Drug
Fentanyl clinical trials
Also written Sublimaze, Duragesic, CEP-25608 and Fentanest.
Includes 6 studies of Fentanyl hydrochloride and 3 studies of Fentanyl Citrate Pectin-Based Nasal Spray.
How each study uses Fentanyl is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Fentanyl studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Approvals
The first approval found in each region, with its record
- United States
- 19 Feb 1968 · SUBLIMAZE PRESERVATIVE FREE · NDA 016619 (FDA, Drugs@FDA)
- European Union
- 24 Jan 2006 · Ionsys · EMEA/H/C/000612 (EMA; now withdrawn)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
424 studies that test it; most in 2024 (33)
| Year | Studies |
|---|---|
| 1996 | 2 |
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 3 |
| 2003 | 7 |
| 2004 | 8 |
| 2005 | 9 |
| 2006 | 13 |
| 2007 | 10 |
| 2008 | 22 |
| 2009 | 14 |
| 2010 | 12 |
| 2011 | 25 |
| 2012 | 15 |
| 2013 | 12 |
| 2014 | 21 |
| 2015 | 24 |
| 2016 | 17 |
| 2017 | 23 |
| 2018 | 16 |
| 2019 | 21 |
| 2020 | 22 |
| 2021 | 12 |
| 2022 | 17 |
| 2023 | 18 |
| 2024 | 33 |
| 2025 | 32 |
| 2026 | 12 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 64 · Other 361
Assiut University (20) · Ain Shams University (15) · Cairo University (9) · Tanta University (8) · M.D. Anderson Cancer Center (7) · Kyowa Kirin Co., Ltd. (6) · INSYS Therapeutics Inc (6) · Cephalon (6)
Often tested with
Tested in the same studies.
Dexmedetomidine (51) · Bupivacaine (37) · Midazolam (33) · Propofol (31) · Morphine (19) · Lidocaine (18) · Ketamine (18) · Ropivacaine (16)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 3 phase 3 studies under way
Fentanyl is the comparator. A study of two new drugs counts under both.
- 2Ketamine · Children's Cancer Hospital Egypt 57357, Jason Sperry · next primary completion Mar 2027
- 1Dexmedetomidine · Indonesia University
Reaching primary completion within a year · 19, 2 in phase 3
Studies that test Fentanyl, phase 3 first.
- Jul 2027Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver SurgeryPhase 3 · M.D. Anderson Cancer Center
- Aug 2027Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer PatientsPhase 3 · M.D. Anderson Cancer Center
- Nov 2026Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous WomenNot applicable · Holy Family Hospital, Nazareth, Israel
- Nov 2026PIEB Compared With CEI on Breakthrough Pain in Nulliparous WomenNot applicable · Holy Family Hospital, Nazareth, Israel
- Nov 2026Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries.Phase 4 · Assiut University
- Dec 2026Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric GastroscopyPhase 4 · Second Affiliated Hospital of Wenzhou Medical University
- Dec 2026Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyNot applicable · Cairo University
- Dec 2026Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted ThoracoscopyPhase 4 · Ain Shams University
- Dec 2026Comparison Between Effect of Systemic Fentanyl Infusion and Fentanyl Added as An Adjuvant to Lidocaine in Bier Block For Controlling Pain in Patients Undergoing Hand SurgeriesPhase 4 · Assiut University
- Dec 2026Role of Prophylactic Antiemetics in Women Receiving Intrathecal Morphine and Lipophilic Opioids Added to Bupivacaine for Cesarean SectionPhase 4 · Assiut University
Studies
Open first, then newest update. How each study uses Fentanyl is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 425
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07877519Written as Fentanyl
- Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyRecruitingNot applicableCairo UniversityNCT07262242Written as Fentanyl (IV)
- A Study to Investigate the Effects of Opioid Exposure on the Ability of the Diaphragm MuscleRecruitingPhase 4Mayo ClinicNCT05856136Written as Fentanyl Injection
- Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the EDRecruitingPhase 4Antonios LikourezosNCT06364540Written as Fentanyl
- Quadro-Iliac Plane Block for Pain Control After Posterior Spinal Instrumentation SurgeryNot yet recruitingEarly Phase 1Istanbul Medipol University HospitalNCT07711522Written as Fentanyl (IV)
- Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric GastroscopyNot yet recruitingPhase 4Second Affiliated Hospital of Wenzhou Medical UniversityNCT07748884Written as Fentanyl and Propofol
- The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .RecruitingNot applicableKasr El Aini HospitalNCT07640516Written as Fentanyl (as Citrate)
- The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding TrialRecruitingPhase 4Huazhong University of Science and TechnologyNCT07697404Written as Fentanyl
- Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm InfantsNot yet recruitingPhase 1/2Marsha Campbell-YeoNCT07112430Written as Fentanyl Citrate (Intranasal)
- Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic CholecystectomyNot yet recruitingPhase 4Assiut UniversityNCT07670052Written as Fentanyl
- Patient Quality of Recovery After TAVR With Different Sedation RegimensRecruitingPhase 4David LyubashevskyNCT07556523Written as Fentanyl
- Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate SurgeryRecruitingPhase 4Duke UniversityNCT06962306Written as Fentanyl/Hydromorphone
- Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous WomenRecruitingNot applicableHoly Family Hospital, Nazareth, IsraelNCT06580327Written as programmed intermittent Bolus epidural analgesia
- PIEB Compared With CEI on Breakthrough Pain in Nulliparous WomenRecruitingNot applicableHoly Family Hospital, Nazareth, IsraelNCT06494280Written as programmed intermittent Bolus epidural analgesia
- Prospective IR-led Sedation FeasibilityRecruitingPhase 1/2CAMC Health SystemNCT07443254Written as Fentanyl (IV)
- Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of LaryngoscopyRecruitingPhase 4Rawalpindi Institute of CardiologyNCT07435337Written as Fentanyl
- Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic ScoliosisRecruitingPhase 4Nashwa AhmedNCT07389096Written as Fentanyl (IV)
- Ropivacaine and Fentanyl for Labor Epidural InitiationRecruitingPhase 3University of California, San FranciscoNCT07076368Written as Ropivacaine + Fentanyl
- Clinical Outcomes of Sedation in Cataract Surgery Performed Under Topical AnesthesiaNot yet recruitingNot applicableIstanbul University - CerrahpasaNCT07347886Written as Fentanyl (IV)
- Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and FentanylRecruitingPhase 4Nashwa AhmedNCT07078201Written as fentanyl
See all 425 studies that test Fentanyl →
Given beside what is tested · 134 — Fentanyl is usual care or a partner of the new treatment
- Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck CancersRecruitingPhase 4OHSU Knight Cancer InstituteNCT07857655Written as Fentanyl
- Dural Sac Area-Guided Spinal Anesthesia Dosing for TURPEnrolling by invitationNot applicableIstanbul UniversityNCT07794852Written as Fentanyl (FEN)
- Fentanyl and Rocuronium for Tracheal Intubation in NewbornsNot yet recruitingPhase 4UEA - Universidade Do Estado Do AmazonasNCT07650552Written as Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Dexmedetomidine and Propofol for Sedation in Cataract Surgery.RecruitingNot applicableSaint-Joseph UniversityNCT07556133Written as Fentanyl (FEN)
- Organ Protective Effect of Cetirizine In Patients With Severe BurnsRecruitingPhase 1/2Ruijin HospitalNCT06126991Written as Midazolam and Fentanyl
- Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA StudyRecruitingPhase 2University of Kansas Medical CenterNCT06017141Written as Fentanyl Citrate
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone BlockadeCompletedPhase 2Clear Scientific, Inc.NCT07459166Written as Fentanyl
- Dexmedetomidine as an add-on Sedative for Endobronchial UltrasoundCompletedNot applicableCentro Hospitalar de Lisboa CentralNCT07926542Written as fentanyl
- Minimal Flow Anesthesia and Infection RiskCompletedNot applicableAnkara City Hospital BilkentNCT07092046Written as Fentanyl (IV)
- Implementation of a Pain Management Protocol for Total Knee ArthroplastyCompletedPhase 4Health Sciences North Research InstituteNCT02474654Written as Fentanyl
- Opiranserin Injections PCA Regimens for Postoperative PainCompletedPhase 2Samsung Medical CenterNCT07821307Written as Fentanyl
- Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic ProcessesCompletedNot applicableIuliu Hatieganu University of Medicine and PharmacyNCT07207304Written as Intraoperative analgesia
- Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia SurgeryCompletedPhase 2Kasr El Aini HospitalNCT06326944Written as Fentanyl
- Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip SurgeriesCompletedPhase 2Kasr El Aini HospitalNCT06417268Written as Fentanyl
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial SurgeryCompletedPhase 1Albert Einstein College of MedicineNCT06867068Written as Fentanyl
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking BuprenorphineWithdrawnPhase 4University of North Carolina, Chapel HillNCT06784180Written as Fentanyl
- The Efficacy of Scalp Block in CraniotomyCompletedPhase 1Ain Shams UniversityNCT06951230Written as Fentanyl injection
- PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast SurgeryCompletedPhase 2Washington University School of MedicineNCT03084536Written as Fentanyl
- Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane BlockCompletedNot applicableTanta UniversityNCT05596227Written as Fentanyl
- Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal ColicCompletedPhase 4Ismail TekinNCT06558916Written as Fentanyl
Showing 20 of 134.
As the comparator · 138 — what is tested is compared with Fentanyl
- A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep SedationRecruitingNot applicableEast Sussex Healthcare NHS TrustNCT07900685Written as Sedation with midazolam and fentanyl
- Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis ReleaseRecruitingPhase 4Northwestern UniversityNCT07840183Written as Fentanyl
- Opioid-Free Versus Opioid-Based Anesthesia in Thyroid SurgeryRecruitingNot applicableMalatya Egitim Ve Arastirma HastanesiNCT07864155Written as Fentanyl (IV)
- Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous NephrolithotomyNot yet recruitingPhase 4Assiut UniversityNCT07855068Written as Fentanyl
- Fast-Track Anesthesia in Minimally Invasive Cardiac Surgery: Dexmedetomidine and Erector Spinae Plane Block vs Opioid-Based AnesthesiaNot yet recruitingNot applicableAssiut UniversityNCT07749274Written as Fentanyl
- Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft SurgeryRecruitingNot applicableIva SmiljanićNCT07557576Written as Fentanyl 5 mcg/kg
- Intravenous Acetaminophen and Ketorolac for Pain Management During Extracorporeal Shockwave LithotripsyEnrolling by invitationPhase 4Horizon Health NetworkNCT07368738Written as IV fentanyl
- Prehospital Analgesia INtervention Trial (PAIN)RecruitingPhase 3Jason SperryNCT05437575Written as Fentanyl Citrate
- Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral MyringotomyNot yet recruitingPhase 4University of South AlabamaNCT07276906Written as Fentanyl
- A Study of Inhaled Fentanyl Aerosol in Chinese Patients With Malignant TumorsRecruitingPhase 1Lee's Pharmaceutical LimitedNCT06953453Written as Fentanyl Citrate Injection
- D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary RetentionNot yet recruitingPhase 4Tribhuvan University Teaching Hospital, Institute Of Medicine.NCT07117565Written as Intervention 2: Intrathecal Fentanyl with Bupivacaine
- Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median SternotomyRecruitingNot applicableCairo UniversityNCT06984276Written as Control
- Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic SurgeryNot yet recruitingPhase 2/3Indonesia UniversityNCT06382831Written as Fentanyl
- Intraoperative Methadone for Postoperative Pain in Patients Undergoing TonsillectomyRecruitingPhase 4University of AarhusNCT05445856Written as Fentanyl
- Comparison of Analgesic Efficacy Between Ultrasound Guided Serratus Anterior Plane Block or Thoracic Paravertebral Block Versus Intravenous Fentanyl for On-pump Coronary Artery Bypass Graft SurgeryActive, not recruitingPhase 1Ain Shams UniversityNCT07911943Written as Intravenous fentanyl 1 μg∙kg-1
- Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart SurgeryCompletedPhase 4Baskent UniversityNCT07839273Written as Fentanyl (IV)
- Hydromorphone for ICU-analgesia in Patients With Non-mechanical VentilationCompletedPhase 4Nanfang Hospital, Southern Medical UniversityNCT04436224Written as Fentanyl
- Opioid-Free Versus Opioid-Based Anesthesia in Modified Radical MastectomyCompletedNot applicableMuhammad Fiqhi AmiruddinNCT07798895Written as Fentanyl
- Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic SurgeryCompletedPhase 2Benha UniversityNCT07443085Written as Fentanyl
- Comparison of Pain Relief Duration With Dexmedetomidine Versus Fentanyl Added to Spinal Anesthesia in Patients Undergoing Lower Limb Orthopedic SurgeryCompletedPhase 4Allama Iqbal Teaching HospitalNCT07770542Written as fentanyl and bupivacaine
Showing 20 of 138.
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
- Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyOct 22, 2026NCT07262242
Newly registered1
Codes
What other systems call Fentanyl · ClinicalTrials.gg INT007483
- MeSH (NLM) D005283FentanylConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) UF599785JZFENTANYLConfirmed FDA, NLM, Wikidata
- RxNorm 4337Confirmed FDA, Wikidata
- Wikidata Q407541fentanylConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C494FentanylOne source FDA
- DrugBank DB00813One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D005283 | Fentanyl | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | UF599785JZ | FENTANYL | Confirmed FDA, NLM, Wikidata |
| RxNorm | 4337 | — | Confirmed FDA, Wikidata |
| Wikidata | Q407541 | fentanyl | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C494 | Fentanyl | One source FDA |
| DrugBank | DB00813 | — | One source Wikidata |
Also registered as fentanyl citrate (UNII MUN5LYG46H · RxNorm 142436).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.