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Substance-Related Disorders clinical trials

The registry lists 2,241 studies for Substance-Related Disorders across more than 10 countries. 410 are recruiting or about to start. 1,164 of them are mainly about Substance-Related Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 25 narrower conditions too, such as Alcoholism: 7,126 studies, 1,207 open.

ClinicalTrials.gov finds 7,492 studies for Substance-Related Disorders. How that becomes 2,236 here

This page counts the studies the registry files under Substance-Related Disorders, and those it files under no condition that list Substance-Related Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 7,492Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −4,854Filed under a narrower condition, counted on its own pageAlcoholism 1,465 · Opioid-Related Disorders 1,203 · Tobacco Use Disorder 946 · Cocaine-Related Disorders 283 · Marijuana Abuse 146 · Hepatitis, Alcoholic 99 · 19 more
  3. −1List Substance-Related Disorders as a condition, but the registry did not file them under itMost often written as “Drug Abuse in Pregnancy” (1). The registry filed them under other conditions only, most often Health Risk Behaviors (1) and Marijuana Abuse (1).
  4. −401Match it another way4 name it in the title, 1 in a keyword, and 396 by a synonym or other text the search reads.
  5. 2,236The count on this page

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Status

Completed
1,470
Recruiting
265
Status unknown
136
Not yet recruiting
114
Active, not recruiting
89
Withdrawn
67

Phase

Phase 2
277
Phase 1
190
Phase 3
97
Phase 4
85
Early Phase 1
24

Where

United States
1,589
Canada
81
France
52
Norway
41
Spain
26
Switzerland
26

Who runs them

National Institute on Drug Abuse (NIDA) (98) · Yale University (63) · VA Office of Research and Development (61) · University of California, Los Angeles (51) · Medical University of South Carolina (48) · Johns Hopkins University (40) · University of Washington (31) · Massachusetts General Hospital (27)

What is being tested here

Drugs under test in Substance-Related Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Dronabinol509
Psilocybin304
Tirzepatide303
Nicotine206
Cannabidiol206
Semaglutide203
N-Methyl-3,4-methylenedioxyamphetamine1011
Cannabis sativa subsp. indica TOP108
Methylphenidate118
Ibogaine hydrochloride103

Drug classes tested here GLP-1 receptor agonists 5 open · Psychedelics 4 open · Serotonin receptor agonists 3 open · Opioids 1 open · Stimulants 1 open

Coming up

5phase 3 studies under way
153studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Who these studies take

Of the 265 Substance-Related Disorders studies recruiting now, 130 (49%) set no upper age limit and 117 (44%) stop at 75 or younger. 55 (21%) take children under 18. 20 (8%) are for women only and 13 (5%) for men only; 89 (34%) take healthy volunteers.

Recruiting studies that take each age, of 265
AgeWomenMen
1015 (6%)14 (5%)
18219 (83%)212 (80%)
30212 (80%)204 (77%)
40211 (80%)202 (76%)
50204 (77%)200 (75%)
65176 (66%)169 (64%)
75145 (55%)137 (52%)
85138 (52%)130 (49%)

Across all 2,241 studies, recruiting or not: 50% stop at 75 or younger and 46% at 65; 23% take children; 7% are for women only and 6% for men only; 35% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Substance-Related Disorders studies take

Of 54 phase 1 interventional studies under Substance-Related Disorders, half reached primary completion within 12 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 112 mo4–33 · 54 studies4 mo3–9 · 24 studies33 mo17–46 · 30 studies
Phase 235 mo24–43 · 51 studies—35 mo24–51 · 47 studies
Phase 320 mo15–54 · 13 studies——
Phase 444 mo21–55 · 21 studies——
Interventional, no phase34 mo17–53 · 854 studies17 mo8–48 · 40 studies35 mo18–53 · 814 studies
Observational36 mo18–56 · 134 studies—36 mo18–60 · 123 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting4

Results posted4

Newly registered14

Show 9 more

Studies

Recruiting first, then most recently updated. Showing 50 of 2,241. Browse all 2,241 → or search them.