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Mood Disorders clinical trials

The registry lists 561 studies for Mood Disorders across more than 10 countries. 105 are recruiting or about to start. 143 of them are mainly about Mood Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 8 narrower conditions too, such as Major Depressive Disorder: 3,860 studies, 743 open.

ClinicalTrials.gov finds 6,878 studies for Mood Disorders. How that becomes 561 here

This page counts the studies the registry files under Mood Disorders, and those it files under no condition that list Mood Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 6,878Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −3,279Filed under a narrower condition, counted on its own pageBipolar Disorder 1,559 · Depressive Disorder 682 · Depression, Postpartum 541 · Depressive Disorder, Treatment-Resistant 372 · Dysthymic Disorder 56 · Premenstrual Dysphoric Disorder 40 · 1 more
  3. −84List Mood Disorders as a condition, but the registry did not file them under itMost often written as “Schizo Affective Disorder” (55), “Schizo-affective Disorder” (8), and “Affective Disorders, Psychotic” (6). The registry filed them under other conditions only, most often Psychotic Disorders (70) and Schizophrenia (67).
  4. −2,954Match it another way48 name it in the title, 10 in a keyword, and 2,896 by a synonym or other text the search reads.
  5. 561The count on this page6 of them list Mood Disorders in their own words; the registry filed them under no condition.

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Status

Completed
363
Recruiting
77
Status unknown
46
Not yet recruiting
21
Terminated
21
Active, not recruiting
18

Phase

Phase 2
77
Phase 1
53
Phase 3
33
Phase 4
30
Early Phase 1
4

Where

United States
269
Canada
48
France
33
Germany
21
United Kingdom
20
Poland
18

Who runs them

National Institute of Mental Health (NIMH) (44) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (25) · University of North Carolina, Chapel Hill (13) · Massachusetts General Hospital (11) · Stanford University (9) · University of Michigan (9) · University of Pittsburgh (8) · VA Office of Research and Development (8)

What is being tested here

Drugs under test in Mood Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Brenipatide222
Escitalopram117
Quetiapine124
Estradiol103
Citalopram103
Nitrous Oxide102
Progesterone102
Psilocybin102
Lurasidone102
Melatonin101

Drug classes tested here SSRIs 2 open · Antipsychotics 1 open · Psychedelics 1 open · Serotonin receptor agonists 1 open · Estrogens 1 open

Coming up

3phase 3 studies under way
39studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 77 Mood Disorders studies recruiting now, 21 (27%) set no upper age limit and 45 (58%) stop at 75 or younger. 20 (26%) take children under 18. 6 (8%) are for women only and 0 (0%) for men only; 23 (30%) take healthy volunteers.

Recruiting studies that take each age, of 77
AgeWomenMen
109 (12%)9 (12%)
1862 (81%)58 (75%)
3060 (78%)56 (73%)
4059 (77%)55 (71%)
5059 (77%)56 (73%)
6556 (73%)54 (70%)
7535 (45%)33 (43%)
8528 (36%)26 (34%)

Across all 561 studies, recruiting or not: 64% stop at 75 or younger and 55% at 65; 23% take children; 7% are for women only and 2% for men only; 33% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Mood Disorders studies take

Of 24 phase 2 interventional studies under Mood Disorders, half reached primary completion within 32 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 114 mo8–59 · 14 studies——
Phase 232 mo20–52 · 24 studies——
Interventional, no phase21 mo11–44 · 162 studies—22 mo11–44 · 151 studies
Observational54 mo27–203 · 57 studies—60 mo28–203 · 55 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting4

Newly registered4

Studies

Recruiting first, then most recently updated. Showing 50 of 561. Browse all 561 → or search them.