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Tobacco Use Disorder clinical trials

The registry lists 1,028 studies for Tobacco Use Disorder across more than 10 countries. 128 are recruiting or about to start. 699 of them are mainly about Tobacco Use Disorder (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.

ClinicalTrials.gov finds 1,338 studies for Tobacco Use Disorder. How that becomes 1,027 here

This page counts the studies the registry files under Tobacco Use Disorder, and those it files under no condition that list Tobacco Use Disorderthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 1,338Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −311Match it another way5 name it in the title, 1 in a keyword, and 305 by a synonym or other text the search reads.
  3. 1,027The count on this page2 of them list Tobacco Use Disorder in their own words; the registry filed them under no condition.

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Status

Completed
740
Recruiting
95
Terminated
51
Status unknown
50
Withdrawn
38
Not yet recruiting
25

Phase

Phase 2
204
Phase 4
95
Phase 1
95
Phase 3
77
Early Phase 1
27

Where

United States
799
Canada
43
Sweden
18
France
17
Germany
15
Turkey
13

Who runs them

National Institute on Drug Abuse (NIDA) (68) · Yale University (58) · University of Pennsylvania (39) · University of California, San Francisco (32) · University of Minnesota (30) · Centre for Addiction and Mental Health (29) · Medical University of South Carolina (28) · University of Wisconsin, Madison (27)

What is being tested here

Drugs under test in Tobacco Use Disorder studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Nicotine619113
Varenicline51974
Nicotine Patch4842
Cannabidiol303
Cytisine204
Semaglutide213
Psilocybin202
Bupropion11142
Cycloserine103
Nicotine Nasal Spray102

Drug classes tested here Serotonin receptor agonists 2 open · NSAIDs 5 · Stimulants 5 · MAO inhibitors (MAOIs) 4 · SSRIs 3

Coming up

6phase 3 studies under way
61studies finish main data collection within a year3 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 95 Tobacco Use Disorder studies recruiting now, 42 (44%) set no upper age limit and 50 (53%) stop at 75 or younger. 6 (6%) take children under 18. 1 (1%) are for women only and 2 (2%) for men only; 37 (39%) take healthy volunteers.

Recruiting studies that take each age, of 95
AgeWomenMen
102 (2%)2 (2%)
1866 (69%)67 (71%)
3085 (89%)86 (91%)
4083 (87%)84 (88%)
5079 (83%)81 (85%)
6567 (71%)69 (73%)
7550 (53%)51 (54%)
8543 (45%)43 (45%)

Across all 1,028 studies, recruiting or not: 57% stop at 75 or younger and 48% at 65; 7% take children; 5% are for women only and 2% for men only; 51% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Tobacco Use Disorder studies take

Of 45 phase 1 interventional studies under Tobacco Use Disorder, half reached primary completion within 20 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 120 mo9–36 · 45 studies—22 mo14–37 · 39 studies
Phase 235 mo19–43 · 41 studies—35 mo19–46 · 37 studies
Phase 441 mo30–55 · 38 studies—41 mo30–55 · 38 studies
Interventional, no phase32 mo16–50 · 267 studies—33 mo18–51 · 257 studies
Observational42 mo17–90 · 27 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 15, 2026.

Started recruiting2

Results posted1

Stopped2

Newly registered4

Studies

Recruiting first, then most recently updated. Showing 50 of 1,028. Browse all 1,028 → or search them.