Stress Disorders, Post-Traumatic clinical trials
The registry lists 2,682 studies for Stress Disorders, Post-Traumatic across more than 10 countries. 601 are recruiting or about to start. 1,890 of them are mainly about Stress Disorders, Post-Traumatic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 2,853 studies for Stress Disorders, Post-Traumatic. How that becomes 2,681 here
This page counts the studies the registry files under Stress Disorders, Post-Traumatic, and those it files under no condition that list Stress Disorders, Post-Traumaticthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,853Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −70List Stress Disorders, Post-Traumatic as a condition, but the registry did not file them under itMost often written as “PTSD - Post Traumatic Stress Disorder” (28), “Post Traumatic Stress Disorder PTSD” (11), and “Stress Disorders, Post Traumatic” (7). The registry filed them under other conditions only, most often Combat Disorders (56) and Anxiety Disorders (10).
- −109Match it another way29 name it in the title, 5 in a keyword, and 75 by a synonym or other text the search reads.
- 2,674Counted here and found by its search21 of them list Stress Disorders, Post-Traumatic in their own words; the registry filed them under no condition.
- +7
Counted here, but its search does not find them
- Integrative Exercise for Post-Deployment StressNCT01674244
- Enhanced Cognitive Rehabilitation to Treat Comorbid TBI and PTSDNCT01943162
- Benefits of the Involvement of Nurses in Meetings Between Physicians and the Families of Patients in the ICU.NCT01745406
- Personalized Pharmacotherapy Using Pharmacogenetics in VeteransNCT06335043
- Considering Racial and Acculturation Stress in Addressing TraumaNCT05974176
- GETSmart: Guided Education and Training Via Smart Phones to Promote ResilienceNCT02170194
- Evaluation of the Effects of Post-Immediate Psychotherapeutic Interventions in Secondary Prevention of Psychotraumatic DisordersNCT00455390
- 2,681The count on this page
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· Enrollment: 300 → 450 participants
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Who runs them
VA Office of Research and Development (263) · US Department of Veterans Affairs (53) · Medical University of South Carolina (45) · University of Washington (35) · Emory University (33) · Yale University (32) · Stanford University (30) · Karolinska Institutet (29)
What is being tested here
Drugs under test in Stress Disorders, Post-Traumatic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Psilocybin | 13 | 4 | 20 |
| N-Methyl-3,4-methylenedioxyamphetamine | 11 | 6 | 38 |
| Ketamine | 4 | 2 | 23 |
| Methylphenidate | 4 | 0 | 7 |
| Propranolol | 3 | 4 | 24 |
| Cannabidiol | 3 | 1 | 9 |
| Suvorexant | 3 | 0 | 6 |
| Estradiol | 3 | 1 | 5 |
| TSND-201 | 3 | 3 | 3 |
| Cycloserine | 2 | 4 | 14 |
Drug classes tested here Psychedelics 23 open · Serotonin receptor agonists 13 open · Stimulants 5 open · Beta blockers 3 open · Antipsychotics 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027MDMA-assisted Massed Prolonged Exposure for PTSD · Phase 3 · Healing Breakthrough
- Mar 2027Repurposing Low-Dose Clonidine for PTSD in Veterans · Phase 3 · Wake Forest University Health Sciences
- May 2027Silexan in the Treatment Of Posttraumatic Stress Disorder Trial · Phase 3 · Deakin University
- Jun 2027Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33) · Phase 3 · University of California, San Diego
- Sep 2027Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the Influence of Propranolol · Phase 3 · University Hospital, Toulouse
- Oct 2027Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder · Phase 3 · Khyber Medical University Peshawar
- Nov 2026Body-oriented Psychotherapy for Individuals With a History of Child Maltreatment and Trauma-related Symptoms · Monique Pfaltz
- Nov 2026Brief-intensive CBT Versus Once-weekly CBT in Anxiety-related Disorders · Amsterdam UMC, location VUmc
- Nov 2026Mobile-Based Resilience Intervention for Moral Injury, Compassion Fatigue, and Distress in ICU Nurses · Alexandria University
- Nov 2026Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building · University of Rhode Island
Who these studies take
Of the 417 Stress Disorders, Post-Traumatic studies recruiting now, 186 (45%) set no upper age limit and 205 (49%) stop at 75 or younger. 63 (15%) take children under 18. 35 (8%) are for women only and 5 (1%) for men only; 89 (21%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 31 (7%) | 31 (7%) |
| 18 | 362 (87%) | 332 (80%) |
| 30 | 373 (89%) | 344 (82%) |
| 40 | 371 (89%) | 342 (82%) |
| 50 | 362 (87%) | 341 (82%) |
| 65 | 320 (77%) | 301 (72%) |
| 75 | 224 (54%) | 206 (49%) |
| 85 | 199 (48%) | 181 (43%) |
Across all 2,682 studies, recruiting or not: 50% stop at 75 or younger and 40% at 65; 13% take children; 9% are for women only and 3% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Stress Disorders, Post-Traumatic studies take
Of 118 phase 2 interventional studies under Stress Disorders, Post-Traumatic, half reached primary completion within 38 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 33 mo17–54 · 52 studies | — | 42 mo17–59 · 47 studies |
| Phase 1/2 | 23 mo17–35 · 17 studies | — | — |
| Phase 2 | 38 mo23–53 · 118 studies | 22 mo17–33 · 31 studies | 46 mo35–59 · 87 studies |
| Phase 3 | 37 mo25–54 · 34 studies | — | — |
| Phase 4 | 52 mo37–77 · 31 studies | — | 52 mo37–77 · 30 studies |
| Interventional, no phase | 34 mo17–53 · 1,092 studies | — | 35 mo17–53 · 1,064 studies |
| Observational | 34 mo14–54 · 149 studies | — | 34 mo13–59 · 142 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting5
- NightWare and Cardiovascular Health in Women With PTSDNov 6, 2026NCT07021014
- The Effects of Orexin Antagonism on Fear Extinction in PTSDNov 5, 2026NCT06788522
- Deep Brain Reorienting in Post-traumatic Stress DisorderNov 3, 2026NCT04317820
- Eye Movement Intervention With Different Memory Reactivation Procedures for Intrusive Traumatic MemoriesOct 15, 2026NCT07767396
- K08 VR Fear ConditioningOct 13, 2026NCT07216222
Results posted6
- Low Intensity Family Support for Refugees in an LMICNov 4, 2026NCT03978533
- Pilot rTMS for AUD+mTBIOct 30, 2026NCT03995173
- Studying the Modification of Attention Bias Remotely After TraumaOct 30, 2026NCT04888169
- An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSDOct 30, 2026NCT06215261
- A Case Formulation Approach to Cognitive Processing TherapyOct 29, 2026NCT04407767
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- Cannabidiol and Prolonged ExposureOct 28, 2026NCT03518801
Stopped3
- Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)WithdrawnNov 6, 2026NCT06378528
- Predictability of the Clinical Global Impression Scale (CGI) in Post Immediate in Psychotraumatic ImpactTerminatedNov 4, 2026NCT05358067
- Pilot rTMS for AUD+mTBITerminatedOct 30, 2026NCT03995173
Newly registered15
- Enhancing the Effect of Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder: A Double-blind Randomized Controlled Trial of Bupivacaine vs Bupivacaine + KetamineNov 9, 2026NCT07927036
- Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient TreatmentNov 5, 2026NCT07920107
- Virtual Reality Assisted Trauma Focused CBTNov 3, 2026NCT07914634
- Trauma-Related Attributions in Trauma Treatment: An Observational StudyOct 30, 2026NCT07908186
- RISE for PTSD and Substance Use Disorder in VeteransOct 29, 2026NCT07903753
Show 10 moreShow fewer
- Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSDOct 29, 2026NCT07904000
- BEAR for Women Who Have Experienced Sexual Assault and Have Suicidal ThoughtsOct 28, 2026NCT07902050
- Mobile-Based Resilience Intervention for Moral Injury, Compassion Fatigue, and Distress in ICU NursesOct 27, 2026NCT07896447
- Trauma Suppression Training for VeteransOct 23, 2026NCT07891559
- Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)Oct 22, 2026NCT07890337
- Salience Network Informed rTMS for PTSDOct 21, 2026NCT07886840
- Coping and Adaptation for Recovery From Moral Injury: A Group Intervention for Clinical Psychology ResidentsOct 21, 2026NCT07887581
- Deep TMS for PTSD With Suicidal IdeationOct 19, 2026NCT07880340
- Postpartum Care in the NICU Multi-Site BreastfeedingOct 19, 2026NCT07881731
- Mindful RAVANS StudyOct 14, 2026NCT07872761
Studies
Recruiting first, then most recently updated. Showing 50 of 2,682. Browse all 2,682 → or search them.
- Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their ChildrenRecruitingNCT06262178Not applicable1 country
- NEST: A Group Intervention for Parents With Complex PTSDRecruitingNCT07766265Not applicable1 country
- Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSDRecruitingNCT07382596Phase 41 country
- Enhancing the Effect of Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder: A Double-blind Randomized Controlled Trial of Bupivacaine vs Bupivacaine + KetamineNot yet recruitingNCT07927036Phase 21 country
- NightWare and Cardiovascular Health in Women With PTSDRecruitingNCT07021014Not applicable1 country
- Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using PropranololNot yet recruitingNCT07792122Phase 31 country
- A Transdiagnostic Sleep Health Intervention for Veterans With PTSDNot yet recruitingNCT06549049Not applicable1 country
- Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient TreatmentNot yet recruitingNCT07920107Not applicable
- The Effects of Orexin Antagonism on Fear Extinction in PTSDRecruitingNCT06788522Phase 41 country
- Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord InjuryEnrolling by invitationNCT05233111Not applicable1 country
- Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress DisorderRecruitingNCT07570654Phase 2/32 countries
- Deep Brain Reorienting in Post-traumatic Stress DisorderRecruitingNCT04317820Not applicable1 country
- An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSDRecruitingNCT07836647Phase 31 country
- Restorative Early Sleep Treatment After the Emergency DepartmentRecruitingNCT07121270Not applicable1 country
- Virtual Reality Assisted Trauma Focused CBTRecruitingNCT07914634Not applicable1 country
- Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral InjuryRecruitingNCT06394284Phase 31 country
- The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among VeteransNot yet recruitingNCT06746727Not applicable1 country
- Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic TherapiesNot yet recruitingNCT07745569Phase 2
- Open-Label Psilocybin Study in Transdiagnostic PopulationRecruitingNCT06442423Phase 11 country
- Recovering Sleep After TraumaRecruitingNCT07196332Not applicable1 country
- Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSDNot yet recruitingNCT07904000Phase 21 country
- RISE for PTSD and Substance Use Disorder in VeteransNot yet recruitingNCT07903753Not applicable1 country
- Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry-Guided Breathing TherapyRecruitingNCT07342530Not applicable1 country
- BEAR for Women Who Have Experienced Sexual Assault and Have Suicidal ThoughtsNot yet recruitingNCT07902050Not applicable1 country
- Mobile-Based Resilience Intervention for Moral Injury, Compassion Fatigue, and Distress in ICU NursesNot yet recruitingNCT07896447Not applicable1 country
- Salience Network Informed rTMS for PTSDNot yet recruitingNCT07886840Not applicable1 country
- PTSD Screening in Pregnant Black WomenRecruitingNCT06522022Not applicable1 country
- Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto RicoRecruitingNCT06332209Not applicable1 country
- Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)RecruitingNCT07890337Phase 11 country
- Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingNCT07226232Phase 31 country
- Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)Not yet recruitingNCT07335276Not applicable
- Exercise and Emotional Learning in Posttraumatic Stress DisorderRecruitingNCT06127342Not applicable1 country
- Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging StudyEnrolling by invitationNCT072223061 country
- Coping and Adaptation for Recovery From Moral Injury: A Group Intervention for Clinical Psychology ResidentsNot yet recruitingNCT07887581Not applicable
- Mindfulness-based Psilocybin Therapy for PTSDRecruitingNCT07104916Phase 21 country
- OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment UnitRecruitingNCT05156112Not applicable1 country
- Postpartum Care in the NICU Multi-Site BreastfeedingNot yet recruitingNCT07881731Not applicable1 country
- Deep TMS for PTSD With Suicidal IdeationNot yet recruitingNCT07880340Not applicable1 country
- Neuromodulation and Neurorehabilitation for mTBIRecruitingNCT03819608Not applicable1 country
- Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma CenterRecruitingNCT06210711Not applicable1 country
- Eye Movement Intervention With Different Memory Reactivation Procedures for Intrusive Traumatic MemoriesRecruitingNCT07767396Not applicable1 country
- Preliminary Effectiveness of Hybrid Individual and Group MDMA-assisted Therapy for War-related PTSDRecruitingNCT05732155Phase 21 country
- Assessing Trauma-related Links Between Affective and Metabolic SystemsNot yet recruitingNCT07862712Phase 41 country
- An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental TraumaNot yet recruitingNCT07863817Not applicable1 country
- Mindful RAVANS StudyNot yet recruitingNCT07872761Not applicable
- EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress DisorderNot yet recruitingNCT07766798Not applicable1 country
- Suvorexant for Treatment of AUD and PTSDRecruitingNCT06679062Phase 21 country
- K08 VR Fear ConditioningRecruitingNCT07216222Not applicable1 country
- The ED-AWARENESS-2 TrialRecruitingNCT05534243Not applicable1 country
- Predictors & Mechanisms of Adolescent PTSDNot yet recruitingNCT07537764Early Phase 11 country