Drug
Estradiol clinical trials
Also written Estrace, Climara and E2.
Includes 2 studies of Estradiol acetate.
- studies test it
- 307
- open now
- 32
- in phase 3
- 79
- first study started
- 1994
Keep track of what changes. Save the Estradiol studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
307 studies that test it; most in 2017 (21)
| Year | Studies |
|---|---|
| 1994 | 2 |
| 1995 | 1 |
| 1996 | 1 |
| 1998 | 3 |
| 2001 | 7 |
| 2002 | 2 |
| 2003 | 4 |
| 2004 | 8 |
| 2005 | 18 |
| 2006 | 16 |
| 2007 | 19 |
| 2008 | 12 |
| 2009 | 13 |
| 2010 | 10 |
| 2011 | 11 |
| 2012 | 13 |
| 2013 | 16 |
| 2014 | 5 |
| 2015 | 12 |
| 2016 | 13 |
| 2017 | 21 |
| 2018 | 12 |
| 2019 | 12 |
| 2020 | 12 |
| 2021 | 7 |
| 2022 | 17 |
| 2023 | 6 |
| 2024 | 14 |
| 2025 | 7 |
| 2026 | 13 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 12
- Phase 1
- 27
- Phase 2
- 62
- Phase 3
- 79
- Phase 4
- 82
- No phase
- 56
What it is tested for
Each study’s main condition, where its own words name it.
- Atrophy
- 10
Who runs them
Industry 77 · Other 230
Bayer (14) · Novo Nordisk A/S (12) · University of Colorado, Denver (11) · Organon and Co (11) · University of North Carolina, Chapel Hill (10) · Massachusetts General Hospital (8) · Myovant Sciences GmbH (7) · Cairo University (4)
Often tested with
Tested in the same studies.
Progesterone (41) · Norethindrone (20) · Norethindrone Acetate (19) · Nomegestrol acetate (13) · Megestrol (13) · Ethinyl Estradiol (12) · Dienogest (10) · Testosterone (8)
Studies
Open first, then newest update. How each study uses Estradiol is read from its arms, and is right about nine times in ten.
Testing it · 307
- Post-traumatic Estradiol Administration and Care Evaluation (PEACE)Not yet recruitingPhase 2University of North Carolina, Chapel HillNCT07868536Written as 17β-estradiol
- Role of Menopause in ThermoregulationRecruitingPhase 4Penn State UniversityNCT06798571Written as Estradiol patch
- VEDA Study (DHEA vs Estradiol)RecruitingNot applicableUniversity of ArizonaNCT07574216Written as Estradiol 0.01% Vag Cream
- Cyclic vs. Constant Estradiol: Regimens' Effects on Brain HealthRecruitingPhase 4University of Colorado, DenverNCT07831499Written as Cyclic Estradiol
- Pre-pubertal Low Dose Transdermal Estradiol in Turner SyndromeNot yet recruitingPhase 2Children's National Research InstituteNCT07784582Written as Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch
- Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-DeficiencyRecruitingNot applicableUniversity Hospital, Basel, SwitzerlandNCT07361263Written as estradiol valerate
- Acute Effects of Estradiol Administration on Brain Function During Fear LearningNot yet recruitingEarly Phase 1University of ArizonaNCT07737613Written as estradiol
- Hormone thERapy Effects on BRAin-HEART Health During the Menopausal TransitionNot yet recruitingPhase 4McGill University Health Centre/Research Institute of the McGill University Health CentreNCT07732452Written as Transdermal estradiol
- Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIVNot yet recruitingPhase 4Albert Einstein College of MedicineNCT07526948Written as Vaginal estradiol tablets
- Postpartum Vaginal Estrogen for Breastfeeding PatientsRecruitingPhase 4University Hospitals Cleveland Medical CenterNCT05457972Written as Estradiol
- Convergent Mechanisms Underlying Reprometabolic Syndrome in WomenRecruitingPhase 2University of Colorado, DenverNCT06686537Written as Estradiol Patches
- Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal WomenRecruitingNot applicableMette HansenNCT07617454Written as Estrogel
- Menopausal HT for Women Living With HIV (HoT)RecruitingPhase 4Advancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsNCT06856174Written as Transdermal estradiol gel
- Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesEnrolling by invitationNot applicableEnhanced Emirates LimitedNCT07568574Written as Estradiol Patch
- STUDY02001740;22SCH740: Estradiol For ER+ Advanced Breast Cancer (ESTHER)RecruitingPhase 2Dartmouth-Hitchcock Medical CenterNCT05716516Written as Estradiol
- Examining the Effects of Estradiol on Neural and Molecular Response to RewardRecruitingPhase 4University of North Carolina, Chapel HillNCT05282277Written as Transdermal Estradiol
- COMPASS - COpenhagen MenoPAuSe StudyRecruitingPhase 2Martin Blomberg JensenNCT07254429Written as Estradiol (E2)
- Estradiol and Intrusive MemoriesRecruitingNot applicableCharite University, Berlin, GermanyNCT07419594Written as Estradiol Valerate
- A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare DiseasesNot yet recruitingPhase 2Universiti Kebangsaan Malaysia Medical CentreNCT07041814Written as Oral estradiol valerate
- Estrogen Deficiency on Cardiovascular RiskNot yet recruitingEarly Phase 1Milton S. Hershey Medical CenterNCT06369363Written as Estradiol
See all 307 studies that test Estradiol →
Given in every arm · 34 — Estradiol is usual care beside what is tested
- Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast CancerRecruitingPhase 2University of WashingtonNCT06179303Written as Therapeutic Estradiol
- Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)Not yet recruitingPhase 4University Hospital, GhentNCT07818278Written as Oestrogel® 0.75 mg (estradiol transdermal gel)
- Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone TherapyNot yet recruitingNot applicableSehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalNCT07496294Written as Transdermal estradiol
- The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in HumansNot yet recruitingNot applicableUniversity of British ColumbiaNCT07212712Written as Estradiol (E2)
- Estradiol Plus Olaparib for Breast Cancer (PHOEBE)RecruitingPhase 1Mary D ChamberlinNCT05900895Written as 17b-estradiol
- Androgen Blockade and Progesterone Augmentation of Gonadotropin SecretionRecruitingEarly Phase 1University of VirginiaNCT04597099Written as Estradiol patch
- The Effect of Sildenafil Citrate on Frozen Embryo Transfer CyclesRecruitingPhase 2/3Beni-Suef UniversityNCT05951413Written as estradiol
- Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.SuspendedPhase 1ART Fertility Clinics LLCNCT05980091Written as Estradiol Valerate 2 MG
- Estrogen Receptor Beta and MoodCompletedPhase 2National Institute of Mental Health (NIMH)NCT03689543Written as Estradiol
- Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort StudyCompletedNot applicableTel-Aviv Sourasky Medical CenterNCT07145281Written as Estradiol (E2)
- Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This DiseaseActive, not recruitingPhase 2City of Hope Medical CenterNCT00080756Written as therapeutic estradiol
- Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer CyclesCompletedNot applicableAlexandria UniversityNCT05189145Written as estradiol valerate
- Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone InhibitionActive, not recruitingNot applicableUniversity of VirginiaNCT01425541Written as estrace
- A Treatment Study for Premenstrual Syndrome (PMS)CompletedPhase 1National Institute of Mental Health (NIMH)NCT00001259Written as Estradiol Patches
- The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo TransferCompletedPhase 4Rahem Fertility CenterNCT04507022Written as Estradiol Valerate
- The Effects of Reproductive Hormones on Mood and BehaviorCompletedPhase 1/2National Institute of Mental Health (NIMH)NCT00001322Written as Estradiol
- Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI CyclesStatus unknownNot applicableMansoura UniversityNCT05112692Written as Estradiol Valerate and progesterone
- Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin EndometriumStatus unknownPhase 1Cairo UniversityNCT04283435Written as Estradiol Valerate
- Study of Relugolix Alone and Relugolix Combined With Hormonal Add-Back Therapy in Healthy Premenopausal Female ParticipantsCompletedPhase 1Myovant Sciences GmbHNCT04978688Written as E2/NETA
- An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine FibroidsCompletedPhase 3AbbVieNCT02925494Written as Estradiol/Norethindrone Acetate
Showing 20 of 34.
As the comparator · 21 — what is tested is compared with Estradiol
- Effect of Tadalafil on Endometrial Thickness and Frozen Embryo Transfer OutcomesRecruitingPhase 4Beni-Suef UniversityNCT07499804Written as estradiol valerate 2 mg
- Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of MenopauseRecruitingNot applicableStratpharma AGNCT05672901Written as Estrace 0.01% Vaginal Cream
- Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled TrialNot yet recruitingPhase 2/3TriHealth Inc.NCT07260825Written as Estradiol 0.01% Vag Cream
- MEdical Versus SUrgical Treatments of Rectal EndometriosisCompletedPhase 3University Hospital, RouenNCT01973816Written as Estradiol 0.5% percutaneous gel; Cyproterone acetate 50 mg oral
- Natural Versus Artificial Cycle for Frozen-Thawed Embryo TransferCompletedPhase 4Universitaire Ziekenhuizen KU LeuvenNCT03642665Written as Estradiol Valerate
- Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract InfectionCompletedNot applicableMayo ClinicNCT04301934Written as Estradiol
- A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of MenopauseCompletedNot applicableNYU Langone HealthNCT04544475Written as Estrace
- A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic VaginitisCompletedPhase 3Mylan Pharmaceuticals IncNCT02195986Written as Estrace® 0.01% cream
- The Impact of Hormone Therapy on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic DisorderCompletedPhase 4Far Eastern Memorial HospitalNCT01822288Written as Estradiol & medroxyprogesterone acetate
- Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal WomenStatus unknownPhase 4Scientific Research Institute of Public Health, Russian FederationNCT05156814Written as Divigel
- Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)WithdrawnPhase 4CRG UZ BrusselNCT04002635Written as estradiol valerate
- The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Pilot Study in Normo-responder IVF PatientsCompletedPhase 4Peter HumaidanNCT01980680Written as Progesterone and Estradiol
- Estradiol as add-on to AntipsychoticsStatus unknownPhase 3Tangent DataNCT04093518Written as Estradiol
- The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal WomenCompletedNot applicableUniversity of Colorado, DenverNCT02256540Written as Climara
- A Study of MK-6913 for the Treatment of Hot Flashes in Postmenopausal Women (6913-004)TerminatedPhase 2Merck Sharp & Dohme LLCNCT01015677Written as 17-β estradiol
- Implantation Enhancement by Elective Cryopreservation of All Viable EmbryosCompletedNot applicableUniversitair Ziekenhuis BrusselNCT02148393Written as Progynova®
- To Study Generic Estradiol 10 mcg Vaginal Tablets in the Treatment of Vulvar and Vaginal Atrophy in Post Menopausal Women.CompletedPhase 3Glenmark Pharmaceuticals Ltd. IndiaNCT02668796Written as Vagifem® (Estradiol Vaginal Tablets) 10 mcg (Novo Nordisk)
- Comparison Between Testosterone and Estradiol Over the Homogenization of Follicular CohortStatus unknownPhase 3Hospital de Clinicas de Porto AlegreNCT03238092Written as Estradiol
- The Effect of Tamoxifen on Clinical Outcome in Women With Thin Endometrium Undergoing Frozen Thawed Cycle.Status unknownPhase 4Sun Yat-sen UniversityNCT03060304Written as estradiol valerate
- Raloxifene and Rimostil for Perimenopause-Related DepressionCompletedPhase 4National Institute of Mental Health (NIMH)NCT00030147Written as Transdermal Estradiol
Showing 20 of 21.
Codes
What other systems call Estradiol · ClinicalTrials.gg INT007441
- MeSH (NLM) D004958EstradiolConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 4TI98Z838EESTRADIOLConfirmed FDA, NLM, Wikidata
- RxNorm 4083Confirmed FDA, Wikidata
- Wikidata Q42241617β-estradiolConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C478Therapeutic EstradiolOne source FDA
- DrugBank DB00783One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004958 | Estradiol | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 4TI98Z838E | ESTRADIOL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 4083 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422416 | 17β-estradiol | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C478 | Therapeutic Estradiol | One source FDA |
| DrugBank | DB00783 | — | One source Wikidata |
Also registered as estradiol hemihydrate (UNII CXY7B3Q98Z · RxNorm 236859) and estradiol valerate (UNII OKG364O896 · RxNorm 24395).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.