DrugSupplement
Melatonin clinical trials
Also written Circadin.
- studies test it
- 395
- open now
- 75
- in phase 3
- 81
- first study started
- 1995
Keep track of what changes. Save the Melatonin studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
- Circadin
- 21
Studies by the year they started
391 studies that test it; most in 2025 (34)
| Year | Studies |
|---|---|
| 1995 | 1 |
| 1996 | 1 |
| 1997 | 2 |
| 1998 | 1 |
| 2002 | 2 |
| 2004 | 6 |
| 2005 | 4 |
| 2006 | 5 |
| 2007 | 8 |
| 2008 | 10 |
| 2009 | 8 |
| 2010 | 10 |
| 2011 | 7 |
| 2012 | 18 |
| 2013 | 14 |
| 2014 | 14 |
| 2015 | 23 |
| 2016 | 28 |
| 2017 | 15 |
| 2018 | 20 |
| 2019 | 23 |
| 2020 | 16 |
| 2021 | 26 |
| 2022 | 26 |
| 2023 | 26 |
| 2024 | 23 |
| 2025 | 34 |
| 2026 | 20 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 21
- Phase 1
- 40
- Phase 2
- 130
- Phase 3
- 81
- Phase 4
- 52
- No phase
- 119
What it is tested for
Each study’s main condition, where its own words name it.
- Delirium
- 13
Who runs them
Industry 17 · Other 378
Ain Shams University (20) · Tanta University (11) · Brigham and Women's Hospital (8) · Cairo University (8) · Oregon Health and Science University (7) · Neurim Pharmaceuticals Ltd. (7) · M.D. Anderson Cancer Center (5) · Benha University (5)
Often tested with
Tested in the same studies.
Dexmedetomidine (5) · Metformin (5) · Chloral Hydrate (4) · Pregabalin (4) · Diphenhydramine (3) · Ascorbic Acid (3) · Hydroxyzine (3) · Inositol (3)
Studies
Open first, then newest update. How each study uses Melatonin is read from its arms, and is right about nine times in ten.
Testing it · 395
- Effect of Melatonin on Pulmonary Hypertension in Full Term NeonatesRecruitingNot applicableAin Shams UniversityNCT07850934Written as Melatonin
- Melatonin and Immunonutrition for Pain Relief in FibromyalgiaRecruitingNot applicableUniversity of ThessalyNCT07863232Written as Melatonin 1mg and intravenous B-complex vitamin drip
- Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic CholecystectomyRecruitingNot applicableArmed Forces Medical Institute BangladeshNCT07553143Written as Melatonin (N-acetyl-5-methoxytryptamine)
- Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in AgingRecruitingNot applicableNatalie DenburgNCT03954899Written as melatonin
- Efficacy of CBT-I With Adjuvant Melatonin in Older Adults Chronic InsomniaRecruitingNot applicableThe University of Hong KongNCT07695246Written as Melatonin 3 mg immediate-release
- MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in ChildrenRecruitingPhase 3Arash AfshariNCT05541276Written as Melatonin
- Efficacy of Melatonin Treatment on Sleep Quality Improvement in Inflammatory Bowel Disease Patients With Clinical RemissionRecruitingPhase 4Mahidol UniversityNCT07737665Written as Melatonin ("Circadin")
- Preventive Role of Melatonin and Propranolol Administration in Pediatric MigraineEnrolling by invitationNot applicableNishtar Medical UniversityNCT07743255Written as Melatonin
- Sleep Quality and the Efficacy of a Multimodal Sleep Pathway in Hospitalized Orthopedic Trauma PatientsRecruitingPhase 3Emory UniversityNCT07336277Written as Melatonin
- Comparison Between the Effect of Two Different Doses of Oral Melatonin on Sleep Quality After Total Hip ArthroplastyNot yet recruitingEarly Phase 1Benha UniversityNCT07732725Written as Melatonin 5 MG
- Affect of Melatonin on Sleep and Cognition in CirrhosisRecruitingNot applicableWeill Medical College of Cornell UniversityNCT07046429Written as Melatonin tablet 3 mg once daily
- Effect of Melatonin Administration on Systemic Lupus Erythematosus PatientsNot yet recruitingPhase 2/3Ain Shams UniversityNCT07721324Written as Melatonin
- Effect of Melatonin in Patients With Diabetic Peripheral NeuropathyRecruitingPhase 2Ain Shams UniversityNCT07036796Written as Melatonin
- Melatonin for Post Tonsillectomy Emergence Agitation in PediatricRecruitingNot applicableBenha UniversityNCT07375342Written as Melatonin
- Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICUNot yet recruitingPhase 4Rutgers, The State University of New JerseyNCT07691996Written as Melatonin
- Melatonin Adolescent Research StudyRecruitingNot applicableLoma Linda UniversityNCT04588233Written as Melatonin
- Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing HypothermiaRecruitingEarly Phase 1University of FloridaNCT02621944Written as Melatonin
- COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONENot yet recruitingPhase 3University of Child Health Sciences and Children's Hospital, LahoreNCT07652801Written as Melatonin , Mgso4
- The Basel BOMP-AID Randomized TrialRecruitingPhase 4University Hospital, Basel, SwitzerlandNCT03438526Written as Melatonin (Circadin ®)
- Melatonin and Solifenacin for Double-J Ureteral Stent SymptomsRecruitingPhase 2Beni-Suef UniversityNCT07617922Written as Melatonin
See all 395 studies that test Melatonin →
Given in every arm · 5 — Melatonin is usual care beside what is tested
- Oral Melatonin as Adjunctive Therapy in Adults With Atopic DermatitisNot yet recruitingNot applicableCan Tho University of Medicine and PharmacyNCT07842900Written as Melatonin
- The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase DisorderCompletedPhase 3University of MichiganNCT03715465Written as Melatonin 0.5 MG
- Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19CompletedNot applicableUnidad Temporal COVID-19 en Centro CitibanamexNCT04570254Written as Melatonin
- Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy VolunteersCompletedPhase 1BiogenNCT02691702Written as Melatonin
- The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy SubjectsCompletedNot applicableTehran University of Medical SciencesNCT02463318Written as Melatonin
As the comparator · 9 — what is tested is compared with Melatonin
- Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary InsomniaRecruitingNot applicableCMH Kharian Medical CollegeNCT06996171Written as Melatonin
- Improving Sleep of Children With Neurodevelopmental Disorders: Pulsed Current Stimulation Versus MelatoninRecruitingNot applicableKK Women's and Children's HospitalNCT06236191Written as Melatonin
- Somato® (Phytomelatonin) Versus Synthetic Melatonin and Placebo on Sleep QualityCompletedNot applicableNutraland USA, Inc.NCT07669766Written as Melatonin
- The Effectiveness of a Proprietary of a Botanical Extract on Sleep QualityCompletedNot applicableNutraceuticals Research InstituteNCT06894108Written as Melatonin
- The Impact of Air Travel on Passenger Cognitive FunctionsStatus unknownPhase 2/3Dinara ZhumanbayevaNCT04802785Written as Melatonin 5 mg
- Melatonin for Prevention of Post Stroke DeliriumStatus unknownPhase 2/3University Hospital TuebingenNCT04122599Written as Melatonin
- Honey to Improve Sleep Quality: a Feasibility StudyCompletedNot applicableUniversity of SaskatchewanNCT03567395Written as Melatonin
- Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.Status unknownPhase 2Hospital de Clinicas de Porto AlegreNCT02195271Written as Melatonin
- Assessment of the Pharmacokinetics of Circadin® in Children With Neurodevelopmental Disorders and Sleep DisturbancesCompletedPhase 1Neurim Pharmaceuticals Ltd.NCT01903681Written as Circadin 2 mg
Codes
What other systems call Melatonin · ClinicalTrials.gg INT007782
- MeSH (NLM) D008550MelatoninConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) JL5DK93RCLMELATONINConfirmed FDA, NLM, Wikidata
- RxNorm 6711Confirmed FDA, Wikidata
- Wikidata Q180912melatoninConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C632Therapeutic MelatoninOne source FDA
- DrugBank DB01065One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008550 | Melatonin | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | JL5DK93RCL | MELATONIN | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6711 | — | Confirmed FDA, Wikidata |
| Wikidata | Q180912 | melatonin | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C632 | Therapeutic Melatonin | One source FDA |
| DrugBank | DB01065 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.