Drug
Ketamine clinical trials
Also written Ketalar and Calypsol.
How each study uses Ketamine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Ketamine studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 19 Feb 1970 · KETALAR · NDA 016812 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
889 studies that test it; most in 2022 (67); 4 more planned to start later
| Year | Studies |
|---|---|
| 2001 | 3 |
| 2002 | 2 |
| 2003 | 3 |
| 2004 | 9 |
| 2005 | 5 |
| 2006 | 7 |
| 2007 | 13 |
| 2008 | 16 |
| 2009 | 16 |
| 2010 | 22 |
| 2011 | 29 |
| 2012 | 33 |
| 2013 | 41 |
| 2014 | 43 |
| 2015 | 61 |
| 2016 | 56 |
| 2017 | 58 |
| 2018 | 50 |
| 2019 | 58 |
| 2020 | 46 |
| 2021 | 54 |
| 2022 | 67 |
| 2023 | 52 |
| 2024 | 50 |
| 2025 | 52 |
| 2026 | 43 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 23 · Other 871
Assiut University (33) · Yale University (22) · Ain Shams University (19) · New York State Psychiatric Institute (14) · Mayo Clinic (13) · Massachusetts General Hospital (13) · Zagazig University (12) · Cairo University (12)
Often tested with
Tested in the same studies.
Dexmedetomidine (85) · Lidocaine (41) · Propofol (41) · Midazolam (38) · Fentanyl (18) · Magnesium Sulfate (16) · Morphine (13) · Sevoflurane (12)
Related medicines
As reviewed, each with the page that says it.
- One of Anesthetics, Dissociative source
- Esketamine is one of its enantiomers, counted on its own page source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 53, 12 in phase 3
Studies that test Ketamine, phase 3 first.
- Nov 2026Ketamine Irrigation Analgesia in Laparoscopic CholecystectomyPhase 3 · Assiut University
- Dec 2026Effect of Ketamine on Intraoperative Motor Evoked PotentialsPhase 3 · University of California, San Francisco
- Dec 2026Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department PatientsPhase 2/3 · Albany Medical College
- Dec 2026Quelling of Excitotoxicity in Acute Stroke With KetaminePhase 2/3 · Lower Merion Neurology Research Foundation
- Dec 2026Ketamine & Crisis Response Plan for Suicidal Ideation in the EDPhase 2/3 · The University of Texas Health Science Center at San Antonio
- Feb 2027Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily HeadachesPhase 3 · University Health Network, Toronto
- Feb 2027Ketamine Treatment of Youth Suicide AttemptersPhase 3 · Tatiana Falcone, MD
- Mar 2027Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).Phase 3 · Children's Cancer Hospital Egypt 57357
- Mar 2027Understanding and Treating Suicidal Ideation With KetaminePhase 2/3 · The Royal's Institute of Mental Health Research
- Apr 2027Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating RoomPhase 3 · Nantes University Hospital
Studies
Open first, then newest update. How each study uses Ketamine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 894
- Exploring Ketamine's Effects on Depression and Anxiety in Adults With Low VisionNot yet recruitingPhase 2Stanford UniversityNCT07934043Written as Ketamine
- Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and RecoveryRecruitingNot applicableAnkara City Hospital BilkentNCT07640243Written as Ketamine
- Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionRecruitingPhase 4Massachusetts General HospitalNCT05450432Written as Ketamine
- Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingPhase 1National Institute of Mental Health (NIMH)NCT03065335Written as Ketamine
- Understanding and Treating Suicidal Ideation With KetamineRecruitingPhase 2/3The Royal's Institute of Mental Health ResearchNCT06891300Written as ketamine hydrochloride
- Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean DeliveryRecruitingPhase 1University of UtahNCT06767566Written as Ketamine (Ketalar)
- Biomarker-Guided Antidepressant SelectionRecruitingPhase 4Weill Medical College of Cornell UniversityNCT07680140Written as Ketamine
- HNC: Human Neural Circuits Electrophysiology During CognitionRecruitingPhase 1Stanford UniversityNCT05962424Written as Ketamine Hydrochloride
- Ketamine Sedation in the ICU (KANINE) RCTRecruitingPhase 3McMaster UniversityNCT06767358Written as ketamine hydrochloride
- Morphine or Ketamine for AnalgesiaRecruitingPhase 3Columbia UniversityNCT06835504Written as Ketamine hydrochloride
- Ketamine for Opioid Use DisorderRecruitingPhase 2University of Maryland, BaltimoreNCT06943859Written as Treatment with Ketamine
- Intravenous Ketamine for Treatment-Resistant DepressionRecruitingPhase 2Mayo ClinicNCT06668571Written as Ketamine
- Neurobiology of SuicideRecruitingPhase 2National Institute of Mental Health (NIMH)NCT02543983Written as Ketamine Hydrochloride
- Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency DepartmentRecruitingPhase 2The University of Texas Health Science Center at San AntonioNCT07868913Written as Ketamine Injectable Solution
- Ketamine Effects on Learning In Eating DisordersEnrolling by invitationPhase 2Amanda Downey, MDNCT06736769Written as Ketamine infusion
- Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus SurgeryNot yet recruitingPhase 4Assiut UniversityNCT07871292Written as Ketamine and Propofol
- Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineRecruitingEarly Phase 1University of PennsylvaniaNCT06788249Written as Ketamine only
- Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean SectionNot yet recruitingPhase 4Assiut UniversityNCT07855523Written as Midazolam and Ketamine
- Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous NephrolithotomyNot yet recruitingPhase 4Assiut UniversityNCT07855068Written as Ketamine and Dexmedetomidine
- A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive EpisodesNot yet recruitingPhase 3Jawaharlal Institute of Postgraduate Medical Education & ResearchNCT07839338Written as Oral ketamine
See all 894 studies that test Ketamine →
Given beside what is tested · 40 — Ketamine is usual care or a partner of the new treatment
- Behavioural Activation Therapy and Ketamine for Treatment-Resistant DepressionRecruitingPhase 2/3The Royal's Institute of Mental Health ResearchNCT07801703Written as Ketamine (0.5 mg/kg)
- Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery EnhancementRecruitingPhase 2University of California, San DiegoNCT07369089Written as Ketamine
- Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT06559826Written as Ketamine
- Glutamatergic Mechanisms: Aim2RecruitingPhase 1New York State Psychiatric InstituteNCT05401227Written as Ketamine
- InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionRecruitingPhase 3Sunnybrook Health Sciences CentreNCT06781697Written as Ketamine
- Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.Not yet recruitingPhase 4Sultan Qaboos UniversityNCT07874919Written as Ketamine (1 mg/kg)
- The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsRecruitingPhase 2Yale UniversityNCT05786066Written as Ketamine
- Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseRecruitingPhase 1Yale UniversityNCT05915013Written as Ketamine
- Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionRecruitingPhase 2VA Office of Research and DevelopmentNCT06419439Written as Ketamine hydrochloride
- Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male AdultsCompletedPhase 1TakedaNCT01892189Written as Ketamine
- Comparison of High Flow vs Standard Nasal Cannula in Children With Burns Under SedoanalgesiaCompletedNot applicableZeliha AlicikusNCT06663293Written as midazolam, ketamine, propofol
- Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy ParticipantsCompletedPhase 1Supernus Pharmaceuticals, Inc.NCT05049343Written as Ketamine
- Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialCompletedPhase 1Yale UniversityNCT03367533Written as Ketamine
- Ketamine + Mindfulness for DepressionCompletedPhase 1/2Rebecca PriceNCT05168735Written as Intravenous Ketamine
- Ketamine + Cognitive Training for Suicidality in the Medical Setting: PilotTerminatedPhase 4Rebecca PriceNCT04154150Written as Intravenous ketamine
- Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion PatientsTerminatedPhase 4Montefiore Medical CenterNCT02989597Written as Ketamine
- Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst StimulationCompletedNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT05360030Written as Ketamine Hydrochloride
- A Study in Healthy Men to Test Whether BI 474121 Can Reverse the Memory Problems Caused by KetamineWithdrawnPhase 1Boehringer IngelheimNCT05451095Written as Ketamine hydrochloride
- Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male SubjectsCompletedPhase 1Yale UniversityNCT00700076Written as Ketamine and Org 25935
- Lamotrigine in Reducing Psychologic Side-Effect of Perioperative KetamineCompletedPhase 3The Cleveland ClinicNCT03831854Written as Ketamine
Showing 20 of 40.
As the comparator · 39 — what is tested is compared with Ketamine
- (2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic PainRecruitingPhase 1/2Rush University Medical CenterNCT05864053Written as Ketamine
- Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft SurgeryRecruitingNot applicableUniversity Medical Centre LjubljanaNCT07340008Written as ketamine
- Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator TrialRecruitingPhase 2University of IowaNCT06405607Written as Ketamine
- Pragmatic Trial of Psilocybin Therapy in Palliative CareRecruitingPhase 2Charles S. Grob, M.D.NCT05403086Written as Ketamine
- Comparison of Intravenous Lidocaine vs Ketamine in Colorectal SurgeryRecruitingNot applicableUniversity Tunis El ManarNCT06272461Written as Ketamine Injectable Solution
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve GastrectomyNot yet recruitingNot applicableIVO JURISICNCT07084753Written as ketamine
- Intranasal Dexmedetomidine Plus Ketamine for Procedural SedationRecruitingPhase 2/3Naveen PoonaiNCT04195256Written as IV Ketamine
- Psilocybin Versus Ketamine in Treatment-Resistant DepressionRecruitingPhase 2National Institute of Mental Health, Czech RepublicNCT05383313Written as Ketamine Hydrochloride
- Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal ShiveringCompletedNot applicableMayo Hospital LahoreNCT07334223Written as Ketamine (0.25 mg/kg)
- Dexmedetomidine Versus Ketamine Loading for Dexmedetomidine Sedation During Elective Cesarean Section Under Spinal AnesthesiaCompletedPhase 4Haseki Training and Research HospitalNCT07676955Written as Ketamine
- ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEptic EffectsCompletedPhase 4Centre Hospitalier Universitaire de NiceNCT06853041Written as Ketamine
- Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive DisorderCompletedNot applicableTanta UniversityNCT07526454Written as Ketamine
- Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot TrialCompletedPhase 4Unity Health TorontoNCT05639322Written as Ketamine Hydrochloride
- IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm FracturesWithdrawnEarly Phase 1Phoenix Children's HospitalNCT03466242Written as Ketamine
- Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use DisorderActive, not recruitingPhase 2Peggy C NopoulosNCT05421065Written as Ketamine
- Comparison of Prophylactic Use of Tramadol Versus Ketamine for Prevention of Post Spinal Anesthesia ShiveringCompletedPhase 3Syed Muhammad AbbasNCT07043049Written as Ketamine
- Ketamine Versus Neostigmine in Ultrasound-Guided Transversus Abdominis Plane Block in Caesarean SectionCompletedPhase 3Alexandria UniversityNCT06871033Written as TAP block with Ketamine
- Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)CompletedPhase 4Medipol UniversityNCT06630364Written as ketamine
- Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001CompletedPhase 2/3Cessatech A/SNCT05508594Written as Ketamine
- Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative FracturesTerminatedPhase 4University of Alabama at BirminghamNCT03781817Written as Intravenous Ketamine
Showing 20 of 39.
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting2
- Ketamine Sedation in the ICU (KANINE) RCTOct 22, 2026NCT06767358
- Morphine or Ketamine for AnalgesiaOct 20, 2026NCT06835504
Results posted1
- Ketamine and Kidney Injury in Cardiac SurgeryOct 20, 2026NCT05268562
Stopped4
- Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)WithdrawnNov 6, 2026NCT06378528
- Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureTerminatedNov 5, 2026NCT05603104
- Dexmedetomidine and Ketamine in VATS SurgeryTerminatedOct 22, 2026NCT03596424
- Ketamine Biomarker ValidationWithdrawnOct 19, 2026NCT07307768
Newly registered1
- Exploring Ketamine's Effects on Depression and Anxiety in Adults With Low VisionNov 12, 2026NCT07934043
Codes
What other systems call Ketamine · ClinicalTrials.gg INT007707
- MeSH (NLM) D007649KetamineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 690G0D6V8HKETAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 6130Confirmed FDA, Wikidata
- Wikidata Q243547(RS)-ketamineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61797KetamineOne source FDA
- DrugBank DB01221One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D007649 | Ketamine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 690G0D6V8H | KETAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6130 | — | Confirmed FDA, Wikidata |
| Wikidata | Q243547 | (RS)-ketamine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61797 | Ketamine | One source FDA |
| DrugBank | DB01221 | — | One source Wikidata |
Also registered as ketamine hydrochloride (UNII O18YUO0I83 · RxNorm 203184).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.