Drug
Esketamine clinical trials
Also written S-ketamine, JNJ-54135419 and Spravato.
A product of Ketamine; its studies count on that page too.
- studies test it
- 235
- open now
- 79
- in phase 3
- 32
- first study started
- 2005
Keep track of what changes. Save the Esketamine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
233 studies that test it; most in 2024 (34); 2 more planned to start later
| Year | Studies |
|---|---|
| 2005 | 1 |
| 2006 | 1 |
| 2007 | 1 |
| 2009 | 3 |
| 2011 | 4 |
| 2012 | 3 |
| 2013 | 2 |
| 2014 | 12 |
| 2015 | 8 |
| 2016 | 7 |
| 2017 | 7 |
| 2018 | 2 |
| 2019 | 2 |
| 2020 | 16 |
| 2021 | 26 |
| 2022 | 24 |
| 2023 | 25 |
| 2024 | 34 |
| 2025 | 27 |
| 2026 | 28 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 11
- Phase 1
- 24
- Phase 2
- 20
- Phase 3
- 32
- Phase 4
- 75
- No phase
- 80
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 46 · Other 189
Janssen Research & Development, LLC (33) · Peking University First Hospital (21) · Beijing Tiantan Hospital (16) · Tianjin Medical University General Hospital (10) · Chinese PLA General Hospital (7) · Second Affiliated Hospital, School of Medicine, Zhejiang University (5) · Second Affiliated Hospital of Wenzhou Medical University (4) · The Second Affiliated Hospital of Chongqing Medical University (4)
Often tested with
Tested in the same studies.
Dexmedetomidine (24) · Propofol (8) · PDCD5 protein, rat (6) · Remimazolam (4) · Midazolam (4) · Remifentanil (3) · Pregabalin (3) · Fentanyl (3)
Studies
Open first, then newest update. How each study uses Esketamine is read from its arms, and is right about nine times in ten.
Testing it · 235
- Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of StayNot yet recruitingPhase 2University of Sao PauloNCT07888933Written as Esketamine
- Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension LaryngoscopyNot yet recruitingNot applicableThe First Hospital of Jilin UniversityNCT07880938Written as Esketamine
- Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial.Not yet recruitingPhase 4Region SkaneNCT07881562Written as Esketamine
- Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After SurgeryNot yet recruitingPhase 4Peking University First HospitalNCT07576517Written as Dex-Esk
- Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After SurgeryNot yet recruitingPhase 4Peking University First HospitalNCT07576543Written as Dex-Esk
- Propofol or Esketamine: Tracheal Intubation ComparisonNot yet recruitingPhase 4Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNCT07847255Written as Esketamine
- A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant DepressionRecruitingPhase 3Janssen Research & Development, LLCNCT07716098Written as Esketamine 56 mg
- A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive DisorderRecruitingPhase 3Janssen Research & Development, LLCNCT07227454Written as Esketamine
- Brain Activity and Changes in Consciousness During General AnesthesiaNot yet recruitingPhase 4Beijing Chao Yang HospitalNCT07836205Written as Esketamine group
- Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)RecruitingPhase 4University of Sao PauloNCT07120477Written as Intravenous Esketamine
- PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyRecruitingPhase 3Yale UniversityNCT06713616Written as Spravato (Esketamine)
- Effect of Esketamine on Postoperative Sleep in Postmenopausal WomenRecruitingNot applicableZhuan ZhangNCT07315074Written as Esketamine
- Efficacy of Esketamine for Patients With Irritable Bowel SyndromeRecruitingNot applicableBeijing Tiantan HospitalNCT06788444Written as Esketamine
- The Effect of Intraoperative Infusion of Esketamine on Cholestatic Pruritus in Patients Undergoing Hepatobiliary SurgeryNot yet recruitingNot applicableTianjin Medical University General HospitalNCT07760740Written as Esketamine
- Positioning of Esketamine Treatment in the Real-world Management of DepressionRecruitingPhase 4Royal North Shore HospitalNCT06103760Written as Esketamine Nasal Spray [Spravato]
- Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric GastroscopyNot yet recruitingPhase 4Second Affiliated Hospital of Wenzhou Medical UniversityNCT07748884Written as Esketamine and remimazolam
- Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.Not yet recruitingNot applicableChina-Japan Friendship HospitalNCT07736352Written as Propofol + Remifentanil + Esketamine
- Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCPNot yet recruitingNot applicableRen DaNCT07702240Written as Esketamine
- The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline AnesthesiaNot yet recruitingNot applicableChina-Japan Friendship HospitalNCT07699523Written as Esketamine
- The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial SurgeryNot yet recruitingNot applicableXijing HospitalNCT07665099Written as esketamine
See all 235 studies that test Esketamine →
Given in every arm · 12 — Esketamine is usual care beside what is tested
- Esketamine With or Without Integration Therapy for Treatment-Resistant DepressionRecruitingPhase 4University of Puerto RicoNCT07369102Written as Esketamine hydrochloride (intranasal)
- Behavioural Activation Therapy and Esketamine for Resistant DepressionTerminatedNot applicableThe Royal's Institute of Mental Health ResearchNCT06431386Written as Esketamine
- Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered EsketamineCompletedPhase 1Janssen Research & Development, LLCNCT02846519Written as Esketamine
- A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT03808259Written as (S)-ketamine Oral Thin Film
- A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive DisorderCompletedPhase 1Janssen Research & Development, LLCNCT02919579Written as Esketamine
- Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver AblationCompletedNot applicablePeking University First HospitalNCT06003218Written as Dexmedetomidine-esketamine combination
- Pharmacokinetic Study of Intranasal Esketamine and Its Effects on the Pharmacokinetics of Orally-Administered Midazolam and Bupropion in Healthy ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT02568176Written as Esketamine
- Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in ChildrenCompletedNot applicableTongji HospitalNCT05686863Written as Esketamine
- Remimazolam Versus Propofol for Painless AbortionCompletedPhase 2Maternal and Child Health Hospital of Hubei ProvinceNCT05635955Written as Esketamine
- Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical VentilationStatus unknownNot applicableThe First Hospital of Jilin UniversityNCT05551910Written as Esketamine
- Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine SprayStatus unknownNot applicableLukas PezawasNCT04843462Written as Esketamine nasal spray
- Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal EsketamineCompletedPhase 1Janssen Research & Development, LLCNCT02154334Written as Esketamine
As the comparator · 4 — what is tested is compared with Esketamine
- Ayahuasca, Esketamine and PTSDRecruitingPhase 2University of Sao PauloNCT07317206Written as Esketamine
- Ayahuasca, Esketamine and Body Image PerceptionRecruitingNot applicableUniversity of Sao PauloNCT07317219Written as Esketamine
- Ayahuasca, Esketamine and Premenstrual SymptomsRecruitingNot applicableUniversity of Sao PauloNCT07317232Written as Esketamine
- Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative SedationRecruitingNot applicableMaternal and Child Health Hospital of Hubei ProvinceNCT07050212Written as esketamine group
Codes
What other systems call Esketamine · ClinicalTrials.gg INT001051
- MeSH (NLM) C000629870EsketamineConfirmed ClinicalTrials.gov, NLM
- UNII (FDA) 50LFG02TXDESKETAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 2119365Confirmed FDA, Wikidata
- Wikidata Q2365493esketamineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C81400EsketamineOne source FDA
- DrugBank DB11823One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000629870 | Esketamine | Confirmed ClinicalTrials.gov, NLM |
| UNII (FDA) | 50LFG02TXD | ESKETAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 2119365 | — | Confirmed FDA, Wikidata |
| Wikidata | Q2365493 | esketamine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C81400 | Esketamine | One source FDA |
| DrugBank | DB11823 | — | One source Wikidata |
Also registered as esketamine hydrochloride (UNII L8P1H35P2Z · RxNorm 2119366).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.