in Patients With Generalized Anxiety Disorder During the 6-week Period of Oral Treatment With Chaihu Jia Longgu Muli Tang (Bupleurum Plus Dragon Bone and Oyster Shell Decoction) Combined With Sertraline.CompletedNot applicableLin XiaoqianNCT06725771Written as Sertraline Hydrochloride Tablets
- Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic AssessmentCompletedPhase 4Azienda Ospedaliera Universitaria Integrata VeronaNCT03779789Written as Sertraline
- Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With SertralineWithdrawnPhase 4Rush University Medical CenterNCT01309074Written as Sertraline
- Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive DisorderStatus unknownPhase 4Second Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT04963257Written as sertraline
- Bioequivalence Of Zoloft ODT To Jzoloft In Healthy Japanese SubjectsCompletedPhase 1Pfizer's Upjohn has merged with Mylan to form Viatris Inc.NCT01699724Written as JZoloft
- NMDA Modulation in Major Depressive Disorder in Late- LifeCompletedPhase 2Chang Gung Memorial HospitalNCT03414931Written as Sertraline
- The Study of Mindfulness Based Cognitive Therapy and Obsessive-Compulsive DisorderCompletedNot applicableShanghai Mental Health CenterNCT03179839Written as sertraline, fluvoxamine
- Postpartum Depression: Transdermal Estradiol Versus SertralineTerminatedPhase 4Northwestern UniversityNCT00744328Written as Sertraline
- Rhodiola Rosea Therapy of Major Depressive DisorderCompletedPhase 3University of PennsylvaniaNCT01098318Written as Sertraline
- Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic SymptomsTerminatedPhase 4Massachusetts General HospitalNCT00955474Written as Sertraline
- Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?TerminatedPhase 4Thomas Jefferson UniversityNCT01856127Written as Sertraline
- Exercise to Treat Depression in Individuals With Coronary Heart DiseaseCompletedPhase 3Duke UniversityNCT00302068Written as Sertraline
- Algorithm Guided Treatment Strategies for Major Depressive DisorderStatus unknownPhase 4Shanghai Mental Health CenterNCT01764867Written as Sertraline
- Quetiapine XR Versus Sertraline in Acute Bipolar Depression as add-on TherapyCompletedPhase 3AstraZenecaNCT00857584Written as Sertraline
- A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe DepressionCompletedPhase 4Eli Lilly and CompanyNCT00666757Written as sertraline
Codes
What other systems call Sertraline · ClinicalTrials.gg INT008759
- MeSH (NLM) D020280SertralineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) QUC7NX6WMBSERTRALINEConfirmed FDA, NLM, Wikidata
- RxNorm 36437Confirmed FDA, Wikidata
- Wikidata Q407617sertralineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61939SertralineOne source FDA
- DrugBank DB01104One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D020280 | Sertraline | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | QUC7NX6WMB | SERTRALINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 36437 | — | Confirmed FDA, Wikidata |
| Wikidata | Q407617 | sertraline | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61939 | Sertraline | One source FDA |
| DrugBank | DB01104 | — | One source Wikidata |
Also registered as sertraline hydrochloride (UNII UTI8907Y6X · RxNorm 155137).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.