Depression clinical trials
The registry lists 8,033 studies for Depression across more than 10 countries. 1,637 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-25.
Status
- Completed
- 4,745
- Recruiting
- 1,081
- Status unknown
- 752
- Not yet recruiting
- 452
- Terminated
- 389
- Active, not recruiting
- 261
Phase
- Phase 2
- 818
- Phase 3
- 618
- Phase 4
- 571
- Phase 1
- 344
- Early Phase 1
- 76
Where
- United States
- 3,477
- Canada
- 579
- China
- 421
- Germany
- 302
- France
- 280
- United Kingdom
- 258
Who runs them
Massachusetts General Hospital (165) · University of Pittsburgh (90) · National Institute of Mental Health (NIMH) (83) · VA Office of Research and Development (79) · New York State Psychiatric Institute (72) · Stanford University (72) · University of California, Los Angeles (69) · University of Washington (61)
Studies
Recruiting first, then most recently updated. Showing 50 of 8,033 — search for more.
- Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)Enrolling by invitationNCT06605105Phase 35 countries
- A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS TrialNot yet recruitingNCT07227103Phase 2/31 country
- Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)RecruitingNCT06455527Not applicable1 country
- Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)Enrolling by invitationNCT071494281 country
- Effectiveness of a Mindfulness-Based Cognitive Behavioral Mobile Intervention for MisophoniaNot yet recruitingNCT07833709Not applicable1 country
- Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).RecruitingNCT06799351Phase 2/31 country
- Thrive at Home: A Virtual Reality Social Intervention for Older AdultsNot yet recruitingNCT07835568Not applicable
- Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe DepressionRecruitingNCT06967857Phase 21 country
- Improving Student Mental Health Through a Universal Trauma-Informed InterventionNot yet recruitingNCT07842432Not applicable
- A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive DisorderRecruitingNCT06793397Phase 38 countries
- Brief Trial of ACT-i for Adults With Chronic InsomniaRecruitingNCT07048600Not applicable1 country
- The WeACT Program for Family Caregivers of People Living With DementiaRecruitingNCT07342569Not applicable1 country
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)RecruitingNCT07621237Phase 21 country
- Ketamine-Assisted Psychotherapy for Treatment-Resistant DepressionNot yet recruitingNCT07247006Phase 21 country
- Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive DisorderEnrolling by invitationNCT06572683Not applicable1 country
- JAK Signaling in Depression and Cognition in Male Football PlayersRecruitingNCT07608796Phase 21 country
- Adapting the ESTEEM Intervention to Improve Mental Health and PrEP Uptake Among Men at Risk of HIVNot yet recruitingNCT07792148Not applicable
- Efficacy of Repetitive Transcranial Magnetic Stimulation for Improving Depressive Symptoms in Patients With Parkinson's DiseaseEnrolling by invitationNCT07569133Not applicable1 country
- Implementing BEAM: A Scalable Digital Mental Health Program, for Families of Children Referred to Neurodevelopmental ServicesNot yet recruitingNCT07837791Not applicable1 country
- WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or AttemptRecruitingNCT05183230Not applicable1 country
- CHW-Enhanced Trauma RecoveryNot yet recruitingNCT07818161Not applicable1 country
- Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.RecruitingNCT073258511 country
- Effects of Digital Detox on Mental Health in Young AdultsNot yet recruitingNCT07827703Not applicable1 country
- Healthy Adaptation to Pregnancy, Postpartum and ParenthoodNot yet recruitingNCT07837193Not applicable1 country
- Psychological Resilience and Quality of Life Among Caregivers of Patients With SchizophreniaNot yet recruitingNCT07837479
- Physical Activity for Depressive Symptoms in Adults With Obesity: A Randomized Controlled Feasibility TrialNot yet recruitingNCT07836582Not applicable1 country
- Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingNCT03065335Phase 11 country
- Shortened LSD Intervention for Major Depressive DisorderNot yet recruitingNCT07503002Phase 11 country
- Characterization and Treatment of Adolescent DepressionRecruitingNCT033886061 country
- Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101Not yet recruitingNCT07785102Early Phase 11 country
- The Medically Tailored Groceries and Mental Health StudyRecruitingNCT07779707Not applicable1 country
- ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality DisorderNot yet recruitingNCT07833761Phase 11 country
- Cognition and Affective Research in ChinaNot yet recruitingNCT078332671 country
- Efficacy of an Integrated Psychological Interventions Combined With Ar_Rahman Listening for Reducing Psychological Distress and Enhancing Hope and Quality of Life Among Cancer Patients: A Randomized Controlled TrialNot yet recruitingNCT07833982Not applicable1 country
- Implementing Depression and Adherence TreatmentRecruitingNCT07032363Not applicable1 country
- Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With FibromyalgiaNot yet recruitingNCT07495943Not applicable1 country
- Neuro-computational Study of Thymic Fluctuations in Mood DisordersRecruitingNCT07033923Not applicable1 country
- Ecological Momentary Assessment of State-Dependent Decision-Making and Metacognition Across a Psychopathology ContinuumNot yet recruitingNCT078010791 country
- Parent-Adolescent Relationships, Emotional Regulation, and HRV in Adolescents With DepressionRecruitingNCT074307741 country
- Transforming Trauma CareNot yet recruitingNCT07829510Not applicable
- Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral NeuropathyRecruitingNCT06706544Phase 2/31 country
- Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan TrialNot yet recruitingNCT07043738Not applicable
- Support for Bereaved Cancer CaregiversRecruitingNCT06662409Not applicable1 country
- Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury DepressionNot yet recruitingNCT07828483Not applicable1 country
- Accelerated iTBS for PTSD and DepressionRecruitingNCT07682207Not applicable1 country
- Alexithymia, Pain Intensity, Quality of Life, and Psychological Symptoms in Chronic Coccydynia Patients Scheduled for Ganglion Impar BlockNot yet recruitingNCT078281451 country
- Confirmatory Efficacy of the Building a Strong Identity and Coping Skills ProgramRecruitingNCT05789446Not applicable1 country
- Virtual Pain Education for Spinal Cord Stimulation PatientsNot yet recruitingNCT07743905Not applicable
- Aerobic Exercise as an Adjunct Therapy for DepressionRecruitingNCT07819448Not applicable1 country
- Prevalence of Primary Headache in Multiple Sclerosis PatientsNot yet recruitingNCT07826221