Drug
Bupropion clinical trials
Also written Zyban, Wellbutrin and Amfebutamone.
Includes 1 study of Bupropion hydrobromide.
- studies test it
- 215
- open now
- 13
- in phase 3
- 47
- first study started
- 1994
Keep track of what changes. Save the Bupropion studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
212 studies that test it; most in 2005 (20); 1 more planned to start later
| Year | Studies |
|---|---|
| 1994 | 1 |
| 1995 | 1 |
| 1998 | 4 |
| 1999 | 3 |
| 2000 | 4 |
| 2001 | 7 |
| 2002 | 10 |
| 2003 | 8 |
| 2004 | 19 |
| 2005 | 20 |
| 2006 | 6 |
| 2007 | 7 |
| 2008 | 5 |
| 2009 | 9 |
| 2010 | 8 |
| 2011 | 5 |
| 2012 | 6 |
| 2013 | 9 |
| 2014 | 8 |
| 2015 | 4 |
| 2016 | 10 |
| 2017 | 8 |
| 2018 | 2 |
| 2019 | 7 |
| 2020 | 12 |
| 2021 | 6 |
| 2022 | 1 |
| 2023 | 4 |
| 2024 | 5 |
| 2025 | 7 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 5
- Phase 1
- 42
- Phase 2
- 51
- Phase 3
- 47
- Phase 4
- 68
- No phase
- 19
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 42 · Other 173
National Institute on Drug Abuse (NIDA) (16) · New York State Psychiatric Institute (10) · Duke University (8) · GlaxoSmithKline (8) · Mayo Clinic (6) · Yale University (5) · Centre for Addiction and Mental Health (5) · University of California, Los Angeles (5)
Often tested with
Tested in the same studies.
Varenicline (19) · Naltrexone (16) · Escitalopram (14) · Nicotine (10) · Midazolam (8) · Bupropion Hydrochloride Controlled-release (8) · Nicotine Patch (7) · Aripiprazole (7)
Studies
Open first, then newest update. How each study uses Bupropion is read from its arms, and is right about nine times in ten.
Testing it · 215
- The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.Not yet recruitingPhase 2Washington University School of MedicineNCT07810738Written as Bupropion Augmentation
- Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)RecruitingPhase 3Axsome Therapeutics, Inc.NCT07766655Written as Bupropion
- Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive DisorderNot yet recruitingPhase 4Bausch Health Americas, Inc.NCT02129751Written as bupropion hydrobromide
- Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic RiskNot yet recruitingPhase 3Uppsala UniversityNCT07806279Written as Bupropion 150 mg
- Bupropion for Fatigue in End-stage Kidney Disease Patients on HemodialysisNot yet recruitingPhase 1/2The University of Texas Health Science Center at San AntonioNCT06609343Written as Bupropion Hydrochloride 150 MG
- A Phase 1, First-in-human Study of VX-433RecruitingPhase 1Vertex Pharmaceuticals IncorporatedNCT07584434Written as Bupropion
- Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)Enrolling by invitationPhase 4Carmen DietvorstNCT06845345Written as Mysimba
- Individualized Pharmacological Approach to Obesity in Patients With Bipolar DisorderRecruitingPhase 4Mayo ClinicNCT07213466Written as naltrexone and bupropion (combination)
- Improving Smoking Abstinence Outcomes in the African American Community Through Extended TreatmentRecruitingPhase 3University of Kansas Medical CenterNCT05732272Written as Bupropion
- Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureRecruitingPhase 3Dr. Inge WinterNCT05603104Written as Bupropion
- The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.RecruitingPhase 3Dr. Inge WinterNCT05973786Written as Bupropion
- Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release TabletRecruitingPhase 4Laval UniversityNCT06620562Written as Naltrexone/Bupropion
- Effectiveness of Combined Tobacco Treatment in Hospitalized SubjectsRecruitingPhase 4National Institute of Respiratory Diseases, MexicoNCT06254001Written as Bupropion
- Combination of Novel Therapies for CKD Comorbid DepressionActive, not recruitingPhase 2Stony Brook UniversityNCT04422652Written as Bupropion
- Bupropion for the Prevention of Postpartum Smoking RelapseCompletedPhase 4University of MinnesotaNCT04098874Written as Bupropion Extended Release Oral Tablet
- Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use DisorderActive, not recruitingPhase 3National Institute on Drug Abuse (NIDA)NCT06233799Written as extended release bupropion (BUP-XL) tablets (BUP-XL)
- Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic CancerCompletedPhase 2NRG OncologyNCT03180294Written as Bupropion 150 mg XL
- Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic PancreatitisWithdrawnPhase 2Mayo ClinicNCT07171112Written as Bupropion 150 mg twice daily
- Predictors of Cognitive Outcomes in Geriatric DepressionActive, not recruitingPhase 4David SteffensNCT05273996Written as Sertraline, bupropion, desvenlafaxine
- A Study in Healthy Men and Women to Test Whether BI 1569912 Influences the Amount of Repaglinide, Midazolam and Bupropion in the BloodCompletedPhase 1Boehringer IngelheimNCT06367153Written as Bupropion
See all 215 studies that test Bupropion →
Given in every arm · 26 — Bupropion is usual care beside what is tested
- A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination TherapyRecruitingPhase 3Hoffmann-La RocheNCT05646862Written as Bupropion
- Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation TrialNot yet recruitingPhase 4Yale UniversityNCT07835555Written as nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion
- BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire DisorderNot yet recruitingPhase 1/2University of Illinois at ChicagoNCT07596212Written as Bupropion
- Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing HomelessnessNot yet recruitingNot applicableVA Office of Research and DevelopmentNCT07714200Written as Bupropion
- Safety and PK Study of BICX104 With or Without Bupropion Compared to VivitrolRecruitingPhase 1BioCorRx Pharmaceuticals IncNCT07269873Written as Bupropion 150 mg XL
- PARQuit Smoking Cessation Intervention for Adults With Serious Mental IllnessCompletedPhase 4University of California, San FranciscoNCT03950427Written as Bupropion
- CPT-SMART for Treatment of PTSD and Cigarette SmokingCompletedPhase 4VA Office of Research and DevelopmentNCT03978442Written as Bupropion
- Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSDCompletedNot applicableDuke UniversityNCT01990079Written as Bupropion
- Metabolism-informed Care for Smoking CessationCompletedNot applicableVanderbilt University Medical CenterNCT03227679Written as Bupropion
- A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant DepressionWithdrawnPhase 3Janssen-Cilag International NVNCT03852160Written as Bupropion
- Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy ParticipantsCompletedPhase 1Alexion Pharmaceuticals, Inc.NCT04526210Written as Bupropion Hydrochloride
- Individualized Obesity PharmacotherapyCompletedPhase 3Mayo ClinicNCT03374956Written as Naltrexone/bupropion
- Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and ZybanTerminatedPhase 4Yale UniversityNCT00511134Written as Bupropion
- Abstinence Reinforcement Therapy (ART) for Homeless Veteran SmokersCompletedPhase 4VA Office of Research and DevelopmentNCT02245308Written as Bupropion
- Connectivity Affecting the Antidepressant REsponse StudyCompletedPhase 4Vanderbilt University Medical CenterNCT02332291Written as Bupropion XL
- Smoking Cessation for People Living With HIV/AIDSStatus unknownNot applicableWayne State UniversityNCT01965405Written as Bupropion
- Mobile Contingency Management for Concurrent Abstinence From Alcohol and SmokingCompletedPhase 4Duke UniversityNCT02995915Written as Bupropion
- Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight GainCompletedPhase 1/2Yale UniversityNCT00129246Written as Bupropion
- Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in SchizophreniaTerminatedPhase 2Yale UniversityNCT03132571Written as Bupropion
- Tailored Tobacco Quitline for Rural VeteransCompletedPhase 2Iowa City Veterans Affairs Medical CenterNCT01592695Written as Bupropion Sustained Release
Showing 20 of 26.
As the comparator · 11 — what is tested is compared with Bupropion
- A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive SymptomsRecruitingPhase 4Axsome Therapeutics, Inc.NCT06223880Written as Bupropion
- A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in AmericaCompletedPhase 4Novo Nordisk A/SNCT05579249Written as Naltrexone/Bupropion
- Addressing Dementia Via Agitation-Centered EvaluationCompletedPhase 2/3Axsome Therapeutics, Inc.NCT03226522Written as Bupropion
- AXS-05 Phase II Trial on Smoking BehaviorCompletedPhase 2James DavisNCT03471767Written as Bupropion SR
- Assessing Symptomatic Clinical Episodes in DepressionCompletedPhase 2Axsome Therapeutics, Inc.NCT03595579Written as Bupropion
- An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent PatientsStatus unknownPhase 2Axsome Therapeutics, Inc.NCT04971291Written as Bupropion SR
- A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive DisorderCompletedPhase 3Axsome Therapeutics, Inc.NCT02741791Written as Bupropion
- Leveraging EEG for Antidepressant Prediction With Duloxetine and BupropionWithdrawnPhase 4Alto NeuroscienceNCT04388189Written as Bupropion
- Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder PatientsTerminatedPhase 4Ministry of Health & Welfare, KoreaNCT00926835Written as Paroxetine+Bupropion
- Varenicline and Smoking Cessation in SchizophreniaCompletedPhase 2University of MinnesotaNCT01111149Written as Bupropion HCl
- Algorithm Guided Treatment Strategies for Major Depressive DisorderStatus unknownPhase 4Shanghai Mental Health CenterNCT01764867Written as Bupropion
Codes
What other systems call Bupropion · ClinicalTrials.gg INT008536
- MeSH (NLM) D016642BupropionConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 01ZG3TPX31BUPROPIONConfirmed FDA, NLM, Wikidata
- RxNorm 42347Confirmed FDA, Wikidata
- Wikidata Q834280bupropionConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62012BupropionOne source FDA
- DrugBank DB01156One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D016642 | Bupropion | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 01ZG3TPX31 | BUPROPION | Confirmed FDA, NLM, Wikidata |
| RxNorm | 42347 | — | Confirmed FDA, Wikidata |
| Wikidata | Q834280 | bupropion | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62012 | Bupropion | One source FDA |
| DrugBank | DB01156 | — | One source Wikidata |
Also registered as bupropion hydrochloride (UNII ZG7E5POY8O · RxNorm 203204).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.