Drug
Nicotine clinical trials
Also written Nicoderm CQ and Nicotrol.
- studies test it
- 173
- open now
- 8
- in phase 3
- 22
- first study started
- 1990
Keep track of what changes. Save the Nicotine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Studies by the year they started
172 studies that test it; most in 2009 (16)
| Year | Studies |
|---|---|
| 1990 | 1 |
| 1993 | 1 |
| 2000 | 1 |
| 2001 | 3 |
| 2002 | 5 |
| 2003 | 5 |
| 2004 | 5 |
| 2005 | 9 |
| 2006 | 6 |
| 2007 | 11 |
| 2008 | 7 |
| 2009 | 16 |
| 2010 | 8 |
| 2011 | 14 |
| 2012 | 11 |
| 2013 | 8 |
| 2014 | 7 |
| 2015 | 11 |
| 2016 | 4 |
| 2017 | 3 |
| 2018 | 6 |
| 2019 | 5 |
| 2020 | 5 |
| 2021 | 5 |
| 2022 | 4 |
| 2023 | 5 |
| 2024 | 2 |
| 2025 | 1 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 16
- Phase 1
- 34
- Phase 2
- 33
- Phase 3
- 22
- Phase 4
- 23
- No phase
- 53
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 31 · Other 142
Yale University (23) · McNeil AB (12) · GlaxoSmithKline (10) · National Institute on Drug Abuse (NIDA) (8) · Vanderbilt University Medical Center (6) · Mclean Hospital (6) · Duke University (5) · Johns Hopkins University (4)
Often tested with
Tested in the same studies.
Bupropion (10) · Varenicline (9) · Nicotine Patch (3) · Cannabis sativa subsp. indica TOP (2) · Nicotine Lozenge (2) · Nicotine Inhaler (2) · Bupropion Hydrochloride Controlled-release (2) · Progesterone (2)
Studies
Open first, then newest update. How each study uses Nicotine is read from its arms, and is right about nine times in ten.
Testing it · 173
- Evaluating the Delivery and Effects of THC Vaping Liquids in the BloodstreamNot yet recruitingEarly Phase 1Roswell Park Cancer InstituteNCT06334016Written as Nicotine
- Impact of Sweeteners on the Addictive Threshold of NicotineNot yet recruitingPhase 1Yale UniversityNCT07771725Written as Nicotine 0.05 mg/pulse and 0.1 mg/pulse
- Evaluation of the Electronic Cigarette Withdrawal SyndromeRecruitingEarly Phase 1Johns Hopkins UniversityNCT06066996Written as Transdermal Nicotine Patch
- Comparative Evaluation of Nicotine AnalogsRecruitingPhase 1Ohio State University Comprehensive Cancer CenterNCT07585006Written as Nicotine
- Addictive Threshold of NicotineRecruitingEarly Phase 1Yale UniversityNCT06096714Written as Nicotine
- Comparative Pharmacokinetics and Pharmacodynamics of Synthetic NicotineRecruitingPhase 1University of California, San FranciscoNCT05962229Written as (S)-Nicotine
- Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administrationRecruitingPhase 2University of California, San FranciscoNCT05999383Written as Nicotine
- Nicotine and Pavlovian BiasRecruitingEarly Phase 1University of Southern CaliforniaNCT06027723Written as Nicotine
- Depressed Mood Improvement Through Nicotine Dosing 3CompletedPhase 2Vanderbilt University Medical CenterNCT05746273Written as Transdermal Nicotine Patch
- Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) ExtensionCompletedPhase 2Vanderbilt University Medical CenterNCT05746546Written as Transdermal Nicotine patch
- Effects of Menthol in E-cigarettes on Smoking BehaviorsCompletedPhase 1Yale UniversityNCT04521647Written as Nicotine
- IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery RateCompletedEarly Phase 1Yale UniversityNCT05176418Written as low dose Nicotine
- Varenicline Versus Transdermal Nicotine Patch for Smoking Cessation in Patients With Coronary Heart DiseaseCompletedPhase 4Ottawa Heart Institute Research CorporationNCT00959972Written as Transdermal Nicotine Patch
- Novel Methods to Reduce Children's Secondhand Smoke Exposure IICompletedNot applicableUniversity of OklahomaNCT01896518Written as Nicotine polacrilex
- Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke ExposureCompletedNot applicableUniversity of OklahomaNCT01935713Written as Nicotine polacrilex
- Effects of Commonly Used Medications on Mood and ChoiceCompletedPhase 1Johns Hopkins UniversityNCT03652740Written as Nicotine
- Effects of E-Cigarette Flavors on Adults TCORS 2.0CompletedPhase 1Yale UniversityNCT03635333Written as Nicotine
- Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE StudyCompletedNot applicableRoswell Park Cancer InstituteNCT04231539Written as Nicotine
- Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot StudyCompletedPhase 1/2Ohio State UniversityNCT02265874Written as Habitrol
- Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit AttemptsCompletedPhase 2/3Brown UniversityNCT04994444Written as Nicoderm CQ 21Mg/24Hr Transdermal System
See all 173 studies that test Nicotine →
Given in every arm · 25 — Nicotine is usual care beside what is tested
- Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health SettingsCompletedNot applicableWake Forest University Health SciencesNCT05030272Written as Nicotine Lozenges
- WeChat Quit Coach Pilot StudyCompletedNot applicableNYU Langone HealthNCT05130788Written as Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges
- RCT of an Internet Cessation Program Plus Online Social Network for HIV+ SmokersCompletedNot applicableMontefiore Medical CenterNCT02781090Written as Nicotine polacrilex
- Comparing Two Treatments That Both Target Smoking Cessation and Weight Loss at the Same Time.WithdrawnPhase 1/2Rhode Island CollegeNCT04130698Written as transdermal nicotine patch
- Reducing Cancer Disparities Among Latinos in TexasCompletedNot applicableM.D. Anderson Cancer CenterNCT01504919Written as Nicotine Patches
- Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive SymptomsCompletedPhase 2University of Maryland, College ParkNCT01199380Written as Transdermal Nicotine Patch
- Behavioral Intervention for Low Income Depressed Smokers in Drug TreatmentCompletedPhase 1/2University of Maryland, College ParkNCT01372254Written as Transdermal Nicotine Patch
- Abstinence Reinforcement Therapy (ART) for Homeless Veteran SmokersCompletedPhase 4VA Office of Research and DevelopmentNCT02245308Written as Nicotine Patches
- Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking CessationCompletedPhase 4University of ChicagoNCT02859142Written as NicodermCQ
- Addressing Racial/Ethnic Tobacco Health Disparities Via Group InterventionCompletedPhase 4University of MiamiNCT02511236Written as Transdermal Nicotine Patch
- Group Therapy for Nicotine Dependence: Mindfulness and SmokingCompletedNot applicableM.D. Anderson Cancer CenterNCT00297479Written as Nicotine
- Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2CompletedPhase 1Yale UniversityNCT03168191Written as Nicotine
- Smoking Cessation InterventionTerminatedPhase 4University of FloridaNCT03072511Written as Transdermal Nicotine Patch
- Smoking Cessation in Hispanic Construction WorkersCompletedPhase 4University of MiamiNCT02873377Written as Nicoderm CQ
- Women Engaging in Quitting Smoking TogetherCompletedNot applicableRhode Island HospitalNCT02453659Written as Transdermal Nicotine Patch
- Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation StudyCompletedNot applicableDuke UniversityNCT00736255Written as Transdermal Nicotine Patch
- Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement TherapyCompletedPhase 2Yale UniversityNCT00699556Written as 21mg transdermal nicotine patch (Nicoderm CQ)
- Mechanistic Evaluations of Pre-Cessation Therapies for Smoking CessationCompletedPhase 3Duke UniversityNCT01406223Written as Nicotine patches
- First Time in Human Study With GSK1018921CompletedPhase 1GlaxoSmithKlineNCT00527020Written as Nicotine Lozenges
- A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless SmokersCompletedNot applicableMassachusetts General HospitalNCT02565381Written as Transdermal nicotine patch
Showing 20 of 25.
As the comparator · 9 — what is tested is compared with Nicotine
- Tobacco Treatment Comparison for Cancer CareCompletedPhase 4University of Wisconsin, MadisonNCT06218823Written as Transdermal Nicotine Patch
- Effects of Exercise and Nicotine on Cognition in SmokersCompletedPhase 3Western University, CanadaNCT03091699Written as Nicotine
- The END Perioperative Smoking Pilot StudyCompletedPhase 4University of California, San FranciscoNCT02482233Written as NRT (NicoDerm CQ)
- Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge FormulationsCompletedPhase 1Niconovum USANCT03087786Written as Nicotine Polacrilex 4Mg Lozenge
- Low-Cost Contingency Management for Smoking CessationCompletedNot applicableUniversity of California, San FranciscoNCT01040260Written as Nicotine patches
- Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop SmokingCompletedNot applicableButler HospitalNCT00790569Written as nicotine
- Safety and Efficacy Study of the NRT CQSS2 System for Smoking Cessation in Treatment-Seeking SubjectsCompletedPhase 2Chrono Therapeutics, Inc.NCT03178422Written as NicoDerm CQ Patch
- e-Cigarettes Versus NRT Gum for Smoking CessationTerminatedPhase 4Creighton UniversityNCT01925781Written as Nicotine polacrilex
- Combined Nortriptyline and Transdermal Nicotine for Smoking CessationCompletedPhase 2US Department of Veterans AffairsNCT00018148Written as transdermal nicotine
Codes
What other systems call Nicotine · ClinicalTrials.gg INT007889
- MeSH (NLM) D009538NicotineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 6M3C89ZY6RNICOTINEConfirmed FDA, NLM, Wikidata
- RxNorm 7407Confirmed FDA, Wikidata
- Wikidata Q28086552(−)-nicotineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C691NicotineConfirmed FDA, Wikidata
- DrugBank DB00184One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D009538 | Nicotine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 6M3C89ZY6R | NICOTINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7407 | — | Confirmed FDA, Wikidata |
| Wikidata | Q28086552 | (−)-nicotine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C691 | Nicotine | Confirmed FDA, Wikidata |
| DrugBank | DB00184 | — | One source Wikidata |
Also registered as nicotine bitartrate (UNII R7M676M8YV · RxNorm 1306107).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.