Depression clinical trials

The registry lists 8,577 studies for Depression across more than 10 countries. 1,720 are recruiting or about to start. 4,338 of them are mainly about Depression (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

ClinicalTrials.gov finds 12,953 studies for Depression. How that becomes 8,569 here

This page counts the studies the registry files under Depression, and those it files under no condition that list Depressionthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

12,953Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
−1,551List Depression as a condition, but the registry did not file them under itMost often written as “Postpartum Depression” (208), “Major Depression” (208), and “Treatment Resistant Depression” (161). The registry filed 10 of them under no condition at all, and the others under other conditions only, most often Depression, Postpartum (419) and Depressive Disorder, Major (360).
−2,836Match it another way1,265 name it in the title, 210 in a keyword, and 1,361 by a synonym or other text the search reads.
8,566Counted here and found by its search318 of them list Depression in their own words; the registry filed them under no condition.
+3
Counted here, but its search does not find them
8,569The count on this page

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Status

Completed: 5,122
Recruiting: 1,088
Status unknown: 812
Not yet recruiting: 508
Terminated: 378
Active, not recruiting: 302

Phase

Phase 2: 689
Phase 3: 471
Phase 4: 455
Phase 1: 322
Early Phase 1: 75

Where

United States: 3,706
Canada: 532
China: 357
Turkey: 340
United Kingdom: 282
Germany: 268

Who runs them

Massachusetts General Hospital (163) · University of Pittsburgh (105) · VA Office of Research and Development (100) · National Institute of Mental Health (NIMH) (97) · University of California, Los Angeles (81) · Stanford University (76) · University of Washington (74) · University of Michigan (71)

What is being tested here

Drugs under test in Depression studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Psilocybin	25	4	47
Ketamine	20	19	113
Esketamine	10	3	25
Fluoxetine	8	9	40
Escitalopram	5	27	105
Sertraline	5	14	75
Duloxetine	5	6	37
Pregnenolone	4	0	7
Osavampator	4	4	5
Vortioxetine	3	16	29

Drug classes tested here Serotonin receptor agonists 31 open · Psychedelics 27 open · SSRIs 19 open · SNRIs 5 open · Antipsychotics 4 open

Coming up

45phase 3 studies under way

647studies finish main data collection within a year14 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Dec 2026Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women · Phase 3 · Cedars-Sinai Medical Center
Dec 2026A Study of the Effectiveness and Safety of JS1-1-01 Tablet in Patients With Moderate to Severe Depression · Phase 3 · Tasly Pharmaceutical Group Co., Ltd
Jan 2027An Open-Label Study of Azetukalner in Major Depressive Disorder · Phase 3 · Xenon Pharmaceuticals Inc.
Feb 2027Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer · Phase 3 · M.D. Anderson Cancer Center
Mar 2027A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder. · Phase 3 · AbbVie
May 2027A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) · Phase 3 · Xenon Pharmaceuticals Inc.
May 2027Allopurinol in Depression · Phase 3 · Tanta University
Jun 2027Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33) · Phase 3 · University of California, San Diego
Jun 2027A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder · Phase 3 · Cybin IRL Limited
Jul 2027NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) · Phase 3 · Neurocrine Biosciences

Who these studies take

Of the 1,088 Depression studies recruiting now, 469 (43%) set no upper age limit and 519 (48%) stop at 75 or younger. 203 (19%) take children under 18. 97 (9%) are for women only and 3 (<1%) for men only; 310 (28%) take healthy volunteers.

Recruiting studies that take each age, of 1,088
Age	Women	Men
10	75 (7%)	70 (6%)
18	844 (78%)	769 (71%)
30	821 (75%)	745 (68%)
40	832 (76%)	751 (69%)
50	830 (76%)	759 (70%)
65	793 (73%)	739 (68%)
75	601 (55%)	553 (51%)
85	527 (48%)	480 (44%)

Across all 8,577 studies, recruiting or not: 48% stop at 75 or younger and 40% at 65; 17% take children; 11% are for women only and 1% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Depression studies take

Of 196 phase 2 interventional studies under Depression, half reached primary completion within 31 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Phase 1	27 mo11–54 · 102 studies	—	33 mo16–61 · 82 studies
Phase 1/2	34 mo12–59 · 42 studies	—	—
Phase 2	31 mo18–47 · 196 studies	17 mo12–29 · 53 studies	38 mo27–57 · 143 studies
Phase 2/3	40 mo27–56 · 32 studies	—	49 mo28–56 · 30 studies
Phase 3	28 mo21–44 · 81 studies	—	28 mo22–44 · 55 studies
Phase 4	32 mo17–59 · 119 studies	—	34 mo17–59 · 110 studies
Interventional, no phase	21 mo9–41 · 3,566 studies	9 mo5–18 · 98 studies	21 mo10–41 · 3,468 studies
Observational	33 mo13–62 · 493 studies	25 mo11–42 · 33 studies	34 mo14–63 · 460 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out