Obsessive-Compulsive Disorder clinical trials
The registry lists 635 studies for Obsessive-Compulsive Disorder across more than 10 countries. 166 are recruiting or about to start. 526 of them are mainly about Obsessive-Compulsive Disorder (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Trichotillomania: 712 studies, 177 open.
ClinicalTrials.gov finds 759 studies for Obsessive-Compulsive Disorder. How that becomes 634 here
This page counts the studies the registry files under Obsessive-Compulsive Disorder, and those it files under no condition that list Obsessive-Compulsive Disorderthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 759Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −77Filed under a narrower condition, counted on its own pageTrichotillomania 41 · Hoarding Disorder 28 · Excoriation Disorder 8
- −4List Obsessive-Compulsive Disorder as a condition, but the registry did not file them under itMost often written as “Obsessive Compulsive Disorders” (3) and “Obsessive Compulsive Disorder OCD” (1). The registry filed them under other conditions only, most often Compulsive Personality Disorder (4) and Anxiety Disorders (2).
- −44Match it another way31 name it in the title and 13 by a synonym or other text the search reads.
- 634The count on this page7 of them list Obsessive-Compulsive Disorder in their own words; the registry filed them under no condition.
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Status
Who runs them
Shanghai Mental Health Center (26) · New York State Psychiatric Institute (24) · Massachusetts General Hospital (23) · Karolinska Institutet (17) · National Institute of Mental Health (NIMH) (16) · Baylor College of Medicine (16) · University of South Florida (16) · Yale University (13)
What is being tested here
Drugs under test in Obsessive-Compulsive Disorder studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ketamine | 2 | 0 | 9 |
| Psilocybin | 2 | 0 | 8 |
| Fluvoxamine | 1 | 2 | 7 |
| Fluoxetine | 1 | 0 | 4 |
| Pramipexole | 1 | 0 | 3 |
| Rituximab | 1 | 0 | 2 |
| Valbenazine | 1 | 0 | 1 |
| 6-hydroxynorketamine | 1 | 0 | 1 |
| Dextromethorphan | 1 | 0 | 1 |
| N-Methyl-3,4-methylenedioxyamphetamine | 1 | 0 | 1 |
Drug classes tested here SSRIs 3 open · Psychedelics 3 open · SNRIs 1 open · Antipsychotics 9 · Antiemetics 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders · Amsterdam UMC, location VUmc
- Nov 2026Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders · Shanghai Mental Health Center
- Dec 2026CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy · Jasper A. Smits
- Dec 2026MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) · Carolyn Rodriguez
- Dec 2026Effects of Psilocybin in Obsessive Compulsive Disorder · Johns Hopkins University
- Dec 2026Caloric Vestibular Stimulation for Modulation of Insight in Obsessive-Compulsive Spectrum Disorders · Stanford University
- Dec 2026Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients · National Institute of Mental Health, Czech Republic
- Dec 2026Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: Outpatients Trial · National Institute of Mental Health, Czech Republic
- Dec 2026Improving Obsessive-compulsive Disorder Treatments: From Lesions to Neuromodulation Targets · Fundacao Champalimaud
- Dec 2026The Effects and Neural Mechanisms of Vitamin D and Iron-Immune Homeostasis on Inhibitory Control in Obsessive-Compulsive Disorder · Guangdong Provincial People's Hospital
Who these studies take
Of the 120 Obsessive-Compulsive Disorder studies recruiting now, 31 (26%) set no upper age limit and 81 (68%) stop at 75 or younger. 28 (23%) take children under 18. 1 (1%) are for women only and 0 (0%) for men only; 18 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 20 (17%) | 20 (17%) |
| 18 | 103 (86%) | 102 (85%) |
| 30 | 102 (85%) | 101 (84%) |
| 40 | 102 (85%) | 101 (84%) |
| 50 | 101 (84%) | 100 (83%) |
| 65 | 80 (67%) | 79 (66%) |
| 75 | 43 (36%) | 42 (35%) |
| 85 | 35 (29%) | 34 (28%) |
Across all 635 studies, recruiting or not: 76% stop at 75 or younger and 67% at 65; 26% take children; 1% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Obsessive-Compulsive Disorder studies take
Of 13 phase 1 interventional studies under Obsessive-Compulsive Disorder, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 30 mo18–57 · 13 studies | — | — |
| Interventional, no phase | 43 mo22–65 · 237 studies | — | 43 mo22–65 · 234 studies |
| Observational | 68 mo41–84 · 27 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Focused Ultrasound for Behavioral HealthOct 27, 2026NCT07851038
Results posted1
- Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.Oct 16, 2026NCT03356483
Newly registered6
- Project Raising Exposure Awareness for Caregiver Help-SeekingNov 10, 2026NCT07929077
- Family Accommodation Reduction in Adult Obsessive Compulsive DisorderNov 3, 2026NCT07912177
- Continuous Theta-Burst Stimulation for Obsessive-Compulsive Disorder: An Open-Label StudyOct 27, 2026NCT07896837
- Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept StudyOct 16, 2026NCT07877363
- Low-intensity Ultrasound for Individuals With Obsessive-compulsive DisorderOct 14, 2026NCT07872917
Show 1 moreShow fewer
- A Digital Mindfulness-Based Program for OCDOct 13, 2026NCT07871344
Studies
Recruiting first, then most recently updated. Showing 50 of 635. Browse all 635 → or search them.
- Brain-Oscillation Synchronized Stimulation of the DMPFCRecruitingNCT06942559Not applicable1 country
- Project Raising Exposure Awareness for Caregiver Help-SeekingNot yet recruitingNCT07929077Not applicable
- The STEP-MIED Trial: Digital Stepped-Care for Emotional DisordersRecruitingNCT07458100Not applicable1 country
- Family Accommodation Reduction in Adult Obsessive Compulsive DisorderEnrolling by invitationNCT07912177Not applicable1 country
- Precision Analytic Research Methods in OCDRecruitingNCT07011901Not applicable1 country
- Focused Ultrasound for Behavioral HealthRecruitingNCT07851038Not applicable1 country
- Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial)Not yet recruitingNCT07895706Not applicable1 country
- tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive DisorderRecruitingNCT06017713Not applicable1 country
- Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept StudyNot yet recruitingNCT07877363Not applicable
- Gamified Combined Cognitive Bias Modification in Adults Diagnosed With OCD: Randomized Controlled TrialRecruitingNCT06941155Not applicable1 country
- Low-intensity Ultrasound for Individuals With Obsessive-compulsive DisorderNot yet recruitingNCT07872917Not applicable1 country
- A Digital Mindfulness-Based Program for OCDNot yet recruitingNCT07871344Not applicable
- Project EMPOWER-OCDRecruitingNCT07158801Not applicable1 country
- Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)RecruitingNCT075664681 country
- Feasibility of Modulating Cognitive Control in OCDNot yet recruitingNCT07419009Not applicable
- OCD LIFU Target EngagementRecruitingNCT07558148Not applicable1 country
- Deep Brain Stimulation for Refractory Obsessive-Compulsive DisorderRecruitingNCT06660225Not applicable1 country
- Neurobehavioral Investigations of Approach Dynamics in the Ventral StriatumNot yet recruitingNCT05422469Not applicable1 country
- Aerobic Exercise and Obsessive-Compulsive Disorder SymptomsRecruitingNCT07103902Not applicable1 country
- Acceptance and Commitment Therapy for Religious OCDRecruitingNCT06647589Not applicable1 country
- Developing Brain, Impulsivity and CompulsivityRecruitingNCT046310421 country
- Clinical and Biological Correlates of Obsessive-Compulsive Disorder and Online Mindfulness-Based Cognitive TherapyRecruitingNCT07834567Not applicable1 country
- Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCDRecruitingNCT04131829Phase 1/21 country
- Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to TreatmentRecruitingNCT07741981Not applicable1 country
- Cohort Study of Obsessive-Compulsive DisorderNot yet recruitingNCT07822516
- ICBT for OCD in Children With AutismRecruitingNCT06582225Not applicable1 country
- Transcutaneous Electrical Acupoint Stimulation Combined With Exposure and Response Prevention in the Treatment of Patients With Obsessive-Compulsive Disorder: A Randomized Controlled TrialNot yet recruitingNCT07811778Not applicable1 country
- OCD Summer Treatment Program for Adolescents in IcelandRecruitingNCT07465354Not applicable1 country
- Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic StimulationRecruitingNCT07065669Not applicable1 country
- Bergen Four-Day Treatment (B4DT) for Obsessive-Compulsive DisorderRecruitingNCT07644130Not applicable1 country
- Physiological Brain Atlas DevelopmentRecruitingNCT005750811 country
- Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental DisordersRecruitingNCT06112067Not applicable1 country
- Anxiety Skills StudyRecruitingNCT07774481Not applicable1 country
- The Effects and Neural Mechanisms of Vitamin D and Iron-Immune Homeostasis on Inhibitory Control in Obsessive-Compulsive DisorderEnrolling by invitationNCT07763977Not applicable1 country
- Pilot Study of RR-HNK in OCDRecruitingNCT06575075Phase 1/21 country
- Neural Mechanisms of Response Inhibition Training for OCRDRecruitingNCT05377125Not applicable1 country
- CBT Augmentation to Promote Medication Discontinuation in Pediatric OCDRecruitingNCT05609916Not applicable1 country
- Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain AxisRecruitingNCT067543191 country
- Testing Delivery Modalities of Team-Based CBT for Pediatric Anxiety in Community Health Settings.RecruitingNCT06934525Not applicable1 country
- Helping Adults With Obsessive-Compulsive Disorder Succeed at WorkRecruitingNCT07124780Not applicable1 country
- Preliminary Explorative Study of Magnetic Resonance-Guided Focused Ultrasound Surgery in Refractory Obsessive-Compulsive Disorder PatientsEnrolling by invitationNCT06816511Not applicable1 country
- Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD)RecruitingNCT07725926Not applicable1 country
- SONATA LIFU for OCDRecruitingNCT07728994Phase 21 country
- Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive DisorderRecruitingNCT06834217Not applicable1 country
- Neurophysiological Investigation of the Approach-avoidance Axis in OCD: Applications to NeuromodulationRecruitingNCT06596447Not applicable1 country
- Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.RecruitingNCT07347405Phase 11 country
- Digital Mindfulness-Based Therapy for Obsessive-Compulsive DisorderRecruitingNCT07701616Not applicable1 country
- Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental IllnessRecruitingNCT06376734Phase 21 country
- Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD)RecruitingNCT07704632Not applicable1 country
- Explore Neural Mechanism of Obsessive-Compulsive Disorder (OCD) by Intervention of Repetitive Transcranial Magnetic Stimulation With Symptom ProvocationRecruitingNCT07587112Not applicable1 country